Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth

Cellular survival: a play in three Akts

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Oncogenic kinase signalling.

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Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Fulton, D. J., Gratton, J., McCabe, T. J. D., Fontana, J. T., Fujio, Y., Walsh, K. X., Franke, T. F., Papapetropoulos, A., & Sessa, W. C. (1999) · Nature · doi:10.1038/21218 · Cited by 2,616

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

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The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

Kureishi, Y., Luo, Z., Shiojima, I., Bialik, A., Fulton, D. J., Lefer, D. J., Sessa, W. C., & Walsh, K. X. (2000) · Nature Medicine · doi:10.1038/79510 · Cited by 1,438

Placental development: Lessons from mouse mutants

Rossant, J., & Cross, J. C. (2001) · Nature Reviews Genetics · doi:10.1038/35080570 · Cited by 1,299

Akt regulates growth by directly phosphorylating Tsc2

Potter, C. J., Pedraza, L. G., & Xu, T. (2002) · Nature Cell Biology · doi:10.1038/ncb840 · Cited by 959

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F., & Birnbaum, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100462200 · Cited by 959

Defining the role of mTOR in cancer

Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833

Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

Hennessy, B. T., Smith, D. L., Ram, P. T., Lu, Y., & Mills, G. B. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1902 · Cited by 2,214

Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

Wee, P., & Wang, Z. (2017) · Cancers · doi:10.3390/cancers9050052 · Cited by 2,027

Akt signalling in health and disease

Hers, I., Vincent, E. E., & Tavaré, J. M. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.05.004 · Cited by 1,268

Advances in protein kinase B signalling: AKTion on multiple fronts

Brazil, D. P., Yang, Z., & Hemmings, B. A. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.03.006 · Cited by 840

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

Schiaffino, S., & Mammucari, C. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-4 · Cited by 816

The two TORCs and Akt

Bhaskar, P. T., & Hay, N. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.020 · Cited by 798

Structure, regulation and function of PKB/AKT—a major therapeutic target

Hanada, M., Feng, J., & Hemmings, B. A. (2003) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2003.11.009 · Cited by 739

Placental Origins of Chronic Disease

Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

Arranz, A., Doxaki, C., Vergadi, E., de la Torre, Y. M., Vaporidi, K., Lagoudaki, E. D., Ieronymaki, E., Androulidaki, A., Venihaki, M., Margioris, A. N., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119038109 · Cited by 605

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial–mesenchymal transition

Irie, H. Y., Pearline, R. V., Grueneberg, D. A., Hsia, M., Ravichandran, P., Kothari, N. H., Natesan, S., & Brugge, J. S. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505087 · Cited by 582

Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis

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Development of Structures and Transport Functions in the Mouse Placenta

Watson, E. D., & Cross, J. C. (2005) · Physiology · doi:10.1152/physiol.00001.2005 · Cited by 580

Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size

Easton, R., Cho, H., Roovers, K., Shineman, D. W., Mizrahi, M., Forman, M. S., Lee, V. M. ‐., Szabolcs, M. J., de Jong, R., Oltersdorf, T., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1869-1878.2005 · Cited by 551

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

Schultze, S. M., Hemmings, B. A., Nießen, M., & Tschopp, O. (2012) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411002109 · Cited by 553

Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia

Burton, G. J., Yung, H.-W., Cindrova-Davies, T., & Charnock-Jones, D. S. (2009) · Placenta · doi:10.1016/j.placenta.2008.11.003 · Cited by 502

Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in glucose homeostasis

Tschopp, O., Yang, Z.-Z., Brodbeck, D., Dummler, B. A., Hemmings-Mieszczak, M., Watanabe, T., Michaelis, T., Frahm, J., & Hemmings, B. A. (2005) · Development · doi:10.1242/dev.01864 · Cited by 426

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

Yung, H.-W., Calabrese, S., Hynx, D., Hemmings, B. A., Cetin, I., Charnock-Jones, D. S., & Burton, G. J. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.071193 · Cited by 388

Akt1/protein kinase B is critical for ischemic and VEGF-mediated angiogenesis

Ackah, E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24726 · Cited by 386

Determinants of trophoblast lineage and cell subtype specification in the mouse placenta

Simmons, D. G., & Cross, J. C. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.05.010 · Cited by 365

Protein kinase B/Akt at a glance

Fayard, E., Tintignac, L. A. J., Baudry, A., & Hemmings, B. A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02724 · Cited by 336

Critical growth factors and signalling pathways controlling human trophoblast invasion

Knfler, M. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082769mk · Cited by 330

The conditional inactivation of the β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility

Cattelino, A., Liebner, S., Gallini, R., Zanetti, A., Balconi, G., Corsi, A., Bianco, P., Wolburg, H., Moore, R. H., Boussadia, O., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212157 · Cited by 323

Physiological roles of PKB/Akt isoforms in development and disease

Dummler, B., & Hemmings, B. A. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350231 · Cited by 316

The influence of the intrauterine environment on human placental development

Burton, G. J., Jauniaux, E., & Charnock-Jones, D. S. (2010) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082764gb · Cited by 307

Stabilization of Mdm2 via Decreased Ubiquitination Is Mediated by Protein Kinase B/Akt-dependent Phosphorylation

Feng, J., Tamaskovic, R., Yang, Z., Brazil, D. P., Merlo, A., Hess, D., & Hemmings, B. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404936200 · Cited by 294

Akt1 in Endothelial Cell and Angiogenesis

Somanath, P. R., Razorenova, O. V., Chen, J., & Byzova, T. V. (2006) · Cell Cycle · doi:10.4161/cc.5.5.2538 · Cited by 298

Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies

Dummler, B. A., Tschopp, O., Hynx, D., Yang, Z., Dirnhofer, S., & Hemmings, B. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00722-06 · Cited by 293

The PKB/AKT Pathway in Cancer

Carnero, A. (2009) · Current Pharmaceutical Design · doi:10.2174/138161210789941865 · Cited by 273

Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt

Matsui, T., & Rosenzweig, A. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.11.005 · Cited by 264

Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling

Kawamura, N., Kugimiya, F., Oshima, Y., Ohba, S., Ikeda, T., Saito, T., Shinoda, Y., Kawasaki, Y., Ogata, N., Hoshi, K., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001058 · Cited by 259

Protein Kinase B (PKB/Akt), a Key Mediator of the PI3K Signaling Pathway

Fayard, E., Xue, G., Parcellier, A., Bozulic, L., & Hemmings, B. A. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_58 · Cited by 250

Regulation of Placental Angiogenesis

Chen, D., & Zheng, J. J. (2013) · Microcirculation · doi:10.1111/micc.12093 · Cited by 256

Origin and characteristics of glycogen cells in the developing murine placenta

Coan, P. M., Conroy, N., Burton, G. J., & Ferguson‐Smith, A. C. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20981 · Cited by 243

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

Nagoshi, T., Matsui, T., Aoyama, T., Leri, A., Anversa, P., Li, L., Ogawa, W., del Monte, F., Gwathmey, J. K., Grazette, L. P., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23073 · Cited by 229

Imprinted genes in the placenta – A review

Coan, P. M., Burton, G. J., & Ferguson‐Smith, A. C. (2005) · Placenta · doi:10.1016/j.placenta.2004.12.009 · Cited by 238

Genetic insights into the mechanisms of Fgf signalingPreprint

Brewer, J. R., Mazot, P., & Soriano, P. M. (2016) · Genes & Development · doi:10.1101/gad.277137.115 · Cited by 230

Dosage-Dependent Effects of Akt1/Protein Kinase Bα (PKBα) and Akt3/PKBγ on Thymus, Skin, and Cardiovascular and Nervous System Development in Mice

Yang, Z., Tschopp, O., Di‐Poï, N., Bruder, E., Baudry, A., Dummler, B. A., Wahli, W., & Hemmings, B. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10407-10418.2005 · Cited by 219

IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro

Kaneshiro, S., Ebina, K., Shi, K., Higuchi, C., Hirao, M., OKAMOTO, M. T., Koizumi, K., Morimoto, T., Yoshikawa, H., & Hashi­moto, J. (2013) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-013-0514-1 · Cited by 225

Role of nitric oxide in placental vascular development and function

Krause, B. J., Hanson, M. A., & Casanello, P. C. (2011) · Placenta · doi:10.1016/j.placenta.2011.06.025 · Cited by 220

The Loss of Glypican-3 Induces Alterations in Wnt Signaling

Song, H. H., Shi, W., Xiang, Y., & Filmus, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410090200 · Cited by 222

Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin

Kitamura, T., Asai, N., Enomoto, A., Maeda, K., Kato, T., Ishida, M., Jiang, P., Watanabe, T., Usukura, J., Kondo, T., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1695 · Cited by 211

Differentiation of Trophoblast Giant Cells and Their Metabolic Functions Are Dependent on Peroxisome Proliferator-Activated Receptor β/δ

Nadra, K., Anghel, S. I., Joye, E., Tan, N. S., Modak, S. B., Trono, D., Wahli, W., & Desvergne, B. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.3266-3281.2006 · Cited by 199

Cell Signaling Pathways Involved During Invasion and Syncytialization of Trophoblast Cells

Sk, G., Malhotra, S. S., Malik, A., Verma, S., & Chaudhary, P. (2015) · American Journal of Reproductive Immunology · doi:10.1111/aji.12436 · Cited by 196

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

Lorenzo, A. D., Fernandez-Hernando, C. F., Cirino, G., & Sessa, W. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904073106 · Cited by 191

Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses

Matsuda, S., Ikeda, Y., Murakami, M., Nakagawa, Y., Tsuji, A., & Kitagishi, Y. (2019) · Diseases · doi:10.3390/diseases7010022 · Cited by 196

Insulin-like growth factor I and II regulate the life cycle of trophoblast in the developing human placenta

Forbes, K. A., Westwood, M., Baker, P. N., & Aplin, J. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00035.2008 · Cited by 187

Placental phenotype and the insulin‐like growth factors: resource allocation to fetal growth

Sferruzzi-Perri, A. N., Sandovici, I., Constância, M., & Fowden, A. L. (2017) · The Journal of Physiology · doi:10.1113/jp273330 · Cited by 185

Only Akt1 Is Required for Proliferation, while Akt2 Promotes Cell Cycle Exit through p21 Binding

Héron‐Milhavet, L., Franckhauser, C., Rana, V., Berthenet, C., Fisher, D., Hemmings, B. A., Fernandez, A., & Lamb, N. J. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00201-06 · Cited by 176

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

Lee, M. Y., Luciano, A. K., Ackah, E., Rodríguez‐Vita, J., Bancroft, T. A., Eichmann, A., Simons, M., Kyriakides, T. R., Morales‐Ruiz, M., & Sessa, W. C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408472111 · Cited by 174

Maternal Protein Restriction in the Rat Inhibits Placental Insulin, mTOR, and STAT3 Signaling and Down-Regulates Placental Amino Acid Transporters

Rosario, F. J., Jansson, N., Kanai, Y., Prasad, P. D., Powell, T. L., & Jansson, T. (2011) · Endocrinology · doi:10.1210/en.2010-1153 · Cited by 176

The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo

Riley, J. K., Carayannopoulos, M. O., Wyman, A., Chi, M. M.-Y., Ratajczak, C. K., & Moley, K. H. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.05.033 · Cited by 173

Mapping of Deletion and Translocation Breakpoints in 1q44 Implicates the Serine/Threonine Kinase AKT3 in Postnatal Microcephaly and Agenesis of the Corpus Callosum

Boland, E., Clayton‐Smith, J., Woo, V. G. H., McKee, S. A., Manson, F. D. C., Medne, L., Zackai, E. H., Swanson, E. A., FitzPatrick, D. R., Millen, K. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519999 · Cited by 168

Regulation and Function of Protein Kinases and Phosphatases

Cheng, H., Qi, R. Z., Paudel, H. K., & Zhu, H. (2011) · Enzyme Research · doi:10.4061/2011/794089 · Cited by 179

The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis

Jaiswal, N., Gavin, M. G., Quinn, W. J., Luongo, T. S., Gelfer, R. G., Baur, J. A., & Titchenell, P. M. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.001 · Cited by 167

Cell survival and metastasis regulation by Akt signaling in colorectal cancer

Agarwal, E., Brattain, M. G., & Chowdhury, S. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.03.025 · Cited by 164

The IGF Axis and Placental Function

Forbes, K. A., & Westwood, M. (2008) · Hormone Research in Paediatrics · doi:10.1159/000112585 · Cited by 164

Differential activation of placental unfolded protein response pathways implies heterogeneity in causation of early‐ and late‐onset pre‐eclampsia

Yung, H. W., Atkinson, D., Campion‐Smith, T., Olovsson, M., Charnock‐Jones, D. S., & Burton, G. J. (2014) · The Journal of Pathology · doi:10.1002/path.4394 · Cited by 156

Endothelial FAK is required for tumour angiogenesis

Tavora, B., Batista, S., Reynolds, L. E., Jadeja, S., Robinson, S. D., Kostourou, V., Hart, I. R., Fruttiger, M., Parsons, M., & Hodivala‐Dilke, K. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000106 · Cited by 154

p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK

Boehme, K. A., Kulikov, R., & Blattner, C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703423105 · Cited by 152

Rapamycin Promotes Vascular Smooth Muscle Cell Differentiation through Insulin Receptor Substrate-1/Phosphatidylinositol 3-Kinase/Akt2 Feedback Signaling

Martin, K. A., Merenick, B. L., Ding, M., Fetalvero, K. M., Rzucidlo, E. M., Kozul, C. D., Brown, D. J., Chiu, H. Y., Shyu, M., Drapeau, B. L., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703914200 · Cited by 149

Calcineurin Signaling Regulates Human Islet β-Cell Survival

Soleimanpour, S. A., Crutchlow, M. F., Ferrari, A., Raum, J. C., Groff, D., Rankin, M. M., Liu, C., León, D. D. D., Naji, A., Kushner, J. A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.154955 · Cited by 145

Protein kinase B: signalling roles and therapeutic targeting

Sale, E. M., & Sale, G. J. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7274-9 · Cited by 148

Maternal growth factor regulation of human placental development and fetal growth

Forbes, K. A., & Westwood, M. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0174 · Cited by 151

The ARE‐dependent mRNA‐destabilizing activity of BRF1 is regulated by protein kinase B

Schmidlin, M., Lu, M., Leuenberger, S. A., Stoecklin, G., Mallaun, M., Gross, B., Gherzi, R., Heß, D., Hemmings, B. A., & Moroni, C. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600477 · Cited by 138

Gα i1 and Gα i3 Are Required for Epidermal Growth Factor–Mediated Activation of the Akt-mTORC1 Pathway

Cao, C., Huang, X., Han, Y., Wan, Y., Birnbaumer, L., Feng, G. S., Marshall, J. J., Jiang, M., & Chu, W. (2009) · Science Signaling · doi:10.1126/scisignal.2000118 · Cited by 137

Akt1 and Akt2 are required for αβ thymocyte survival and differentiation

Juntilla, M. M., Wofford, J. A., Birnbaum, M. J., Rathmell, J. C., & Koretzky, G. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705285104 · Cited by 146

Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia

Burton, G. J., & Yung, H. W. (2010) · Pregnancy Hypertension · doi:10.1016/j.preghy.2010.12.002 · Cited by 133

Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients

Huang, Z., Huang, S., Song, T., Yin, Y., & Tan, C. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab070 · Cited by 138

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

Bayascas, J. R., Wullschleger, S., Sakamoto, K., García‐Martínez, J. M., Clacher, C., Komander, D., van Aalten, D. M. F., Boini, K. M., Lang, F. J. W., Lipina, C., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02032-07 · Cited by 136

Cytotrophoblast, Not Syncytiotrophoblast, Dominates Glycolysis and Oxidative Phosphorylation in Human Term Placenta

Kolahi, K. S., Valent, A. M., & Thornburg, K. L. R. (2017) · Scientific Reports · doi:10.1038/srep42941 · Cited by 130

Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway

Ain, R., Kent, L. N., & Soares, M. J. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06039 · Cited by 124

Adiponectin Inhibits Osteoclastogenesis and Bone Resorption via APPL1-mediated Suppression of Akt1

Tu, Q., Zhang, J., Dong, L., Saunders, E., Luo, E., Tang, J., & Chen, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152405 · Cited by 122

Genetic inactivation of AKT1 , AKT2 , and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

Ericson, K., Gan, C. M., Cheong, I., Rago, C., Samuels, Y., Velculescu, V. E., Kinzler, K. W., Huso, D. L., Vogelstein, B., & Papadopoulos, N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914018107 · Cited by 122

Akt Pathway Inhibitors

Uko, N. E., Güner, O. F., Matesic, D. F., & Bowen, J. P. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200224101808 · Cited by 125

Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non‐native women at high altitude

Yung, H. W., Cox, M., van Patot, M. T., & Burton, G. J. (2012) · The FASEB Journal · doi:10.1096/fj.11-190082 · Cited by 112

Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta

Withington, S. L., Scott, A., Saunders, D. N., Floro, K. L., Preis, J. I., Michalicek, J., Maclean, K., Sparrow, D. B., Martínez-Barberá, J. P., & Dunwoodie, S. L. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.02.025 · Cited by 113

Potential role of Akt signaling in chronic kidney disease

Lan, A., & Du, J. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu196 · Cited by 108

Suppression of survival signalling pathways by the phosphatase PHLPP

O’Neill, A., Niederst, M. J., & Newton, A. C. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08537.x · Cited by 107

Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development

Zhou, F., Chang, Z., Zhang, L., Hong, Y., Shen, B., Wang, B., Zhang, F., Lu, G., Tvorogov, D., Alitalo, K. K., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091301 · Cited by 104

Targeting the Akt Kinase to Modulate Survival, Invasiveness and Drug Resistance of Cancer Cells

Cassinelli, G., Zuco, V., Gatti, L., Lanzi, C., Zaffaroni, N., Colombo, D., & Perego, P. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990106 · Cited by 104

Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases

Rodgers, S. J., Ferguson, D. T., Mitchell, C. A., & Ooms, L. M. (2017) · Bioscience Reports · doi:10.1042/bsr20160432 · Cited by 105

Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy

Higgins, J., Vaughan, O. R., de Liger, E. F., Fowden, A. L., & Sferruzzi-Perri, A. N. (2015) · The Journal of Physiology · doi:10.1113/jp271057 · Cited by 104

SGK1

Cristofano, A. D. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.11.006 · Cited by 108

The role of Akt1 in terminal stages of endochondral bone formation: Angiogenesis and ossification

Ulici, V., Hoenselaar, K. D., Agoston, H., McErlain, D. D., Umoh, J. U., Chakrabarti, S., Holdsworth, D. W., & Beier, F. (2009) · Bone · doi:10.1016/j.bone.2009.08.003 · Cited by 101

Nonredundant Role of Akt2 for Neuroprotection of Rod Photoreceptor Cells from Light-Induced Cell Death

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