The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Certain Metals Trigger Fibrillation of Methionine-oxidized α-Synuclein
Open accessAbstract
The aggregation and fibrillation of alpha-synuclein has been implicated as a key step in the etiology of Parkinson's disease and several other neurodegenerative disorders. In addition, oxidative stress and certain environmental factors, including metals, are believed to play an important role in Parkinson's disease. Previously, we have shown that methionine-oxidized human alpha-synuclein does not fibrillate and also inhibits fibrillation of unmodified alpha-synuclein (Uversky, V. N., Yamin, G., Souillac, P. O., Goers, J., Glaser, C. B., and Fink, A. L. (2002) FEBS Lett. 517, 239-244). Using dynamic light scattering, we show that the inhibition results from stabilization of the monomeric form of Met-oxidized alpha-synuclein. We have now examined the effect of several metals on the structural properties of methionine-oxidized human alpha-synuclein and its propensity to fibrillate. The presence of metals induced partial folding of both oxidized and non-oxidized alpha-synucleins, which are intrinsically unstructured under conditions of neutral pH. Although the fibrillation of alpha-synuclein was completely inhibited by methionine oxidation, the presence of certain metals (Ti3+, Zn2+, Al3+, and Pb2+) overcame this inhibition. These findings indicate that a combination of oxidative stress and environmental metal pollution could play an important role in triggering the fibrillation of alpha-synuclein and thus possibly Parkinson's disease.
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AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
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Evidence for a Partially Folded Intermediate in α-Synuclein Fibril Formation
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Self-citationImmunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.
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Protein Nitration in Parkinsonʼs Disease
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Neurodegenerative diseases and oxidative stress
Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
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Metals in Alzheimer's and Parkinson's Diseases
Barnham, K. J., & Bush, A. I. (2008) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2008.02.019 · Cited by 695
α-Synuclein misfolding and Parkinson's disease
Breydo, L., Wu, J. W., & Uversky, V. N. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.002 · Cited by 657
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Metadata
- Authors
- Yamin, G., Glaser, C. B., Uversky, V. N., & Fink, A. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 278
- Issue
- 30
- Pages
- 27630-27635
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2001916137
- Cited by
- 178
- References
- 6
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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