The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Molecular Identification and Functional Roles of a Ca2+-activated K+ Channel in Human and Mouse Hearts
Open accessAbstract
The repolarization phase of cardiac action potential is prone to aberrant excitation that is common in cardiac patients. Here, we demonstrate that this phase is markedly sensitive to Ca2+ because of the surprising existence of a Ca2+-activated K+ currents in cardiac cells. The current was revealed using recording conditions that preserved endogenous Ca2+ buffers. The Ca2+-activated K+ current is expressed differentially in atria compared with ventricles. Because of the significant contribution of the current toward membrane repolarization in cardiac myocytes, alterations of the current magnitude precipitate abnormal action potential profiles. We confirmed the presence of a small conductance Ca2+-activated K+ channel subtype (SK2) in human and mouse cardiac myocytes using Western blot analysis and reverse transcription-polymerase chain reaction and have cloned SK2 channels from human atria, mouse atria, and ventricles. Because of the marked differential expression of SK2 channels in the heart, specific ligands for Ca2+-activated K+ currents may offer a unique therapeutic opportunity to modify atrial cells without interfering with ventricular myocytes.
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Cited by
Pathophysiological mechanisms of atrial fibrillation: a translational appraisal
Schotten, U., Verheule, S., Kirchhof, P., & Goette, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2009 · Cited by 1,273
Common variants in KCNN3 are associated with lone atrial fibrillation
Ellinor, P. T., Lunetta, K. L., Glazer, N. L., Pfeufer, A., Alonso, A., Chung, M. K., Sinner, M. F., de Bakker, P. I. W., Mueller, M., Lubitz, S. A., et al. (2010) · Nature Genetics · doi:10.1038/ng.537 · Cited by 485
Molecular Architecture of the Human Sinus Node: Insights Into the Function of the Cardiac Pacemaker
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Antiarrhythmic therapy in atrial fibrillation
Ravens, U. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.06.004 · Cited by 48
Metadata
- Authors
- Xu, Y., Tuteja, D., Zhang, Z., Xu, D., Zhang, Y., Rodriguez, J., Nie, L., Tuxson, H. R., Young, J. N., Glatter, K. A., Vázquez, A. E., Yamoah, E. N., & Chiamvimonvat, N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 278
- Issue
- 49
- Pages
- 49085-49094
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2161163873
- Cited by
- 284
- References
- 24
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Xu, Y., Tuteja, D., Zhang, Z., Xu, D., Zhang, Y., Rodriguez, J., Nie, L., Tuxson, H. R., Young, J. N., Glatter, K. A., Vázquez, A. E., Yamoah, E. N., & Chiamvimonvat, N. (2003). Molecular Identification and Functional Roles of a Ca2+-activated K+ Channel in Human and Mouse Hearts. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m307508200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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