Cited by 48Atrial Fibrillation Management and OutcomesCardiac electrophysiology and arrhythmiasCardiac Arrhythmias and Treatments

Antiarrhythmic therapy in atrial fibrillation

Ravens, Ursula·2010·Pharmacology & Therapeutics

Abstract

Currently available antiarrhythmic drugs for the management of AF are not sufficiently effective and are burdened with cardiac and extracardiac side effects that may offset their therapeutic benefits. Better knowledge about the mechanisms underlying generation and maintenance of AF may lead to the discovery of new targets for pharmacological interventions. These could include atrial-selective ion channels (e.g. atrial I(Na), I(Kur) and I(K,ACh)), pathology-selective ion channels (constitutively active I(K,ACh), TRP channels), ischemia-uncoupled gap junctions, proteins related to malfunctioning intracellular Ca2+ homeostasis (e.g., "leaky" ryanodine receptors, overactive Na+, Ca2+ exchanger) or risk factors for arrhythmias ("upstream" therapies). The review will briefly summarize the current pathophysiological and therapeutic concepts of AF. A description of recently developed antiarrhythmic drugs and their proposed pharmacological action will follow. The final section will speculate about some putative targets for antiarrhythmic drug action in the context of the remodelled atria.

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Crossref · 10.1016/j.pharmthera.2010.06.004

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Authors
Ravens, U.
Affiliations
Technische Universität Dresden (DE)
Corresponding author
Ravens, Ursula
Venue
Pharmacology & Therapeutics
Publisher
Elsevier BV
Published
2010-10
Volume
128
Issue
1
Pages
129-145
ISSN
0163-7258 (ISSN-L)
OpenAlex
W2036266917
Cited by
48
References
263
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 6 · 2012: 2
FWCI
0.80
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords
atrial fibrillation, antiarrhythmic drugs, atrial fibrillation pathophysiology, gap junctions, intracellular calcium homeostasis, ryanodine receptor, TRP channels, atrial remodeling, adverse drug reactions, upstream therapy
MeSH terms
Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Atrial Fibrillation, Clinical Trials as Topic, Heart Atria, Humans, Ion Channels, Drugs, Investigational, Gap Junctions

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