Antiarrhythmic therapy in atrial fibrillation
Abstract
Currently available antiarrhythmic drugs for the management of AF are not sufficiently effective and are burdened with cardiac and extracardiac side effects that may offset their therapeutic benefits. Better knowledge about the mechanisms underlying generation and maintenance of AF may lead to the discovery of new targets for pharmacological interventions. These could include atrial-selective ion channels (e.g. atrial I(Na), I(Kur) and I(K,ACh)), pathology-selective ion channels (constitutively active I(K,ACh), TRP channels), ischemia-uncoupled gap junctions, proteins related to malfunctioning intracellular Ca2+ homeostasis (e.g., "leaky" ryanodine receptors, overactive Na+, Ca2+ exchanger) or risk factors for arrhythmias ("upstream" therapies). The review will briefly summarize the current pathophysiological and therapeutic concepts of AF. A description of recently developed antiarrhythmic drugs and their proposed pharmacological action will follow. The final section will speculate about some putative targets for antiarrhythmic drug action in the context of the remodelled atria.
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The link between female sex and stroke might vary across populations and age groups.
“The link between female sex and stroke might vary across populations and age groups.75–84”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [76]
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Voigt, N., Rozmaritsa, N., Trausch, A., Zimniak, T., Christ, T., Wettwer, E., Matschke, K., Dobrev, D., & Ravens, U. (2009) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-009-0452-6 · Cited by 58 · see citing works
Self-citationAtrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation
Antzelevitch, C. N., & Burashnikov, A. (2009) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2009.07.007 · Cited by 58 · see citing works
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Na channels that remain open throughout the cardiac action potential plateau
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Flagged first, then by citations
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Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis
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Self-citationLoose, S., Mueller, J., Wettwer, E., Knaut, M., Ford, J., Milnes, J., & Ravens, U. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00026 · Cited by 49 · see citing works
Self-citationMechanisms of termination and prevention of atrial fibrillation by drug therapy
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Self-citationAtria-selective antiarrhythmic drugs in need of alliance partners
Peyronnet, R., & Ravens, U. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104262 · Cited by 40 · see citing works
Self-citationWalfridsson, H., Anfinsen, O.-G., Berggren, A., Frison, L., Jensen, S. M., Linhardt, G., Nordkam, A.-K., Sundqvist, M., & Carlsson, L. G. (2014) · EP Europace · doi:10.1093/europace/euu192 · Cited by 39 · see citing works
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New drugs vs. old concepts: A fresh look at antiarrhythmics
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Atrial-selective K+ channel blockers: potential antiarrhythmic drugs in atrial fibrillation?
Ravens, U. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2017-0024 · Cited by 30 · see citing works
Self-citationNovel pharmacological targets for the rhythm control management of atrial fibrillation
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- Authors
- Ravens, U.
- Affiliations
- Technische Universität Dresden (DE)
- Corresponding author
- Ravens, Ursula
- ORCID
- Ravens, Ursula
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 128
- Issue
- 1
- Pages
- 129-145
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2036266917
- Cited by
- 48
- References
- 263
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 6 · 2012: 2
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- atrial fibrillation, antiarrhythmic drugs, atrial fibrillation pathophysiology, gap junctions, intracellular calcium homeostasis, ryanodine receptor, TRP channels, atrial remodeling, adverse drug reactions, upstream therapy
- MeSH terms
- Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Atrial Fibrillation, Clinical Trials as Topic, Heart Atria, Humans, Ion Channels, Drugs, Investigational, Gap Junctions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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