Cited by 759Angiogenesis and VEGF in CancerAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

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Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells

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Ouchi, Noriyuki, Kobayashi, Hideki, Kihara, Shinji, Kumada, Masahiro, Sato, Kaori, Inoue, Tatsuya, Funahashi, Tohru, Walsh, Kenneth·2004·Journal of Biological Chemistry

DOI 10.1074/jbc.m310389200PMC PMC4374490

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Abstract

Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties. Here, we investigated whether adiponectin regulates angiogenic processes in vitro and in vivo. Adiponectin stimulated the differentiation of human umbilical vein endothelium cells (HUVECs) into capillary-like structures in vitro and functioned as a chemoattractant in migration assays. Adiponectin promoted the phosphorylation of AMP-activated protein kinase (AMPK), protein kinase Akt/protein kinase B, and endothelial nitric oxide synthesis (eNOS) in HUVECs. Transduction with either dominant-negative AMPK or dominant-negative Akt abolished adiponectin-induced eNOS phosphorylation as well as adiponectin-stimulated HUVEC migration and differentiation. Dominant-negative AMPK also inhibited adiponectin-induced Akt phosphorylation, suggesting that AMPK is upstream of Akt. Dominant-negative Akt or the phosphatidylinositol 3-kinase inhibitor LY294002 blocked adiponectin-stimulated Akt and eNOS phosphorylation, migration, and differentiation without altering AMPK phosphorylation. Finally, adiponectin stimulated blood vessel growth in vivo in mouse Matrigel plug implantation and rabbit corneal models of angiogenesis. These data indicate that adiponectin can function to stimulate the new blood vessel growth by promoting cross-talk between AMP-activated protein kinase and Akt signaling within endothelial cells.

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Background
Metformin action on AMP‐activated protein kinase: a translational research approach to understanding a potential new therapeutic target
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Background
Mechanism and Role of High Density Lipoprotein-induced Activation of AMP-activated Protein Kinase in Endothelial Cells
Kimura, T., Tomura, H., Sato, K., Ito, M., Matsuoka, I., Im, D., Kuwabara, A., Mogi, C., Itoh, H., Kurose, H., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.043869 · Cited by 81
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“It has been shown that AMPK signalling mediates adiponectininduced angiogenic and anti-apoptotic cellular responses in British Journal of Pharmacology (2014) 171 595–617 607 endothelial cells (Kobayashi et al., 2004; Ouchi et al., 2004).”
Background
Transdermal Photothermal-Pharmacotherapy to Remodel Adipose Tissue for Obesity and Metabolic Disorders
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“adiponectin could be attributed to the following: (i) it inhibits the expression and activity of tissue factors from macrophages,(101) (ii) it stimulates the production of NO from vascular endothelial cells or platelet NO synthases to regulate platelet activation,(102,103) and (iii) it promotes crosstalk between AMP-a…”
Background
Synergistic effect of curcumin and insulin on muscle cell glucose metabolism
Kang, C., & Kim, E. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.05.073 · Cited by 80
“However, some other reports suggest that AMPK functions were upstream of Akt signaling (Ouchi et al., 2004).”
Background
Glycine increases mRNA adiponectin and diminishes pro-inflammatory adipokines expression in 3T3-L1 cells
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Targeting Heme Oxygenase
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Background
Diabetes Impairs the Vascular Recruitment of Normal Stem Cells by Oxidant Damage, Reversed by Increases in pAMPK, Heme Oxygenase-1, and Adiponectin
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Result
Adiponectin protects hippocampal neurons against kainic acid-induced excitotoxicity
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“In addition, (4) AMPK kinase pathway has demonstrated its protective effect against inflammation induced chronic renal injury and lastly (Ouchi et al., 2004; Li et al., 2010), (5) APNR1 and APNR2 adaptor protein (APPL1) protein has implicated its regulation on APN transduction to activate ERK1/2MAP…”
Background
Chronic Hexosamine Flux Stimulates Fatty Acid Oxidation by Activating AMP-activated Protein Kinase in Adipocytes
Luo, B., Parker, G. J., Cooksey, R. C., Soesanto, Y., Evans, M. L., Jones, D., & McClain, D. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607362200 · Cited by 77
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Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177
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“Several studies have now reported that AMPK can stimulate NO synthesis by phosphorylation of eNOS-Ser(1177) (9, 11, 37, 55).”
Background
Metabolic syndrome and collateral vessel formation in patients with documented occluded coronary arteries: association with hyperglycaemia, insulin-resistance, adiponectin and plasminogen activator inhibitor-1
Mouquet, F., Cuilleret, F., Susen, S., Sautière, K., Marboeuf, P., Ennezat, P. V., McFadden, E. P., Pigny, P., Richard, F., Hennache, B., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehn569 · Cited by 74
“High triglycerides 6 (27) 45 (49) 41 (40) 57 (41) 26 (34) 0.”
Mitochondrial redox plays a critical role in the paradoxical effects of NAPDH oxidase-derived ROS on coronary endothelium
Shafique, E., Torina, A. G., Reichert, K., Colantuono, B. J., Nur, N., Zeeshan, K., Ravichandran, V. S., Liu, Y., Feng, J., Zeeshan, K., et al. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw249 · Cited by 74
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D’Ippolito, S., Tersigni, C., Scambia, G., & Simone, N. D. (2012) · BioFactors · doi:10.1002/biof.201 · Cited by 74
“showed that the adipokine enhances the differentiation of human umbilical vein endothelial cells (HUVECs) into capillary-like structures and promotes blood vessel growth in vivo [75].”
Background
Adiponectin, Adipocyte Fatty Acid Binding Protein, and Epidermal Fatty Acid Binding Protein: Proteins Newly Identified in Human Breast Milk
Bronský, J., Karpíšek, M., Bronská, E., Pechová, M., Jančíková, B., Kotolová, H., Stejskal, D., Průša, R., & Nevoral, J. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.063032 · Cited by 73
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Wu, X., Mahadev, K., Fuchsel, L., Ouedraogo, R., Xu, S., & Goldstein, B. J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00115.2007 · Cited by 75
“nectin enhancement of endothelial NO availability (3, 13, 22).”
Background
PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt
Ahn, J., Hu, Y., Kroll, T. G., Allard, P., & Ye, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400921101 · Cited by 73
Adiponectin Inhibits Lipopolysaccharide-Induced Adventitial Fibroblast Migration and Transition to Myofibroblasts via AdipoR1-AMPK-iNOS Pathway
Cai, X., Chen, L., Li, L., Feng, M., Li, X., Zhang, K., Rong, Y., Hu, X., Zhang, M., Zhang, M., et al. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0128 · Cited by 72
Physiological role of adiponectin in different tissues: a review
Esmaili, S., Hemmati, M., & Karamian, M. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1493606 · Cited by 73
“It also prevents endothelial apoptosis (Kobayashi et al. 2004, Ouchi et al. 2004).”
Background
Activation of AMP-activated Protein Kinase Is Essential for Lysophosphatidic Acid-induced Cell Migration in Ovarian Cancer Cells
Kim, E., Park, J., Lim, S., Choi, J. W., Kim, H. S., Seok, H., Seo, J. K., Oh, K., Lee, D., Kim, K., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.209908 · Cited by 69
What is the best biomarker for metabolic syndrome diagnosis?
Falahi, E., Rad, A., & Roosta, S. (2013) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2013.06.014 · Cited by 73
“But we could see that the most active form of adiponectin is the best biomarker for Met [20,49,50].”
Background
Telmisartan induces proliferation of human endothelial progenitor cells via PPARγ-dependent PI3K/Akt pathway
Honda, A., Matsuura, K., Fukushima, N., Tsurumi, Y., Kasanuki, H., & Hagiwara, N. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.12.036 · Cited by 69
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Advances in the molecular mechanisms of statins in regulating endothelial nitric oxide bioavailability: Interlocking biology between eNOS activity and L-arginine metabolism
Chen, W., Chen, C.-H., Hsu, M., Chang, R.-W., Wang, C., & Lee, T. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116192 · Cited by 70
Shear stress-induced activation of the AMP-activated protein kinase regulates FoxO1a and angiopoietin-2 in endothelial cells
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Leptin-Stimulated Endothelial Nitric-Oxide Synthase via an Adenosine 5′-Monophosphate-Activated Protein Kinase/Akt Signaling Pathway Is Attenuated by Interaction with C-Reactive Protein
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“There is evidence that AMPK lies upstream of Akt in the pathway leading to eNOS activation and NO production (27, 29, 30), although this issue is an object of debate (31).”
BackgroundInfluential
Adiponectin expression in the porcine pituitary during the estrous cycle and its effect on LH and FSH secretion
Kieżun, M., Smolińska, N., Maleszka, A., Dobrzyń, K., Szeszko, K., & Kamiński, T. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00299.2014 · Cited by 70
“Several studies have demonstrated that different multimeric forms can determine the activity of adiponectin (17, 47, 33).”
Background
Adiponectin Promotes Endotoxin Tolerance in Macrophages by Inducing IRAK-M Expression
Zacharioudaki, V., Androulidaki, A., Arranz, A., Vrentzos, G. E., Margioris, A. N., & Tsatsanis, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803694 · Cited by 68
Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy
SHARMA, N., Okere, I. C., Duda, M. K., Chess, D. J., O’Shea, K. M., & Stanley, W. C. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.11.007 · Cited by 69
“Studies in endothelial cells have shown that adiponectin promotes cell growth and angiogenesis by promoting cross-talk between AMPK and Akt signaling pathways [155].”
Background
Assessment of anti-angiogenic and anti-tumoral potentials of Origanum onites L. essential oil
Bostancıoğlu, R. B., Kürkçüoğlu, M., Başer, K. H. C., & Koparal, A. T. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.03.074 · Cited by 69
“The matrigel tube formation assay was performed as previously described (Ouchi et al., 2004).”
Method
High-molecular-weight adiponectin is a predictor of progression to metabolic syndrome: a population-based 6-year follow-up study in Japanese men
Seino, Y., Hirose, H., Saito, I., & Itoh, H. (2009) · Metabolism · doi:10.1016/j.metabol.2008.10.008 · Cited by 68
Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid
Koparal, A. T. (2015) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2014-4178 · Cited by 69
“Endothelial tube formation assays were performed as previously described [24].”
Method
Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy
Lim, J. H., Kim, H. W., Kim, M. Y., Kim, T. W., Kim, E. N., Kim, Y., Chung, S., Kim, Y. S., Choi, B. S., Kim, Y., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0324-4 · Cited by 69
Adipocytokines and obesity-linked disorders.
Ouchi, N., Ohashi, K., Shibata, R., & Murohara, T. (2012) · PubMed Central · doi:10.18999/nagjms.74.1-2.19 · Cited by 67
Angiotensin II‐induced apoptosis in human endothelial cells is inhibited by adiponectin through restoration of the association between endothelial nitric oxide synthase and heat shock protein 90
Lin, L., Lin, C., Su, T., & Liau, C. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.08.012 · Cited by 68
Effects of increased milking frequency on gene expression in the bovine mammary gland
Connor, E. E., Siferd, S., Elsasser, T. H., Evock-Clover, C. M., Tassell, C. P. V., Sonstegard, T. S., Fernandes, V. M., & Capuco, A. V. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-362 · Cited by 68
“Multiple genes controlling proliferation of blood vessels were affected by increased milking frequency including down regulation of inhibitors of angiogenesis such as SERPINF1, THBS2, TIMP1, TIMP2 and ADIPOQ [30], and up regulation of pro-angiogenic genes CTGF, NRG1 and ANTXR1.”
Background
Chemerin promotes angiogenesis in vivo
Nakamura, N., Naruse, K., Kobayashi, Y., Miyabe, M., Saiki, T., Enomoto, A., Takahashi, M., & Matsubara, T. (2018) · Physiological Reports · doi:10.14814/phy2.13962 · Cited by 66
“Eight-week-old male C57BL mice were used for modified mouse corneal angiogenesis assay using previously described methods (Ouchi et al. 2004).”
Method
Oleanolic acid induces relaxation and calcium‐independent release of endothelium‐derived nitric oxide
Rodríguez‐Rodríguez, R., Stankevıčıus, E., Herrera, M. D., Østergaard, L., Andersen, M. R., Ruíz-Gutiérrez, V., & Simonsen, U. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.289 · Cited by 67
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Background
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Vildagliptin Stimulates Endothelial Cell Network Formation and Ischemia-induced Revascularization via an Endothelial Nitric-oxide Synthase-dependent Mechanism
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Lentiviral-Human Heme Oxygenase Targeting Endothelium Improved Vascular Function in Angiotensin II Animal Model of Hypertension
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The Emerging Role of Adiponectin in Female Malignancies
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Background

Authors: Ouchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T., & Walsh, K.
Affiliations: Boston University (US)
The University of Osaka (JP)
Corresponding author: Walsh, Kenneth
ORCID: Ouchi, Noriyuki
Kobayashi, Hideki
Kihara, Shinji
Inoue, Tatsuya
Walsh, Kenneth
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2004-01
Volume: 279
Issue: 2
Pages: 1304-1309
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m310389200
PMC: PMC4374490
OpenAlex: W2008967025
Cited by: 759
References: 49
Citations by year: 2026: 5 · 2025: 10 · 2024: 20 · 2023: 15 · 2022: 21 · 2021: 23 · 2020: 23 · 2019: 25 · 2018: 22 · 2017: 40 · 2016: 26 · 2015: 39 · 2014: 30 · 2013: 58 · 2012: 58
FWCI: 14.45
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6145 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Uehara Memorial Foundation
National Institutes of Health (HD23681, AG15052)
National Institute on Aging (R01AG015052, AG17241, R37AG015052, AG15052, R01AG017241)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-40197, R01AR040197)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD023681, HD23681)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: adiponectin, angiogenesis, AMPK, Akt signaling, endothelial cells, endothelial nitric oxide synthase, endothelial cell migration, endothelial differentiation, capillary tube formation, phosphatidylinositol 3-kinase, signaling crosstalk, blood vessel development
MeSH terms: Adenoviridae, Animals, Cell Differentiation, Cell Movement, Cells, Cultured, Chromones, Collagen, Drug Combinations, Endothelium, Vascular, Enzyme Inhibitors, Genes, Dominant, Humans, Laminin, Models, Biological, Morpholines, Multienzyme Complexes, Neovascularization, Pathologic, Phosphorylation, Proteins, Proteoglycans, Rabbits, Recombinant Proteins, Time Factors, Umbilical Veins, Blotting, Western, Signal Transduction, Protein Serine-Threonine Kinases, Nitric Oxide Synthase, Phosphatidylinositol 3-Kinases, Intercellular Signaling Peptides and Proteins, Endothelial Cells, Mice, Adiponectin, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III, AMP-Activated Protein Kinases

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Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells

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