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Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells
Open accessAbstract
Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties. Here, we investigated whether adiponectin regulates angiogenic processes in vitro and in vivo. Adiponectin stimulated the differentiation of human umbilical vein endothelium cells (HUVECs) into capillary-like structures in vitro and functioned as a chemoattractant in migration assays. Adiponectin promoted the phosphorylation of AMP-activated protein kinase (AMPK), protein kinase Akt/protein kinase B, and endothelial nitric oxide synthesis (eNOS) in HUVECs. Transduction with either dominant-negative AMPK or dominant-negative Akt abolished adiponectin-induced eNOS phosphorylation as well as adiponectin-stimulated HUVEC migration and differentiation. Dominant-negative AMPK also inhibited adiponectin-induced Akt phosphorylation, suggesting that AMPK is upstream of Akt. Dominant-negative Akt or the phosphatidylinositol 3-kinase inhibitor LY294002 blocked adiponectin-stimulated Akt and eNOS phosphorylation, migration, and differentiation without altering AMPK phosphorylation. Finally, adiponectin stimulated blood vessel growth in vivo in mouse Matrigel plug implantation and rabbit corneal models of angiogenesis. These data indicate that adiponectin can function to stimulate the new blood vessel growth by promoting cross-talk between AMP-activated protein kinase and Akt signaling within endothelial cells.
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“Further evidence also shows that AMPK lies upstream of the phosphatidylinositol-3-kinase-protein kinase B pathway, which also leads to eNOS activation and NO production [162,164,165].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [164]
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BackgroundAdiponectin Deficiency Promotes Tumor Growth in Mice by Reducing Macrophage Infiltration
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“Although adiponectin has been suggested to be one of the regulators of angiogenesis, its precise role in regulating this process is still not clear. One group, employing in vitro cell culture systems and other angiogenesis models, showed that adiponectin can stimulate angiogenesis”
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BackgroundFibromodulin Enhances Angiogenesis during Cutaneous Wound Healing
Zheng, Z. S., Jia, J., Velasco, O., Hsu, C., Zhang, K., Levin, A., Murphy, M. C., Zhang, X., Ting, K., & Soo, C. B. (2014) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000000243 · Cited by 48
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“Effects of adiponectin on angiogenesis were also found to be dependent on adiponectin-stimulated phosphorylation of both AMPK and Akt [ 31 ].”
BackgroundResultInfluentialObesity, Cholesterol, and Clear-Cell Renal Cell Carcinoma (RCC)
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“Specifically, pharmacological inhibition of AMPK activity or genetic inhibition of AMPK expression virtually abolishes the metabolic (3, 38), anti-inflammatory (17), and vasculoprotective (24, 29) effects of adiponectin.”
Adiponectin Resistance in Obesity: Adiponectin Leptin/Insulin Interaction
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The role of adiponectin in placentation and preeclampsia
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“Previous studies have shown that regular aerobic exercise can reduce fat content and increase adiponectin secretion, which in turn reduces arterial stiffness (27, 30, 48).”
BackgroundIshii, N., Matsumura, T., Kinoshita, H., Motoshima, H., Kojima, K., Tsutsumi, A., Kawasaki, S., Yano, M., Senokuchi, T., Asano, T., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.028043 · Cited by 43
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“Endothelial AMPK is activated by a broad range of stimuli, including hypoxia (17); metformin, peroxynitrite (18), and adiponectin (19); and vasoactive mediators such as S1P, VEGF (20, 21), bradykinin (29), or thrombin (22).”
BackgroundYang, S., & Wang, J. (2015) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-015-0521-z · Cited by 41
“One of the putative downstream targets suggested to be phosphorylated by AMPK in ECs is eNOS [18–22, 26, 29].”
BackgroundInfluentialCraven, K. E., Gore, J., Wilson, J. L., & Korc, M. (2015) · Oncotarget · doi:10.18632/oncotarget.6345 · Cited by 42
“For example, ADIPOQ which rescues impaired angiogenesis in ADIPOQ-null mice [68, 69] and stimulates endothelial migration and tube formation [70] was increased by ~11-fold, whereas pro-angiogenic GHSR and NLRP3 [71–74] were increased by ~4.8-and ~4-fold, respectively.”
InfluentialMercurio, L., Morelli, M., Scarponi, C., Scaglione, G. L., Pallotta, S., Avitabile, D., Albanesi, C., & Madonna, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136860 · Cited by 40
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“However, several contradictory studies have suggested that adiponectin promotes angiogenesis in vitro cell culture systems and other angiogenesis models by activation of AMPK and PI3K/Akt signaling pathways [18,19].”
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Metabolic Influences on Reproduction: Adiponectin Attenuates GnRH Neuronal Activity in Female Mice
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LKB1 Deficiency in Tie2-Cre-expressing Cells Impairs Ischemia-induced Angiogenesis
Ohashi, K., Ouchi, N., Higuchi, A., Shaw, R. J., & Walsh, K. X. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.123794 · Cited by 43
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“Our results are also in keeping with the report that adiponectin is critical for endothelial cell survival and function (Ouchi et al., 2004) via the activation of eNOS and pAKT and pAMPK signaling.”
Zhang, L., Yuan, M., Zhang, L. N., Wu, B., & Sun, X. Y. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.143 · Cited by 41
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“Adiponectin, is also upregulated, which has been shown to both inhibit [11–13] and enhance angiogenesis [5, 14].”
BackgroundAdiponectin Provides Cardiovascular Protection in Metabolic Syndrome
Okamoto, Y. (2011) · Cardiology Research and Practice · doi:10.4061/2011/313179 · Cited by 40
Angiogenesis inhibition by a lichen compound olivetoric acid
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“The Matrigel tube formation assay was performed as previously described (Ouchi et al., 2004).”
MethodHeme Oxygenase-Derived Carbon Monoxide Restores Vascular Function in Type 1 Diabetes
Rodella, L. F., Vanella, L., Peterson, S. J., Drummond, G., Rezzani, R., Falck, J. R., & Abraham, N. G. (2008) · Drug Metabolism Letters · doi:10.2174/187231208786734058 · Cited by 41
“and others who, in a series of elegant studies, have reported that adiponectin is critical for endothelial cell survival and function [57-59] via the activation of eNOS and AKT, and the inhibition of cell adhesion.”
BackgroundApelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia
Novakova, V., Sandhu, G. S., Dragomir‐Daescu, D., & Klabusay, M. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.08.005 · Cited by 39
Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase
Izumi, Y., Shiota, M., Kusakabe, H., Hikita, Y., Nakao, T., Nakamura, Y., Muro, T., Miura, K., Yoshiyama, M., & Iwao, H. (2009) · Hypertension Research · doi:10.1038/hr.2009.77 · Cited by 39
Adipocytokines in Cardiovascular and Metabolic Diseases
Ouchi, N. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.34918 · Cited by 39
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“Kenneth Walsh (Boston University School of Medicine).(21) Cholangiocarcinoma cells were grown in six-well plates and infected for 2 hours in DMEM/F12 and 16 hours in serum-containing media with recombinant adenovirus stocks at a multiplicity of infection of 100 pfu/cell and subsequently cultured in growth medium for 4…”
MethodRole of hormones in bone remodeling in the craniofacial complex: A review
Tunheim, E. G., Skallevold, H. E., & Rokaya, D. (2023) · Journal of Oral Biology and Craniofacial Research · doi:10.1016/j.jobcr.2023.01.009 · Cited by 38
Adiponectin deficiency exacerbates age-related hearing impairment
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“APN supplementation has also been shown to stimulate blood vessel growth in both rabbit corneal angiogenesis and mouse Matrigel plug implantation models.(26) The present study showed that APN deficiency leads to decreased CBF and capillary density of the SV.”
BackgroundMethodOmae, T., Nagaoka, T., Tanano, I., & Yoshida, A. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-11756 · Cited by 38
Hasegawa, N., Fujie, S. J., Horii, N., Uchida, M., Kurihara, T., Sanada, K., Hamaoka, T., & Iemitsu, M. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00212.2017 · Cited by 38
Li, Y., Cai, X., Guan, Y., Wang, L., Wang, S., Li, Y., Fu, Y., Gao, X., & Su, G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148482 · Cited by 38
Sasaki, M., Otani, T., Kawakami, M., & Ishikawa, S. (2009) · Metabolism · doi:10.1016/j.metabol.2009.08.015 · Cited by 37
“Furthermore, adiponectin produces nitric oxide synthesis and angiogenesis [32,33].”
BackgroundAdiponectin and sporadic Alzheimer’s disease: Clinical and molecular links
Letra, L., Rodrigues, T., Matafome, P. N., Santana, I. J., & Seiça, R. M. F. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.002 · Cited by 38
“, 2008) and regulates angiogenesis (Ouchi et al., 2004; Shibata et al., 2004) potentially protecting the brain against β–induced vascular impairment.”
Lieberthal, W., Zhang, L., Patel, V. A., & Levine, J. S. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00034.2011 · Cited by 37
“Finally, Akt-mediated increases in angiogenesis, induced by both hypoxic stress (50) and adiponectin (52), have been shown to depend upon activation of AMPK.”
BackgroundKusmic, C., L’Abbate, A., Sambuceti, G., Drummond, G., Barsanti, C., Matteucci, M., Cao, J. J., Piccolomini, F., Cheng, J., & Abraham, N. G. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22486 · Cited by 38
“However, drugs which increase pAMPK in vivo, in muscle and myocytes [Al-Khalili et al., 2004; LeBrasseur et al., 2006] also increase pAMPK in the vascular system [Ouchi et al., 2004; Rodella et al., 2008].”
BackgroundInfluentialInhibition of cyclooxygenase-2 enhances myocardial damage in a mouse model of viral myocarditis
Takahashi, T., Zhu, S., Sumino, H., Saegusa, S., Nakahashi, T., Iwai, K., Morimoto, S., & Kanda, T. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.04.060 · Cited by 37
Fu, X., Wang, Y., Lu, Y. P., Liu, J., & Li, H. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123192 · Cited by 45
Age-related cardiovascular disease and the beneficial effects of calorie restriction
Sung, M. M. Y., & Dyck, J. R. B. (2011) · Heart Failure Reviews · doi:10.1007/s10741-011-9293-8 · Cited by 38
Systemic Adiponectin Malfunction as a Risk Factor for Cardiovascular Disease
Lau, W. B., Tao, L., Wang, Y., Li, R., & Ma, X. L. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3743 · Cited by 36
“The influence of Ad upon angiogenesis is dependent upon Ad-induced phosphorylation of both AMPK and Akt (protein kinase B), with AMPK upstream of Akt, as disruption of AMPK activation inhibits Ad-induced Akt phosphorylation (44).”
Adipose tissue-derived omentin-1 attenuates arterial calcification via AMPK/Akt signaling pathway
Xu, F., Li, F., Lin, X., Zhong, J., Wu, F., Shan, S., Tan, C., Yuan, L., & Liao, X. (2019) · Aging · doi:10.18632/aging.102251 · Cited by 36
“In addition, accumulating evidence verifies that Akt, also known as protein kinase B (PKB), lies downstream of AMPK signaling pathway and mediates various physiologic and pathological cell processes and multiple diseases progression [22, 23].”
BackgroundMcCarty, M. F. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.01.042 · Cited by 35
“) The recently characterized hormone adiponectin, produced exclusively by adipocytes, is now known to activate endothelial AMPK via a membrane receptor [33,34].”
BackgroundZhu, W., & Smart, E. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501238200 · Cited by 36
RetractedChou, I., Lin, Y., Ding, S., & Chen, C. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0594-7 · Cited by 35
“Many studies indicate that adiponectin increases phosphorylation of AKT and thus affects cell physiology [34, 35].”
BackgroundExpression of adiponectin and its receptors in type 1 diabetes mellitus in human and mouse retinas.
Lin, T., Qiu, Y., Liu, Y., Mohan, R. R., Li, Q., & Lei, B. (2013) · Europe PMC (PubMed Central) · Cited by 35
Voluntary exercise increases adult hippocampal neurogenesis by increasing GSK-3β activity in mice
Zang, J., Liu, Y., Li, W., Xiao, D., Zhang, Y., Luo, Y., Liang, W., Liu, F., & Wei, W. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.024 · Cited by 35
Natural AMPK Activators in Cardiovascular Disease Prevention
Moghaddam, R. H., Samimi, Z., Asgary, S., Mohammadi, P., Hozeifi, S., Hoseinzadeh‐Chahkandak, F., Xu, S., & Farzaei, M. H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.738420 · Cited by 39
The impact of adipokines on vascular networks in adipose tissue
Vliora, M., Ravelli, C., Grillo, E., Corsini, M., Flouris, A. D., & Mitola, S. M. F. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.07.008 · Cited by 37
Adiponectin and Interleukin-6 in Inflammation-Associated Disease
Li, L., & Wu, L. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-398313-8.00014-2 · Cited by 36
“Adiponectin induces nitric oxide release from endothelial cells by enhancing the expression and activity of endothelial nitric oxide synthase via an AMPK-dependent pathway (Chen, Montagnani, Funahashi, Shimomura, & Quon, 2003; Ouchi et al., 2004).”
BackgroundJung, T. W., Lee, Y. J., Lee, M. W., Kim, S. M., & Jung, T. W. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.06955.x · Cited by 35
Regulation of adipolin/CTRP12 cleavage by obesity
Enomoto, T., Shibata, R., Ohashi, K., Kambara, T., Kataoka, Y., Uemura, Y., Yuasa, D., Murohara, T., & Ouchi, N. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.10.031 · Cited by 35
Wang, Y., Zhang, K., Shi, X., Wang, C., Wang, F., Fan, J., Shen, F., Xu, J., Bao, W., Liu, M., et al. (2016) · The FASEB Journal · doi:10.1096/fj.201500019r · Cited by 36
Adiponectin as a Potential Therapeutic Target for Prostate Cancer
Karnati, H. K., Panigrahi, M. K., Li, Y., Tweedie, D., & Greig, N. H. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666170208123553 · Cited by 36
“Indeed, input from a number of studies has indicated that AdipoR1/R2, activation of AMPK [111], AKT and endothelial nitric oxide synthase (eNOS) [112,118], (MAPK) pathway, and RAS-ERK1/2 [112–114] are necessary to mediate adiponectin-mediated signals that have been reported in endothelial cells.”
BackgroundOu, H.-C., Hsieh, Y.-L., Yang, N.-C., Tsai, K.-L., Chen, K.-L., Tsai, C.-S., Chen, I.-J., Wu, B.-T., & Lee, S.-D. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00367.2012 · Cited by 34
“However, they also noted that transduction of HUVECs with a dominant-negative form of Akt blocked the adiponectin-stimulated phosphorylation of Akt and eNOS and inhibited the migration and differentiation of cells without altering AMPK phosphorylation, suggesting that AMPK is upstream of Akt in this pathway (29).”
BackgroundInfluentialNagata, D., Kiyosue, A., Takahashi, M., Satonaka, H., Tanaka, K., Sata, M., Nagano, T., Nagai, R., & Hirata, Y. (2009) · Hypertension Research · doi:10.1038/hr.2008.25 · Cited by 33
Jiang, X., Song, D., Ye, B., Wang, X., Song, G., Yang, S.-K., & Hu, J. (2011) · Journal of Orthopaedic Research® · doi:10.1002/jor.21355 · Cited by 34
“In previous studies, the reduction of secretion of necessary angiogenic factors and the proliferation, differentiation, and recruitment of the angiogenic cells were regarded as the possible mechanism of the poor osteogenesis of the rapid DO.16,18 Adiponectin was proven to promote pro-angiogenic cellular responses in e…”
BackgroundTotal and High Molecular Weight Adiponectin and Hepatocellular Carcinoma with HCV Infection
Sumie, S., Kawaguchi, T., Kuromatsu, R., Takata, A., Nakano, M., Satani, M., Yamada, S., Niizeki, T., Torimura, T., & Sata, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026840 · Cited by 33
“HMW adiponectin is thought to have higher biological activity than the other forms of adiponectin, especially in the liver [12,13].”
BackgroundKim, S., Kim, H. J., Park, M. K., Huh, J. W., Park, H. Y., Ha, S. Y., Shin, J., & Lee, Y. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0377oc · Cited by 33
Adiponectin Signaling Regulates Lipid Production in Human Sebocytes
Jung, Y. R., Lee, J.-H., Sohn, K., Lee, Y., Seo, Y., Kim, C. D., Lee, J., Hong, S., Seo, S., Kim, S., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169824 · Cited by 33
“We further examined Akt, which is an intracellular molecule influenced by AMPK signaling [15, 16], and found that the levels of phosphorylated Akt were significantly induced by adiponectin.”
BackgroundOmae, T., Nagaoka, T., & Yoshida, A. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-16447 · Cited by 33
Targeting adiponectin for cardioprotection
Ouchi, N., Shibata, R., & Walsh, K. X. (2006) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.10.4.573 · Cited by 33
“The full-length adiponectin (unfractionated) stimulates nitric oxide (NO) production, a key determinant of endothelial function, through its ability to promote the phosphorylation of endothelial nitric oxide synthase (eNOS) through AMPK-dependent signalling mechanisms [54,55].”
BackgroundObesity, Insulin Resistance, and Capillary Recruitment
Rattigan, S., Bussey, C. T., Ross, R. M., & Richards, S. M. (2007) · Microcirculation · doi:10.1080/10739680701282796 · Cited by 34
“Adiponectin inhibits apoptosis in HUVECs [36] and promotes angiogenesis both in vivo [62] and in vitro [48].”
Background
Metadata
- Authors
- Ouchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T., & Walsh, K.
- Affiliations
- Boston University (US)
- The University of Osaka (JP)
- Corresponding author
- Walsh, Kenneth
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 279
- Issue
- 2
- Pages
- 1304-1309
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC4374490
- OpenAlex
- W2008967025
- Cited by
- 759
- References
- 49
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 20 · 2023: 15 · 2022: 21 · 2021: 23 · 2020: 23 · 2019: 25 · 2018: 22 · 2017: 40 · 2016: 26 · 2015: 39 · 2014: 30 · 2013: 58 · 2012: 58
- FWCI
- 14.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Uehara Memorial Foundation
- National Institutes of Health (HD23681, AG15052)
- National Institute on Aging (R01AG015052, AG17241, R37AG015052, AG15052, R01AG017241)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-40197, R01AR040197)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD023681, HD23681)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- adiponectin, angiogenesis, AMPK, Akt signaling, endothelial cells, endothelial nitric oxide synthase, endothelial cell migration, endothelial differentiation, capillary tube formation, phosphatidylinositol 3-kinase, signaling crosstalk, blood vessel development
- MeSH terms
- Adenoviridae, Animals, Cell Differentiation, Cell Movement, Cells, Cultured, Chromones, Collagen, Drug Combinations, Endothelium, Vascular, Enzyme Inhibitors, Genes, Dominant, Humans, Laminin, Models, Biological, Morpholines, Multienzyme Complexes, Neovascularization, Pathologic, Phosphorylation, Proteins, Proteoglycans, Rabbits, Recombinant Proteins, Time Factors, Umbilical Veins, Blotting, Western, Signal Transduction, Protein Serine-Threonine Kinases, Nitric Oxide Synthase, Phosphatidylinositol 3-Kinases, Intercellular Signaling Peptides and Proteins, Endothelial Cells, Mice, Adiponectin, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III, AMP-Activated Protein Kinases
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