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Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells
Open accessAbstract
Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties. Here, we investigated whether adiponectin regulates angiogenic processes in vitro and in vivo. Adiponectin stimulated the differentiation of human umbilical vein endothelium cells (HUVECs) into capillary-like structures in vitro and functioned as a chemoattractant in migration assays. Adiponectin promoted the phosphorylation of AMP-activated protein kinase (AMPK), protein kinase Akt/protein kinase B, and endothelial nitric oxide synthesis (eNOS) in HUVECs. Transduction with either dominant-negative AMPK or dominant-negative Akt abolished adiponectin-induced eNOS phosphorylation as well as adiponectin-stimulated HUVEC migration and differentiation. Dominant-negative AMPK also inhibited adiponectin-induced Akt phosphorylation, suggesting that AMPK is upstream of Akt. Dominant-negative Akt or the phosphatidylinositol 3-kinase inhibitor LY294002 blocked adiponectin-stimulated Akt and eNOS phosphorylation, migration, and differentiation without altering AMPK phosphorylation. Finally, adiponectin stimulated blood vessel growth in vivo in mouse Matrigel plug implantation and rabbit corneal models of angiogenesis. These data indicate that adiponectin can function to stimulate the new blood vessel growth by promoting cross-talk between AMP-activated protein kinase and Akt signaling within endothelial cells.
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“Further evidence also shows that AMPK lies upstream of the phosphatidylinositol-3-kinase-protein kinase B pathway, which also leads to eNOS activation and NO production [162,164,165].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [164]
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“However, adiponectin has also been reported to activate adenosine monophosphate kinase in endothelial cells, leading to enhanced in vivo angiogenesis in murine Matrigel plug and rabbit cornea assays and to inhibition of caspase 3-mediated apoptosis in HUVECs cultured in vitro (Kobayashi et al., 2004; Ouchi et al., 200…”
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BackgroundInfrapatellar fat pad features in osteoarthritis: a histopathological and molecular study
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BackgroundResultInfluentialAdiponectin Deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling
Medoff, B. D., Okamoto, Y., Leyton, P., Weng, M., Sandall, B. P., Raher, M. J., Kihara, S., Bloch, K. D., Libby, P., & Luster, A. D. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0415oc · Cited by 212
Adiponectin protects against the development of systolic dysfunction following myocardial infarction
Shibata, R., Izumiya, Y., Sato, K., Papanicolaou, K. N., Kihara, S., Colucci, W. S., Sam, F., Ouchi, N., & Walsh, K. X. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.03.808 · Cited by 213
“In accordance with these observations, we have previously shown that adiponectin can function as a survival factor for endothelial cells [41] and that APN-KO mice exhibit impaired angiogenic repair in ischemic hindlimbs whereas adiponectin overexpression stimulates blood vessel growth [14,42].”
Zhang, Y., Lee, T.-S., Kolb, E. M., Sun, K., Lu, X., Sladek, F. M., Kassab, G. S., Garland, T., & Shyy, J. Y.-J. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000221230.08596.98 · Cited by 212
Nishimura, M., Izumiya, Y., Higuchi, A., Shibata, R., Qiu, J., Kudo, C., Shin, H. K., Moskowitz, M. A., & Ouchi, N. (2007) · Circulation · doi:10.1161/circulationaha.107.725044 · Cited by 207
Agonist-modulated Regulation of AMP-activated Protein Kinase (AMPK) in Endothelial Cells
Levine, Y. C., Li, G. K., & Michel, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702182200 · Cited by 207
Han, S., Khuri, F. R., & Roman, J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2367 · Cited by 207
“AMPK has been shown to diminish protein synthesis by activating TSc2, leading to inhibition of mTOR and subsequent inhibition of p70S6K protein activity (20, 33).”
BackgroundZheng, Q., Yuan, Y., Yi, W., Lau, W. B., Wang, Y., Wang, X., Sun, Y., Lopez, B. L., Christopher, T. A., Peterson, J. M., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.231050 · Cited by 202
Adiponectin Acts as an Endogenous Antithrombotic Factor
Kato, H., Kashiwagi, H., Shiraga, M., Tadokoro, S., Kamae, T., Ujiie, H., Honda, S., Miyata, S., Ijiri, Y., Yamamoto, J., et al. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000194076.84568.81 · Cited by 202
Guerre-Millo, M. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.08.002 · Cited by 203
Adiponectin: Anti-inflammatory and cardioprotective effects
Villarreal-Molina, M. T., & Antuna-Puente, B. (2012) · Biochimie · doi:10.1016/j.biochi.2012.06.030 · Cited by 206
Adiponectin, an adipocyte-derived protein
Nedvidkova, J., Smitka, K., Kopský, V., & Hainer, V. (2005) · Physiological Research · doi:10.33549/physiolres.930600 · Cited by 194
Walnuts (Juglans regia) Chemical Composition and Research in Human Health
Hayes, D., Angove, M. J., Tucci, J., & Dennis, C. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.760516 · Cited by 214
“These molecules are known for their anti-inflammatory (Ouchi et al., 2004; Ohashia et al., 2012) and insulin resistance properties (Yamauchi et al.”
BackgroundIdentification of Adiponectin as a Novel Hemopoietic Stem Cell Growth Factor
DiMascio, L. N., Voermans, C., Uqoezwa, M., Duncan, A. W., Lu, D., Wu, J., Sankar, U., & Reya, T. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3511 · Cited by 201
“First, we cultured HSCs infected with either a wild-type or dominant-negative form of AMPK in the presence or absence of adiponectin.”
BackgroundResultInfluentialThe fat and the bad: Mature adipocytes, key actors in tumor progression and resistance
Duong, M. N., Geneste, A., Fallone, F., Li, X., Dumontet, C., & Muller, C. (2017) · Oncotarget · doi:10.18632/oncotarget.18038 · Cited by 198
“While some studies showed that adiponectin may be pro-angiogenesis [77, 115, 116, 119, 120], other studies reported an inhibition of angiogenesis both in vitro and in vivo [121, 122].”
BackgroundAdiponectin Induces Periovulatory Changes in Ovarian Follicular Cells
Ledoux, S., Campos, D. B., Lopes, F. L., Dobias-Goff, M., Palin, M., & Murphy, B. D. (2006) · Endocrinology · doi:10.1210/en.2006-0679 · Cited by 188
Yu, J., Deng, Y., Han, X., Ren, G., Cai, J., & Jiang, G. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0408-3 · Cited by 188
Salt, I. P., & Hardie, D. G. (2017) · Circulation Research · doi:10.1161/circresaha.117.309633 · Cited by 190
Chabrolle, C., Tosca, L., & Dupont, J. (2007) · Reproduction · doi:10.1530/rep-06-0244 · Cited by 191
“…(2007) 133 719–731 Adiponectin activates various signalling pathways in rat granulosa cells Recombinant adiponectin is known to stimulate different signalling pathways including AMPK, MAPK and Akt in various cell types (Yamauchi et al. 2002, Wu et al. 2003, Ouchi et al. 2004, Luo et al. 2005).”
BackgroundRole of Adiponectin in Central Nervous System Disorders
Bloemer, J., Pinky, P. D., Govindarajulu, M., Hong, H., Judd, R. L., Amin, R., Moore, T., Dhanasekaran, M., Reed, M. N., & Suppiramaniam, V. D. (2018) · Neural Plasticity · doi:10.1155/2018/4593530 · Cited by 187
“AMPK signaling is also required for vascular endothelial growth factor -stimulated endothelial cell NO production, migration, and differentiation in response to hypoxic conditions and increased oxidative stress in stroke [76], which also promotes angiogenesis in vivo.”
BackgroundAdipokines, Myokines and Cardiovascular Disease
Walsh, K. X. (2008) · Circulation Journal · doi:10.1253/circj.cj-08-0961 · Cited by 178
Nonclassic Endogenous Novel Regulators of Angiogenesis
Ribatti, D., Conconi, M. T., & Nussdorfer, G. G. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.2.3 · Cited by 185
“Adiponectin has been reported to activate adenosine monophosphate kinase in ECs, leading to enhanced in vivo angiogenesis in murine Matrigel plug and rabbit cornea assays and inhibition of caspase 3-mediated apoptosis in HUVECs cultured in vitro (Kobayashi et al., 2004; Ouchi et al., 2004).”
BackgroundRole of Adipokines in Cardiovascular Disease
Lau, W. B., Ohashi, K., Wang, Y., Ogawa, H., Murohara, T., Ma, X., & Ouchi, N. (2017) · Circulation Journal · doi:10.1253/circj.cj-17-0458 · Cited by 183
AMPK, metabolism, and vascular function
Rodríguez, C., Muñoz, M., Contreras, C., & Prieto, D. (2021) · FEBS Journal · doi:10.1111/febs.15863 · Cited by 181
Kim, H.-S., Kim, M.-J., Kim, E. J., Yang, Y. D., Lee, M., & Lim, J. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.11.008 · Cited by 175
“AMPK activation also increases human umbilical vein endothelial cell migration and contributes to transendothelial lymphocyte migration [39,40].”
BackgroundNicolai, A., Li, M., Kim, D. H., Peterson, S. J., Vanella, L., Positano, V., Gastaldelli, A., Rezzani, R., Rodella, L. F., Drummond, G., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.124701 · Cited by 171
T-cadherin Is Essential for Adiponectin-mediated Revascularization*
Parker, J., Nakamura, K., Silver, M., Kikuchi, R., Tigges, U., Yoshida, S., Denzel, M. S., Ranscht, B., & Walsh, K. X. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.454835 · Cited by 170
“It has been reported previously that adiponectin promotes endothelial cell migration and proliferation in vitro (9, 50, 51).”
BackgroundMaruyama, S., Shibata, R., Kikuchi, R., Izumiya, Y., Rokutanda, T., Araki, S., Kataoka, Y., Ohashi, K., Daida, H., Kihara, S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.261818 · Cited by 167
Hebbard, L., Garlatti, M., Young, L. J. T., Cardiff, R. D., Oshima, R. G., & Ranscht, B. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2953 · Cited by 172
“With T-cadherin regulating neovascularization in vivo , the primary question arising from our studies is ‘‘How does T-cadherin regulate blood vessel growth?’’ T-cadherin is a binding partner for the hexameric and high molecular weight forms of adiponectin (21) and adiponectin is implicated in vascular functions (32, 3…”
BackgroundHu, T., RamachandraRao, S., Siva, S., Valancius, C., Zhu, Y., Mahadev, K., Toh, I., Goldstein, B. J., Woolkalís, M. J., & Sharma, K. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00024.2005 · Cited by 166
“Transduction efficiency as measured by percent of cells expressing -galactosidase was 90–95%, similar to prior studies with adenoviral transduction efficiency in HUVEC (22, 24).”
Result
Metadata
- Authors
- Ouchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T., & Walsh, K.
- Affiliations
- Boston University (US)
- The University of Osaka (JP)
- Corresponding author
- Walsh, Kenneth
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 279
- Issue
- 2
- Pages
- 1304-1309
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC4374490
- OpenAlex
- W2008967025
- Cited by
- 759
- References
- 49
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 20 · 2023: 15 · 2022: 21 · 2021: 23 · 2020: 23 · 2019: 25 · 2018: 22 · 2017: 40 · 2016: 26 · 2015: 39 · 2014: 30 · 2013: 58 · 2012: 58
- FWCI
- 14.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Uehara Memorial Foundation
- National Institutes of Health (HD23681, AG15052)
- National Institute on Aging (R01AG015052, AG17241, R37AG015052, AG15052, R01AG017241)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-40197, R01AR040197)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD023681, HD23681)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- adiponectin, angiogenesis, AMPK, Akt signaling, endothelial cells, endothelial nitric oxide synthase, endothelial cell migration, endothelial differentiation, capillary tube formation, phosphatidylinositol 3-kinase, signaling crosstalk, blood vessel development
- MeSH terms
- Adenoviridae, Animals, Cell Differentiation, Cell Movement, Cells, Cultured, Chromones, Collagen, Drug Combinations, Endothelium, Vascular, Enzyme Inhibitors, Genes, Dominant, Humans, Laminin, Models, Biological, Morpholines, Multienzyme Complexes, Neovascularization, Pathologic, Phosphorylation, Proteins, Proteoglycans, Rabbits, Recombinant Proteins, Time Factors, Umbilical Veins, Blotting, Western, Signal Transduction, Protein Serine-Threonine Kinases, Nitric Oxide Synthase, Phosphatidylinositol 3-Kinases, Intercellular Signaling Peptides and Proteins, Endothelial Cells, Mice, Adiponectin, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III, AMP-Activated Protein Kinases
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