Regulation of Tissue Inhibitor of Metalloproteinase 1 Gene Transcription by RUNX1 and RUNX2
Open accessAbstract
Tissue inhibitor of metalloproteinase 1 (TIMP1) is a contributory factor to fibrosis of a variety of organs including the liver. UTE-1 is a regulatory DNA motif essential for TIMP1 promoter activity in a variety of cell types including hepatic stellate cells (HSC), the key profibrogenic cells of the liver. In this study we identify RUNX1 and RUNX2 as UTE-1-binding proteins that are induced at the post-transcriptional level during activation of HSC. RUNX1 is expressed in at least two major isoforms, RUNX1B and RUNX1A. Overexpression of full-length RUNX1B isoform in HSC repressed TIMP1 promoter activity, whereas the truncated RUNX1A isoform and RUNX2 functioned as stimulators. To gain further understanding of the way in which RUNX1 isoforms differentially regulate TIMP1 transcription, we investigated the relationship between the UTE-1 site and its adjacent upstream serum-response element (SRE) in the promoter. The UTE-1 and SRE sites cooperate in a synergistic fashion to stimulate transcription of a heterologous minimal active promoter providing that they are in close proximity. The key regulatory sequence within the SRE is an AP-1 site that in HSC directs high level transcription via its interaction with JunD. RUNX1A was shown to interact directly with JunD, and by contrast RUNX1B failed to interact with JunD. Co-expression studies showed that RUNX1B can repress JunD-stimulated TIMP1 promoter activity. From these observations we propose that JunD and RUNX factors assemble at the adjacent SRE and UTE-1 sites in the TIMP1 promoter and form functional interactions that stimulate transcription. However, RUNX1B is unable to interact with JunD, and as such its occupancy at the UTE-1 site disrupts the optimal assembly of transcriptional activators required for directing high level TIMP1 promoter function.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GLI2, RUNX1, and CREB3L1 promote fibrotic gene expression in hepatic stellate cells.
“such as GLI2 54 , RUNX1 (that upregulates Timp1 55 and is thought to promote liver fibrosis 56 ), and CREB3L1, which was previously identified as a potential master regulator of the fibrotic response in hepatic stellate cells 57 .”
From Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis (2024) · cites this paper as [55]
The citation is attached to the claim that RUNX1 upregulates Timp1, not to the statements about GLI2 or CREB3L1. The Discussion reports that RUNX1A stimulates TIMP1 promoter activity in activated hepatic stellate cells, but RUNX1B represses it; the unqualified claim about RUNX1 therefore overstates the finding. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Visse, R., & Nagase, H. (2003) · Circulation Research · doi:10.1161/01.res.0000070112.80711.3d · Cited by 4,575 · see citing works
Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury
Friedman, S. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2247 · Cited by 2,090 · see citing works
The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis
Sternlicht, M. D., Lochter, A., Sympson, C. J., Huey, B., Rougier, J., Gray, J. W., Pinkel, D., Bissell, M. J., & Werb, Z. (1999) · Cell · doi:10.1016/s0092-8674(00)81009-0 · Cited by 924 · see citing works
Hayakawa, T., Yamashita, K., Tanzawa, K., Uchijima, E., & Iwata, K. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80015-9 · Cited by 695 · see citing works
The Matrix Metalloproteinases and Their Inhibitors
Murphy, G., & Docherty, A. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/7.2.120 · Cited by 605 · see citing works
ECM signalling: orchestrating cell behaviour and misbehaviour
Lukashev, M. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01362-2 · Cited by 551 · see citing works
Giese, K., Kingsley, C., Kirshner, J. R., & Grosschedl, R. (1995) · Genes & Development · doi:10.1101/gad.9.8.995 · Cited by 541 · see citing works
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
Levanon, D., Goldstein, R. E., Bernstein, Y., Tang, H., Goldenberg, D., Stifani, S., Paroush, Z., & Groner, Y. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11590 · Cited by 467 · see citing works
Murphy, F. R., Issa, R., Zhou, X., Ratnarajah, S., Arthur, M. J. P., Benyon, C., Iredale, J. P., & Nagase, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111490200 · Cited by 432 · see citing works
Self-citationGuédez, L., Stetler‐Stevenson, W. G., Wolff, L., Wang, J., Fukushima, P. I., Mansoor, A., & Stetler-Stevenson, M. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2881 · Cited by 397 · see citing works
Friedman, S. L., Roll, F. J., Boyles, J. K., Arenson, D. M., & Bissell, D. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81686-6 · Cited by 354 · see citing works
Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin–proteasome‐mediated degradation
Huang, G., Shigesada, K., Ito, K., Wee, H., Yokomizo, T., & Ito, Y. (2001) · The EMBO Journal · doi:10.1093/emboj/20.4.723 · Cited by 283 · see citing works
Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells.
Li, G., Fridman, R., & Kim, H.-R. C. (1999) · PubMed · Cited by 256 · see citing works
Yoshiji, H., Kuriyama, S., Miyamoto, Y., Thorgeirsson, U. P., Gomez, D. E., Kawata, M., Yoshii, J., Ikenaka, Y., Noguchi, R., Tsujinoue, H., et al. (2000) · Hepatology · doi:10.1053/jhep.2000.20521 · Cited by 254 · see citing works
Groucho-Dependent and -Independent Repression Activities of Runt Domain Proteins
Aronson, B. D., Fisher, A. L., Blechman, K. M., Caudy, M. A., & Gergen, J. P. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5581 · Cited by 251 · see citing works
Lutterbach, B. A., Westendorf, J. J., Linggi, B. E., Isaac, S., Seto, E., & Hiebert, S. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.651 · Cited by 245 · see citing works
Javed, A., Guo, B., Hiebert, S. W., Choi, J., Green, J., Zhao, S.-C., Osborne, M. A., Stifani, S., Stein, J. L., Lian, J. B., et al. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.12.2221 · Cited by 232 · see citing works
Kim, W., Sieweke, M., Ogawa, E., Wee, H., Englmeier, U., Graf, T., & Ito, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.6.1609 · Cited by 230 · see citing works
Taimr, P., Higuchi, H., Kočová, E., Rippe, R. A., Friedman, S. L., & Gores, G. J. (2003) · Hepatology · doi:10.1053/jhep.2003.50002 · Cited by 228 · see citing works
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation
Lutterbach, B. A., & Hiebert, S. W. (2000) · Gene · doi:10.1016/s0378-1119(00)00014-7 · Cited by 209 · see citing works
Matrix Metalloproteinases in Lung Diseases
Ohbayashi, H. (2002) · Current Protein and Peptide Science · doi:10.2174/1389203023380549 · Cited by 204 · see citing works
Heß, J., Porte, D., Münz, C., & Angel, P. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010601200 · Cited by 188 · see citing works
Prince, M., Banerjee, C., Javed, A., Green, J., Lian, J. B., Stein, G. S., Bodine, P. V. N., & Komm, B. S. (2000) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20010301)80:3 · Cited by 182 · see citing works
Javed, A., Barnes, G. B., Jasanya, B. O., Stein, J. L., Gerstenfeld, L. C., Lian, J. B., & Stein, G. S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.8.2891-2905.2001 · Cited by 177 · see citing works
Porphyromonas gingivalis Gingipains: The Molecular Teeth of a Microbial Vampire
O’brien-simpson, N. M., Veith, P. D., Dashper, S. G., & Reynolds, E. C. (2003) · Current Protein and Peptide Science · doi:10.2174/1389203033487009 · Cited by 173 · see citing works
DʼAlonzo, R. C., Selvamurugan, N., Karsenty, G., & Partridge, N. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107082200 · Cited by 163 · see citing works
Matrix metalloproteinases and TIMPs: properties and implications for the rheumatic diseases
Cawston, T. E. (1998) · Molecular Medicine Today · doi:10.1016/s1357-4310(97)01192-1 · Cited by 160 · see citing works
Gaça, M., Zhou, X., Issa, R., Kiriella, K., Iredale, J. P., & Benyon, R. C. (2003) · Matrix Biology · doi:10.1016/s0945-053x(03)00017-9 · Cited by 144 · see citing works
DNA binding by c‐Ets‐1, but not v‐Ets, is repressed by an intramolecular mechanism.
Lim, F., Kraut, N., Framptom, J., & Graf, T. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05096.x · Cited by 137 · see citing works
Smart, D. E., Vincent, K. J., Arthur, M. J. P., Eickelberg, O., Castellazzi, M., Mann, J., & Mann, D. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101840200 · Cited by 97 · see citing works
Self-citationBahr, M. J., Vincent, K. J., Arthur, M. J. P., Fowler, A. V., Smart, D. E., Wright, M. C., Clark, I. M., Benyon, C. R., Iredale, J. P., & Mann, D. A. (1999) · Hepatology · doi:10.1002/hep.510290333 · Cited by 82 · see citing works
Self-citationTissue Inhibitors of Metalloproteinases: Role in Liver Fibrosis and Alcoholic Liver Disease
Arthur, M. J. P., Iredale, J. P., & Mann, D. A. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04208.x · Cited by 70 · see citing works
Self-citationTrim, J. E., Samra, S. K., Arthur, M. J. P., Wright, M. C., McAulay, M., Beri, R. K., & Mann, D. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.9.6657 · Cited by 58 · see citing works
Self-citationThe extracellular matrix in balloon arterial injury: A novel target for restenosis prevention
Batchelor, W., Robinson, R., & Strauss, B. H. (1998) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(98)80021-2 · Cited by 40 · see citing works
Inhibition of apoptosis in rat mesangial cells by tissue inhibitor of metalloproteinase-1
Lin, H., Chen, X., Wang, J., & Yu, Z. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00403.x · Cited by 30 · see citing works
Matrix metalloproteinases in multiple sclerosis
Bever, C. T., & Rosenberg, G. A. (1999) · Neurology · doi:10.1212/wnl.53.7.1380 · Cited by 23 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Levanon, D., Goldstein, R. E., Bernstein, Y., Tang, H., Goldenberg, D., Stifani, S., Paroush, Z., and Groner, Y. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 11590 -11595
Cited by
Sorted by citations
The regulation of matrix metalloproteinases and their inhibitors
Clark, I. M., Swingler, T. E., Sampieri, C. L., & Edwards, D. R. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.12.006 · Cited by 555 · see citing works
Pratap, J., Javed, A., Languino, L. R., van Wijnen, A. J., Stein, J. L., Stein, G. S., & Lian, J. B. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.19.8581-8591.2005 · Cited by 312 · see citing works
Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis
Guo, J., & Friedman, S. L. (2010) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-3-21 · Cited by 315 · see citing works
Integrated spatial multiomics reveals fibroblast fate during tissue repair
Foster, D. S., Januszyk, M., Yost, K. E., Chinta, M. S., Gulati, G. S., Nguyen, A. T., Burcham, A. R., Salhotra, A., Ransom, R. C., Henn, D., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2110025118 · Cited by 194 · see citing works
Depner, C. M., Philbrick, K. A., & Jump, D. Β. (2013) · Journal of Nutrition · doi:10.3945/jn.112.171322 · Cited by 145 · see citing works
Runx2 Regulates G Protein-coupled Signaling Pathways to Control Growth of Osteoblast Progenitors
Teplyuk, N. M., Galindo, M. A., Teplyuk, V. I., Pratap, J., Young, D. W., Lapointe, D. S., Javed, A., Stein, J. L., Lian, J. B., Stein, G. S., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802453200 · Cited by 128 · see citing works
Transcriptional regulation of hepatic stellate cells
Mann, J., & Mann, D. A. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.011 · Cited by 119 · see citing works
Self-citationSavage, T. M., Fortson, K. T., de los Santos-Alexis, K., Oliveras-Alsina, A., Rouanne, M., Rae, S. S., Gamarra, J. R., Shayya, H., Kornberg, A., Cavero, R., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.01.009 · Cited by 115 · see citing works
Role of iron in hepatic fibrosis: One piece in the puzzle
Philippe, M. A. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i35.4746 · Cited by 95 · see citing works
Jo, M., & Curry, T. E. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0512 · Cited by 75 · see citing works
Novel sulfasalazine analogues with enhanced NF-kB inhibitory and apoptosis promoting activity
Habens, F., Srinivasan, N., Oakley, F., Mann, D. A., Ganesan, A., & Packham, G. (2005) · APOPTOSIS · doi:10.1007/s10495-005-1877-0 · Cited by 64 · see citing works
Self-citationRunx1 promotes angiogenesis by downregulation of insulin-like growth factor-binding protein-3
Iwatsuki, K., Tanaka, K., Kaneko, T., Kazama, R., Okamoto, S., Nakayama, Y., Ito, Y., Satake, M., Takahashi, S., Miyajima, A., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1208287 · Cited by 59 · see citing works
Takahashi, I., Onodera, K., Nishimura, M., Mitnai, H., Sasano, Y., & Mitani, H. (2006) · Journal of Molecular Histology · doi:10.1007/s10735-006-9060-7 · Cited by 59 · see citing works
Smart, D. E., Green, K., Oakley, F., Weitzman, J. B., Yaniv, M., Reynolds, G. M., Mann, J., Millward‐Sadler, H., & Mann, D. A. (2006) · Hepatology · doi:10.1002/hep.21436 · Cited by 52 · see citing works
Self-citationWilczynska, K. M., Gopalan, S. M., Bugno, M., Kasza, A., Konik, B. S., Bryan, L., Wright, S., Griswold‐Prenner, I., & Kordula, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604616200 · Cited by 52 · see citing works
Runx family genes, niche, and stem cell quiescence
Wang, C. Q., Jacob, B., Nah, G. S. S., & Osato, M. (2010) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2010.01.006 · Cited by 48 · see citing works
Lin, S., Saxena, N. K., Ding, X., Stein, L. L., & Anania, F. A. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0177 · Cited by 48 · see citing works
RUNX1 isoform disequilibrium promotes the development of trisomy 21–associated myeloid leukemia
Gialesaki, S., Bräuer-Hartmann, D., Issa, H., Bhayadia, R., Alejo-Valle, O., Verboon, L., Schmell, A. L., Laszig, S., Regényi, E., Schuschel, K., et al. (2022) · Blood · doi:10.1182/blood.2022017619 · Cited by 47 · see citing works
Kaur, S., Rawal, P., Siddiqui, H., Rohilla, S., Sharma, S., Tripathi, D. M., Baweja, S., Hassan, M., Vlaic, S., Guthke, R., et al. (2019) · Cells · doi:10.3390/cells8101277 · Cited by 45 · see citing works
Zhong, L., Zhao, J., Huang, L., Liu, Y., Pang, X., Zhan, K., Li, S., Xue, Q., Pan, X., & Deng, L. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1316 · Cited by 43 · see citing works
Altered Transforming Growth Factor-Beta Signaling in a Murine Model of Thoracic Aortic Aneurysm
Jones, J. A., Barbour, J. R., Stroud, R. E., Bouges, S., Stephens, S. L., Spinale, F. G., & Ikonomidis, J. S. (2008) · Journal of Vascular Research · doi:10.1159/000127437 · Cited by 43 · see citing works
Rashid, H., Chen, H., & Javed, A. (2021) · Matrix Biology Plus · doi:10.1016/j.mbplus.2021.100088 · Cited by 41 · see citing works
Optimal Low-Energy Laser Irradiation Causes Temporal G2/M Arrest on Rat Calvarial Osteoblasts
Fukuhara, E., Goto, T., Matayoshi, T., Kobayashi, S., & Takahashi, T. (2006) · Calcified Tissue International · doi:10.1007/s00223-006-0072-9 · Cited by 39 · see citing works
FosB Regulates Stretch-Induced Expression of Extracellular Matrix Proteins in Smooth Muscle
Ramachandran, A., Gong, E. M.-L., Pelton, K., Ranpura, S. A., Mulone, M. D., Seth, A., Gomez, P., & Adam, R. M. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.08.034 · Cited by 38 · see citing works
Dowson, C., & O’Reilly, S. (2016) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2016.06.003 · Cited by 37 · see citing works
An evolutionarily conserved PTEN-C/EBPα-CTNNA1 axis controls myeloid development and transformation
Fu, C., Zhu, K.-Y., Mi, J., Liu, Y., Murray, S. T., Fu, Y., Ren, C., Dong, Z., Liu, Y., Dong, M., et al. (2010) · Blood · doi:10.1182/blood-2009-11-255778 · Cited by 35 · see citing works
Guo, J., Hong, F., Loke, J. C., Yea, S., Lim, C. L., Lee, U., Mann, D. A., Walsh, M. J., Sninsky, J. J., & Friedman, S. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.035295 · Cited by 35 · see citing works
Self-citationNegative regulation of TIMP1 is mediated by transcription factor TWIST1
Haneji (2009) · International Journal of Oncology · doi:10.3892/ijo_00000327 · Cited by 34 · see citing works
Wu, K., Liu, Y., Xia, J. L., Liu, J., Wang, K., Liang, H., Xu, F., Liu, D., Nie, D., Tang, X., et al. (2023) · Advanced Science · doi:10.1002/advs.202304408 · Cited by 27 · see citing works
Zhong, L., Huang, L., Xue, Q., Liu, C., Xu, K., Shen, W., & Deng, L. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28456 · Cited by 27 · see citing works
Morgan, X. C., Ni, S., Miranker, D. P., & Iyer, V. R. (2007) · BMC Bioinformatics · doi:10.1186/1471-2105-8-445 · Cited by 23 · see citing works
Hattori, S., Dhar, D. K., Hara, N., Tonomoto, Y., Onoda, T., Ono, T., Yamanoi, A., Tachibana, M., Tsuchiya, M., & Nagasue, N. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700539 · Cited by 23 · see citing works
Benhassine, M., & Guérin, S. L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103272 · Cited by 21 · see citing works
Kelly, K. J., Liu, Y., Zhang, J., Goswami, C. P., Lin, H., & Dominguez, J. H. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00028.2013 · Cited by 22 · see citing works
RUN(X) out of blood: emerging RUNX1 functions beyond hematopoiesis and links to Down syndrome
Rozen, E. J., Ozeroff, C. D., & Allen, M. A. (2023) · Human Genomics · doi:10.1186/s40246-023-00531-2 · Cited by 17 · see citing works
Devi, Y. S., Shehu, A., Halperín, J., Stocco, C. O., Le, J., Seibold, A. M., & Gibori, G. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-87 · Cited by 17 · see citing works
Ohnishi, Y. N., Sakumi, K., Yamazaki, K., Ohnishi, Y. H., Miura, T., Tominaga, Y., & Nakabeppu, Y. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-08-0768 · Cited by 15 · see citing works
Engers, R., Springer, E., Kehren, V., Simic, T. P., Young, D. A., Beier, J. I., Klotz, L., Clark, I. M., Sies, H., & Gabbert, H. E. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05476.x · Cited by 15 · see citing works
Bertran, L., Eigbefoh-Addeh, A., Portillo-Carrasquer, M., Barrientos‐Riosalido, A., Binetti, J., Aguilar, C., Chicote, J. U., Bartra, H., Artigas, L., Coma, M., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10061315 · Cited by 13 · see citing works
He, Z., Li, H., Zhang, Y., Gao, S., Liang, K., Su, Y., Wang, D., Yang, Z., Du, Y., Xing, D., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.12.007 · Cited by 13 · see citing works
Estellé, J., Sastre, Y., Merchán, M., Peiró, R. M., Santacreu, M. A., & Folch, J. M. (2006) · Molecular Reproduction and Development · doi:10.1002/mrd.20476 · Cited by 10 · see citing works
Zheng, M., Li, H., Gao, Y., Brigstock, D. R., & Gao, R. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176000 · Cited by 8 · see citing works
Feng, Y., Mao, T., Yi, J., Zhang, N., Gu, Y., Shen, H., & Chen, J. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1528645 · Cited by 7 · see citing works
Jia, D., Ni, Y., Zhang, Y., Rao, C., Hou, J., Tang, H.-Q., Liu, C.-B., & Wu, J. (2016) · Cell & Bioscience · doi:10.1186/s13578-016-0094-6 · Cited by 4 · see citing works
RUNX1 isoform disequilibrium in the development of trisomy 21 associated myeloid leukemiaPreprint
Gialesaki, S., Bräuer-Hartmann, D., Bhayadia, R., Alejo-Valle, O., Issa, H., Regényi, E., Beyer, C., Labuhn, M., Ihling, C. H., Sinz, A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.07.483334 · Cited by 2 · see citing works
Chen, K., & Wang, S. (2025) · Biomedicines · doi:10.3390/biomedicines13122999 · Cited by 1 · see citing works
Embryonic Diapause as a Model for Pluripotent Stem Cell Quiescence
Margaretha, L. (2012) · ResearchWorks at the University of Washington (University of Washington)
Wilczynska, K. M. (2008) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/m03z-a606
- Authors
- Bertrand-Philippe, M., Ruddell, R. G., Arthur, M. J. P., Thomas, J., Mungalsingh, N., & Mann, D. A.
- Affiliations
- Southampton General Hospital (GB)
- Corresponding author
- Mann, Derek A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-06
- Volume
- 279
- Issue
- 23
- Pages
- 24530-24539
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2087011813
- Cited by
- 49
- References
- 36
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 2 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- TIMP-1, RUNX1, Runx2, serum response element, AP-1, JunD, hepatic stellate cells, liver fibrosis, transcriptional regulation, promoter activity, transcription factor binding sites
- MeSH terms
- Animals, Chromatin, DNA, DNA-Binding Proteins, Electrophoresis, Polyacrylamide Gel, Gene Expression Regulation, HeLa Cells, Humans, Liver, Male, Models, Genetic, Neoplasm Proteins, Plasmids, Precipitin Tests, Promoter Regions, Genetic, Protein Binding, Proto-Oncogene Proteins, Time Factors, Transcription Factors, Transcription, Genetic, Transfection, Immunoblotting, Blotting, Northern, Proto-Oncogene Proteins c-jun, Rats, Sprague-Dawley, Genes, Reporter, COS Cells, Tissue Inhibitor of Metalloproteinase-1, Protein Isoforms, Reverse Transcriptase Polymerase Chain Reaction, Two-Hybrid System Techniques, Amino Acid Motifs, Serum Response Element, Cell Line, Tumor, Core Binding Factor alpha Subunits, Core Binding Factor Alpha 1 Subunit, Core Binding Factor Alpha 2 Subunit, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
