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Cited by 448

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

The G Protein-coupled Receptor GPR30 Mediates c-fos Up-regulation by 17β-Estradiol and Phytoestrogens in Breast Cancer Cells

Open access
Maggiolini, Marcello, Vivacqua, Adele, Fasanella, Giovanna, Recchia, Anna Grazia, Sisci, Diego, Pezzi, Vincenzo, Montanaro, Daniela, Musti, Anna Maria, Picard, Didier, Andò, Sebastiano·2004·Journal of Biological Chemistry
DOI 10.1074/jbc.m403588200
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Abstract

A growing body of evidence concerning estrogen effects cannot be explained by the classic model of hormone action, which involves the binding to estrogen receptors (ERs) alpha and ERbeta and the interaction of the steroid-receptor complex with specific DNA sequences associated with target genes. Using c-fos proto-oncogene expression as an early molecular sensor of estrogen action in ERalpha-positive MCF7 and ER-negative SKBR3 breast cancer cells, we have discovered that 17beta-estradiol (E2), and the two major phytoestrogens, genistein and quercetin, stimulate c-fos expression through ERalpha as well as through an ER-independent manner via the G protein-coupled receptor homologue GPR30. The c-fos response is repressed in GPR30-expressing SKBR3 cells transfected with an antisense oligonucleotide against GPR30 and reconstituted in GPR30-deficient MDA-MB 231 and BT-20 breast cancer cells transfected with a GPR30 expression vector. GPR30-dependent activation of ERK1/2 by E2 and phytoestrogens occurs via a Gbetagamma-associated pertussis toxin-sensitive pathway that requires both Src-related and EGF receptor tyrosine kinase activities. The ability of E2 and phytoestrogens to regulate the expression of growth-related genes such as c-fos even in the absence of ER has interesting implications for understanding breast cancer progression.

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Citations

Cites

Show all 75 references

Research works printed but not linked: 30

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Metadata

Authors
Maggiolini, M., Vivacqua, A., Fasanella, G., Recchia, A. G., Sisci, D., Pezzi, V., Montanaro, D., Musti, A. M., Picard, D., & Andò, S.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2004-06
Volume
279
Issue
26
Pages
27008-27016
ISSN
0021-9258 (ISSN-L)
DOI
10.1074/jbc.m403588200
OpenAlex
W2028893107
Cited by
448
References
75
FWCI
10.78
Type
journal article
Language
en
Open access
hybrid
Licence

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CoChat. (2026). Citation check: The G Protein-coupled Receptor GPR30 Mediates c-fos Up-regulation by 17β-Estradiol and Phytoestrogens in Breast Cancer Cells. https://app.cochat.ai/papers/10.1074/jbc.m403588200
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Maggiolini, M., Vivacqua, A., Fasanella, G., Recchia, A. G., Sisci, D., Pezzi, V., Montanaro, D., Musti, A. M., Picard, D., & Andò, S. (2004). The G Protein-coupled Receptor GPR30 Mediates c-fos Up-regulation by 17β-Estradiol and Phytoestrogens in Breast Cancer Cells. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m403588200

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