Peptide Blockers of the Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Amyloid β

Magdesian, Margaret H.; Nery, Arthur A.; Martins, A. Henrique B.; Juliano, Maria Aparecida; Juliano, Luiz; Ulrich, Henning; Ferreira, Sérgio T.

doi:10.1074/jbc.m502406200

Cited by 44Nicotinic Acetylcholine Receptors StudyAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Peptide Blockers of the Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Amyloid β

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Magdesian, Margaret H., Nery, Arthur A., Martins, A. Henrique B., Juliano, Maria Aparecida, Juliano, Luiz, Ulrich, Henning, Ferreira, Sérgio T.·2005·Journal of Biological Chemistry

DOI 10.1074/jbc.m502406200

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Abstract

Alzheimer disease (AD) is characterized by accumulation of the neurotoxic amyloid beta peptide (Abeta) and by the loss of cholinergic neurons and nicotinic acetylcholine receptors (nAChRs) throughout the brain. Direct inhibition of nAChRs by Abeta has also been suggested to contribute to cholinergic dysfunction in AD. In an effort to find ligands capable of blocking Abeta-induced inhibition of nAChRs, we have screened a phage display library to identify peptides that bind to Abeta. Using this approach, we identified a heptapeptide denoted IQ, which binds with nanomolar affinity to Abeta and is homologous to the acetylcholine-binding protein and to most subtypes of nAChRs. Rapid kinetic whole-cell current-recording measurements showed that Abeta inhibits nAChR function in a dose-dependent manner in neuronal differentiated PC12 cells and that nanomolar concentrations of IQ completely block the inhibition by Abeta. These results indicate that the Abeta binding site in nAChRs is homologous to the IQ peptide and that this is a relevant target for Abeta neurotoxicity in AD and, more generally, for the regulation of nAChR function by soluble Abeta in a physiological context. Furthermore, the results suggest that the IQ peptide may be a lead for the development of novel drugs to block the inhibition of nAChRs in AD.

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Other putative receptors/co-receptors involved in neuronal binding of Aβ oligomers include the p75 neurotrophin receptor, RAGE, nicotinic acetylcholine receptors and Frizzled.
“Other putative receptors/co-receptors involved in neuronal binding of Aβ oligomers include the p75 neurotrophin receptor (p75NTR) (Knowles et al., 2009), the receptor for advanced glycation end products (RAGE) (Sturchler et al., 2008), nicotinic acetylcholine receptors (Magdesian et al., 2005) and Frizzled (Magdesian et al., 2008).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Magdesian et al., 2005

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Authors: Magdesian, M. H., Nery, A. A., Martins, A. H. B., Juliano, M. A., Juliano, L., Ulrich, H., & Ferreira, S. T.
Affiliations: Universidade Federal do Rio de Janeiro (BR)
Universidade de São Paulo (BR)
Universidade Federal de São Paulo (BR)
ORCID: Nery, Arthur A.
Martins, A. Henrique B.
Juliano, Luiz
Ulrich, Henning
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2005-09
Volume: 280
Issue: 35
Pages: 31085-31090
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m502406200
OpenAlex: W1986686062
Cited by: 44
References: 35
Citations by year: 2026: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 3
FWCI: 1.38
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 5505 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Americanae (AECID Library) (publishedVersion, other-oa)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: amyloid-beta, neuronal nicotinic acetylcholine receptors, Alzheimer's disease, peptide antagonists, phage display, acetylcholine binding protein, receptor binding sites, cholinergic dysfunction, PC12 cells, neurotoxicity
MeSH terms: Alzheimer Disease, Amino Acid Sequence, Animals, Carbachol, Electrophysiology, Humans, Models, Molecular, Neurons, Peptides, Receptors, Nicotinic, Amyloid beta-Peptides, Sequence Alignment, PC12 Cells, Protein Structure, Tertiary, Cholinergic Agonists, Peptide Library, Rats

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Peptide Blockers of the Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Amyloid β

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