Amyloid-beta oligomers increase the localization of prion protein at the cell surface: PrPC trafficking and Alzheimer’s disease

Caetano, Fabiana A.; Beraldo, Flavio H.; Hajj, Glaucia N. M.; Guimaraes, Andre L.; Jürgensen, Sofia; Wasilewska-Sampaio, Ana Paula; Hirata, Pedro H. F.; Souza, Ivana; Machado, Cleiton F.; Wong, Daisy Y.-L.; De Felice, Fernanda G.; Ferreira, Sergio T.; Prado, Vania F.; Rylett, R. Jane; Martins, Vilma R.; Prado, Marco A. M.

doi:10.1111/j.1471-4159.2011.07225.x

Cited by 74Alzheimer's disease research and treatmentsPrion Diseases and Protein MisfoldingNeuroinflammation and Neurodegeneration Mechanisms

Amyloid-beta oligomers increase the localization of prion protein at the cell surface: PrPC trafficking and Alzheimer’s disease

Caetano, Fabiana A., Beraldo, Flavio H., Hajj, Glaucia N. M., Guimaraes, Andre L., Jürgensen, Sofia, Wasilewska-Sampaio, Ana Paula, Hirata, Pedro H. F., Souza, Ivana +8 more·2011·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.2011.07225.x

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Abstract

In Alzheimer's disease, the amyloid-β peptide (Aβ) interacts with distinct proteins at the cell surface to interfere with synaptic communication. Recent data have implicated the prion protein (PrP(C)) as a putative receptor for Aβ. We show here that Aβ oligomers signal in cells in a PrP(C)-dependent manner, as might be expected if Aβ oligomers use PrP(C) as a receptor. Immunofluorescence, flow cytometry and cell surface protein biotinylation experiments indicated that treatment with Aβ oligomers, but not monomers, increased the localization of PrP(C) at the cell surface in cell lines. These results were reproduced in hippocampal neuronal cultures by labeling cell surface PrP(C). In order to understand possible mechanisms involved with this effect of Aβ oligomers, we used live cell confocal and total internal reflection microscopy in cell lines. Aβ oligomers inhibited the constitutive endocytosis of PrP(C), but we also found that after Aβ oligomer-treatment PrP(C) formed more clusters at the cell surface, suggesting the possibility of multiple effects of Aβ oligomers. Our experiments show for the first time that Aβ oligomers signal in a PrP(C)-dependent way and that they can affect PrP(C) trafficking, increasing its localization at the cell surface.

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Crossref · 10.1111/j.1471-4159.2011.07225.x

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Aβ oligomers cause a rapid increase in surface exposure and clustering of PrPC in hippocampal neurons and cell lines.
“Aβ oligomers were recently shown to cause a rapid increase in surface exposure and clustering of PrPC in hippocampal neurons and cell lines (Caetano et al., 2011).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Caetano et al., 2011
Initial ADDL binding recruits more PrPC molecules to form a higher order complex that may initiate toxic signaling at the neuronal membrane.
“This suggests that initial ADDL binding recruits more PrPC molecules (presumably by exocytosis of vesicles located proximal to the plasma membrane; (Caetano et al., 2011)) to form a higher order complex that may initiate toxic signaling at”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Caetano et al., 2011

1 retracted

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Jürgensen, S., Antonio, L. L., Mussi, G. E. A., Brito-Moreira, J., Bomfim, T. R., De Felice, F. G., Garrido-Sanabria, E. R., Cavalheiro, É. A., & Ferreira, S. T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.177790 · Cited by 88 · see citing works
PrPc on the road: trafficking of the cellular prion protein
Prado, M. A. M., Alves‐Silva, J., Magalhães, A. C., Prado, V. F., Linden, R., Martins, V. R., & Brentani, R. R. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02199.x · Cited by 84 · see citing works
Green Fluorescent Protein-Tagged β-Arrestin Translocation as a Measure of G Protein-Coupled Receptor Activation
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Cell Surface Dynamics of GPI-Anchored Proteins
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Nicotinic Receptors, Amyloid-β, and Synaptic Failure in Alzheimer’s Disease
Jürgensen, S., & Ferreira, S. T. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9237-0 · Cited by 57 · see citing works
Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4
Jen, A., Parkyn, C. J., Mootoosamy, R. C., Ford, M. J., Warley, A., Liu, Q., Bu, G., Baskakov, I. V., Moestrup, S. K., McGuinness, L., et al. (2010) · Journal of Cell Science · doi:10.1242/jcs.058099 · Cited by 54 · see citing works
The ups and downs of Aβ
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Oligomeric aggregates of amyloid β peptide 1–42 activate ERK/MAPK in SH-SY5Y cells via the α7 nicotinic receptor
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Peptide Blockers of the Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Amyloid β
Magdesian, M. H., Nery, A. A., Martins, A. H. B., Juliano, M. A., Juliano, L., Ulrich, H., & Ferreira, S. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502406200 · Cited by 44 · see citing works
A new take on prions: preventing Alzheimer's disease.
Hooper, N., & Turner, A. (2008) · TIBS -Trends in Biochemical Sciences. Regular ed · doi:10.1016/j.tibs.2008.01.004 · Cited by 32 · see citing works
Prion infection of mice transgenic for human APPSwe: increased accumulation of cortical formic acid extractable Aβ(1–42) and rapid scrapie disease development
Baier, M., Apelt, J., Riemer, C., Gültner, S., Schwarz, A., Bamme, T., Burwinkel, M., & Schliebs, R. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.07.001 · Cited by 22 · see citing works

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The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade
Cline, E. N., Bicca, M. A., Viola, K. L., & Klein, W. L. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179941 · Cited by 870 · see citing works
The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease
Ferreira, S. T., & Klein, W. L. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.003 · Cited by 442 · see citing works
The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases
Lackie, R. E., Maciejewski, A., Ostapchenko, V. G., Marques-Lopes, J., Choy, W., Duennwald, M. L., Prado, V. F., & Prado, M. A. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00254 · Cited by 375 · see citing works
Soluble amyloid-Î² oligomers as synaptotoxins leading to cognitive impairment in Alzheimerâ€™s disease
Ferreira, S. T., Lourenco, M. V., Oliveira, M. M., & De Felice, F. G. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00191 · Cited by 373 · see citing works
Self-citation
α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B
Ferreira, D. G., Temido‐Ferreira, M., Miranda, H. V., Batalha, V. L., Coelho, J. E., Szegő, É. M., Marques-Morgado, I., Vaz, S. H., Rhee, J. S., Schmitz, M., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4648 · Cited by 276 · see citing works
RETRACTED: The Complex PrPc-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease
Larson, M. E., Sherman, M. A., Amar, F., Nuvolone, M., Schneider, J. A., Bennett, D. A., Aguzzi, A., & Lesné, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1858-12.2012 · Cited by 274 · see citing works
Retracted
A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer’s brain
Li, S., & Selkoe, D. J. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15007 · Cited by 264 · see citing works
Prion protein at the crossroads of physiology and disease
Biasini, E., Turnbaugh, J. A., Unterberger, U., & Harris, D. A. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.10.002 · Cited by 169 · see citing works
Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1
Rushworth, J. V., Jarosz-Griffiths, H., Watt, N. T., & Hooper, N. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.400358 · Cited by 151 · see citing works
The Biological Function of the Prion Protein: A Cell Surface Scaffold of Signaling Modules
Linden, R. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00077 · Cited by 146 · see citing works
The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment
Ostapchenko, V. G., Chen, M., Guzmán, M. S., Xie, Y., Lavine, N. E., Fan, J., Beraldo, F. H., Martyn, A. C., Belrose, J. C., Mori, Y., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4081-14.2015 · Cited by 139 · see citing works
Alzheimer's disease: An overview of amyloid beta dependent pathogenesis and its therapeutic implications along with in silico approaches emphasizing the role of natural products
Awasthi, M., Singh, S., Pandey, V. P., & Dwivedi, U. N. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.01.008 · Cited by 135 · see citing works
Cellular prion protein is essential for oligomeric amyloid- -induced neuronal cell death
Kudo, W., Hp, L., Zou, W.-Q., Wang, X., Perry, G., Zhu, X., Smith, M. A., Petersen, R. B., & Lee, H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr542 · Cited by 116 · see citing works
Biophysical Studies of the Amyloid β‐Peptide: Interactions with Metal Ions and Small Molecules
Wärmländer, S. K. T. S., Tiiman, A., Abelein, A., Luo, J., Jarvet, J., Söderberg, K. L., Danielsson, J., & Gräslund, A. (2013) · ChemBioChem · doi:10.1002/cbic.201300262 · Cited by 101 · see citing works
The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers
Younan, N. D., Sarell, C. J., Davies, P., Brown, D. R., & Viles, J. H. (2013) · The FASEB Journal · doi:10.1096/fj.12-222588 · Cited by 100 · see citing works
Alzheimer's disease: β‐amyloid plaque formation in human brain
Seeman, P. M., & Seeman, N. (2011) · Synapse · doi:10.1002/syn.20957 · Cited by 97 · see citing works
α-Secretase-derived Fragment of Cellular Prion, N1, Protects against Monomeric and Oligomeric Amyloid β (Aβ)-associated Cell Death
Guillot‐Sestier, M., Sunyach, C., Ferreira, S. T., Marzolo, M., Bauer, C., Thevenet, A., & Checler, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.323626 · Cited by 95 · see citing works
Proteolytic processing of the prion protein in health and disease.
Altmeppen, H. C., Puig, B., Dohler, F., Thurm, D., Falker‐Gieske, C., Krasemann, S., & Glatzel, M. (2012) · Europe PMC (PubMed Central) · Cited by 93 · see citing works
Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer’s disease
Leshchyns’ka, I., Liew, H. T., Shepherd, C. E., Halliday, G. M., Stevens, C. H., Ke, Y. D., Ittner, L. M., & Sytnyk, V. (2015) · Nature Communications · doi:10.1038/ncomms9836 · Cited by 92 · see citing works
The Prion Protein Ligand, Stress-Inducible Phosphoprotein 1, Regulates Amyloid-β Oligomer Toxicity
Ostapchenko, V. G., Beraldo, F. H., Mohammad, A. H., Xie, Y., Hirata, P. H. F., Magalhães, A. C., Lamour, G., Li, H., Maciejewski, A., Belrose, J. C., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3214-13.2013 · Cited by 84 · see citing works
Prion Protein as a Toxic Acceptor of Amyloid-β Oligomers
Purro, S. A., Nicoll, A. J., & Collinge, J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.020 · Cited by 80 · see citing works
Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer’s disease and normal physiology
Pfundstein, G., Nikonenko, A. G., & Sytnyk, V. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.969547 · Cited by 83 · see citing works
Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex
Beraldo, F. H., Ostapchenko, V. G., Caetano, F. A., Guimarães, A. L. S., Ferretti, G. D. S., Daude, N., Bertram, L. N., Nogueira, K. D. O. P. C., Silva, J. L., Westaway, D. A., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.738286 · Cited by 65 · see citing works
The prion protein unstructured N‐terminal region is a broad‐spectrum molecular sensor with diverse and contrasting potential functions
Béland, M., & Roucou, X. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07613.x · Cited by 65 · see citing works
Roles of endoproteolytic α‐cleavage and shedding of the prion protein in neurodegeneration
Altmeppen, H. C., Prox, J., Puig, B., Dohler, F., Falker‐Gieske, C., Krasemann, S., & Glatzel, M. (2013) · FEBS Journal · doi:10.1111/febs.12196 · Cited by 52 · see citing works
Allosteric function and dysfunction of the prion protein
Linden, R., Cordeiro, Y., & Lima, L. M. T. R. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0847-7 · Cited by 49 · see citing works
Advances in amyloid beta oligomer detection applications in Alzheimer's disease
Jamerlan, A., An, S. S. A., & Hulme, J. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.115919 · Cited by 46 · see citing works
Amyloid‐β oligomers interact with neurexin and diminish neurexin‐mediated excitatory presynaptic organization
Naito, Y., Tanabe, Y., Lee, A. K., Hamel, E., & Takahashi, H. (2017) · Scientific Reports · doi:10.1038/srep42548 · Cited by 42 · see citing works
Functions of the Prion Protein
Hirsch, T. Z., Martin‐Lannerée, S., & Mouillet‐Richard, S. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.06.001 · Cited by 39 · see citing works
Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease
Ostapchenko, V. G., Beraldo, F. H., Guimarães, A. L. S., Mishra, S., Guzmán, M. S., Fan, J., Martins, V. R., Prado, V. F., & Prado, M. A. M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12296 · Cited by 38 · see citing works
Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer's disease
Younan, N. D., Chen, K., Rose, R., Crowther, D. C., & Viles, J. H. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003319 · Cited by 38 · see citing works
Pathogenic prions deviate PrPC signaling in neuronal cells and impair A-beta clearance
Pradines, E., Hernandez-Rapp, J., Villa-Díaz, A., Dakowski, C., Ardila-Osorio, H., Haïk, S., Schneider, B., Launay, J., Kellermann, O., Torres, J., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2012.195 · Cited by 33 · see citing works
Prion Disease: A Tale of Folds and Strains
Kretzschmar, H. A., & Tatzelt, J. (2013) · Brain Pathology · doi:10.1111/bpa.12045 · Cited by 35 · see citing works
PrPC signalling in neurons: From basics to clinical challenges
Hirsch, T. Z., Hernandez-Rapp, J., Martin‐Lannerée, S., Launay, J., & Mouillet‐Richard, S. (2014) · Biochimie · doi:10.1016/j.biochi.2014.06.009 · Cited by 33 · see citing works
Alzheimer’s Amyloid-β Oligomers Rescue Cellular Prion Protein Induced Tau Reduction via the Fyn Pathway
Chen, R.-J., Chang, W.-W., Lin, Y., Cheng, P., & Chen, Y. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400085q · Cited by 30 · see citing works
LRP/LR Antibody Mediated Rescuing of Amyloid-β-Induced Cytotoxicity is Dependent on PrPc in Alzheimer’s Disease
Pinnock, E. C., Jovanovic, K., Pinto, M. G., Ferreira, E., Dias, B. D. C., Penny, C. B., Knackmuss, S. H. J., Reusch, U., Little, M., Schätzl, H. M., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150482 · Cited by 29 · see citing works
Protein Misfolding in Prion and Prion-Like Diseases: Reconsidering a Required Role for Protein Loss-of-Function
Leighton, P. L. A., & Allison, W. T. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160361 · Cited by 29 · see citing works
Cellular Prion Protein Mediates Toxic Signaling of Amyloid Beta
Resenberger, U. K., Winklhofer, K. F., & Tatzelt, J. (2011) · Neurodegenerative Diseases · doi:10.1159/000332596 · Cited by 28 · see citing works
Accumulation of cellular prion protein within β‐amyloid oligomer plaques in aged human brains
Takahashi, R. H., Yokotsuka, M., Tobiume, M., Sato, Y., Hasegawa, H., Nagao, T., & Gouras, G. K. (2021) · Brain Pathology · doi:10.1111/bpa.12941 · Cited by 27 · see citing works
The Quest for Cellular Prion Protein Functions in the Aged and Neurodegenerating Brain
Gavı́n, R., Lidón, L., Ferrer, I., & del Rı́o, J. A. (2020) · Cells · doi:10.3390/cells9030591 · Cited by 25 · see citing works
Impact of the Cellular Prion Protein on Amyloid-β and 3PO-Tau Processing
Schmitz, M., Wulf, K., Signore, S. C., Schulz‐Schaeffer, W., Kermer, P., Bähr, M., Wouters, F. S., Zafar, S., & Zerr, I. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130566 · Cited by 25 · see citing works
Fyn Kinase in Alzheimer’s Disease: Unraveling Molecular Mechanisms and Therapeutic Implications
Meur, S., & Karati, D. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04286-2 · Cited by 23 · see citing works
Neurotoxicity of Prion Peptides Mimicking the Central Domain of the Cellular Prion Protein
Vilches, S., Vergara, C., Nicolás, O., Sanclimens, G., Merino, S. T., Varón, S., Acosta, G., Alberício, F., Royo, M., del Rı́o, J. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070881 · Cited by 24 · see citing works
The cellular prion protein beyond prion diseases
Manni, G., Lewis, V., Senesi, M., Spagnolli, G., Fallarino, F., Collins, S. J., Mouillet‐Richard, S., & Biasini, E. (2020) · Swiss Medical Weekly · doi:10.4414/smw.2020.20222 · Cited by 25 · see citing works
Zebrafish Prion Protein PrP2 Controls Collective Migration Process during Lateral Line Sensory System Development
Huc-Brandt, S., Hieu, N., Imberdis, T., Cubedo, N., Silhol, M., Leighton, P. L. A., Domaschke, T., Allison, W. T., Perrier, V., & Rossel, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113331 · Cited by 22 · see citing works
Immunization with either prion protein fragment 95–123 or the fragment-specific antibodies rescue memory loss and neurodegenerative phenotype of neurons in olfactory bulbectomized mice
Bobkova, N. V., Medvinskaya, N. I., Kamynina, A. V., Aleksandrova, I. Y., Nesterova, I. V., Samokhin, A. N., Koroev, D. O., Филатова, М. П., Nekrasov, P. V., Abramov, A. Y., et al. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.10.019 · Cited by 21 · see citing works
Hijacking PrPc-dependent signal transduction: when prions impair Aβ clearance
Hernandez-Rapp, J., Martin‐Lannerée, S., Hirsch, T. Z., Launay, J., & Mouillet‐Richard, S. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00025 · Cited by 21 · see citing works
A Rational Structured Epitope Defines a Distinct Subclass of Toxic Amyloid-beta Oligomers
Silverman, J. M., Gibbs, E., Peng, X., Martens, K. M., Balducci, C., Wang, J., Yousefi, M., Cowan, C. M., Lamour, G., Louadi, S., et al. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00469 · Cited by 19 · see citing works
Unraveling the neuroprotective mechanisms of PrP C in excitotoxicity
Llorens, F., & del Rı́o, J. A. (2012) · Prion · doi:10.4161/pri.19639 · Cited by 21 · see citing works
High HIF-1α expression genotypes in oral lichen planus
Fraga, C. A. D. C., Alves, L. R., Marques-Silva, L., de Sousa, A. A., Jorge, A. S. B., de Jesus, S. F., Vilela, D. N., Pinheiro, U. B., Jones, K. M., de Paula, A. M. B., et al. (2013) · Clinical Oral Investigations · doi:10.1007/s00784-013-0920-8 · Cited by 19 · see citing works
Soluble Aβ aggregates can inhibit prion propagation
Sarell, C. J., Quarterman, E., Yip, D. C.-M., Terry, C., Nicoll, A. J., Wadsworth, J. D. F., Farrow, M. A., Walsh, D. M., & Collinge, J. (2017) · Open Biology · doi:10.1098/rsob.170158 · Cited by 14 · see citing works
Disease-associated Mutations in the Prion Protein Impair Laminin-induced Process Outgrowth and Survival
Machado, C. F., Beraldo, F. H., Santos, T. G., Bourgeon, D., Landemberger, M. C., Roffé, M., & Martins, V. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.428235 · Cited by 12 · see citing works
Sleep deprivation regulates availability of PrPC and Aβ peptides which can impair interaction between PrPC and laminin and neuronal plasticity
da Luz, M. H. M., Pino, J. M. V., Santos, T. G., Antunes, H. K. M., Martins, V. R., de Souza, A. A. L., Torquato, R. J. S., & Lee, K. S. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14960 · Cited by 11 · see citing works
The Heat Shock Response Is Modulated by and Interferes with Toxic Effects of Scrapie Prion Protein and Amyloid β
Resenberger, U. K., Müller, V., Munter, L. M., Baier, M., Multhaup, G., Wilson, M. R., Winklhofer, K. F., & Tatzelt, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.389007 · Cited by 9 · see citing works
LRP/LR specific antibody IgG1-iS18 impedes neurodegeneration in Alzheimer's disease mice
Ferreira, E., Bignoux, M. J., Otgaar, T. C., Tagliatti, N., Jovanovic, K., Letsolo, B. T., & Weiss, S. F. T. (2018) · Oncotarget · doi:10.18632/oncotarget.25473 · Cited by 9 · see citing works
How many amyloid‐β peptides can a neuron bind before it dies?
Munter, L. M. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13502 · Cited by 3 · see citing works
Preface: Special issue “Brain Proteostasis in Health and Disease”
Lourenco, M. V. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15879 · Cited by 3 · see citing works
Effects of FlAsH/Tetracysteine (TC) Tag on PrP Proteolysis and PrPres Formation by TC‐Scanning
Taguchi, Y., Hohsfield, L. A., Hollister, J. R., & Baron, G. S. (2013) · ChemBioChem · doi:10.1002/cbic.201300255 · Cited by 1 · see citing works
Prion (PRNP)
Linden, R., Martins, V. R., & Prado, M. A. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_390 · Cited by 1 · see citing works
Structural and Toxic Properties of Protein Aggregates: Towards a Molecular Understanding of Alzheimer's Disease
Wang, L., & Campioni, S. (2011) · InTech eBooks · doi:10.5772/20922
Prion protein gene in Alzheimer's disease
Caramelli, P. (2013) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20130093
Functional characterization of Shadoo, a PrP-like protein with neuroprotective activity
Haass, C. (2011)
Papel do complexo PrPc-HOP e vesículas extracelulares em câncer colorretal
de Lacerda, T. C. S. (2016) · doi:10.11606/t.46.2016.tde-20092016-101001
Über die Interaktionen des zellulären Prion-Proteins (PrPc) mit relevanten Proteinen der Alzheimer Erkrankung
Maibach-Wulf, K. (2014) · doi:10.53846/goediss-4587
In vivo and in vitro analysis on the effect of LRP/LR on alzheimer's disease related proteins, TERT expression and telomerase activity in alzheimer's disease models
Bignoux, M. J. (2018)
Faculty Opinions recommendation of Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease.
Rujescu, D., & Jung, M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725966450.793557761
Faculty Opinions recommendation of Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.
Zamponi, G. W. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.14264039.15777157
Prion (PRNP)
Linden, R., Martins, V. R., & Prado, M. A. M. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_390-1
Alzheimer’s disease as a syndrome of overloaded amyloidic synaptic tagging in memory networksPreprint
Murphy, N. (2021) · doi:10.31219/osf.io/7gsaz
Rôle de la protéine prion cellulaire (PRPC) dans la différenciation neuronale : Infection par les prions (PRPSC) et bases moléculaires de la neurodégénérescence
Dakowski, C. (2012) · theses.fr (ABES) · doi:10.70675/07004703z70dbz4d25zba3dzb2e9c8d963c2
Characterisation of non-covalent PrP assemblies
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Du rôle physiologique de la protéine prion cellulaire à l'infection par les prions : régulation/dérégulation du module de signalisation PDK1/TACE α-secrétase
Ezpeleta, J. (2019) · doi:10.70675/4e7ccce5z4f1ez4a57zac28z5380a39dd820
Maladies neurodégénératives et stress oxydant
Lévy, E. (2020) · theses.fr (ABES) · doi:10.70675/75371581z194fz4cb4zb457z91bf72dc0320 · Cited by 4 · see citing works
Étude de la conformation et de la dynamique conformationnelle de molécules biologiques en phase gazeuse
Bouakil, M. (2020) · theses.fr (ABES) · doi:10.70675/acd6af1dz6ff0z4966z9e5dzb1021e13dae0

Cellular prion protein as a receptor for amyloid-β oligomers in Alzheimer's disease
Salazar, S. V., & Strittmatter, S. M. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.062 · Cited by 90 · see citing works
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
Laurén, J., Gimbel, D. A., Nygaard, H. B., Gilbert, J. W., & Strittmatter, S. M. (2009) · Nature · doi:10.1038/nature07761 · Cited by 1,560 · see citing works
The cellular prion protein as a receptor for amyloid-beta oligomers
Rushworth, J. V. H. (2012) · OpenGrey (Institut de l'Information Scientifique et Technique)
Preferential Recruitment of Conformationally Distinct Amyloid-β Oligomers by the Intrinsically Disordered Region of the Human Prion Protein
Madhu, P., & Mukhopadhyay, S. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00646 · Cited by 20 · see citing works
Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1
Rushworth, J. V., Jarosz-Griffiths, H., Watt, N. T., & Hooper, N. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.400358 · Cited by 151 · see citing works

Authors: Caetano, F. A., Beraldo, F. H., Hajj, G. N. M., Guimaraes, A. L., Jürgensen, S., Wasilewska-Sampaio, A. P., Hirata, P. H. F., Souza, I., Machado, C. F., Wong, D. Y.-L., De Felice, F. G., Ferreira, S. T., Prado, V. F., Rylett, R. J., Martins, V. R., & Prado, M. A. M.
Affiliations: Universidade Federal de Minas Gerais (BR)
AC Camargo Hospital (BR)
Universidade Federal do Rio de Janeiro (BR)
Western University (CA)
Corresponding author: Prado, Marco A. M.
ORCID: Hajj, Glaucia N. M.
Souza, Ivana
Machado, Cleiton F.
Ferreira, Sergio T.
Rylett, R. Jane
Martins, Vilma R.
Prado, Marco A. M.
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2011-03-23
Volume: 117
Issue: 3
Pages: 538-553
ISSN: 0022-3042 (ISSN-L)
DOI: 10.1111/j.1471-4159.2011.07225.x
OpenAlex: W1500301897
Cited by: 74
References: 81
Citations by year: 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 15 · 2012: 7
FWCI: 7.85
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1623 d)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: amyloid-beta oligomers, prion protein, cell surface localization, Alzheimer's disease, endocytosis, protein trafficking, synaptic dysfunction, hippocampal neurons
MeSH terms: Analysis of Variance, Animals, Cell Membrane, Cells, Cultured, Embryo, Mammalian, Flow Cytometry, Hippocampus, Humans, Neurons, Peptide Fragments, Time Factors, Transfection, Amyloid beta-Peptides, Microscopy, Confocal, PrPC Proteins, Biotinylation, rab5 GTP-Binding Proteins, Protein Transport, Mitogen-Activated Protein Kinase 3, Green Fluorescent Proteins, Mice

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Amyloid-beta oligomers increase the localization of prion protein at the cell surface: PrPC trafficking and Alzheimer’s disease

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