Activation of a Methylated Promoter Mediated by a Sequence-specific DNA-binding Protein, RFX
Open accessAbstract
The roles of eukaryotic DNA methylation in the repression of mRNA transcription and in the formation of heterochromatin have been extensively elucidated over the past several years. However, the role of DNA methylation in transcriptional activation remains a mystery. In particular, it is not known whether the transcriptional activation of methylated DNA is promoter-specific, depends directly on sequence-specific DNA-binding proteins, or is facilitated by the methylation. Here we report that the sequence-specific DNA-binding protein, RFX, previously shown to mediate the transition from an inactive to an active chromatin structure, activates a methylated promoter. RFX is capable of mediating enhanceosome formation on a methylated promoter, thereby mediating a transition from a methylation-dependent repression of the promoter to a methylation-dependent activation of the promoter. These results indicate novel roles for DNA methylation and sequence-specific DNA-binding proteins in transcriptional activation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
DNA methylation of a promoter or enhancer is correlated with increased transcription of a target gene.
“DNA methylation of a promoter or an enhancer has been shown to be correlated with increased transcription of a target gene47,49”
From Transcription factors as readers and effectors of DNA methylation (2016) · cites this paper as [49]
Single-gene studies have demonstrated that DNA methylation can activate gene expression.
“Single-gene studies have also demonstrated that DNA methylation can activate gene expression47–49.”
From Transcription factors as readers and effectors of DNA methylation (2016) · cites this paper as [49]
The sequence-specific DNA-binding protein RFX activates a methylated promoter.
“the sequence-specific DNA-binding protein RFX activates a methylated promoter49.”
From Transcription factors as readers and effectors of DNA methylation (2016) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nan, X., Ng, H.-H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., & Bird, A. (1998) · Nature · doi:10.1038/30764 · Cited by 3,440 · see citing works
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
Bannister, A. J., Zegerman, P., Partridge, J. F., Miska, E. A., Thomas, J. O., Allshire, R. C., & Kouzarides, T. (2001) · Nature · doi:10.1038/35065138 · Cited by 2,903 · see citing works
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., & Jenuwein, T. (2001) · Nature · doi:10.1038/35065132 · Cited by 2,868 · see citing works
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845 · see citing works
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,734 · see citing works
Lewis, J. D., Meehan, R. R., Henzel, W. J., Maurer-Fogy, I., Jeppesen, P., Klein, F., & Bird, A. (1992) · Cell · doi:10.1016/0092-8674(92)90610-o · Cited by 1,371 · see citing works
Steimle, V., Otten, L., Zufferey, M., & Mach, B. (1993) · Cell · doi:10.1016/s0092-8674(05)80090-x · Cited by 849 · see citing works
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
Chaudhuri, J., & Alt, F. W. (2004) · Nature reviews. Immunology · doi:10.1038/nri1395 · Cited by 623 · see citing works
The Bare Lymphocyte Syndrome and the Regulation of MHC Expression
Reith, W., & Mach, B. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.331 · Cited by 517 · see citing works
Mühlethaler‐Mottet, A., Berardino, W. D., Otten, L., & Mach, B. (1998) · Immunity · doi:10.1016/s1074-7613(00)80468-9 · Cited by 376 · see citing works
Masternak, K., Barras, E., Zufferey, M., Conrad, B., Corthals, G. L., Aebersold, R. H., Sanchez, J., Hochstrasser, D. F., Mach, B., & Reith, W. (1998) · Nature Genetics · doi:10.1038/3081 · Cited by 275 · see citing works
Transcription — guarding the genome by sensing DNA damage
Ljungman, M. E., & Lane, D. P. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1435 · Cited by 233 · see citing works
RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency
Durand, B., Sperisen, P., Emery, P., Barras, E., Zufferey, M., Mach, B., & Reith, W. (1997) · The EMBO Journal · doi:10.1093/emboj/16.5.1045 · Cited by 227 · see citing works
Zhu, X., Linhoff, M. W., Li, G., Chin, K.-C., Maity, S. N., & Ting, J. P.-Y. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.6051-6061.2000 · Cited by 201 · see citing works
CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter
Beresford, G., & Boss, J. M. (2001) · Nature Immunology · doi:10.1038/89810 · Cited by 185 · see citing works
Self-citationNagarajan, U. M., Louis‐Plence, P., DeSandro, A. M., Nilsen, R., Long, A. B., & Boss, J. M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80016-3 · Cited by 165 · see citing works
Self-citationVaute, O. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.2.475 · Cited by 162 · see citing works
Scholl, T., Mahanta, S. K., & Strominger, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6330 · Cited by 137 · see citing works
Reith, W., Ucla, C., Barras, E., Gaud, A., Durand, B., Sanchez, C. H., Kobr, M., & Mach, B. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.2.1230 · Cited by 136 · see citing works
Raval, A., Howcroft, T. K., Weissman, J. D., Kirshner, S., Zhu, X.-S., Yokoyama, K. K., Ting, J. P. ‐., & Singer, D. S. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00159-9 · Cited by 108 · see citing works
Disruption of the Rb-Raf-1 Interaction Inhibits Tumor Growth and Angiogenesis
Dasgupta, P., Sun, J., Wang, S., Fusaro, G., Betts, V., Padmanabhan, J., Sebti, S. M., & Chellappan, S. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9527-9541.2004 · Cited by 98 · see citing works
Self-citationAssociations and Interactions between Bare Lymphocyte Syndrome Factors
DeSandro, A. M., Nagarajan, U. M., & Boss, J. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.17.6587-6599.2000 · Cited by 94 · see citing works
Self-citationVillard, J., Peretti, M., Masternak, K., Barras, E., Caretti, G., Mantovani, R., & Reith, W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3364-3376.2000 · Cited by 86 · see citing works
Warnecke, P. M., & Clark, S. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.164 · Cited by 84 · see citing works
Larco, J. E. D., Wuertz, B. R. K., Yee, D., Rickert, B. L., & Furcht, L. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2335921100 · Cited by 79 · see citing works
Methylation at CpG islands in intron 1 of EGR2 confers enhancer‐like activity
Unoki, M., & Nakamura, Y. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01092-5 · Cited by 77 · see citing works
The RFX Family Interacts at the Collagen (COL1A2) Start Site and Represses Transcription
Sengupta, P. K., Fargo, J. H., & Smith, B. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111712200 · Cited by 63 · see citing works
Promoter‐specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation
Masternak, K., & Reith, W. (2002) · The EMBO Journal · doi:10.1093/emboj/21.6.1379 · Cited by 55 · see citing works
Morotomi‐Yano, K., Yano, K., Saito, H., Sun, Z., Iwama, A., & Miki, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108638200 · Cited by 55 · see citing works
MHC class II enhanceosome: how is the class II transactivator recruited to DNA-bound activators?
Jabrane‐Ferrat, N. (2003) · International Immunology · doi:10.1093/intimm/dxg048 · Cited by 52 · see citing works
Lembo, F., Pero, R., Angrisano, T., Vitiello, C., Iuliano, R., Bruni, C. B., & Chiariotti, L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.5.1656-1665.2003 · Cited by 50 · see citing works
Jabrane‐Ferrat, N., Nekrep, N., Tosi, G., Esserman, L. J., & Peterlin, B. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5616-5625.2002 · Cited by 50 · see citing works
Zhang, X. Y., Jabrane‐Ferrat, N., Asiedu, C. K., Samac, S., Peterlin, B. M., & Ehrlich, M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.11.6810 · Cited by 48 · see citing works
Horvath, G. C., Kistler, W. S., & Kistler, M. K. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.032268 · Cited by 45 · see citing works
Osborne, A. R., Zhang, H., Yang, W., Seto, E., & Blanck, G. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.19.6495-6506.2001 · Cited by 42 · see citing works
Self-citationGönczy, P., Reith, W., Barras, E., Lisowska‐Grospierre, B., Griscelli, C., Hadam, M. R., & Mach, B. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.1.296 · Cited by 41 · see citing works
Lu, Y., Boss, J. M., Hu, S. X., Xu, H., & Blanck, G. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.7.2495 · Cited by 40 · see citing works
Self-citationA Methylation-responsive MDBP/RFX Site Is in the First Exon of the Collagen α2(I) Promoter
Sengupta, P. K., Ehrlich, M., & Smith, B. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.51.36649 · Cited by 39 · see citing works
Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter
Caretti, G., Cocchiarella, F., Sidoli, C., Villard, J., Peretti, M., Reith, W., & Mantovani, R. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4028 · Cited by 39 · see citing works
Physical association between the histone acetyl transferase CBP and a histone methyl transferase
Vandel, L., & Trouche, D. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve002 · Cited by 38 · see citing works
The Ankyrin Repeat-containing Adaptor Protein Tvl-1 Is a Novel Substrate and Regulator of Raf-1
Lin, J., Makris, A. M., McMahon, C. M., Bear, S. E., Patriotis, C., Prasad, V. R., Brent, R., Golemis, E. A., & Tsichlis, P. N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.14706 · Cited by 35 · see citing works
Zhang, H., Shepherd, A. T., Eason, D. D., Wei, S., Diaz, J. I., Djeu, J. Y., Wu, G. D., & Blanck, G. (1999) · PubMed · Cited by 31 · see citing works
Self-citationWesterheide, S. D. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.7.1635 · Cited by 29 · see citing works
Vandaele, C., Coulon-Bublex, M., Couble, P., & Durand, B. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00340-9 · Cited by 28 · see citing works
Blanck, G., Lok, M., Kok, K., Downie, E., Korn, J. H., & Strominger, J. L. (1990) · Human Immunology · doi:10.1016/0198-8859(90)90078-4 · Cited by 26 · see citing works
Self-citationOct-1 Maintains an Intermediate, Stable State of HLA-DRA Promoter Repression in Rb-defective Cells
Osborne, A. R., Zhang, H., Fejér, G., Palubin, K. M., Niesen, M. I., & Blanck, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403118200 · Cited by 26 · see citing works
Self-citationMultiple interactions between BRG1 and MHC class II promoter binding proteins
Mudhasani, R., & Fontes, J. D. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.09.021 · Cited by 22 · see citing works
Late transient expression of human hepatitis B virus genes in monkey cells.
Colbère-Garapin, F., Horodniceanu, F., Kourilsky, P., & Garapin, A. C. (1983) · The EMBO Journal · doi:10.1002/j.1460-2075.1983.tb01374.x · Cited by 21 · see citing works
DNA Acrobats of the Ig Class Switch
Wang, C. L., & Wabl, M. R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.5815 · Cited by 12 · see citing works
Itoh-Lindstrom, Y., Peterlin, B. M., & Ting, J. P. ‐. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.282 · Cited by 10 · see citing works
Samac, S., Rice, J. C., & Ehrlich, M. (1998) · PubMed · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- De Larco, J. E., Wuertz, B. R., Yee, D., Rickert, B. L., and Furcht, L. T. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 13988 -13993
- Scholl, T., Mahanta, S. K., and Strominger, J. L. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 6330 -6334
Cited by
Sorted by citations
Transcription factors as readers and effectors of DNA methylation
Zhu, H., Wang, G., & Qian, J. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.83 · Cited by 649 · see citing works
Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions
Klengel, T., & Binder, E. B. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.036 · Cited by 353 · see citing works
Loss of FOXA1/2 Is Essential for the Epithelial-to-Mesenchymal Transition in Pancreatic Cancer
Song, Y., Washington, M. K., & Crawford, H. C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2979 · Cited by 256 · see citing works
Pogribny, I. P., Karpf, A. R., James, S. R., Melnyk, S., Han, T., & Tryndyak, V. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.077 · Cited by 123 · see citing works
Bahar Halpern, K., Vana, T., & Walker, M. D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.573469 · Cited by 119 · see citing works
Defective Homocysteine Metabolism: Potential Implications for Skeletal Muscle Malfunction
Veeranki, S., & Tyagi, S. C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140715074 · Cited by 118 · see citing works
Yoo, S., Takikawa, S., Geraghty, P. M., Argmann, C., Campbell, J. D., Lin, L., Huang, T., Tu, Z., Feronjy, R., Spira, A. E., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004898 · Cited by 100 · see citing works
Sadakierska−Chudy, A., Kostrzewa, R. M., & Filip, M. (2014) · Neurotoxicity Research · doi:10.1007/s12640-014-9497-5 · Cited by 100 · see citing works
He, R., Liu, Y., Fu, W., He, X., Liu, S., Xiao, D., & Tao, Y. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02172-y · Cited by 99 · see citing works
Gustems, M., Woellmer, A., Rothbauer, U., Eck, S. H., Wieland, T., Lutter, D., & Hammerschmidt, W. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1323 · Cited by 82 · see citing works
Kohan‐Ghadr, H., Kadam, L., Jain, C. V., Armant, D. R., & Drewlo, S. (2016) · Cell Adhesion & Migration · doi:10.1080/19336918.2015.1098800 · Cited by 74 · see citing works
DNA-Methylation: Master or Slave of Neural Fate Decisions?
Stricker, S. H., & Götz, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00005 · Cited by 64 · see citing works
Dynamic Regulation of DNA Methylation and Brain Functions
Xie, J., Xie, L., Wei, H., Li, X., & Li, L. (2023) · Biology · doi:10.3390/biology12020152 · Cited by 54 · see citing works
Invited Review: DNA methylation‐based classification of paediatric brain tumours
Pérez, E., & Capper, D. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12598 · Cited by 50 · see citing works
Zhang, W., Young, J. I., Gomez, L., Schmidt, M. A., Lukacsovich, D., Varma, A., Chen, X. S., Martin, E. R., & Wang, L. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01216-7 · Cited by 38 · see citing works
Promoter analysis of epigenetically controlled genes in bladder cancer
Veerla, S., Panagopoulos, I., Jin, Y., Lindgren, D., & Höglund, M. (2008) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20542 · Cited by 38 · see citing works
Genome-wide bisulphite-sequencing reveals organ-specific methylation patterns in chickpea
Bhatia, H., Khemka, N., Jain, M., & Garg, R. (2018) · Scientific Reports · doi:10.1038/s41598-018-27979-w · Cited by 36 · see citing works
An Epigenome-Wide DNA Methylation Map of Testis in Pigs for Study of Complex Traits
Wang, X. Q., & Kadarmideen, H. N. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00405 · Cited by 35 · see citing works
Seguín-Estévez, Q., Palma, R. D., Krawczyk, M., Leimgruber, E., Villard, J., Pïcard, C., Tagliamacco, A., Abbate, G., Gorski, J., Nocera, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900376 · Cited by 30 · see citing works
Amyloid-β Alters the DNA Methylation Status of Cell-fate Genes in an Alzheimer's Disease Model
Taher, N., McKenzie, C. E., Garrett, R., Baker, M. S., Fox, N., & Isaacs, G. D. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-131061 · Cited by 27 · see citing works
Logan, P. C., Mitchell, M. D., & Lobie, P. E. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00265 · Cited by 25 · see citing works
Proteome‐Wide Profiling of Readers for DNA Modification
Bai, L., Yang, G., Qin, Z., Lyu, J., Wang, Y., Feng, J., Liu, M., Gong, T., Li, X., Li, Z., et al. (2021) · Advanced Science · doi:10.1002/advs.202101426 · Cited by 19 · see citing works
Conti, A., Rota, F., Ragni, E., Favero, C., Motta, V., Lazzari, L., Bollati, V., Fustinoni, S., & Dieci, G. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.05.010 · Cited by 19 · see citing works
Lizio, M., Ishizu, Y., Itoh, M., Lassmann, T., Hasegawa, A., Kubosaki, A., Severin, J., Kawaji, H., Nakamura, Y., Suzuki, H., et al. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00331 · Cited by 16 · see citing works
Khadka, J., Yadav, N. S., Guy, M., Grafi, G., & Golan‐Goldhirsh, A. (2019) · Journal of Experimental Botany · doi:10.1093/jxb/erz379 · Cited by 18 · see citing works
Wang, X. Q., & Kadarmideen, H. N. (2019) · Animal Genetics · doi:10.1111/age.12842 · Cited by 12 · see citing works
Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene
Tshuikina, M., Nilsson, K., & Oberg, F. G. (2008) · Gene · doi:10.1016/j.gene.2007.12.013 · Cited by 12 · see citing works
Vincent, Z. L., Mitchell, M. D., & Ponnampalam, A. P. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0132-y · Cited by 11 · see citing works
Vidarsdóttir, L., Fernandes, R. V., Zachariadis, V., Das, I., Edsbäcker, E., Sigvaldadóttir, I., Azimi, A., Höiom, V., Hansson, J., Grandér, D., et al. (2020) · Melanoma Research · doi:10.1097/cmr.0000000000000675 · Cited by 6 · see citing works
DNA Methylation in Eukaryotes: Regulation and Function
Niller, H. H., Demcsák, A., & Minárovits, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-20796-4_24-1 · Cited by 4 · see citing works
Niesen, M. I., Osborne, A. R., Lagor, W. R., Zhang, H., Kazemfar, K., Ness, G. C., & Blanck, G. (2009) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmp002 · Cited by 3 · see citing works
Self-citationRay, S., Tillo, D., Ufot, A., Assad, N., Durell, S. R., & Vinson, C. (2020) · Biochemistry · doi:10.1021/acs.biochem.0c00475 · Cited by 3 · see citing works
Identification of HPV16-p16INK4a mediated methylation in oral potentially malignant disorder
Buenahora, M. R., Lafaurie, G. I., & Perdomo, S. J. (2020) · Epigenetics · doi:10.1080/15592294.2020.1834923 · Cited by 3 · see citing works
The epigenetic regulation of the immune system during pregnancy
Liao, A., & Liu, H. Q. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818508-7.00005-1 · Cited by 3 · see citing works
Palubin, K. M., Goodwin, B. L., Niesen, M. I., Le, E. A., Osborne, A. R., & Blanck, G. (2006) · PubMed · Cited by 2 · see citing works
Self-citationDNA Methylation in Eukaryotes: Regulation and Function
Niller, H. H., Demcsák, A., & Minárovits, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-50542-8_24 · Cited by 1 · see citing works
Interindividual Variability of DNA Methylation
Watanabe, L. P., & Riddle, N. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420135-4.00002-4 · Cited by 1 · see citing works
Investigating the role of epigenetics in scar maintenance
Stevenson, A. W. (2016) · UWA Profiles and Research Repository (University of Western Australia)
Grzybek, M., Flisikowski, K., Giles, T. C., Dyjak, M., Płoski, R., Gasperowicz, P., Emes, R. D., & Lisowski, P. (2023) · Applied Sciences · doi:10.3390/app13084798
Epigenetic regulation of gene transcription in hematopoietic tumors.
Tshuikina, M. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
- Authors
- Niesen, M. I., Osborne, A. R., Yang, H., Rastogi, S., Chellappan, S., Cheng, J. Q., Boss, J. M., & Blanck, G.
- Affiliations
- University of South Florida (US)
- Emory University (US)
- Corresponding author
- Blanck, George
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 280
- Issue
- 47
- Pages
- 38914-38922
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2129969493
- Cited by
- 42
- References
- 51
- Citations by year
- 2024: 1 · 2023: 3 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 4
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- University of South Florida
- Moffitt Cancer Center
- National Institutes of Health (5r01ca081497-04, R01 CA81497, AI34000)
- National Cancer Institute (R01 CA81497, R01CA063136, R01CA089242)
- National Institute of General Medical Sciences (R01GM047310)
- National Institute of Allergy and Infectious Diseases (R01AI034000)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- DNA methylation, transcriptional activation, RFX, sequence-specific DNA-binding proteins, enhanceosome, chromatin structure, transcriptional repression, heterochromatin, promoter activation
- MeSH terms
- Regulatory Factor X Transcription Factors, B-Lymphocytes, Base Sequence, Binding Sites, Cell Line, DNA, DNA-Binding Proteins, Gene Expression Regulation, HLA-DR Antigens, Humans, Models, Biological, Molecular Sequence Data, Promoter Regions, Genetic, Transcription Factors, Transfection, DNA Methylation, Octamer Transcription Factor-1, YY1 Transcription Factor, HLA-DR alpha-Chains
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review