Effects of DNA methylation on DNA-binding proteins and gene expression

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984 · see citing works

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA

Lewis, J. D., Meehan, R. R., Henzel, W. J., Maurer-Fogy, I., Jeppesen, P., Klein, F., & Bird, A. (1992) · Cell · doi:10.1016/0092-8674(92)90610-o · Cited by 1,371 · see citing works

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

Monk, M., Boubelı́k, M., & Lehnert, S. A. (1987) · Development · doi:10.1242/dev.99.3.371 · Cited by 1,100 · see citing works

The essentials of DNA methylation

Bird, A. (1992) · Cell · doi:10.1016/0092-8674(92)90526-i · Cited by 948 · see citing works

CpG islands as gene markers in the human genome

Larsen, F., Gundersen, G., Lopez, R., & Prydz, H. (1992) · Genomics · doi:10.1016/0888-7543(92)90024-m · Cited by 922 · see citing works

DNA methylation and gene activity

Cedar, H. (1988) · Cell · doi:10.1016/0092-8674(88)90479-5 · Cited by 907 · see citing works

Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line.Preprint

Kafri, T., Ariel, M. S., Brandeis, M., Shemer, R., Urven, L. E., McCarrey, J. R., Cedar, H., & Razin, A. (1992) · Genes & Development · doi:10.1101/gad.6.5.705 · Cited by 736 · see citing works

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

Boyes, J., & Bird, A. P. (1991) · Cell · doi:10.1016/0092-8674(91)90267-3 · Cited by 733 · see citing works

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs

Meehan, R. R., Lewis, J., McKay, S. J., Kleiner, E., & Bird, A. P. (1989) · Cell · doi:10.1016/0092-8674(89)90430-3 · Cited by 659 · see citing works

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.Preprint

Watt, F., & Molloy, P. L. (1988) · Genes & Development · doi:10.1101/gad.2.9.1136 · Cited by 611 · see citing works

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.

Iguchi-Ariga, S. M., & Schaffner, W. (1989) · Genes & Development · doi:10.1101/gad.3.5.612 · Cited by 559 · see citing works

Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

Prendergast, G. C., Lawe, D., & Ziff, E. B. (1991) · Cell · doi:10.1016/0092-8674(91)90457-a · Cited by 558 · see citing works

Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA

Meehan, R. R., Lewis, J., & Bird, A. P. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.19.5085 · Cited by 515 · see citing works

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl‐CpG binding protein.

Boyes, J., & Bird, A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05055.x · Cited by 471 · see citing works

Parental legacy determines methylation and expression of an autosomal transgene: a molecular mechanism for parental imprinting.

Swain, J. L., Stewart, T., & Leder, P. (1987) · Cell · doi:10.1016/0092-8674(87)90330-8 · Cited by 466 · see citing works

CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

Comb, M., & Goodman, H. M. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.13.3975 · Cited by 422 · see citing works

X-chromosome inactivation and cell memory

Riggs, A. D., & Pfeifer, G. P. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90219-t · Cited by 328 · see citing works

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated

Höller, M., Westin, G., Jiricny, J., & Schaffner, W. (1988) · Genes & Development · doi:10.1101/gad.2.9.1127 · Cited by 305 · see citing works

Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation.

Wolf, S. F., Jolly, D. J., Lunnen, K. D., Friedmann, T., & Migeon, B. R. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.9.2806 · Cited by 298 · see citing works

Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.Preprint

Sasaki, H., Jones, P. A., Chaillet, J. R., Ferguson‐Smith, A. C., Barton, S. C., Reik, W., & Surani, M. A. (1992) · Genes & Development · doi:10.1101/gad.6.10.1843 · Cited by 274 · see citing works

Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability.

Pfeifer, G. P., Steigerwald, S. D., Hansen, R. S., Gartler, S. M., & Riggs, A. D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8252 · Cited by 255 · see citing works

In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1.Preprint

Pfeifer, G. P., Tanguay, R. L., Steigerwald, S. D., & Riggs, A. D. (1990) · Genes & Development · doi:10.1101/gad.4.8.1277 · Cited by 238 · see citing works

Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis.

Saluz, H. P., Jiricny, J., & Jost, J. P. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.19.7167 · Cited by 223 · see citing works

Cloning, characterization, and expression inEscherichia coliof the gene coding for the CpG DNA methylase fromSpiroplasma sp.strain MQ1(M Sssl)

Renbaum, P., Abrahamove, D., Fainsod, A., Wilson, G. G., Rottem, S., & Razin, A. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.5.1145 · Cited by 217 · see citing works

Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation

Hadchouel, M., Farza, H., Simon, D., Tiollais, P., & Pourcel, C. (1987) · Nature · doi:10.1038/329454a0 · Cited by 194 · see citing works

Cytosine methylation does not affect binding of transcription factor Sp1.

Harrington, M. A., Jones, P. A., Imagawa, M., & Karin, M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.7.2066 · Cited by 193 · see citing works

CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication.

Hsieh, C. L., & Lieber, M. R. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05054.x · Cited by 167 · see citing works

CpG methylation inhibits binding of several sequence-specific DNA-binding proteins from pea, wheat, soybean and cauliflower

Inamdar, N. M., Ehrlich, K. C., & Ehrlich, M. (1991) · Plant Molecular Biology · doi:10.1007/bf00036811 · Cited by 120 · see citing works

Site specific demethylation in the promoter of human gamma‐globin gene does not alleviate methylation mediated suppression.

Murray, E. J., & Grosveld, F. G. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02508.x · Cited by 103 · see citing works

Analysis of CpG methylation and genomic footprinting at the tyrosine aminotransferase gene: DNA methylation alone is not sufficient to prevent protein binding in vivo.

Weih, F., Nitsch, D., Reik, A., Schütz, G., & Becker, P. B. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07796.x · Cited by 92 · see citing works

Overlapping and CpG Methylation-Sensitive Protein-DNA Interactions at the Histone H4 Transcriptional Cell Cycle Domain: Distinctions between Two Human H4 Gene Promoters

van Wijnen, A. J., van den Ent, F. M. I., Lian, J. B., Stein, J. L., & Stein, G. S. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.7.3273 · Cited by 82 · see citing works

The repressor MDBP-2 is a member of the histone H1 family that binds preferentially in vitro and in vivo to methylated nonspecific DNA sequences.

Jost, J. P., & Hofsteenge, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9499 · Cited by 79 · see citing works

Cytosine methylation in CTF and Spl recognition sites of an HSV tk promoter: effects on transcriptionin vivoand on factor bindingin vitro

Benhattar, J., Beard, P., & Jiricny, J. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.24.10179 · Cited by 77 · see citing works

DNA hypomethylation and germ cell-specific expression of testis-specific H2B histone gene.

Choi, Y., & Chae, C. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54953-x · Cited by 63 · see citing works

DNA CpG methylation inhibits binding of NF-kappa B proteins to the HIV-1 long terminal repeat cognate DNA motifs.

Bednarik, D. P., Duckett, C. S., Kim, S. U., Perez, V. L., Griffis, K., Guenthner, P. C., & Folks, T. M. (1991) · PubMed · Cited by 62 · see citing works

Methylation of discrete sites within the enhancer region regulates the activity of the Epstein-Barr virus BamHI W promoter in Burkitt lymphoma lines

Jansson, A., Masucci, M. G., & Rymo, L. (1992) · Journal of Virology · doi:10.1128/jvi.66.1.62-69.1992 · Cited by 57 · see citing works

Estradiol down regulates the binding activity of an avian vitellogenin gene repressor (MDBP-2) and triggers a gradual demethylation of the mCpG pair of its DNA binding site

Jost, J., Saluz, H., & Pawlak, A. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.20.5771 · Cited by 54 · see citing works

Gene silencing in mammalian cells by uptake of 5-methyl deoxycytidine-5?-triphosphate

Holliday, R., & Ho, T. (1991) · Somatic Cell and Molecular Genetics · doi:10.1007/bf01233618 · Cited by 43 · see citing works

A Plant DNA-Binding Protein That Recognizes 5-Methylcytosine Residues

Zhang, D., Ehrlich, K. C., Supakar, P. C., & Ehrlich, M. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.3.1351-1356.1989 · Cited by 41 · see citing works

An avian 40 KDa nucleoprotein binds preferentially to a promoter sequence containing one single pair of methylated CpG

Pwlak, A., Bryans, M., & Jost, J. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.5.1029 · Cited by 41 · see citing works

Binding of the transcription factor EBP-80 mediates the methylation response of an intracisternal A-particle long terminal repeat promoter.

Falzon, M., & Kuff, E. L. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.1.117 · Cited by 37 · see citing works

Gene silencing in mammalian cells by direct incorporation of electroporated 5-methyl-2?-deoxycytidine 5?-triphosphate

Nyce, J. W. (1991) · Somatic Cell and Molecular Genetics · doi:10.1007/bf01233619 · Cited by 35 · see citing works

Methylated DNA-binding protein is present in various mammalian cell types

Supalcar, P. C., Weist, D., Zhang, D., Inamdar, N. M., Zhang, X., Khan, R., Ehrlich, K. C., & Ehrlich, M. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.16.8029 · Cited by 34 · see citing works

Isolation and characterization of nuclear proteins that bind to T cell receptor V beta decamer motif

Lee, M. R., Chung, C. S., Liou, M.-L., Wu, M., Li, W.-F., Hsueh, Y., & Lai, M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.6.1906 · Cited by 32 · see citing works

The combination of DNA methylation and H1 histone binding inhibits the action of a restriction nuclease on plasmid DNA

Higurashi, M., & Cole, R. D. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93019-x · Cited by 31 · see citing works

A broad bean cDNA clone encoding a DNA-binding protein resembling mammalian CREB in its sequence specificity and DNA methylation sensitivity

Ehrlich, K. C., Cary, J. W., & Ehrlich, M. (1992) · Gene · doi:10.1016/0378-1119(92)90726-6 · Cited by 30 · see citing works

The involvement of demethylation in the myeloid-specific function of the mouse M lysozyme gene downstream enhancer

Klages, S., Möllers, B., & Renkawitz, R. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.8.1925 · Cited by 30 · see citing works

DNA methylation inhibits transcription of procollagen α2(I) promoters

Guenette, D. K., Ritzenthaler, J. D., Foley, J., Jackson, J. D., & Smith, B. D. (1992) · Biochemical Journal · doi:10.1042/bj2830699 · Cited by 29 · see citing works

CpG methylation of an endogenous retroviral enhancer inhibits transcription factor binding and activity.

Lamb, B. T., Satyamoorthy, K., Li, L., Solter, D., & Howe, C. C. (1991) · Europe PMC (PubMed Central) · Cited by 24 · see citing works

Methylation of an α-foetoprotein gene intragenic site modulates gene activity

Opdecamp, K., Rivière, M., Molné, M., Szpirer, J., & Szpirer, C. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.2.171 · Cited by 16 · see citing works

Highly repeated sites in the apolipoprotein(a) gene recognized by methylated DNA-binding protein, a sequence-specific DNA-binding protein.

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Methylation inhibits the interaction of dna binding proteins with a potential C-ABL intron regulatory element

Hengst-Zhang, J. A., & Weitzman, S. A. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81578-5 · Cited by 5 · see citing works

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325 · see citing works

DNA Methylation and Cancer

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MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin.

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Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects

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DNA methylation in health and disease

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Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate's Role

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DNA methyltransferase Dnmt1 associates with histone deacetylase activity

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An expansive human regulatory lexicon encoded in transcription factor footprints

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DNA methylation, methyltransferases, and cancer

Robertson, K. D. (2001) · Oncogene · doi:10.1038/sj.onc.1204341 · Cited by 732 · see citing works

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

Schmitges, F. W., Prusty, A. B., Faty, M., Stützer, A., Lingaraju, G. M., Aiwazian, J., Sack, R., Heß, D., Li, L., Zhou, S., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.025 · Cited by 725 · see citing works

Transcription factors as readers and effectors of DNA methylation

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Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies

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Genomic Imprinting in MammalsPreprint

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Widespread plasticity in CTCF occupancy linked to DNA methylation

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GENOMIC IMPRINTING IN MAMMALS

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DNA methylation: past, present and future directions

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ABERRANT DNA METHYLATION AS A CANCER-INDUCING MECHANISM

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How does DNA methylation repress transcription?

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Competition between DNA methylation and transcription factors determines binding of NRF1

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Epigenetic Modification of the Renin-Angiotensin System in the Fetal Programming of Hypertension

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Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes

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Methylation matters

Costello, J., & Plass, C. (2001) · Journal of Medical Genetics · doi:10.1136/jmg.38.5.285 · Cited by 447 · see citing works

Epigenetic diet: impact on the epigenome and cancer

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DNA Methylation

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Interaction between CD44 and the repeat domain of ankyrin promotes hyaluronic acid-mediated ovarian tumor cell migration

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DNA methylation, chromatin inheritance, and cancer

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Gene methylation in gastric cancer

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Genome-wide approaches to studying chromatin modifications

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Review: Chromatin Structural Features and Targets That Regulate Transcription

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Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts

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DNA Methylation Specifies Chromosomal Localization of MeCP2

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Sensitivity of transcription factors to DNA methylation

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Comparative Genome Organization in Plants: From Sequence and Markers to Chromatin and Chromosomes

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Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: An overview

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Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis

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DNA methylation and silencing of gene expression.

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DNA methylation in genomic imprinting, development, and disease

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Role of DNA Methylation in Modulating Transcription Factor Occupancy

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DNA methyltransferase inhibitors—state of the art

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DNA Methylation Increases Nucleosome Compaction and Rigidity

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Methylation QTLs Are Associated with Coordinated Changes in Transcription Factor Binding, Histone Modifications, and Gene Expression Levels

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Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)

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Active Repression of Methylated Genes by the Chromosomal Protein MBD1

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Epigenetics and the Environment

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Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

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Gene-Nutrient Interactions and DNA Methylation

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Methylation of Adjacent CpG Sites Affects Sp1/Sp3 Binding and Activity in the p21 Cip1 Promoter

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