Allelic Expression Imbalance of Human mu Opioid Receptor (OPRM1) Caused by Variant A118G

Mfold web server for nucleic acid folding and hybridization prediction

Zuker, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg595 · Cited by 13,404

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

Basbaum, A. I., & Fields, H. L. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001521 · Cited by 2,687

Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

Maquat, L. E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1310 · Cited by 1,214

Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction

Bond, C. E., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., Gong, J., Schluger, J. H., Strong, J. A., Leal, S. M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9608 · Cited by 1,072

Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor

Duan, J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg055 · Cited by 931

Evolutionary changes in cis and trans gene regulation

Wittkopp, P. J., Haerum, B. K., & Clark, A. G. (2004) · Nature · doi:10.1038/nature02698 · Cited by 873

Endogenous opioid systems and alcohol addiction

Herz, A. (1997) · Psychopharmacology · doi:10.1007/s002130050169 · Cited by 755

A Functional Polymorphism of the μ-Opioid Receptor Gene is Associated with Naltrexone Response in Alcohol-Dependent Patients

Oslin, D. W., Berrettini, W., Kranzler, H. R., Pettinati, H., Gelernter, J., Volpicelli, J. R., & O'Brien, C. P. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300219 · Cited by 571

Allelic Variation in Gene Expression Is Common in the Human GenomePreprint

Lo, H. S., Wang, Z., Hu, Y., Yang, H. H., Gere, S., Buetow, K. H., & Lee, M. P. (2003) · Genome Research · doi:10.1101/gr.1006603 · Cited by 446

A Haplotype Implicated in Schizophrenia Susceptibility Is Associated with Reduced COMT Expression in Human Brain

Bray, N. J., Buckland, P. R., Williams, N. M., Williams, H. J., Norton, N., Owen, M. J., & O’Donovan, M. C. (2003) · The American Journal of Human Genetics · doi:10.1086/376578 · Cited by 335

Pharmacological Approaches to the Treatment of Alcohol Dependence in the Young

Johnson, B. A. (2011) · Wiley eBooks · doi:10.1002/9781118785089.ch16

Functional Characterization of the OPRM1 A118G Single Nucleotide Polymorphism in Mice

Mague, S. D. (2011) · ScholarlyCommons (University of Pennsylvania)

Valoración de la efectividad de una pauta analgésica con buprenorfina transdérmica en pacientes afectos de isquemia arterial crónica evolucionada de las extremidades inferiores: perfil genético

Antona, F. B. (2010) · doi:10.14201/gredos.76405

Effects of chronic nicotine on behavioural and neurochemical responses to morphine

Kivinummi, T. (2009) · Työväentutkimus Vuosikirja

Cognitive and biological individual differences in problematic alcohol use

Wildenberg, E. V. D. (2007) · Research Publications (Maastricht University) · doi:10.26481/dis.20070614ew

Pain: Postoperative Analgesia in Infants and Neonates

Ceelie, I. (2011) · RePub (Erasmus University Rotterdam)

Recherche de facteurs génétiques intervenant dans la variabilité de la réponse aux opioïdes dans le traitement de la douleur et les traitements de substitution

Hajj, A. (2012) · theses.fr (ABES) · doi:10.70675/48256896z23a9z4940zbf44ze342e1db4d80

Influencia genética en la respuesta analgésica a la buprenorfina transdérmica en cirugía torácica

Rincón, J. A. S. (2011) · doi:10.14201/gredos.110629

Variation at candidate gene loci and their fuctional importance in rodent models of ethanol dependence

Björk, K. (2008) · Figshare

Addiction and action: Aristotle and Aquinas in dialogue with addiction studies

Dunnington, K. (2007) · OakTrust (Texas A&M University Libraries)

Peter Riederer “70th birthday” Neurobiological foundations of modern addiction treatment

Jacob, C. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0886-8

Allelic Imbalance in TOR1A mRNA Expression in Manifesting and Non-Manifesting Carriers of the GAG-Deletion

Armata, I. A., Diplas, A. I., Ozelius, L. J., & Shashidharan, P. (2012) · Journal of Nucleic Acids · doi:10.1155/2012/985260

POST MORTEM STUDIES ON THE HUMAN ALCOHOLIC BRAIN: DNA METHYLATION AND MOLECULAR RESPONSES

Johansson, S. (2008) · Figshare · Cited by 1

Meeleolu- ja ärevushäirete kujunemise geneetiline komponent:21 neurotransmissiooniseoselise kandidaatgeeni polümorfismide analüüs

Tammekivi, V. (2006) · DSpace repository (University of Tartu)

ORIGINAL ARTICLE µ-Opioid Receptor Gene (OPRM1) Polymorphism A118G: Lack of Association in Finnish Populations with Alcohol Dependence or Alcohol Consumption

Rouvinen-Lagerström, N., Lahti, J. M. T., Alho, H., Kovanen, L., Aalto, M., Partonen, T., Sil, K., Sinclair, D., Räikkönen, K., Eriksson, J. G., et al. (2016)

Association between Common Genetic Variants in the Opioid Pathway and Smoking Behaviors in

Fang, J., Wang, X., & He, B. (2014)

potential: preliminary findings in human subjects

Weerts, E. M., McCaul, M. E., Kuwabara, H., Yang, X., Xu, X., Dannals, R. F., Frost, J. J., Wong, D. F., & Wand, G. S. (2013)

«In-vitro» functional studies of the «LTA+80A» leprosy risk factor

Clouatre, E. (2009) · doi:10.82308/40816

ELUCIDATING THE GENETIC INFLUENCES IN PAIN SENSITIVITY AND ANALGESIC EFFECT

Kaplan, L. M. (2005)

Pharmscogenetic characteristics of substance abuse patients who are receiving therapy for their addiction

AL-Eitan, L. N. (2012) · UWA Profiles and Research Repository (University of Western Australia)

Epigenetic Dysregulations in the Brain of Human Alcoholics : Analysis of Opioid Genes

Bazov, I. (2016) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Smoking-Related Genes and Functional Consequences

Ibáñez-Tallon, I., & Ables, J. L. (2014) · The Receptors · doi:10.1007/978-1-4939-1167-7_17 · Cited by 1

mRNA expression levels may contribute to phenotypic variability in malignant hyperthermia

Grievink, H., & Stowell, K. M. (2010)

Genetic Variants of μ Opioid Receptor and Its Interacting Proteins in Smoking

Fang, J., & He, B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00021-3

OPRM1 rs1799971 Genotype Predicts Drinking Behavior in Males, but Not Females

Hughes-Berheim, S. S., Ochoa, C. F., Sullivan, G. A., & Stoltenberg, S. F. (2015) · Lincoln (University of Nebraska)

IMPROVING MAINTENANCE TREATMENT OF HEROIN ADDICTION

Kakko, K. J. (2009)

Human molecular genetics of opioid addiction

Kreek, M. J., Proudnikov, D., Nielsen, D. A., & Yuferov, V. P. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139025997.025

Opioid toxicity following breastfeeding in infants

Lam, J., Madadi, P., & Koren, G. (2013) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-764-6_41

Objective: This study sought to clarify the impact of distinct genetic variations on pain, opioid consumption, and opioid side effects in patients with postoperative pain. Study Design: A systematic review and meta-analysis of associations between genetic single- nucleotide polymorphisms (SNPs) and opioids used for acute postoperative pain.

Lu, L., Ren, Z., Xu, X., Bao, Y., He, J., Shi, L., Deng, J., Gao, X., Tang, H., & Wang, Y. (2015)

P.1.g.070 Amygdala inactivation produces antinociception without changing threatening-induced pain inhibition in mice

Sorregotti, T., Cipriano, A. C., & Nunes‐de‐Souza, R. L. (2015) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(15)30321-7

Optimising opioids for cancer pain: Investigating the basis of inter-individual analgesic response and side-effect profile

Droney, J. (2012) · Spiral (Imperial College London) · doi:10.25560/9252

A Novel Approach to Investigate Functional Exonic SNPs Associated with Lung Diseases at Post-Transcriptional Stage

Zhou, T. (2014) · International Journal of Respiratory and Pulmonary Medicine · doi:10.23937/2378-3516/1410002

Elucidating the contributions of genetic variants associated with addiction phenotypes

Oni, E. N. (2016) · doi:10.7282/t3rn3b50

Therapeutic and Substance Abuse Biomarkers in the Immediate Postpartum Period

Baber, M. (2017) · TSpace (University of Toronto)

Assessment of Missense Alterations in MLH1 and their Pathogenic Significance

Perera, N. S. (2010) · TSpace (University of Toronto)

Pharmacogenetics of Opioid Therapy in Treatment of Postoperative Pain: A Review

Trajkovska, V., Nojkov, J., Kartalov, A., Кузмановска, Б., Spiroska, T., Трајковски, Ѓ., Matevska-Geshkovska, N., & Dimovski, A. J. (2016) · Macedonian Medical Review · doi:10.1515/mmr-2016-0012

Differential Allele Expression of SOD1 in Biomphalaria glabrata

Carolla, S. M. (2010)

Pharmacogenomics

Martin, Y. N., & Nicholson, W. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805299-0.00058-0

Polimorfismos genéticos e o câncer de cavidade oral e laringe: contribuição do álcool e fumo

Antonio, J. D. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2020.tde-13012020-121533

Placebo Hypoalgesic Effects and Genomics

Colloca, L., & Raghuraman, N. (2020) · Springer eBooks · doi:10.1007/978-3-030-21657-3_15

The effect of opioid receptor gene polymorphism (A118G) on postoperative tramadol consumption after gynecological surgery performed with a pfannenstiel incision

GÜVEN, B. B., Şen, H., Özkan, S., & Dağlı, G. (2021) · Anatolian Current Medical Journal · doi:10.38053/acmj.822786

Genetik

Cascorbi, I. (2016) · Springer eBooks · doi:10.1007/978-3-642-29775-5_7

Faculty Opinions recommendation of Mu opioids and their receptors: evolution of a concept.

Davis, M. (2014) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718242989.793489851

Opioid Tolerance

Rebstock, S. E., Eckert, J. M., & Abdallah, C. (2011) · Springer eBooks · doi:10.1007/978-1-4419-0350-1_21

Symbiotic Relationship of Pharmacogenetics and Drugs of Abuse

Rutter, J. L. (2008) · Springer eBooks · doi:10.1007/978-0-387-76678-2_4

Drug Abuse in Pakistan

Jabeen, S., Abdullah, U., Ahmad, M. S., Zafar, M., Pinsonneault, J. K., Sadée, W., & Raja, G. K. (2022) · Springer eBooks · doi:10.1007/978-3-030-67928-6_145-1

Data from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) Sample

Hardin, J., He, Y., Javitz, H. S., Wessel, J., Krasnow, R. E., Tildesley, E. A., Hops, H., Swan, G. E., & Bergen, A. W. (2023) · doi:10.1158/1055-9965.c.6514797

Data from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) Sample

Hardin, J., He, Y., Javitz, H. S., Wessel, J., Krasnow, R. E., Tildesley, E. A., Hops, H., Swan, G. E., & Bergen, A. W. (2023) · doi:10.1158/1055-9965.c.6514797.v1

BER genes expression in oral and pre-oral cancer: Combinatorial approach to propose potential biomarker

Nigam, K., Verma, Y., Dwivedi, M., & Sanyal, S. (2024) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2024.101104

Introduction: Approved treatments for alcohol use disorder by regulatory agencies

Camarini, R., & Cruz, F. C. (2024) · International review of neurobiology · doi:10.1016/bs.irn.2024.07.001 · Cited by 1

The Mental Roots of Performance: A Preliminary Meta-Analysis of Cognitive Genes and Athlete Status

İpekoğlu, G., Er, F., Gönülateş, S., Çetin, T., Çelik, M. E., Çakır, Z., Türkeri, R., & Çöten, E. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05596-9

Social trauma and the mu-opioid system in depression

Malcolm‐Smith, S. (2011) · Open University of Cape Town (University of Cape Town)

Modulación de los canales de calcio presinápticos por variantes de receptores acoplados a proteína G humanos: "el receptor opioide mu y el receptor de ghrelina"

Soto, E. J. L. (2015) · doi:10.35537/10915/44545

Additional file 1 of Rapid detection of single nucleotide polymorphisms using the MinION nanopore sequencer: a feasibility study for perioperative precision medicine

Tabata, Y., Matsuo, Y., Fujii, Y., Ohta, A., & Hirota, K. (2022) · Figshare · doi:10.6084/m9.figshare.19311805

Additional file 1 of A systematic review of GWAS identified SNPs associated with outcomes of medications for opioid use disorder

Chawar, C., Hillmer, A., Sanger, S., D’Elia, A., Panesar, B., Guan, L., Xie, D. X., Bansal, N., Abdullah, A., Kapczinski, F., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17087947

Additional file 3 of Rapid detection of single nucleotide polymorphisms using the MinION nanopore sequencer: a feasibility study for perioperative precision medicine

Tabata, Y., Matsuo, Y., Fujii, Y., Ohta, A., & Hirota, K. (2022) · Figshare · doi:10.6084/m9.figshare.19311811

Additional file 4 of Rapid detection of single nucleotide polymorphisms using the MinION nanopore sequencer: a feasibility study for perioperative precision medicine

Tabata, Y., Matsuo, Y., Fujii, Y., Ohta, A., & Hirota, K. (2022) · Figshare · doi:10.6084/m9.figshare.19311817

Additional file 2 of Rapid detection of single nucleotide polymorphisms using the MinION nanopore sequencer: a feasibility study for perioperative precision medicine

Tabata, Y., Matsuo, Y., Fujii, Y., Ohta, A., & Hirota, K. (2022) · Figshare · doi:10.6084/m9.figshare.19311808

Additional file 5 of Rapid detection of single nucleotide polymorphisms using the MinION nanopore sequencer: a feasibility study for perioperative precision medicine

Tabata, Y., Matsuo, Y., Fujii, Y., Ohta, A., & Hirota, K. (2022) · Figshare · doi:10.6084/m9.figshare.19311820

Identification and molecular functional analysis of genes associated with addiction using integrated genetic web-based programs and databases

Hossain, W. A., & Butler, M. G. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1763510

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

Khan, R., Becker, E., Bata, B. B., & Gruber, C. W. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70540

Influence of Opioid Receptor Gene Polymorphisms on the Analgesic Effects of Fentanyl and Alfentanil in Pediatric Perioperative Patients

Martins, B., Pereira, L., Azevedo, R., & Costa, P. (2025) · Annals of Pharmacy Practice and Pharmacotherapy · doi:10.51847/u2pg39roja

Genetic variation in BDNF is associated with opioid use disorder severity

Kusic, D., Salzman, M., Heil, J., Grant, S. F. A., Trang, K. B., Zajic, S. C., Madžo, J., Brown, C., Jelı́nek, J., Calendo, G., et al. (2026) · Human Genetics · doi:10.1007/s00439-026-02866-x

Gene Variant Suggests Link To Addiction Vulnerability

Milne, D. (2005) · Psychiatric News · doi:10.1176/pn.40.21.0028

Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?

Mura, E., Govoni, S. M., Racchi, M., Carossa, V., Ranzani, G. N., Allegri, M., & van Schaik, R. H. N. (2013) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 7

Single‐nucleotide polymorphism (A118G) in exon 1 ofOPRM1gene causes alteration in downstream signaling by mu‐opioid receptor and may contribute to the genetic risk for addiction

Deb, I., Chakraborty, J., Gangopadhyay, P. K., Choudhury, S. R., & Das, S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06472.x · Cited by 105

OPRM1 SNP (A118G): Involvement in disease development, treatment response, and animal models

Mague, S. D., & Blendy, J. A. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.12.016 · Cited by 138

Synaptic Regulation by OPRM1 Variants in Reward Neurocircuitry

Popova, D., Desai, N., Blendy, J. A., & Pang, Z. P. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2317-18.2019 · Cited by 22