The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Allelic Expression Imbalance of Human mu Opioid Receptor (OPRM1) Caused by Variant A118G
Open accessAbstract
As a primary target for opioid drugs and peptides, the mu opioid receptor (OPRM1) plays a key role in pain perception and addiction. Genetic variants of OPRM1 have been implicated in predisposition to drug addiction, in particular the single nucleotide polymorphism A118G, leading to an N40D substitution, with an allele frequency of 10-32%, and uncertain functions. We have measured allele-specific mRNA expression of OPRM1 in human autopsy brain tissues, using A118G as a marker. In 8 heterozygous samples measured, the A118 mRNA allele was 1.5-2.5-fold more abundant than the G118 allele. Transfection into Chinese hamster ovary cells of a cDNA representing only the coding region of OPRM1, carrying adenosine, guanosine, cytidine, and thymidine in position 118, resulted in 1.5-fold lower mRNA levels only for OPRM1-G118, and more than 10-fold lower OPRM1 protein levels, measured by Western blotting and receptor binding assay. After transfection and inhibition of transcription with actinomycin D, analysis of mRNA turnover failed to reveal differences in mRNA stability between A118 and G118 alleles, indicating a defect in transcription or mRNA maturation. These results indicate that OPRM1-G118 is a functional variant with deleterious effects on both mRNA and protein yield. Clarifying the functional relevance of polymorphisms associated with susceptibility to a complex disorder such as drug addiction provides a foundation for clinical association studies.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The A118G variant has enhanced binding and signaling properties, but low expression of mRNA (Zhang et al 2005; Kroslak et al 2007).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Zhang et al 2005
Citations
Cites
Mfold web server for nucleic acid folding and hybridization prediction
Zuker, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg595 · Cited by 13,404
Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry
Basbaum, A. I., & Fields, H. L. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001521 · Cited by 2,687
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics
Maquat, L. E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1310 · Cited by 1,214
Bond, C. E., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., Gong, J., Schluger, J. H., Strong, J. A., Leal, S. M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9608 · Cited by 1,072
Duan, J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg055 · Cited by 931
Evolutionary changes in cis and trans gene regulation
Wittkopp, P. J., Haerum, B. K., & Clark, A. G. (2004) · Nature · doi:10.1038/nature02698 · Cited by 873
Endogenous opioid systems and alcohol addiction
Herz, A. (1997) · Psychopharmacology · doi:10.1007/s002130050169 · Cited by 755
Oslin, D. W., Berrettini, W., Kranzler, H. R., Pettinati, H., Gelernter, J., Volpicelli, J. R., & O'Brien, C. P. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300219 · Cited by 571
Allelic Variation in Gene Expression Is Common in the Human GenomePreprint
Lo, H. S., Wang, Z., Hu, Y., Yang, H. H., Gere, S., Buetow, K. H., & Lee, M. P. (2003) · Genome Research · doi:10.1101/gr.1006603 · Cited by 446
Bray, N. J., Buckland, P. R., Williams, N. M., Williams, H. J., Norton, N., Owen, M. J., & O’Donovan, M. C. (2003) · The American Journal of Human Genetics · doi:10.1086/376578 · Cited by 335
Research works printed but not linked: 1
- Kreek, 1996, Mol. Psychiatry, 1, 232
Cited by
Sorted by citations
Items 201–300 of 563
Ripley, T. L., & Stephens, D. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01406.x · Cited by 41
Bart, G. B., LaForge, K. S., Borg, L., Lilly, C., Ho, A., & Kreek, M. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301128 · Cited by 38
Nobile, B., Ramoz, N., Jaussent, I., Gorwood, P. A. P. M., Olié, É., Castroman, J. L., Guillaume, S., & Courtet, P. (2019) · Scientific Reports · doi:10.1038/s41598-019-39622-3 · Cited by 39
Clozapine-Associated Restless Legs Syndrome
Duggal, H. S., & Mendhekar, D. N. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31802e7587 · Cited by 39
Johnson, A., Gong, Y., Wang, D., Langaee, T. Y., Shin, J., Cooper-DeHoff, R., Schork, N. J., Binkley, P. F., Pepine, C. J., Johnson, J. A., et al. (2008) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2008.194 · Cited by 38
Self-citationWoodcock, E. A., Lundahl, L. H., Burmeister, M., & Greenwald, M. K. (2015) · American Journal on Addictions · doi:10.1111/ajad.12187 · Cited by 38
The Cholinergic System as a Treatment Target for Opioid Use Disorder
Jensen, K. P., DeVito, E. E., Yip, S. W., Carroll, K. M., & Sofuoglu, M. (2018) · CNS Drugs · doi:10.1007/s40263-018-0572-y · Cited by 37
Blackwood, C. A., McCoy, M. T., Ladenheim, B., & Cadet, J. L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01392 · Cited by 39
Ducat, E. A., Ray, B. M., Bart, G. B., Umemura, Y., Varon, J., Ho, A., & Kreek, M. J. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00313.x · Cited by 37
Walter, C., Doehring, A., Oertel, B. G., & Lötsch, J. (2013) · Pharmacogenomics · doi:10.2217/pgs.13.187 · Cited by 36
Du, Y., & Wan, Y. Y. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01050.x · Cited by 36
van der Zwaluw, C. S., Wildenberg, E. V. D., Wiers, R. W. H. J., Franke, B., Buitelaar, J. K., Scholte, R. H. J., & Engels, R. C. M. E. (2007) · Pharmacogenomics · doi:10.2217/14622416.8.10.1427 · Cited by 35
Wang, S., Li, Y., Liu, X.-D., Zhao, C., & Kun-qing, Y. (2012) · International Journal of Clinical Oncology · doi:10.1007/s10147-012-0441-5 · Cited by 36
Structural Basis for μ-Opioid Receptor Binding and Activation
Serohijos, A. W. R., Yin, S., Ding, F., Gauthier, J., Gibson, D. G., Maixner, W. D., Dokholyan, N. V., & Diatchenko, L. B. (2011) · Structure · doi:10.1016/j.str.2011.08.003 · Cited by 36
Hirasawa-Fujita, M., Bly, M. J., Ellingrod, V. L., Dalack, G. W., & Domino, E. F. (2017) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/1935-1232-11.1.39 · Cited by 36
Symbiotic relationship of pharmacogenetics and drugs of abuse
Rutter, J. L. (2006) · The AAPS Journal · doi:10.1208/aapsj080121 · Cited by 36
Alcohol: A stimulant activating brain stress responsive systems with persistent neuroadaptation
Zhou, Y., & Kreek, M. J. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.044 · Cited by 34
A118G Polymorphism of OPRM1 Gene is Associated with Schizophrenia
Šerý, O., Přikryl, R., Častulík, L., & Šťastný, F. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9327-z · Cited by 33
Candidate gene polymorphisms predicting individual sensitivity to opioids
Kasai, S., Hayashida, M., Sora, I., & Ikeda, K. (2007) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0205-3 · Cited by 33
Nikolov, M. A., Beltcheva, O., Galabova, A., Ljubenova, A., Jankova, E., Gergov, G., Russev, A. A., Lynskey, M. T., Nelson, E. C., Nesheva, E., et al. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.12.026 · Cited by 33
An overview of the genetic susceptibility to alcoholism
Buscemi, L., & Turchi, C. (2011) · Medicine Science and the Law · doi:10.1258/msl.2010.010054 · Cited by 34
Pharmacogenetics and prediction of adverse events in prescription opioid use disorder patients
Muriel, J., Margarit, C., Barrachina, J., Ballester, P., Flor, A., Morales, D., Horga, J. F., Fernández, E., & Peiró, A. M. (2018) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13155 · Cited by 32
μ-Opioid receptor activation prevents acute hepatic inflammation and cell death
Chakass, D. N., Philippe, D., Erdual, E., Dharancy, S., Body–Malapel, M., Dubuquoy, C., Thuru, X., Gay, J., Gavériaux‐Ruff, C., Dubus, P. R., et al. (2007) · Gut · doi:10.1136/gut.2006.105122 · Cited by 32
Allelic imbalance (AI) identifies novel tissue-specificcis-regulatory variation for humanUGT2B15
Sun, C., Southard, C., Witonsky, D., Olopade, O. I., & Rienzo, A. D. (2009) · Human Mutation · doi:10.1002/humu.21145 · Cited by 32
A functional polymorphism of the µ-opioid receptor gene is associated with completed suicides
Hishimoto, A., Cui, H., Mouri, K., Nushida, H., Ueno, Y., Maeda, K., & Shirakawa, O. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-007-0853-y · Cited by 34
Kim, E., Choi, C., Kang, C., & Bae, S. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.124347 · Cited by 32
Hajj, A., Halepian, L., Osta, N. E., Chahine, G. Y., Kattan, J. G., & Khabbaz, L. R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040669 · Cited by 32
Pharmacogenetics of Addiction Therapy
Nielsen, D. A., Nielsen, E. M., Dasari, T., & Spellicy, C. J. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0956-8_15 · Cited by 32
Lack of association between DRD2 and OPRM1 genotypes and adiposity
Hardman, C. A., Rogers, P. J., Timpson, N. J., & Munafo, M. R. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.144 · Cited by 31
Browne, C. A., Erickson, R. L., Blendy, J. A., & Lucki, I. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.02.005 · Cited by 31
Placebo effects and the molecular biological components involved
Cai, L., & He, L. (2019) · General Psychiatry · doi:10.1136/gpsych-2019-100089 · Cited by 33
Bertoletti, E., Zanoni, A., Giorda, R., & Battaglia, M. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.05.001 · Cited by 31
Verhagen, M., Kleinjan, M., & Engels, R. C. M. E. (2012) · Pharmacogenomics · doi:10.2217/pgs.12.76 · Cited by 32
Gerra, M. L., Gerra, M. C., Tadonio, L., Pellegrini, P., Marchesi, C., Mattfeld, E., Gerra, G., & Ossola, P. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.052 · Cited by 36
Pharmacogenetics of Chronic Pain and Its Treatment
Světlík, S., Hronová, K., Bakhouche, H., Matoušková, O., & Slanař, O. (2013) · Mediators of Inflammation · doi:10.1155/2013/864319 · Cited by 30
Lee, M. G., Kim, H. J., Lee, K. H., & Choi, Y. S. (2016) · The Korean journal of pain · doi:10.3344/kjp.2016.29.1.34 · Cited by 30
Association of μ-opioid receptor gene (OPRM1) haplotypes with postoperative nausea and vomiting
Sugino, S., Hayase, T., Higuchi, M., Saito, K., Moriya, H., Kumeta, Y., Kurosawa, N., Namiki, A., & Janicki, P. K. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-3987-9 · Cited by 28
The pharmacogenetics of codeine pain relief in the postpartum period
Baber, M., Chaudhry, S., Kelly, L. E., Ross, C. J., Carleton, B., Berger, H. M., & Koren, G. (2015) · The Pharmacogenomics Journal · doi:10.1038/tpj.2015.3 · Cited by 29
Truncated μ-Opioid Receptors With 6 Transmembrane Domains Are Essential for Opioid Analgesia
Lu, Z., Xu, J., Xu, M., Rossi, G. C., Majumdar, S., Pasternak, G. W., & Pan, Y. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002538 · Cited by 29
Pharmacogenetics in Pain Treatment
Peiró, A. M. (2018) · Advances in pharmacology · doi:10.1016/bs.apha.2018.04.004 · Cited by 29
Knapman, A., Santiago, M., & Connor, M. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12785 · Cited by 29
Neuroimaging, genetics and the treatment of nicotine addiction
Ray, R., Loughead, J., Wang, Z., Detre, J. A., Yang, E., Gur, R. C., & Lerman, C. E. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.05.021 · Cited by 29
Evidence for population variation in TSC1 and TSC2 gene expression
Jentarra, G. M., Rice, S. G., Olfers, S., Saffen, D. W., & Narayanan, V. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-29 · Cited by 29
Lloret‐Linares, C., Hajj, A., Poitou, C., Simoneau, G., Clément, K., Laplanche, J., Lépine, J., Bergmann, J., Mouly, S. J., & Peoc’h, K. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0143-x · Cited by 28
Lötsch, J., & Ultsch, A. (2013) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2013.07.010 · Cited by 29
Rouvinen-Lagerström, N., Lahti, J. M. T., Alho, H., Kovanen, L., Aalto, M., Partonen, T., Silander, K., Sinclair, D., Räikkönen, K., Eriksson, J. G., et al. (2013) · Alcohol and Alcoholism · doi:10.1093/alcalc/agt050 · Cited by 29
Nicotine-specific and non-specific effects of cigarette smoking on endogenous opioid mechanisms
Nuechterlein, E. B., Ni, L., Domino, E. F., & Zubieta, J. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.04.006 · Cited by 28
Rogacki, M. K., Golfetto, O., Tobin, S. J., Li, T., Biswas, S., Jorand, R., Zhang, H., Radoi, V., Yu, M., Svenningsson, P., et al. (2018) · Traffic · doi:10.1111/tra.12582 · Cited by 27
Bidirectional translational research: Progress in understanding addictive diseases
Kreek, M. J., Schlussman, S. D., Reed, B., Zhang, Y., Nielsen, D. A., Levran, O., Zhou, Y., & Butelman, E. R. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.042 · Cited by 28
Self-citationRobinson, J. E., Vardy, E., DiBerto, J. F., Chefer, V. I., White, K. L., Fish, E. W., Chen, M., Gigante, E. D., Krouse, M. C., Sun, H., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.109 · Cited by 28
Menon, S., Lea, R. A., Roy, B., Hanna, M., Wee, S., Haupt, L. M., & Griffiths, L. R. (2012) · The Journal of Headache and Pain · doi:10.1007/s10194-012-0468-z · Cited by 28
An update on the safety of prescribing opioids in pediatrics
Parikh, J. M., Amolenda, P., Rutledge, J., Szabova, A., & Chidambaran, V. (2019) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2019.1571037 · Cited by 30
Lee, M. R., Gallen, C. L., Zhang, X., Hodgkinson, C. A., Goldman, D., Stein, E. A., & Barr, C. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024203 · Cited by 27
A review of the role of genetic testing in pain medicine.
Trescot, A. M., & Faynboym, S. (2014) · PubMed · Cited by 27
Polymorphisms of the μ‐opioid receptor gene influence cerebral pain processing in fibromyalgia
Ellerbrock, I., Sandström, A., Tour, J., Kadetoff, D., Schalling, M., Jensen, K. B., & Kosek, E. (2020) · European Journal of Pain · doi:10.1002/ejp.1680 · Cited by 26
Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese population
Ding, S., Chen, B., Zheng, Y., Lu, Q., Liu, L., & Zhuge, Q. C. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-107 · Cited by 27
Neuroimaging Studies of Primary Dysmenorrhea
Low, I., Wei, S., Lee, P.-S., Li, W., Lee, L.-C., Hsieh, J., & Chen, L. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1756-9_16 · Cited by 27
Pharmacogenetics of Methadone Response
Fonseca, F., & Torrens, M. (2017) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-017-0311-y · Cited by 26
Sloan, M. E., Klepp, T., Gowin, J. L., Swan, J. E., Sun, H., Stangl, B. L., & Ramchandani, V. A. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-017-0002-8 · Cited by 29
Taurisano, P., Romano, R., Mancini, M., Giorgio, A. D., Antonucci, L. A., Fazio, L., Rampino, A., Quarto, T., Gelao, B., Porcelli, A., et al. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00235 · Cited by 27
Sex heterogeneity in pharmacogenetic smoking cessation clinical trials
Schnoll, R. A., & Patterson, F. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.11.012 · Cited by 26
Capraris, A. D., Cinnella, G., Marolla, A., Salatto, P., Lima, S. D., Vetuschi, P., Consoletti, L., Gesualdo, L., & DAMBROSIO, M. (2011) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201102400417 · Cited by 26
OPRM1 and ABCB1 Polymorphisms and Their Effect on Postoperative Pain Relief With Piritramide
Bartošová, O., Polanecký, O., Perlík, F., Adámek, S., & Slanař, O. (2015) · Physiological Research · doi:10.33549/physiolres.933210 · Cited by 26
Nielsen, L. M., Christrup, L. L., Sato, H., Drewes, A. M., & Olesen, A. E. (2017) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12757 · Cited by 26
Expectancy Modulation of Opioid Neurotransmission
Peciña, M., & Zubieta, J.-K. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.02.003 · Cited by 27
Bonenberger, M., Plener, P. L., Groschwitz, R. C., Grön, G., & Abler, B. (2015) · Experimental Brain Research · doi:10.1007/s00221-015-4322-9 · Cited by 28
Genotyping panel for assessing response to cancer chemotherapy
Zunyan Dai, Y., Papp, A. C., Wang, D., Hampel, H., & Sadée, W. (2008) · BMC Medical Genomics · doi:10.1186/1755-8794-1-24 · Cited by 25
Self-citationGenetics and implications in perioperative analgesia
Trescot, A. M. (2014) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2014.03.004 · Cited by 25
The Value of CYP2D6 and OPRM1 Pharmacogenetic Testing for Opioid Therapy
Reynolds, K. K., Ramey-Hartung, B., & Jortani, S. A. (2008) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2008.10.003 · Cited by 25
Johnson, A. D. (2011) · Cited by 24
Self-citationGenetic variability of pain perception and treatment—clinical pharmacological implications
Lötsch, J. (2011) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-011-1012-9 · Cited by 24
Molecular Genetics and New Medication Strategies for Opioid Addiction
Hurd, Y. L., & O’Brien, C. P. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.18030352 · Cited by 27
The Role of Opiates in Social Pain and Suicidal Behavior
Nobile, B., Lutz, P.-E., Olie, E., & Courtet, P. (2020) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2020_167 · Cited by 24
AL-Eitan, L. N., Jaradat, S. A., Su, S., Tay, G. K., & Hulse (2012) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s33351 · Cited by 27
Marteau, T. M., Munafo, M. R., Aveyard, P. N., Hill, C., Whitwell, S., Willis, T. A., Crockett, R. A., Hollands, G. J., Johnstone, E. C., Wright, A. J., et al. (2010) · BMC Public Health · doi:10.1186/1471-2458-10-680 · Cited by 23
Regional brain [ 11 C]carfentanil binding following tobacco smoking
Domino, E. F., Hirasawa-Fujita, M., Ni, L., Guthrie, S. K., & Zubieta, J. K. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.01.007 · Cited by 23
Setiawan, E., Pihl, R. O., Benkelfat, C., & Leyton, M. (2012) · Pharmacogenomics · doi:10.2217/pgs.12.99 · Cited by 24
Endogenous opioid system: a promising target for future smoking cessation medications
Norman, H., & D’Souza, M. S. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4582-0 · Cited by 23
Henderson, A. N., Yuill, M. B., Lowe, T. E., Kline, A. M., Zee, M. L., Guindon, J., & Morgan, D. J. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.10.007 · Cited by 22
μ-Opioid Receptor Gene A118G Polymorphism Predicts Pain Recovery After Sexual Assault
Ballina, L. E., Ulirsch, J. C., Soward, A. C. M., Rossi, C., Rotolo, S., Linnstaedt, S. D., Heafner, T., Foley, K. A., Batts, J. J., Collette, R., et al. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.10.013 · Cited by 22
In Vitro and Ex Vivo Analysis of CHRNA3 and CHRNA5 Haplotype Expression
Doyle, G. A. R., Wang, M., Chou, A. D., Oleynick, J. U., Arnold, S. E., Buono, R. J., Ferraro, T. N., & Berrettini, W. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023373 · Cited by 23
Evolving Knowledge of Opioid Genetics in Cancer Pain
Droney, J., Riley, J. L., & Ross, J. R. (2011) · Clinical Oncology · doi:10.1016/j.clon.2011.04.015 · Cited by 22
Muriel, J., Margarit, C., Planelles, B., Serralta, M. J., Puga, C., Inda, M., Cutillas, E., Morales, D., Horga, J. F., & Peiró, A. M. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13735 · Cited by 22
Positron emission tomography imaging of endogenous mu-opioid mechanisms during pain and migraine
DaSilva, A. F. M., Zubieta, J.-K., & DosSantos, M. F. H. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000769 · Cited by 24
Knapman, A., & Connor, M. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12644 · Cited by 22
Human Expression Variation in the Mu-Opioid Receptor is Paralleled in Rhesus Macaque
Vallender, E. J., Priddy, C. M., Chen, G., & Miller, G. M. (2008) · Behavior Genetics · doi:10.1007/s10519-008-9207-2 · Cited by 22
Margolis, E. B., Moulton, M. G., Lambeth, P. S., & O’Meara, M. J. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109376 · Cited by 23
Comparison of the Effects of OPRM1 A118G Polymorphism Using Different Opioids: A Prospective Study
Takemura, M., Niki, K., Okamoto, Y., Kawamura, T., Kohno, M., Matsuda, Y., & Ikeda, K. (2023) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2023.09.017 · Cited by 21
A118G Mu Opioid Receptor polymorphism increases inhibitory effects on CaV2.2 channels
Soto, E. J. L., & Raingo, J. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.06.074 · Cited by 21
Chassin, L., Lee, M. R., Cho, Y. I., Wang, F. L., Arpana Agrawal, A., Sher, K. J., & Lynskey, M. T. (2012) · Development and Psychopathology · doi:10.1017/s0954579412000478 · Cited by 22
The Asp40 μ-Opioid Receptor Allele Does Not Predict Naltrexone Treatment Efficacy in Heavy Drinkers
Mitchell, J., Fields, H. L., White, R. L., Meadoff, T., Joslyn, G., & Rowbotham, M. C. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31802e68b0 · Cited by 21
Antona, F. B., Muriel, C., Labrador, J., González‐Porras, J. R., González‐Sarmiento, R., & Lozano, F. S. (2015) · Pain Practice · doi:10.1111/papr.12343 · Cited by 21
Genetics of fat intake in the determination of body mass
Chmurzyńska, A., & Młodzik-Czyżewska, M. A. (2017) · Nutrition Research Reviews · doi:10.1017/s0954422417000014 · Cited by 21
Recent advances in the use of opioids for cancer pain
Droney, J. (2009) · Journal of Pain Research · doi:10.2147/jpr.s6905 · Cited by 21
Zmorzyński, S., Styk, W., Klinkosz, W., Iskra, J., & Filip, A. A. (2021) · Annals of General Psychiatry · doi:10.1186/s12991-021-00328-4 · Cited by 21
Tchalova, K., Sadikaj, G., Moskowitz, D. S., Zuroff, D. C., & Bartz, J. A. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0600-4 · Cited by 22
Patterns of evolutionary constraints on genes in humans
De, S., López-Bigas, N., & Teichmann, S. A. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-275 · Cited by 21
Madadi, P., Sistonen, J., Silverman, G. L., Gladdy, R. A., Ross, C. J., Carleton, B., Carvalho, J. C. A., Hayden, M. R., & Koren, G. (2013) · Pain Research and Management · doi:10.1155/2013/518012 · Cited by 20
Curley, J. P. (2011) · Behavioral Neuroscience · doi:10.1037/a0022939 · Cited by 19
Mascarenhas, R., Pietrzak, M., Smith, R. M., Webb, A., Wang, D., Papp, A. C., Pinsonneault, J. K., Seweryn, M. T., Rempała, G. A., & Sadée, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136798 · Cited by 18
Self-citation
Metadata
- Authors
- Zhang, Y., Wang, D., Johnson, A. D., Papp, A. C., & Sadée, W.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Sadée, Wolfgang
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 280
- Issue
- 38
- Pages
- 32618-32624
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1996783118
- Cited by
- 563
- References
- 44
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 9 · 2023: 11 · 2022: 27 · 2021: 14 · 2020: 21 · 2019: 24 · 2018: 24 · 2017: 26 · 2016: 22 · 2015: 41 · 2014: 39 · 2013: 37 · 2012: 46
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA018744, R21DA018744)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- mu-opioid receptor, OPRM1, A118G polymorphism, gene dosage imbalance, mRNA stability, transcriptional defects, receptor expression, human brain tissue
- MeSH terms
- Alleles, Animals, Brain, Cell Line, Dactinomycin, DNA, Gene Frequency, Genotype, Cricetinae, Heterozygote, Humans, Nucleic Acid Conformation, Plasmids, Polymorphism, Genetic, RNA, Messenger, Time Factors, Transcription, Genetic, Transfection, Genetic Variation, Blotting, Western, Mutagenesis, Mutagenesis, Site-Directed, CHO Cells, Receptors, Opioid, mu, DNA, Complementary, Nucleic Acid Synthesis Inhibitors, Substance-Related Disorders, Genetic Predisposition to Disease, Reverse Transcriptase Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Allelic Imbalance
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review