SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

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Inflammation and Alzheimer’s disease

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

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hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

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Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

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RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

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Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors

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Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

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Mammalian SIRT1 Represses Forkhead Transcription Factors

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Impact of Gut Microbiota in Brain Ageing: Polyphenols as Beneficial Modulators

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Neuroprotective effects of Lycium barbarum polysaccharides in lipopolysaccharide-induced BV2 microglial cells

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Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats

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Emerging Roles of Sirtuins in Ischemic Stroke

She, D. T., Jo, D., & Arumugam, T. V. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0544-4 · Cited by 41

Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra

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Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review

Jalili, C., Kiani, A., Gholami, M., Bahrehmand, F., Fakhri, S., Kakehbaraei, S., & Kakebaraei, S. (2023) · IET Nanobiotechnology · doi:10.1049/nbt2.12127 · Cited by 43

Sirtuins as pharmacological targets in neurodegenerative and neuropsychiatric disorders

Leite, J. A., Ghirotto, B., Targhetta, V. P., de Lima, J., & Câmara, N. O. S. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15570 · Cited by 42

Comprehensive Overview of Alzheimer’s Disease: Etiological Insights and Degradation Strategies

Singh, M. K., Shin, Y., Ju, S., Han, S., Kim, S. S., & Kang, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136901 · Cited by 43

Blocking SIRT1 inhibits cell proliferation and promotes aging through the PI3K/AKT pathway

Li, H., & Wang, R. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.09.037 · Cited by 39

A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model

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Sirtuin Modulators in Cellular and Animal Models of Human Diseases

Hong, J. Y., & Lin, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.735044 · Cited by 40

Glial epigenetics in neuroinflammation and neurodegeneration

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Nutrient-Dependent Changes of Protein Palmitoylation: Impact on Nuclear Enzymes and Regulation of Gene Expression

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Circadian Rhythm Disruption and Alzheimer's Disease: The Dynamics of a Vicious Cycle

Sharma, A., Sethi, G., Tambuwala, M. M., Aljabali, A. A. A., Chellappan, D. K., Dua, K., & Goyal, R. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200429013041 · Cited by 50

Role of nuclear factor kappa B in central nervous system regeneration

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The Effects of SIRT1 on Alzheimer's Disease Models

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Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor

Yeong, K. Y., Khaw, K. Y., Takahashi, Y., Itoh, Y., Murugaiyah, V., & Suzuki, T. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103403 · Cited by 37

SIRT1 activation by minocycline on regulation of microglial polarization homeostasis

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Gene expression patterns of the liver in response to alcohol: In vivo and in vitro models compared

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Alzheimer’s Amyloid‐ β Accelerates Cell Senescence and Suppresses the SIRT1/NRF2 Pathway in Human Microglial Cells

An, Y., Li, Y., Hou, Y., Huang, S., & Pei, G. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3086010 · Cited by 37

Anti-inflammatory effects of quinolinyl analog of resveratrol targeting TLR4 in MCAO/R ischemic stroke rat model

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Resveratrol as a Protective Molecule for Neuroinflammation: A Review of Mechanisms

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Emerging Roles of Sirtuin 6 in Alzheimer’s Disease

Nasir, N. F. M., Zainuddin, A., & Shamsuddin, S. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-1005-y · Cited by 36

Sirt1’s Complex Roles in Neuroprotection

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Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit

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Resveratrol derivatives: a patent review (2009 – 2012)

Pezzuto, J. M., Kondratyuk, T. P., & Ogas, T. (2013) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2013.834888 · Cited by 36

Sirtuins in Neurodegenerative Diseases: A Biological-Chemical Perspective

Raghavan, A., & Shah, Z. A. (2011) · Neurodegenerative Diseases · doi:10.1159/000329724 · Cited by 36

Piceatannol, a natural analogue of resveratrol, effectively reduces beta-amyloid levels via activation of alpha-secretase and matrix metalloproteinase-9

Choi, B., Kim, S., Jang, B.-G., & Kim, M.-J. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.02.024 · Cited by 35

Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins

Kang, H., Oka, S., Lee, D., Park, J. H., Aponte, A. M., Jung, Y., Bitterman, J. L., Zhai, P., He, Y., Kooshapur, H., et al. (2017) · Nature Communications · doi:10.1038/ncomms15560 · Cited by 36

Amyloid β Induces Early Changes in the Ribosomal Machinery, Cytoskeletal Organization and Oxidative Phosphorylation in Retinal Photoreceptor Cells

Deng, L., Pushpitha, K., Joseph, C., Gupta, V. B., Rajput, R., Chitranshi, N., Dheer, Y., Amirkhani, A., Kamath, K. S., Pascovici, D., et al. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00024 · Cited by 34

Nuclear Sirtuins and the Aging of the Immune System

Gámez-García, A., & Vázquez, B. N. (2021) · Genes · doi:10.3390/genes12121856 · Cited by 36

Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders

Martínez-Iglesias, O. A., Naidoo, V., Carrera, I., Corzo, L., & Cacabelos, R. (2023) · Pharmaceuticals · doi:10.3390/ph16020216 · Cited by 39

Nanotechnology for microglial targeting and inhibition of neuroinflammation underlying Alzheimer’s pathology

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Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease

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Kaempferol Protects Against Hydrogen Peroxide-Induced Retinal Pigment Epithelium Cell Inflammation and Apoptosis by Activation of SIRT1 and Inhibition of PARP1

Sabaani, N. A. A. (2020) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2019.0151 · Cited by 34

SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin

Caruso, G. I., Spampinato, S. F., Costantino, G., Merlo, S., & Sortino, M. A. (2021) · Biomedicines · doi:10.3390/biomedicines9050466 · Cited by 35

Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice

Lattanzio, F., Carboni, L., Carretta, D., Rimondini, R., Candeletti, S., & Romualdi, P. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.017 · Cited by 34

SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-κB p65

Li, P., Jin, Y., Qi, F., Wu, F., Luo, S., Cheng, Y., Montgomery, R. R., & Qian, F. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00113 · Cited by 34

A Potential Role for Sirtuin-1 in Alzheimer’s Disease: Reviewing the Biological and Environmental Evidence

Mehramiz, M., Porter, T., O’Brien, E. K., Rainey‐Smith, S. R., & Laws, S. M. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220088 · Cited by 37

Microglial SIRT1 activation attenuates synapse loss in retinal inner plexiform layer via mTORC1 inhibition

Yao, K., Mou, Q., Lou, X., Ye, M., Zhao, B., Hu, Y., Luo, J., Zhang, H., Li, X., & Zhao, Y. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02886-8 · Cited by 33

Lentiviral Vector-Mediated Gene Transfer and RNA Silencing Technology in Neuronal Dysfunctions

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Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy

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Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1G93A transgenic mice as an in vivo model of amyotrophic lateral sclerosis

Lee, J. C., Shin, J.-H., Park, B.-W., Kim, G. S., Kim, J. C., Kang, K.-S., & Cha, C. I. (2012) · Brain Research · doi:10.1016/j.brainres.2011.11.019 · Cited by 32

Small-Molecule Chromatin-Modifying Agents: Therapeutic Applications

Mai, A. (2010) · Epigenomics · doi:10.2217/epi.10.7 · Cited by 33

Piperlongumine activates Sirtuin1 and improves cognitive function in a murine model of Alzheimer’s disease

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Analysis of miRNA expression in patients with rheumatoid arthritis during remission and relapse after a 5-year trial of tofacitinib treatment

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Recovery of Olfactory Function After Excitotoxic Lesion of the Olfactory Bulbs Is Associated with Increases in Bulbar SIRT1 and SIRT4 Expressions

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Resveratrol Mitigates Cerebral Ischemic Injury by Altering Levels of Trace Elements, Toxic Metal, Lipid Peroxidation, and Antioxidant Activity

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Role of Sirtuins in Physiology and Diseases of the Central Nervous System

Chojdak-Łukasiewicz, J., Bizoń, A., Waliszewska‐Prosół, M., Piwowar, A., Budrewicz, S. P., & Pokryszko‐Dragan, A. (2022) · Biomedicines · doi:10.3390/biomedicines10102434 · Cited by 33

TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women

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Differential Modulation of NF-κB in Neurons and Astrocytes Underlies Neuroprotection and Antigliosis Activity of Natural Antioxidant Molecules

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SIRT1 regulates O-GlcNAcylation of tau through OGT

Lu, S., Yin, X., Wang, J., Gu, Q., Huang, Q., Jin, N., Chu, D., Xu, Z., Liu, F., & Qian, W. (2020) · Aging · doi:10.18632/aging.103062 · Cited by 31

Pregnancy as a model for aging

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Caspase‐mediated changes in Sir2α during apoptosis

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Effect and mechanism of fuzhisan and donepezil on the sirtuin 1 pathway and amyloid precursor protein metabolism in PC12 cells

GUO, P., WANG, D., WANG, X., FENG, H., TANG, Y., SUN, R., ZHENG, Y., DONG, L., ZHAO, J., ZHANG, X., et al. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4957 · Cited by 30

Hydrogen sulfide prevents homocysteine-induced endoplasmic reticulum stress in PC12 cells by upregulating SIRT-1

Wang, C., Zou, W., Liang, X., Jiang, Z., Li, X., Wei, H., Tang, Y.-Y., Zhang, P., & Tang, X. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7004 · Cited by 29

Carbon monoxide attenuates amyloidogenesis via down‐regulation of NF‐κB‐mediated BACE1 gene expression

Kim, H. J., Joe, Y., Chen, Y., Park, G. H., Kim, U., & Chung, H. (2018) · Aging Cell · doi:10.1111/acel.12864 · Cited by 32

Potential implications of polyphenolic compounds in neurodegenerative diseases

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CYB5R3: a key player in aerobic metabolism and aging?

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HSP60 is involved in the neuroprotective effects of naloxone

Cheng, W., Li, Y., Hou, X., Zhang, N., Ma, J., Ding, F., LI, F., MIAO, Z., ZHANG, Y., Qi, Q., et al. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2411 · Cited by 30

Interaction between resveratrol and SIRT1: role in neurodegenerative diseases

Zhu, L., Yang, M., Fan, L., Yan, Q., Zhang, L., Mu, P., & Lu, F. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03319-w · Cited by 31

The neuroprotective effect of resveratrol on retinal ganglion cells after optic nerve transection.

Kim, S., Park, J. H., Kim, K. G., & Park, K. H. (2013) · Europe PMC (PubMed Central) · Cited by 28

Groundnut (Peanut) (Arachis hypogaea)

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Sirtuins promote brain homeostasis, preventing Alzheimer’s disease through targeting neuroinflammation

Wątroba, M., & Szukiewicz, D. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.962769 · Cited by 29

Patchouli alcohol ameliorates the learning and memory impairments in an animal model of Alzheimer's disease via modulating SIRT1

Xu, Q., Su, Z., Hu, Z. J., Yang, W., Xian, Y., & Lin, Z. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154441 · Cited by 30

Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration

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CD38 is a key enzyme for the survival of mouse microglial BV2 cells

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Mesenchymal stem cells ( MSCs ) and MSC ‐derived exosomes in animal models of central nervous system diseases: Targeting the NLRP3 inflammasome

Nazari, S., Pourmand, S. M., Motevaseli, E., & Hassanzadeh, G. (2023) · IUBMB Life · doi:10.1002/iub.2759 · Cited by 29

NF-κΒ Signaling in Neurite Growth and Neuronal Survival

Teng, F. Y. H., & Tang, B. L. (2010) · Reviews in the Neurosciences · doi:10.1515/revneuro.2010.21.4.299 · Cited by 28

Nicotinamide adenine dinucleotide and its related precursors for the treatment of Alzheimer's disease

Braidy, N., Grant, R., & Sachdev, P. S. (2017) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000394 · Cited by 27

Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies

Chowdhury, S., Sripathy, S. P., Webster, A. A., Park, A., Lao, U., Hsu, J. H., Loe, T. K., Bedalov, A., & Simon, J. A. (2020) · Molecules · doi:10.3390/molecules25030455 · Cited by 28

Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF-κB via activation of SIRT1 in mice

Lei, J., Shen, Y., Xv, G., Di, Z., Li, Y., & Li, G. (2020) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2020.1765373 · Cited by 28

Lifestyle modifications with anti-neuroinflammatory benefits in the aging population

Muscat, S. M., & Barrientos, R. M. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111144 · Cited by 30

Type A and B monoamine oxidases distinctly modulate signal transduction pathway and gene expression to regulate brain function and survival of neurons

Naoi, M., Maruyama, W., & Shamoto‐Nagai, M. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1832-6 · Cited by 30

Structural Modifications of Benzimidazoles via Multi‐Step Synthesis and Their Impact on Sirtuin‐Inhibitory Activity

Yeong, K. Y., & Choon, T. S. (2015) · Archiv der Pharmazie · doi:10.1002/ardp.201500337 · Cited by 27

Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia

Kılıç, Ü., Elibol, B., Uysal, Ö., Kılıç, E., Yuluğ, B., Şakul, A., & Yıldız, G. B. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.07.018 · Cited by 28

Prednisolone suppresses adriamycin-induced vascular smooth muscle cell senescence and inflammatory response via the SIRT1-AMPK signaling pathway

Sung, J. Y., Kim, S. G., Kim, J.-R., & Choi, H. C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239976 · Cited by 26

Microglial activation in Alzheimer's disease: The role of flavonoids and microRNAs

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Targeting Mitochondrial Sirtuins in Age-Related Neurodegenerative Diseases and Fibrosis

Xiao, H., Xie, Y., Xi, K., Xie, J., Liu, M., Zhang, Y., Cheng, Z., Wang, W., Guo, B., & Wu, S. (2023) · Aging and Disease · doi:10.14336/ad.2023.0203 · Cited by 29

Resveratrol ameliorates lipopolysaccharide-induced anxiety-like behavior by attenuating YAP-mediated neuro-inflammation and promoting hippocampal autophagy in mice

Tian, Q., Fan, X., Ma, J., Han, Y., Li, D., Jiang, S., Zhang, F., Guang, H., Shan, X., Chen, R., et al. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115261 · Cited by 28

Activation of Microglia by Borna Disease Virus Infection: In Vitro Study

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Involvement of small GTPase RhoA in the regulation of superoxide production in BV2 cells in response to fibrillar Aβ peptides

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β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis

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