Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1G93A transgenic mice as an in vivo model of amyotrophic lateral sclerosis
Abstract
SIRT1, which is a mammalian homolog of yeast nicotinamide adenine dinucleotide-dependent deacetylase silent information regulator 2 (SIR2), is the best-characterized SIRT family member. SIRT1 regulates longevity in several model organisms and is involved in several processes in mammalian cells, including cell survival, differentiation, and metabolism. In the present study, we used SOD1(G93A) mutant transgenic mice as an in vivo model of amyotrophic lateral sclerosis (ALS) and performed immunohistochemical studies, RT-PCR and western blotting analysis in order to investigate the changes of SIRT1 immunoreactivity in the central nervous system of these mice. An increased expression of SIRT1 was obvious in the cerebral cortex, hippocampal formation, thalamus and spinal cord of symptomatic SOD1(G93A) transgenic mice. In the cerebral cortex, SIRT1 immunoreactivity was significantly increased in pyramidal cells of SOD1(G93A) transgenic mice. In the hippocampal formation of these mice, SIRT1 immunoreactivity was increased in the pyramidal cells of the CA1-3 areas and in the granule cells of the dentate gyrus. In addition, SIRT1 immunoreactivity was increased in the spinal cord and thalamus of symptomatic SOD1(G93A) transgenic mice. This study, which showed increased SIRT1 in different brain regions of SOD1(G93A) transgenic mice, may provide clues to the understanding of selective neuronal loss in ALS. These findings suggest a role for SIRT1 in the motor functions in ALS but the mechanisms and functional implications of increased SIRT1 require elucidation.
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SIRT1 activity is altered in ALS mouse models and in postmortem ALS tissue, but the direction of the change is disputed.
“SIRT1 activity is altered in mouse models of ALS and in postmortem tissue samples from ALS patients; however, the direction of change has been debated”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Lee et al., 2012
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- Authors
- Lee, J. C., Shin, J.-H., Park, B.-W., Kim, G. S., Kim, J. C., Kang, K.-S., & Cha, C. I.
- Affiliations
- Seoul National University (KR)
- Yonsei University (KR)
- Asan Medical Center (KR)
- Corresponding author
- Kang, Kyung-Sun
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 1433
- Pages
- 20-28
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1981073919
- Cited by
- 32
- References
- 62
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 4 · 2022: 2 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Seoul National University Hospital
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Keywords
- SIRT1, amyotrophic lateral sclerosis, SOD1 G93A mice, central nervous system, cerebral cortex, hippocampus, thalamus, spinal cord, pyramidal neurons, dentate gyrus granule cells, selective neuronal loss, motor function
- MeSH terms
- Amyotrophic Lateral Sclerosis, Animals, Central Nervous System, Disease Models, Animal, Gene Expression Regulation, Mice, Transgenic, Superoxide Dismutase, Mice, Sirtuin 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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