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SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling
Open accessAbstract
Accumulating evidence suggests that neurodegeneration induced by pathogenic proteins depends on contributions from surrounding glia. Here we demonstrate that NF-kappaB signaling in microglia is critically involved in neuronal death induced by amyloid-beta (Abeta) peptides, which are widely presumed to cause Alzheimer disease. Constitutive inhibition of NF-kappaB signaling in microglia by expression of the nondegradable IkappaBalpha superrepressor blocked neurotoxicity, indicating a pivotal role for microglial NF-kappaB signaling in mediating Abeta toxicity. Stimulation of microglia with Abeta increased acetylation of RelA/p65 at lysine 310, which regulates the NF-kappaB pathway. Overexpression of SIRT1 deacetylase and the addition of the SIRT1 agonist resveratrol markedly reduced NF-kappaB signaling stimulated by Abeta and had strong neuroprotective effects. Our results support a glial loop hypothesis by demonstrating a critical role for microglial NF-kappaB signaling in Abeta-dependent neurodegeneration. They also implicate SIRT1 in this pathway and highlight the therapeutic potential of resveratrol and other sirtuin-activating compounds in Alzheimer disease.
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“In a recent study it was found that over expression of SIRT1 deacetylase and SIRT1 activation by resveratrol significantly protects against microglia-dependent amyloid-β toxicity by inhibiting NF-kB signaling199.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [199]
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THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 5,882
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,690
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D. (2002) · Science · doi:10.1126/science.1067081 · Cited by 1,992
Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation
Brown, K., Gerstberger, S., Carlson, L., Franzoso, G., & Siebenlist, U. (1995) · Science · doi:10.1126/science.7878466 · Cited by 1,434
Mammalian SIRT1 Represses Forkhead Transcription Factors
Motta, M. C., Divecha, N., Lemieux, M. E., Kamel, C., Chen, D., Gu, W. J., Bultsma, Y., McBurney, M. W., & Guarente, L. (2004) · Cell · doi:10.1016/s0092-8674(04)00126-6 · Cited by 1,366
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Items 101–200 of 743
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy
Kitada, M., Kume, S., Takeda‐Watanabe, A., Kanasaki, K., & Koya, D. (2012) · Clinical Science · doi:10.1042/cs20120190 · Cited by 212
Transcriptional targets of sirtuins in the coordination of mammalian physiology
Feige, J. N., & Auwerx, J. H. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.03.012 · Cited by 209
An overview of Sirtuins as potential therapeutic target: Structure, function and modulators
Wang, Y., He, J., Liao, M., Hu, M., Li, W., Ouyang, H., Wang, X., Ye, T., Zhang, Y., & Ouyang, L. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.10.028 · Cited by 210
NF-κB functions in the nervous system: From development to disease
Mémet, S. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.09.003 · Cited by 203
Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults
Okawara, M., Katsuki, H., Kurimoto, E., Shibata, H., Kume, T., & Akaike, A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.11.003 · Cited by 202
The neurobiology of sirtuins and their role in neurodegeneration
Dönmez, G. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.05.007 · Cited by 199
The brain, sirtuins, and ageing
Satoh, A., Imai, S., & Guarente, L. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.42 · Cited by 197
Roles of NF-κB in health and disease: mechanisms and therapeutic potential
Wong, E. T., & Tergaonkar, V. (2009) · Clinical Science · doi:10.1042/cs20080502 · Cited by 196
Resveratrol in prevention and treatment of common clinical conditions of aging.
Markus, M. A., & Morris, B. J. (2008) · Europe PMC (PubMed Central) · Cited by 196
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases
Manjula, R., Anuja, K., & Alcain, F. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.585821 · Cited by 197
Gao, Z., Zhang, J., Kheterpal, I., Kennedy, N., Davis, R. J., & Ye, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.228874 · Cited by 187
Resveratrol: A Natural Compound with Pharmacological Potential in Neurodegenerative Diseases
Rocha-González, H. I., Ambriz‐Tututi, M., & Granados‐Soto, V. (2008) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2008.00045.x · Cited by 190
SIR2: a potential target for calorie restriction mimetics
Chen, D., & Guarente, L. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.12.004 · Cited by 187
SIRT1 in the brain—connections with aging-associated disorders and lifespan
Ng, F. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00064 · Cited by 192
Neuroprotective properties of resveratrol in different neurodegenerative disorders
Albani, D., Polito, L., Signorini, A., & Forloni, G. (2010) · BioFactors · doi:10.1002/biof.118 · Cited by 188
Pallàs, M., Casadesús, G., Smith, M. A., Coto‐Montes, A. M., Pelegrı́, C., Vilaplana, J., & Camins, A. (2009) · Current Neurovascular Research · doi:10.2174/156720209787466019 · Cited by 184
Molecular and cellular pathways contributing to brain aging
Zia, A., Pourbagher‐Shahri, A. M., Farkhondeh, T., & Samarghandian, S. (2021) · Behavioral and Brain Functions · doi:10.1186/s12993-021-00179-9 · Cited by 195
Novel Approaches for the Treatment of Alzheimer’s and Parkinson’s Disease
Bulck, M. V., Sierra‐Magro, A., Alarcón-Gil, J., Pérez‐Castillo, A., & Morales-Garcia, J. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030719 · Cited by 186
NF-κB as a Key Mediator of Brain Inflammation in Alzheimer’s Disease
Hwang, C. J., Choi, D., Park, M. H., & Hong, J. T. (2017) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527316666170807130011 · Cited by 178
Multiple Defects in Energy Metabolism in Alzheimers Disease
Ferreira, I. L., Resende, R., Ferreiro, E. B., Rego, A. C., & Pereira, C. (2010) · Current Drug Targets · doi:10.2174/1389450111007011193 · Cited by 185
Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
Knutson, M. D., & Leeuwenburgh, C. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00109.x · Cited by 178
Zinc Triggers Microglial Activation
Kauppinen, T. M., Higashi, Y., Suh, S. W., Escartin, C., Nagasawa, K., & Swanson, R. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1236-08.2008 · Cited by 174
Paths of Convergence: Sirtuins in Aging and Neurodegeneration
Gan, L., & Mucke, L. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.015 · Cited by 173
Self-citationHigh Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions
Elibol, B., & Kilic, U. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00614 · Cited by 171
NAD metabolism and sirtuins: Metabolic regulation of protein deacetylation in stress and toxicity
Yang, T., & Sauve, A. A. (2006) · The AAPS Journal · doi:10.1208/aapsj080472 · Cited by 170
Resveratrol: A Natural Polyphenol with Multiple Chemopreventive Properties (Review)
Brisdelli, F., D’Andrea, G., & Bozzi, A. (2009) · Current Drug Metabolism · doi:10.2174/138920009789375423 · Cited by 173
Salminen, A., Kauppinen, A., Suuronen, T., & Kaarniranta, K. (2008) · BioEssays · doi:10.1002/bies.20799 · Cited by 169
Kubota, S., Kurihara, T., Mochimaru, H., Satofuka, S., Noda, K., Ozawa, Y., Oike, Y., Ishida, S., & Tsubota, K. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2666 · Cited by 168
Srinivasan, M., & Lahiri, D. K. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.989834 · Cited by 164
Ramis, M. R., Esteban, S., Miralles, A., Tan, D., & Reiter, R. J. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.008 · Cited by 165
Neuronal Sirt3 Protects against Excitotoxic Injury in Mouse Cortical Neuron Culture
Kim, S. H., Lu, H., & Alano, C. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014731 · Cited by 164
Guo, W., Qian, L., Zhang, J., Zhang, W., Morrison, A., Hayes, P. D., Wilson, S., Chen, T., & Zhao, J. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22725 · Cited by 163
Jenwitheesuk, A., Nopparat, C., Mukda, S., Wongchitrat, P., & Govitrapong, P. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150916848 · Cited by 164
Epigenetic Regulatory Mechanisms Induced by Resveratrol
Fernandes, G., Silva, G., Pavan, A. R., Chiba, D. E., Chin, C. M., & dos Santos, J. L. (2017) · Nutrients · doi:10.3390/nu9111201 · Cited by 166
Selective Toxicity by HDAC3 in Neurons: Regulation by Akt and GSK3β
Bardai, F. H., & D’Mello, S. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5704-10.2011 · Cited by 164
Rajendrasozhan, S., Yang, S., Edirisinghe, I., Yao, H., Adenuga, D., & Rahman, I. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1938 · Cited by 160
Biswas, K. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578180 · Cited by 164
Feng, X., Liang, N., Zhu, D., Gao, Q., Peng, L., Dong, H., Yue, Q., Liu, H., Bao, L., Zhang, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059888 · Cited by 160
Bao, J., Zheng, L., Zhang, Q., Li, X., Zhang, X., Li, Z., Bai, X., Zhang, Z., Huo, W., Zhao, X., et al. (2016) · Protein & Cell · doi:10.1007/s13238-016-0269-2 · Cited by 159
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Pasinetti, G. M., & Eberstein, J. A. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05454.x · Cited by 160
Kim, M., Seong, A., Yoo, J., Jin, C., Lee, Y., Kim, Y. J., Lee, J., Jun, W. J., & Yoon, H. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100262 · Cited by 158
Kaminska, B., Mota, M., & Pizzi, M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.026 · Cited by 161
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Theendakara, V., Peters-Libeu, C. A., Spilman, P., Poksay, K. S., Bredesen, D. E., & Rao, R. V. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.3562-15.2016 · Cited by 152
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Coussens, M. J., Maresh, J. G., Yanagimachi, R., Maeda, G., & Allsopp, R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001571 · Cited by 158
Boselli, M. G., Lee, B., Robert, J., Prado, M. A., Min, S., Cheng, C., Silva, M. C., Seong, C., Elsasser, S., Hatle, K. M., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.815126 · Cited by 151
Self-citationSirtuin 1 (SIRT1): The Misunderstood HDAC
Stünkel, W., & Campbell, R. M. (2011) · SLAS DISCOVERY · doi:10.1177/1087057111422103 · Cited by 154
Nayagam, V. M., Wang, X., Tan, Y. C., Poulsen, A., Goh, K. C., Ng, T., Wang, H., Song, H. Y., Ni, B., Entzeroth, M., et al. (2006) · SLAS DISCOVERY · doi:10.1177/1087057106294710 · Cited by 150
Wang, J., & Puel, J. (2018) · Physiological Reviews · doi:10.1152/physrev.00053.2017 · Cited by 150
Differential expression of sirtuins in the aging rat brain
Braidy, N., Poljak, A., Grant, R., Jayasena, T., Mansour, H., Chan‐Ling, T., Smythe, G. A., Sachdev, P. S., & Guillemin, G. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00167 · Cited by 146
RetractedEffects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging
Sarubbo, F., Esteban, S., Miralles, A., & Moranta, D. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170703113212 · Cited by 146
Hernandez-Rapp, J., Rainone, S., Goupil, C., Dorval, V., Smith, P. Y., Saint‐Pierre, M., Vallée, M., Planel, E., Droit, A., Calon, F., et al. (2016) · Scientific Reports · doi:10.1038/srep30953 · Cited by 144
Shinozaki, S., Chang, K., Sakai, M., Shimizu, N., Yamada, M., Tanaka, T., Nakazawa, H., Ichinose, F., Yamada, Y., Ishigami, A., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2005375 · Cited by 145
Glial cell dysregulation: a new perspective on Alzheimer disease
Rommy von Bernhardi, M. (2007) · Neurotoxicity Research · doi:10.1007/bf03033906 · Cited by 141
Hayashida, S., Arimoto, A., Kuramoto, Y., Kozako, T., Honda, S., Shimeno, H., & Soeda, S. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0391-z · Cited by 139
Histone Deacetylase-1 (HDAC1) Is a Molecular Switch between Neuronal Survival and Death
Bardai, F. H., Price, V. J., Zaayman, M., Wang, L., & D’Mello, S. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.394544 · Cited by 136
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
Boily, G., He, X. H., Pearce, B., Jardine, K. E., & McBurney, M. W. (2009) · Oncogene · doi:10.1038/onc.2009.147 · Cited by 137
Cellular and molecular effects of sirtuins in health and disease
Horio, Y., Hayashi, T., Kuno, A., & Kunimoto, R. (2011) · Clinical Science · doi:10.1042/cs20100587 · Cited by 138
sirt1-null mice develop an autoimmune-like condition
Sequeira, J., Boily, G., Bazinet, S., Saliba, S., He, X., Jardine, K. E., Kennedy, C., Staines, W. A., Rousseaux, C. G., Mueller, R., et al. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.07.011 · Cited by 140
Liu, P., & Wilson, M. J. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22993 · Cited by 136
Yuk, J., Kim, T. S., Kim, S. Y., Lee, H., Han, J., Dufour, C. R., Kim, J. K., Jin, H. S., Yang, C., Park, K.-S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.003 · Cited by 136
Zhao, Y., Luo, P., Guo, Q., Li, S., Zhang, L., Zhao, M., Xu, H., Yang, Y., Poon, W. S., & Fei, Z. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.07.004 · Cited by 135
Little, K., Llorián‐Salvador, M., Scullion, S., Hernández, C., Simó‐Servat, O., del Marco, À., Bosma, E. K., Vargas-Soria, M., Carranza-Naval, M. J., Bergen, T. V., et al. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.10.008 · Cited by 142
The evolutionary theories of aging revisited - a mini-review
Ljubuncic, P., & Reznick, A. Z. (2009) · Gerontology · doi:10.1159/000200772 · Cited by 133
Mincheva-Tasheva, S., & Soler, R. M. (2012) · The Neuroscientist · doi:10.1177/1073858412444007 · Cited by 135
Longpré, F., Garneau, P., Christen, Y., & Ramassamy, C. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.08.015 · Cited by 132
Abraham, J., & Johnson, R. W. (2009) · Rejuvenation Research · doi:10.1089/rej.2009.0888 · Cited by 131
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Lutz, M. I., Milenković, I., Regelsberger, G., & Kovács, G. G. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8288-8 · Cited by 134
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Soliman, M. L., Puig, K. L., Combs, C. K., & Rosenberger, T. A. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07955.x · Cited by 131
Nimmagadda, V. K. C., Bever, C. T., Vattikunta, N. R., Talat, S., Ahmad, V., Nagalla, N. K., Trisler, D. N., Judge, S. I. V., Royal, W., Chandrasekaran, K., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202584 · Cited by 131
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Edwards, J., Perrien, D. S., Fleming, N., Nyman, J. S., Ono, K., Connelly, L., Moore, M. M., Lwin, S. T., Yull, F. E., Mundy, G. R., et al. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1824 · Cited by 127
Gao, J., Zhou, R., You, X., Luo, F., He, H., Chang, X., Zhu, L., Ding, X., & Yan, T. (2016) · Metabolic Brain Disease · doi:10.1007/s11011-016-9813-2 · Cited by 128
Divino da Rocha, M., Pereira Dias Viegas, F., Cristina Campos, H., Carolina Nicastro, P., Calve Fossaluzza, P., Alberto Manssour Fraga, C., J. Barreiro, E., & Viegas, C. (2011) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152711794480429 · Cited by 126
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Oomen, C. A. (2009) · Frontiers in Aging Neuroscience · doi:10.3389/neuro.24.004.2009 · Cited by 128
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Harting, K., & Knöll, B. (2009) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2009.11.006 · Cited by 127
Butterfield, D. A., & Rukhsana Sultana, A. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12107 · Cited by 126
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Dietz, K. C., & Casaccia, P. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.01.011 · Cited by 128
Kang, H., Jung, J., Kim, M. K., & Chung, J. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006611 · Cited by 133
Gräff, J., Kahn, M., Samiei, A., Gao, J., Ota, K. T., Rei, D., & Tsai, L.-H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5657-12.2013 · Cited by 124
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Nguyen‐Ngo, C., Jayabalan, N., Salomón, C., & Lappas, M. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0274 · Cited by 129
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Min, S., Sohn, P., Cho, S.-H., Swanson, R. A., & Gan, L. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00053 · Cited by 124
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Choi, D., Koppula, S., & Suk, K. (2011) · Molecules · doi:10.3390/molecules16021021 · Cited by 123
Askanas, V., & Engel, W. K. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0449-0 · Cited by 124
Albani, D., Polito, L., & Forloni, G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1215 · Cited by 122
Jayasena, T., Poljak, A., Smythe, G. A., Braidy, N., Münch, G. W., & Sachdev, P. S. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.06.003 · Cited by 122
He, P., Yan, S., Zheng, J., Gao, Y., Zhang, S., Liu, Z., Liu, X., & Xiao, C. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03731 · Cited by 122
Therapeutic role of sirtuins in neurodegenerative disease
Outeiro, T. F., Marques, O., & Kazantsev, A. G. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.02.010 · Cited by 122
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Cianciulli, A., Dragone, T., Calvello, R., Porro, C., Trotta, T., Lofrumento, D. D., & Panaro, M. A. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2014.12.035 · Cited by 125
Nakazawa, H., Chang, K., Shinozaki, S., Yasukawa, T., Ishimaru, K., Yasuhara, S., Yu, Y., Martyn, J. A. J., Tompkins, R. G., Shimokado, K., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170391 · Cited by 118
SIRT1 Is a Novel Regulator of Key Pathways of Human Labor1
Lappas, M., Mitton, A., Lim, R., Barker, G., Riley, C. B., & Permezel, M. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.086983 · Cited by 118
Inoue, T., Tanaka, M., Masuda, S., Ohue‐Kitano, R., Yamakage, H., Muranaka, K., Wada, H., Kusakabe, T., Shimatsu, A., Hasegawa, K., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.02.010 · Cited by 117
Histone Acetylation Modifiers in the Pathogenesis of Alzheimer’s Disease
Lu, X., Wang, L., Yu, C., Yu, D., & Yu, G. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00226 · Cited by 124
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Polymeric nanoparticle system to target activated microglia/macrophages in spinal cord injury
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Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β
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Self-citationChen, X., Li, Y., Wang, C., Tang, Y., Mok, S.-A., Tsai, R. M., Rojas, J. C., Karydas, A., Miller, B. L., Boxer, A. L., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0354-0 · Cited by 107
Self-citationSirt1 Promotes Axonogenesis by Deacetylation of Akt and Inactivation of GSK3
Li, X., Chen, C., Tu, Y., Sun, H., Zhao, M., Cheng, S., Qu, Y., & Zhang, S. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8437-3 · Cited by 117
Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
Pallàs, M., Pizarro, J. G., Cuesta, J., Crespo‐Biel, N., Alvira, D., Tajes, M., Yeste‐Velasco, M., Folch, J., Canudas, A. M., Sureda, F. X., et al. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.065 · Cited by 114
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RetractedPharmacogenomics in Alzheimer's Disease
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Metadata
- Authors
- Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L.-F., Kwon, H., Yi, S., Mucke, L., & Gan, L.
- Affiliations
- Gladstone Institutes (US)
- Corresponding author
- Gan, Li
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 280
- Issue
- 48
- Pages
- 40364-40374
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2074916731
- Cited by
- 740
- References
- 54
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 35 · 2023: 36 · 2022: 22 · 2021: 39 · 2020: 49 · 2019: 30 · 2018: 46 · 2017: 40 · 2016: 26 · 2015: 35 · 2014: 35 · 2013: 48 · 2012: 43
- FWCI
- 17.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- University of California, San Francisco
- National Institute of Neurological Disorders and Stroke (NS43945, R01NS043945)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- SIRT1, microglia, amyloid-beta, NF-κB signaling, Alzheimer's disease, neurodegeneration, resveratrol, neuroprotection
- MeSH terms
- Resveratrol, Alzheimer Disease, Animals, Bromodeoxyuridine, Cells, Cultured, Genetic Vectors, Humans, Immunohistochemistry, Lysine, Microscopy, Fluorescence, Models, Biological, Models, Genetic, Neurons, Stilbenes, Signal Transduction, Lentivirus, Amyloid beta-Peptides, NF-kappa B, Rats, Sprague-Dawley, Microglia, Genes, Reporter, Reverse Transcriptase Polymerase Chain Reaction, Sirtuins, Green Fluorescent Proteins, Rats, Sirtuin 1
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