Regulation of MDMX Expression by Mitogenic Signaling

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mdm2 expression is induced by wild type p53 activity.

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A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

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Targeting the mitogen-activated protein kinase cascade to treat cancer

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

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ERK phosphorylation potentiates Elk‐1‐mediated ternary complex formation and transactivation.

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MDMX: a novel p53‐binding protein with some functional properties of MDM2.

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Regulation of HDM2 activity by the ribosomal protein L11

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Inactivation of the p53 pathway in retinoblastoma

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Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

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Diverse Signaling Pathways Activated by Growth Factor Receptors Induce Broadly Overlapping, Rather Than Independent, Sets of Genes

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HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53

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Opposing Effects of Ras on p53

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MDM2 interacts with MDMX through their RING finger domains

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Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

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Amplification of <i>Mdmx</i> (or <i>Mdm4</i> ) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity

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Effect of Extracellular Signal-regulated Kinase on p53 Accumulation in Response to Cisplatin

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Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein

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Mutual Dependence of MDM2 and MDMX in Their Functional Inactivation of p53

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ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

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Essential role of ribosomal protein L11 in mediating growth inhibition‐induced p53 activation

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Role of insulin-like growth factor 1 receptor signalling in cancer

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Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.

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MDM2 promotes ubiquitination and degradation of MDMX

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MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin

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Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

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mdmx is a negative regulator of p53 activity in vivo.

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Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53.

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MDMX regulation of p53 response to ribosomal stress

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DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

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Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3

LeBron, C., Chen, L., Gilkes, D. M., & Chen, J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601032 · Cited by 122 · see citing works

Haploinsufficiency of <i>Mdm2</i> and <i>Mdm4</i> in Tumorigenesis and Development

Terzian, T., Wang, Y., Van Pelt, C. S., Box, N. F., Travis, E. L., & Lozano, G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00555-06 · Cited by 116 · see citing works

Insulin-Like Growth Factor-1 Induces Mdm2 and Down-Regulates p53, Attenuating the Myocyte Renin-Angiotensin System and Stretch-Mediated Apoptosis

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Insulin-like Growth Factor I Induces MDM2-dependent Degradation of p53 via the p38 MAPK Pathway in Response to DNA Damage

Héron‐Milhavet, L., & LeRoith, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111142200 · Cited by 111 · see citing works

Induction of Mdm2 and enhancement of cell survival by bFGF

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Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone

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Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage

Pereg, Y., Lam, S., Teunisse, A., Biton, S., Meulmeester, E., Mittelman, L., Buscemi, G., Okamoto, K., Taya, Y., Shiloh, Y., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00562-06 · Cited by 93 · see citing works

Regulation of p53-MDMX interaction by casein kinase 1 alpha

Chen, L., Li, C., Pan, Y., & Chen, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6509-6520.2005 · Cited by 88 · see citing works

DNA Damage Induces MDMX Nuclear Translocation by p53-Dependent and -Independent Mechanisms

Li, C., Chen, L., & Chen, J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7562-7571.2002 · Cited by 82 · see citing works

Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors

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Regulation of p53 expression by the RAS-MAP kinase pathway

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Ets-1 Protects Vascular Smooth Muscle Cells from Undergoing Apoptosis by Activating p21WAF1/Cip1

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ATM: Ready, Set, Go

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HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target

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ERK-dependent Signaling Pathway and Transcriptional Factor Ets-1 Regulate Matrix Metalloproteinase-9 Production in Transforming Growth Factor-β1 Stimulated Glomerular Podocytes

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Expression of p14ARF overcomes tumor resistance to p53.

Lu, W., Lin, J., & Chen, J. (2002) · PubMed · Cited by 34 · see citing works

Hdm2 Nuclear Export, Regulated by Insulin-like Growth Factor-I/MAPK/p90Rsk Signaling, Mediates the Transformation of Human Cells

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Organization, expression, and localization of the murine mdmx gene and pseudogene

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MDM2, MDMX and p53 in oncogenesis and cancer therapy

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Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment

Zhao, Y., Aguilar, A., Bernard, D., & Wang, S. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501092z · Cited by 462 · see citing works

The Role of p53 Signaling in Colorectal Cancer

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The Roles of MDM2 and MDMX in Cancer

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Molecular Pathways: Targeting Mdm2 and Mdm4 in Cancer Therapy

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Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

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The role of ubiquitin modification in the regulation of p53

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The roles and regulation of MDM2 and MDMX: it is not just about p53Preprint

Klein, A. M., de Queiroz, R. M., Venkatesh, D., & Prives, C. L. (2021) · Genes & Development · doi:10.1101/gad.347872.120 · Cited by 132 · see citing works

MDM2 and MDMX: Alone and together in regulation of p53.

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A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis

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MdmX Protein Is Essential for Mdm2 Protein-mediated p53 Polyubiquitination

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Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy: advances and perspectives

Fang, Y., Liao, G., & Yu, B. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.01.003 · Cited by 106 · see citing works

MicroRNA-34a Modulates MDM4 Expression via a Target Site in the Open Reading Frame

Mandke, P., Wyatt, N., Fraser, J., Bates, B., Berberich, S. J., & Markey, M. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042034 · Cited by 90 · see citing works

MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and BeyondPreprint

Marine, J., & Jochemsen, A. G. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026237 · Cited by 81 · see citing works

α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions

Sang, P., Shi, Y., Lu, J., Chen, L., Yang, L., Borcherds, W. M., Abdulkadir, S., Li, Q., Daughdrill, G. W., Chen, J., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00993 · Cited by 78 · see citing works

The long and the short of it: the MDM4 tail so far

Haupt, S., Mejía-Hernández, J. O., Vijayakumaran, R., Keam, S. P., & Haupt, Y. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz007 · Cited by 69 · see citing works

Whole genome sequence analysis links chromothripsis to EGFR, MDM2, MDM4, and CDK4 amplification in glioblastoma

Furgason, J. M., Koncar, R. F., Michelhaugh, S. K., Sarkar, F. H., Mittal, S., Sloan, A. E., Barnholtz‐Sloan, J. S., & Bahassi, E. M. (2015) · Oncoscience · doi:10.18632/oncoscience.178 · Cited by 65 · see citing works

p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors

Li, B., Cheng, Q., Li, Z., & Chen, J. (2010) · Cell Cycle · doi:10.4161/cc.9.7.11255 · Cited by 64 · see citing works

Interplay between MDM2, MDMX, Pirh2 and COP1: the negative regulators of p53

Wang, L., He, G., Zhang, P., Wang, X., Jiang, M. H., & Yu, L. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0099-x · Cited by 60 · see citing works

Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin‐3 in gastric cancer cells

Endo, S., Yamato, K., Hirai, S., Moriwaki, T., Fukuda, K., Suzuki, H., Abei, M., Nakagawa, I., & Hyodo, I. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01821.x · Cited by 58 · see citing works

Targeting the Ubiquitin-Mediated Proteasome Degradation of p53 for Cancer Therapy

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Critical review about MDM2 in cancer: Possible role in malignant mesothelioma and implications for treatment

Urso, L., Calabrese, F., Favaretto, A. G., Conte, P., & Pasello, G. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.08.019 · Cited by 54 · see citing works

p53 and RAD9, the DNA Damage Response, and Regulation of Transcription Networks

Lieberman, H. B., Panigrahi, S. K., Hopkins, K. M., Wang, L., & Broustas, C. G. (2017) · Radiation Research · doi:10.1667/rr003cc.1 · Cited by 47 · see citing works

Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer

Swetzig, W. M., Wang, J., & Das, G. M. (2016) · Oncotarget · doi:10.18632/oncotarget.7533 · Cited by 42 · see citing works

PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA

Yano, K., Takahashi, R., Shiotani, B., Abe, J., Shidooka, T., Sudo, Y., Yamamoto, Y., Kan, S., Sakagami, H., & Tahara, H. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100882 · Cited by 40 · see citing works

Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitryPreprint

Zhu, Y. Y., Regunath, K., Jacq, X., & Prives, C. L. (2013) · Genes & Development · doi:10.1101/gad.212258.112 · Cited by 39 · see citing works

Functions of MDMX in the Modulation of the p53‐Response

Lenos, K., & Jochemsen, A. G. (2011) · BioMed Research International · doi:10.1155/2011/876173 · Cited by 38 · see citing works

Puzzling over MDM4–p53 network

Mancini, F., Conza, G. D., Monti, O., Macchiarulo, A., Pellicciari, R., Pontecorvi, A., & Moretti, F. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.04.010 · Cited by 30 · see citing works

MiR-1205 functions as a tumor suppressor by disconnecting the synergy between KRAS and MDM4/E2F1 in non-small cell lung cancer.

Yan, H., Chen, X., Li, Y., Fan, L., Tai, Y., Zhou, Y., Chen, Y., Qi, X., Huang, R., & Ren, J. (2019) · Europe PMC (PubMed Central) · Cited by 30 · see citing works

Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis

Timmerman, D. M., Remmers, T. L., Hillenius, S., & Looijenga, L. H. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105377 · Cited by 26 · see citing works

<scp>TP</scp>53 pathway analysis in paediatric <scp>B</scp>urkitt lymphoma reveals increased <i><scp>MDM</scp>4</i> expression as the only <scp>TP</scp>53 pathway abnormality detected in a subset of cases

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The p53 network as therapeutic target in gastroenteropancreatic neuroendocrine neoplasms

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MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild‐type CLL with a poor cytotoxic response to Nutlin‐3

Bo, M. D., Secchiero, P., Degan, M., Marconi, D., Bomben, R., Pozzato, G., Gaïdano, G., Poeta, G. D., Forconi, F., Zauli, G., et al. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08185.x · Cited by 26 · see citing works

Mdm2 protein Expression is Strongly Associated with Survival in Malignant Pleural Mesothelioma

Mairinger, F. D., Walter, R. F. H., Ting, S. C., Vollbrecht, C., Kollmeier, J., Griff, S., Hager, T., Mairinger, T., Christoph, D. C., Theegarten, D., et al. (2014) · Future Oncology · doi:10.2217/fon.13.261 · Cited by 24 · see citing works

Regulation of MDM4

Markey, M. P. (2010) · Frontiers in bioscience · doi:10.2741/3780 · Cited by 24 · see citing works

MiR‑370 promotes apoptosis in colon cancer by directly targeting MDM4

Shen, X., Zuo, X., Zhang, W., Bai, Y., Qin, X., & Hou, N. (2017) · Oncology Letters · doi:10.3892/ol.2017.7524 · Cited by 24 · see citing works

Augmented antitumor activity of 5‐fluorouracil by double knockdown of MDM 4 and MDM 2 in colon and gastric cancer cells

Imanishi, M., Yamamoto, Y., Wang, X., Sugaya, A., Hirose, M., Endo, S., Natori, Y., Yamato, K., & Hyodo, I. (2018) · Cancer Science · doi:10.1111/cas.13893 · Cited by 24 · see citing works

A p53-JAK-STAT connection involved in myeloproliferative neoplasm pathogenesis and progression to secondary acute myeloid leukemia

Goyal, H., Chachoua, I., Pecquet, C., Vainchenker, W., & Constantinescu, S. N. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100712 · Cited by 23 · see citing works

XI-006 induces potent p53-independent apoptosis in Ewing sarcoma

Pishas, K. I., Adwal, A., Neuhaus, S. J., Clayer, M., Farshid, G., Staudacher, A. H., & Callen, D. F. (2015) · Scientific Reports · doi:10.1038/srep11465 · Cited by 23 · see citing works

Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex

Gerarduzzi, C., de Polo, A., Liu, X.-S., El Kharbili, M., Little, J. B., & Yuan, Z.-M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.752303 · Cited by 19 · see citing works

Screening of Pleural Mesotheliomas for DNA-damage Repair Players by Digital Gene Expression Analysis Can Enhance Clinical Management of Patients Receiving Platin-Based Chemotherapy

Walter, R. F. H., Vollbrecht, C., Werner, R., Mairinger, T., Schmeller, J., Flom, E., Wohlschlaeger, J., Barbetakis, N. G., Paliouras, D., Chatzinikolaou, F. G., et al. (2016) · Journal of Cancer · doi:10.7150/jca.16390 · Cited by 18 · see citing works

Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor KLF5

Wang, P., Lu, Y., Li, Y. F., Wang, L., & Lee, S. C. (2018) · Journal of Diabetes Research · doi:10.1155/2018/3274084 · Cited by 18 · see citing works

MDMX in Cancer: A Partner of p53 and a p53-Independent Effector

Wu, L., Yan, Y., Huang, Q., & Zheng, D. (2024) · Biologics · doi:10.2147/btt.s436629 · Cited by 16 · see citing works

MDM4 expression as an indicator of TP53 reactivation by combined targeting of MDM2 and MDM4 in cancer cells without TP53 mutation

Hirose, M., Yamato, K., Endo, S., Saito, R., Ueno, T., Hirai, S., Suzuki, H., Abei, M., Natori, Y., & Hyodo, I. (2014) · Oncoscience · doi:10.18632/oncoscience.103 · Cited by 13 · see citing works

Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons

Tipanee, J., Matteo, M. D., Tulalamba, W., Samara-Kuko, E., Keirsse, J., Ginderachter, J. A. V., Chuah, M., & VandenDriessche, T. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.01.015 · Cited by 11 · see citing works

miR‑205 suppresses cell migration, invasion and EMT of colon cancer by targeting mouse double minute 4

Fan, Y., & Wang, K. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11150 · Cited by 12 · see citing works

Mdm2 and MdmX Involvement in Human Cancer

Berberich, S. J. (2014) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-9211-0_15 · Cited by 12 · see citing works

MDM4 overexpression contributes to synoviocyte proliferation in patients with rheumatoid arthritis

Xu, N., Wang, Y., Li, D., Chen, G., Sun, R., Zhu, R., Sun, S., Liu, H., Yang, G., & Dong, T. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.09.069 · Cited by 11 · see citing works

Serum Response Factor (SRF) Drives the Transcriptional Upregulation of the MDM4 Oncogene in HCC

Pellegrino, R., Thavamani, A., Calvisi, D. F., Budczies, J., Neumann, A., Geffers, R., Kroemer, J., Greule, D., Schirmacher, P., Nordheim, A., et al. (2021) · Cancers · doi:10.3390/cancers13020199 · Cited by 11 · see citing works

Rare MDM4 gene amplification in colorectal cancer: The principle of a mutually exclusive relationship between MDM alteration and TP53 inactivation is not applicable

Miyagi, Y. (2011) · Oncology Reports · doi:10.3892/or.2011.1270 · Cited by 10 · see citing works

p53 in the Clinics

Hainaut, P. L., Wiman, K. G., & Olivier, M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3676-8 · Cited by 10 · see citing works

Transcriptome and Gene Fusion Analysis of Synchronous Lesions Reveals lncMRPS31P5 as a Novel Transcript Involved in Colorectal Cancer

Panza, A., Castellana, S., Biscaglia, G., Piepoli, A., Parca, L., Gentile, A., Latiano, A., Mazza, T., Perri, F., Andriulli, A., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197120 · Cited by 9 · see citing works

Reduction of serum IGF-I levels in patients affected with Monoclonal Gammopathies of undetermined significance or Multiple Myeloma. Comparison with bFGF, VEGF and K-ras gene mutation

Greco, C., Vitelli, G., Vercillo, G., Vona, R., Giannarelli, D., Sperduti, I., Pisani, F., Capoluongo, E., Petti, M. C., & Ameglio, F. (2009) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-28-35 · Cited by 9 · see citing works

Association analysis of indel variants and gene expression identifies MDM4 as a novel locus for skeletal muscle hypertrophy and power athlete status

Kazan, H. H., Kasakolu, A., Koncagül, S., Ergün, M. A., John, G., Илгизович, С. Р., Викторович, Ж. А., Semenova, E. A., Yusupov, R. A., Kulemin, N. A., et al. (2024) · Experimental Physiology · doi:10.1113/ep091992 · Cited by 7 · see citing works

MDMX/MDM4 is highly expressed and contributes to cell growth and survival in anaplastic large cell lymphoma

Sinatkas, V., Σταθοπούλου, Κ., Xagoraris, I., Ye, J., Vyrla, D., Atsaves, V., Leventaki, V., Medeiros, L. J., Rassidakis, G. Z., & Drakos, E. (2021) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2021.1876871 · Cited by 6 · see citing works

DNA Duplex-Based Photodynamic Molecular Beacon for Targeted Killing of Retinoblastoma Cell

Wei, Y., Lu, C., Chen, Q., & Xing, D. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-18723 · Cited by 6 · see citing works

MDMX under stress: the MDMX-MDM2 complex as stress signals hub

de Polo, A., Vivekanandan, V., Little, J. B., & Yuan, Z.-M. (2016) · Translational Cancer Research · doi:10.21037/tcr.2016.12.18 · Cited by 4 · see citing works

HDM2 and HDMX Proteins in Human Cancer

Hároníková, L., & Vojtěšek, B. (2018) · Klinicka onkologie · doi:10.14735/amko20182s63 · Cited by 4 · see citing works

Cellular, Structural Basis, and Recent Progress for Targeting Murine Double Minute X (MDMX) in Tumors

Yin, Q., Hu, Y., Dong, Z., Lu, J., & Wang, H. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00913 · Cited by 3 · see citing works

Cooperation between MDM2 and MDMX in the Regulation of p53

Blaydes, J. P. (2010) · Molecular biology intelligence unit · doi:10.1007/978-1-4419-8231-5_6 · Cited by 2 · see citing works

Manipulation of p53 Protein in Bladder Cancer Treatment

Mansor, S. F. (2020) · IIUM Medical Journal Malaysia · doi:10.31436/imjm.v20i1.1764 · Cited by 2 · see citing works

ELK1

Odrowaz, Z., & Sharrocks, A. D. (2011) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a000830.01 · Cited by 1 · see citing works

All activated signaling pathways lead to anaplastic large cell lymphoma (ALCL)

Bonzheim, I., & Quintanilla‐Martínez, L. (2021) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2021.1924373 · Cited by 1 · see citing works

Upstream Targets in the p53 Pathway

McCarthy, A. R., & Laı́n, S. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3676-8_12

Expression levels of MDM2 and MDMX proteins and their associated effects on P53 in human liposarcomas

Touqan, N. (2014) · UPT. Syiah Kuala University Library (Syiah Kuala University)

Modulation of the Mdm2 signaling axis sensitizes triple-negative breast cancer cells to carboplatin

Tonsing-Carter, E. Y. (2014) · ProQuest Demo Repository · doi:10.7912/c2/308

Induction of p53 Dependent Cellular Senescence Through HdmX Inhibition or YPEL3 Expression

Miller, K. L. (2010) · Journal of Bioresource Management

IN VIVO SIGNIFICANCE OF THE MDM4 AND P73 INTERACTION DURING DEVELOPMENT AND TUMORIGENESIS

Tashakori, M. (2015) · Digital Commons-TMC (Texas Medical Center)

A regulatory network of Mdm2 and members of the Polycomb Group (PcG) family

Wienken, M. M. (2016) · doi:10.53846/goediss-5475

Study of MicroRNA-34a mediated post transcriptional regulation of MDM4

Mandke, P. (2012) · CORE Scholar (Wright State University)

Exploring Chromatin-bound MDM2 Functions in Compromised Transcriptional Regulation of p53 Target Genes

Rosso, M. (2015) · CUNY Academic Works (City University of New York)

Controlling insulin resistance through modulation of interplay between mediators of cellular senescence: A mathematical studyPreprint

Arora, C. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/269738

Data from A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis

Wang, H., Ma, X., Ren, S., Buolamwini, J. K., & Yan, C. (2023) · doi:10.1158/1535-7163.c.6531407

Data from A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis

Wang, H., Ma, X., Ren, S., Buolamwini, J. K., & Yan, C. (2023) · doi:10.1158/1535-7163.c.6531407.v1

Germ cell tumor treatment resistance and liquid biopsy-based microRNA biomarkers

Timmerman, D. M. (2024) · doi:10.33540/2055

Das Onkoprotein Mdm4 und seine Wirkung auf die DNA-Replikation

Wohlberedt, K. (2024) · doi:10.53846/goediss-10645

CAV1 Stabilizes EPAS1 via VHL in Colon Cancer to Promote Autophagy‐Dependent Ferroptosis, Inhibits Stemness and Improves Anti‐ PD ‐1 Efficacy

Li, L., Li, R., Zhan, W., Zhuo, Z., Zhang, J., Li, Q., Mu, S., Chen, W., Li, L., & He, S. (2025) · The FASEB Journal · doi:10.1096/fj.202501953r

The role of NEDD8 pathway in cell invasion and strategies for the use of NEDD8 inhibitors in the clinic

Malhab, L. J. B. (2016) · theses.fr (ABES) · doi:10.70675/a9a79207z0857z4ed5zb207z749cdceb9430

Implication de la voie p53 dans les syndromes d'insuffisance médullaire

Durand, R. (2020) · theses.fr (ABES) · doi:10.70675/6ccc120bz65f7z4c6czabf5z9bea26651b66

BindingDB Entry 50007118: α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53-MDM2/MDMX Protein-Protein Interactions.

BindingDB (2021) · UC San Diego · doi:10.7270/q2d79fph

BindingDB Entry 50045594: Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

BindingDB (2016) · UC San Diego · doi:10.7270/q21g0nz5

BindingDB Entry 50021995: Cellular, Structural Basis, and Recent Progress for Targeting Murine Double Minute X (MDMX) in Tumors.

BindingDB (2025) · UC San Diego · doi:10.7270/q2tf032p

Multiple modes of Mdmx regulation affect p53 activation

Gilkes, D. M. (2008) · Digital Commons - University of South Florida (University of South Florida)

MDMX Regulates Transcriptional Activity of p53 and FOXO Proteins to Stimulate Proliferation of Melanoma Cells

Heijkants, R. C., Teunisse, A. F. A. S., de Jong, D., Glinkina, K., Mei, H., Kiełbasa, S. M., Szuhai, K., & Jochemsen, A. G. (2022) · Cancers · doi:10.3390/cancers14184482 · Cited by 13 · see citing works

MdmX Is Required for p53 Interaction with and Full Induction of the Mdm2 Promoter after Cellular Stress

Biderman, L., Poyurovsky, M. V., Assia, Y., Manley, J. L., & Prives, C. L. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06150-11 · Cited by 26 · see citing works

MDM2 and MDMX Regulators of p53 Activity

Momand, J. A., Aspuria, P. J., & Furuta, S. (2007) · Springer eBooks · doi:10.1007/0-387-30127-5_7 · Cited by 1 · see citing works

Constitutive mdmx Expression During Cell Growth, Differentiation, and DNA Damage

Jackson, M. W., & Berberich, S. J. (1999) · DNA and Cell Biology · doi:10.1089/104454999314971 · Cited by 27 · see citing works