Zinc Transport Complexes Contribute to the Homeostatic Maintenance of Secretory Pathway Function in Vertebrate Cells

Ishihara, Kaori; Yamazaki, Tomohiro; Ishida, Yoko; Suzuki, Tomoyuki; Oda, Kimimitsu; Nagao, Masaya; Yamaguchi-Iwai, Yuko; Kambe, Taiho

doi:10.1074/jbc.m602470200

Zinc Transport Complexes Contribute to the Homeostatic Maintenance of Secretory Pathway Function in Vertebrate Cells

Zinc transporters play important roles in a wide range of biochemical processes. Here we report an important function of ZnT5/ZnT6 hetero-oligomeric complexes in the secretory pathway. The activity of human tissue-nonspecific alkaline phosphatase (ALP) expressed in ZnT5–ZnT7–/– cells was signific…