Hypoxia-inducible Factor 1α (HIF-1α)-mediated Hypoxia Increases BACE1 Expression and β-Amyloid Generation

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The relationship between hypoxia and Alzheimer’s disease: an updated review

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Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex

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Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain

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Hypertension and Alzheimer’s disease: indirect effects through circle of Willis atherosclerosis

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Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease

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The vascular contribution to cognitive decline in ageing and dementia

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Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer’s disease cybrid cells

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Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia

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Caspase-3 Cleavage of GGA3 Stabilizes BACE: Implications for Alzheimer's Disease

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SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease

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MRI of the ‘Alzheimer syndrome’

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Brain ischemia and ischemic blood–brain barrier as etiological factors in sporadic Alzheimer’s disease

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Interactions between nanoparticles and pathological changes of vascular in Alzheimer’s disease

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Apoptogenic interactions of plasmalemmal type-1 VDAC and Aβ peptides via GxxxG motifs induce Alzheimer's disease – a basic model of apoptosis?*

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Regulation of β-amyloid level in the brain of rats with cerebrovascular hypoperfusion

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Serum Amyloid-Beta Levels are Increased in Patients with Chronic Obstructive Pulmonary Disease

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Brain Capillaries in Alzheimer’s Disease

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Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease

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Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders

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Changing Perspectives on Alzheimer's Disease: Thinking Outside the Amyloid Box

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The Importance of Diagnosing and the Clinical Potential of Treating Obstructive Sleep Apnea to Delay Mild Cognitive Impairment and Alzheimer’s Disease: A Special Focus on Cognitive Performance

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Ischemia signalling to Alzheimer-related genes

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Potential Roles of Hypoxia-Inducible Factor-1 in Alzheimer’s Disease: Beneficial or Detrimental?

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HIF-1α serves as a co-linker between AD and T2DM

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Oxygen Sensing: A Common Crossroad in Cancer and Neurodegeneration

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Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1

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Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APPswe/PS1dE9 Mice and Their Wild Type Littermates

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Reduced Cardiovascular Functions in Patients with Alzheimer’s Disease

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Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study

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The Potential Dual Effects of Anesthetic Isoflurane on Hypoxia-Induced Caspase-3 Activation and Increases in β-Site Amyloid Precursor Protein-Cleaving Enzyme Levels

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Environmental exposures and the etiopathogenesis of Alzheimer's disease: The potential role of BACE1 as a critical neurotoxic target

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Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease

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Scutellarin Ameliorates Learning and Memory Deficit via Suppressing β-Amyloid Formation and Microglial Activation in Rats with Chronic Cerebral Hypoperfusion

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Amyloid Beta Hypothesis in Alzheimer's Disease: Major Culprits and Recent Therapeutic Strategies

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A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer’s Pathogenesis—And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder

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Obesity impacts the expression of Alzheimer's disease–related genes: The Framingham Heart Study

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Polydopamine/Ruthenium Nanoparticle Systems as Photothermal Therapy Reagents and Reactive Oxygen Species Scavengers for Alzheimer’s Disease Treatment

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Thiacremonone Potentiates Anti-Oxidant Effects to Improve Memory Dysfunction in an APP/PS1 Transgenic Mice Model

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Non-canonical pathways associated to Amyloid beta and tau protein dyshomeostasis in Alzheimer’s disease: A narrative review

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Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 × Tg-AD mouse model of Alzheimer's disease

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Platelet-Derived Secreted Amyloid-Precursor Protein-β as a Marker for Diagnosing Alzheimer’s Disease

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Calcium sensing receptor mediated the excessive generation of β-amyloid peptide induced by hypoxia in vivo and in vitro

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The Potential Regulators of Amyloidogenic Pathway of APP Processing in Alzheimer’s Disease

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Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?

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Twenty-five years of the amyloid hypothesis of alzheimer disease: advances, failures and new perspectives

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BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid

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Molecular Pathobiology of the Cerebrovasculature in Aging and in Alzheimers Disease Cases With Cerebral Amyloid Angiopathy

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Muscarinic activation attenuates abnormal processing of β-amyloid precursor protein induced by cobalt chloride-mimetic hypoxia in retinal ganglion cells

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The loss of NDRG2 expression improves depressive behavior through increased phosphorylation of GSK3β

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Apolipoprotein E4 exacerbates ethanol-induced neurotoxicity through augmentation of oxidative stress and apoptosis in N2a-APP cells

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Cholinergic Hypofunction in Presbycusis-Related Tinnitus With Cognitive Function Impairment: Emerging Hypotheses

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Epigenetic modifications of chronic hypoxia-mediated neurodegeneration in Alzheimer’s disease

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Aβ Deposits in the Neocortex of Adult and Infant Hypoxic Brains, Including in Cases of COVID-19

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Exploring the role of HIF-1α on pathogenesis in Alzheimer’s disease and potential therapeutic approaches

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Hypoxic stress, brain vascular system, and β-amyloid: A primary cell culture study

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Dysregulation of Hypoxia-Inducible Factor by Presenilin/γ-Secretase Loss-of-Function Mutations

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Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo

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The Role of Secretase Pathway in Long-term Brain Inflammation and Cognitive Impairment in an Animal Model of Severe Sepsis

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Altered Amyloid-β and Tau Proteins in Neural-Derived Plasma Exosomes of Type 2 Diabetes Patients with Orthostatic Hypotension

Zhang, J., Chi, H., Wang, T., Zhang, S., Shen, T., Leng, B., Sun, H., Li, Z., & Li, F. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210216 · Cited by 20

Involvement of cerebrovascular abnormalities in the pathogenesis and progression of Alzheimer’s disease: an adrenergic approach

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Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brain

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Hexahydrocurcumin Attenuates Neuronal Injury and Modulates Synaptic Plasticity in Chronic Cerebral Hypoperfusion in Rats

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Brain ischemia with Alzheimer phenotype dysregulates Alzheimer's disease-related proteins

Ułamek-Kozioł, M., Pluta, R. M., Bogucka‐Kocka, A., Januszewski, S., Kocki, J., & Czuczwar, S. J. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.01.006 · Cited by 19

Mutant Amyloid Precursor Protein Differentially Alters Adipose Biology under Obesogenic and Non-Obesogenic Conditions

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BACE1 levels are elevated in congestive heart failure

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Chronic cerebral hypoperfusion upregulates leptin receptor expression in astrocytes and tau phosphorylation in tau transgenic mice

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LncRNA OIP5-AS1 Regulates the Warburg Effect Through miR-124-5p/IDH2/HIF-1α Pathway in Cervical Cancer

Li, L., Ma, Y., Maerkeya, K., Reyanguly, D., & Han, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.655018 · Cited by 19

Novel multi-target compounds in the quest for new chemotherapies against Alzheimer’s disease: An experimental and theoretical study

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Dysregulation of Transcription Factors: A Key Culprit Behind Neurodegenerative Disorders

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COVID-19 and Alzheimer’s Disease Share Common Neurological and Ophthalmological Manifestations: A Bidirectional Risk in the Post-Pandemic Future

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Oxygen-glucose deprivation regulates BACE1 expression through induction of autophagy in Neuro-2a/APP695 cells

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