Lipton, Stuart A.

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 3,399

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

Lipton, S. A., Choi, Y.-B., Pan, Z.-H., Lei, S. Z., Chen, H.-S. V., Sucher, N. J., Loscalzo, J., Singel, D. J., & Stamler, J. S. (1993) · Nature

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 2,433

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 2,421

Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function

Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A., & Nicotera, P. (1995) · Neuron

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 1,884

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

Cho, D.-H., Nakamura, T., Fang, J., Cieplak, P., Godzik, A., Gu, Z., & Lipton, S. A. (2009) · Science

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 1,092

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., et al. (2015) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 1,002

S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death

Gu, Z., Kaul, M., Yan, B., Kridel, S. J., Cui, J., Strongin, A., Smith, J. W., Liddington, R. C., & Lipton, S. A. (2002) · Science

Protease and Inhibitor MechanismsRedox biology and oxidative stress

Cited by 950

Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond

Lipton, S. A. (2006) · Nature Reviews Drug Discovery

Neuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

Cited by 909

Molecular pathways to neurodegeneration

Bossy-Wetzel, E., Schwarzenbacher, R., & Lipton, S. A. (2004) · Nature Medicine

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Cited by 740

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Talantova, M., Sanz-Blasco, S., Zhang, X., Xia, P., Akhtar, M. W., Okamoto, S.-I., Dziewczapolski, G., Nakamura, T., Cao, G., Pratt, A. E., et al. (2013) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

Cited by 600

Hypoxia-inducible Factor 1α (HIF-1α)-mediated Hypoxia Increases BACE1 Expression and β-Amyloid Generation

Zhang, X., Zhou, K., Wang, R., Cui, J., Lipton, S. A., Liao, F.-F., Xu, H., & Zhang, Y.-W. (2007) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 436

Cysteine regulation of protein function – as exemplified by NMDA-receptor modulation

Lipton, S. A., Choi, Y.-B., Takahashi, H., Zhang, D., Li, W., Godzik, A., & Bankston, L. A. (2002) · Trends in Neurosciences

Redox biology and oxidative stressNeuroscience and Neuropharmacology Research

Cited by 375

Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

Ghatak, S., Dolatabadi, N., Trudler, D., Zhang, X., Wu, Y., Mohata, M., Ambasudhan, R., Talantova, M., & Lipton, S. A. (2019) · eLife

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 227

Role of p38 Mitogen-Activated Protein Kinase in Axotomy-Induced Apoptosis of Rat Retinal Ganglion Cells

Kikuchi, M., Tenneti, L., & Lipton, S. A. (2000) · The Journal of Neuroscience

Glaucoma and retinal disordersCell death mechanisms and regulation

Cited by 197

Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer’s disease and other neurologic disorders.

Lipton, S. A. (2005) · Journal of Alzheimer's Disease

Neuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

Cited by 194

Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor

Choi, Y.-B., & Lipton, S. A. (1999) · Neuron

Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and Metabolism

Cited by 180

Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases

Nakamura, T., Prikhodko, O. A., Pirie, E., Nagar, S., Akhtar, M. W., Oh, C.-K., McKercher, S. R., Ambasudhan, R., Okamoto, S.-I., & Lipton, S. A. (2015) · Neurobiology of Disease

Redox biology and oxidative stressNitric Oxide and Endothelin Effects

Cited by 165

Candidal infection in the central nervous system

Lipton, S. A., Hickey, W. F., Morris, J. H., & Loscalzo, J. (1984) · The American Journal of Medicine

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 157

Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+Modulation of the NMDA Receptor

Choi, Y.-B., Chen, H.-S. V., & Lipton, S. A. (2001) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Cited by 132

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss

Trudler, D., Sanz-Blasco, S., Eisele, Y. S., Ghatak, S., Bodhinathan, K., Akhtar, M. W., Lynch, W. P., Piña-Crespo, J. C., Talantova, M., Kelly, J. W., et al. (2021) · The Journal of Neuroscience

Parkinson's Disease Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

Cited by 104

Mechanistic insight into female predominance in Alzheimer’s disease based on aberrant protein S-nitrosylation of C3

Yang, H., Oh, C.-K., Amal, H., Wishnok, J. S., Lewis, S., Schahrer, E., Trudler, D., Nakamura, T., Tannenbaum, S. R., & Lipton, S. A. (2022) · Science Advances

Alzheimer's disease research and treatmentsRedox biology and oxidative stress

Cited by 70

The transcriptional and cellular landscape of cognitive resilience to Alzheimer’s disease

Khera, N., Raju, R. M., & Lipton, S. A. (2025) · Frontiers in Molecular Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 3