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The Alzheimer’s Disease–Associated Protein BACE1 Modulates T Cell Activation and Th17 Function

Hernandez-Mir, Gerard, Raphael, Itay, Revu, Shankar, Poholek, Catherine H, Avery, Lyndsay, Hawse, William F, Kane, Lawrence P, McGeachy, Mandy J·2019·The Journal of Immunology
DOI 10.4049/jimmunol.1800363PMC PMC6650361
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Abstract

β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is best known for its role in Alzheimer's disease amyloid plaque formation but also contributes to neurodegenerative processes triggered by CNS injury. In this article, we report that BACE1 is expressed in murine CD4+ T cells and regulates signaling through the TCR. BACE1-deficient T cells have reduced IL-17A expression under Th17 conditions and reduced CD73 expression in Th17 and inducible T regulatory cells. However, induction of the Th17 and T regulatory transcription factors RORγt and Foxp3 was unaffected. BACE1-deficient T cells showed impaired pathogenic function in experimental autoimmune encephalomyelitis. These data identify BACE1 as a novel regulator of T cell signaling pathways that impact autoimmune inflammatory T cell function.

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  • BACE1 has been shown to be important in Th17 differentiation.

    “BACE1 has been shown to be important in Th17 differentiation.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [158]

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Metadata

Authors
Hernandez-Mir, G., Raphael, I., Revu, S., Poholek, C. H., Avery, L., Hawse, W. F., Kane, L. P., & McGeachy, M. J.
Affiliations
  • Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15261
  • Department of Immunology, University of Pittsburgh , Pittsburgh, PA 15261
ORCID
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2019-08-01
Volume
203
Issue
3
Pages
665-675
ISSN
  • 0022-1767
  • 1550-6606
DOI
10.4049/jimmunol.1800363
PMC
PMC6650361
Cited by
14
References
10
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)

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