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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

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HIF-1α serves as a co-linker between AD and T2DM

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Gene expression microarray analysis of heat stress in the soil invertebrate Folsomia candida

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Pyruvate Is Superior to Citrate in Oral Rehydration Solution in the Protection of Intestine via Hypoxia‐Inducible Factor‐1 Activation in Rats With Burn Injury

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Enhanced leukocyte HIF-1α and HIF-1 DNA binding in humans after rapid ascent to 4300 m

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Complex role of the HIF system in cardiovascular biology

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The hypoxia-inducible factor 1 pathway plays a critical role in the development of breast muscle myopathies in broiler chickens: a comprehensive review

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Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells

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Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase

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Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy

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Revisiting reactive oxygen species production in hypoxia

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Overexpression of mitochondrial uncoupling protein 1 (UCP1) induces a hypoxic response inNicotiana tabacumleaves

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Trained immunity in diabetes and hyperlipidemia: Emerging opportunities to target cardiovascular complications and design new therapies

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The impact of mitochondria on cancer treatment resistance

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Human PRP19 interacts with prolyl-hydroxylase PHD3 and inhibits cell death in hypoxia

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Fumarate integrates metabolism and immunity in diseases

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Regulation of intrinsic and extrinsic metabolic pathways in tumour‐associated macrophages

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Gastrodin alleviates NTG-induced migraine-like pain via inhibiting succinate/HIF-1α/TRPM2 signaling pathway in trigeminal ganglion

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Functional importance of blood flow dynamics and partial oxygen pressure in the anterior pituitary

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Structural basis for GPCR signaling by small polar versus large lipid metabolites—discovery of non-metabolite ligands

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Polarization of Macrophages in Insects: Opening Gates for Immuno-Metabolic Research

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Human Oxygenase Variants Employing a Single Protein Fe II Ligand Are Catalytically Active

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Renal and Cardiovascular Metabolic Impact Caused by Ketogenesis of the SGLT2 Inhibitors

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Hypoxia‐inducible factors – regulation, role and comparative aspects in tumourigenesis

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Requirements for Skp1 Processing by Cytosolic Prolyl 4(trans)-Hydroxylase and α-N-Acetylglucosaminyltransferase Enzymes Involved in O2 Signaling in Dictyostelium

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Molecular genetics of paragangliomas of the skull base and head and neck region: implications for medical and surgical management

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Genetically Modeled Mice with Mutations in Mitochondrial Metabolic Enzymes for the Study of Cancer

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Mitochondrial Signaling in Hypoxia

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Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1

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α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4)

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Revisiting the role of hypoxia-inducible factors and nuclear factor erythroid 2-related factor 2 in regulating macrophage inflammation and metabolism

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Breaking the cycle

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In Vitro Inhibitory Effect of Succinic Acid on T-Cell Acute Lymphoblastic Leukemia Cell Lines

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The epigenetic and morphogenetic effects of molecular oxygen and its derived reactive species in development

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Pyruvate in oral rehydration salt improves hemodynamics, vasopermeability and survival after burns in dogs

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Metabolite signaling in the heart

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Parent-of-origin tumourigenesis is mediated by an essential imprinted modifier inSDHD-linked paragangliomas:SLC22A18andCDKN1Care candidate tumour modifiers

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Role of Succinates in Critical Conditions

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Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins

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TAp73 transcriptionally represses BNIP3 expression

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Complete Response of Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC)-Associated Renal Cell Carcinoma to Pembrolizumab Immunotherapy: A Case Report

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Collagen Hydroxylases

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Hypothesis: Why Different Types of SDH Gene Variants Cause Divergent Tumor Phenotypes

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SDHC Promoter Methylation, a Novel Pathogenic Mechanism in Parasympathetic Paragangliomas

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Intracellular Succinylation of 8-Chloroadenosine and Its Effect on Fumarate Levels

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New insights in the targets of action of dimethyl fumarate in endothelial cells: effects on energetic metabolism and serine synthesis in vitro and in vivo

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Immuno-metabolic changes in herpes virus infection

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Axonal Mitochondria Modulate Neuropeptide Secretion Through the Hypoxic Stress Response in Caenorhabditis elegans

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Role of tRNA derived fragments in renal ischemia–reperfusion injury

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Trained Immunity and Cardiovascular Risk: An Immunological Perspective

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Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia

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Mitonuclear Communication in Stem Cell Function

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Characterization of a Robust Enzymatic Assay for Inhibitors of 2-Oxoglutarate-Dependent Hydroxylases

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Effect of sodium ( S )-2-hydroxyglutarate in male, and succinic acid in female Wistar rats against renal ischemia-reperfusion injury, suggesting a role of the HIF-1 pathway

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15 YEARS OF PARAGANGLIOMA: Metabolism and pheochromocytoma/paraganglioma

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Tolerance of DNA Replication Stress Is Promoted by Fumarate Through Modulation of Histone Demethylation and Enhancement of Replicative Intermediate Processing inSaccharomyces cerevisiae

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Effect of Citric Acid Cycle Genetic Variants and Their Interactions with Obesity, Physical Activity and Energy Intake on the Risk of Colorectal Cancer: Results from a Nested Case-Control Study in the UK Biobank

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IRG1 controls host responses to restrict Mycobacterium tuberculosis infectionPreprint

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Effects of hypoxia on respiratory diseases: perspective view of epithelial ion transport

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Chromatin as a sensor of metabolic changes during early development

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Trained immunity in diabetes: emerging targets for cardiovascular complications

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Direct and quantitative analysis of altered metabolic flux distributions and cellular ATP production pathway in fumarate hydratase-diminished cells

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Heat acclimation mediated cardioprotection is controlled by mitochondrial metabolic remodeling involving HIF-1α

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New cancer targets emerging from studies of the Von Hippel‐Lindau tumor suppressor protein

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Mitochondrial Factors in the Cell Nucleus

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Co-expression of HIF-1α, MDR1 and LAPTM4B in peripheral blood of solid tumors

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From Metabolism to Genetics and Vice Versa: The Rising Role of Oncometabolites in Cancer Development and Therapy

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Altered Dynamics of Intestinal Cell Maturation in Apc1638N/+ Mice

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Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ

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