The Extremely Conserved C-terminal Region of Reelin Is Not Necessary for Secretion but Is Required for Efficient Activation of Downstream Signaling

Nakano, Yoshimi; Kohno, Takao; Hibi, Terumasa; Kohno, Shiori; Baba, Atsushi; Mikoshiba, Katsuhiko; Nakajima, Kazunori; Hattori, Mitsuharu

doi:10.1074/jbc.m702300200

The Extremely Conserved C-terminal Region of Reelin Is Not Necessary for Secretion but Is Required for Efficient Activation of Downstream Signaling

Reelin is a very large secreted glycoprotein essential for correct development of the mammalian brain. It is also implicated in higher functions and diseases of human brain. However, whether or not secretion of Reelin is regulated and how Reelin transmits signals remain largely unknown. Reelin pr…