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Similarities and differences in structure, expression, and functions of VLDLR and ApoER2

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Reddy, Sunil S, Connor, Teal E, Weeber, Edwin J, Rebeck, William·2011·Molecular Neurodegeneration
DOI 10.1186/1750-1326-6-30PMC PMC3113299
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Abstract

Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) are important receptors in the brain for mediating the signaling effects of the extracellular matrix protein Reelin, affecting neuronal function in development and in the adult brain. VLDLR and ApoER2 are members of the low density lipoprotein family, which also mediates the effects of numerous other extracellular ligands, including apolipoprotein E. Although VLDLR and ApoER2 are highly homologous, they differ in a number of ways, including structural differences, expression patterns, alternative splicing, and binding of extracellular and intracellular proteins. This review aims to summarize important aspects of VLDLR and ApoER2 that may account for interesting recent findings that highlight the unique functions of each receptor.

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  • ApoER2 is mostly located in lipid-rafts and functions primarily in cell signaling and as a scaffold for intracellular adaptor molecules.

    “In comparison, ApoER2 is mostly located in lipid-rafts and functions primarily in cell signaling and as a scaffold for intracellular adaptor molecules [12].”

    From PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling (2012) · cites this paper as [12]

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Cited by

Sorted by citations

Authors
Reddy, S. S., Connor, T. E., Weeber, E. J., & Rebeck, W.
Affiliations
  • Georgetown University (US)
  • Georgetown University Medical Center (US)
  • University of South Florida (US)
Corresponding author
Rebeck, William
ORCID
Weeber, Edwin J
Venue
Molecular Neurodegeneration
Publisher
Springer Science and Business Media LLC
Published
2011-05-09
Volume
6
Issue
1
Pages
30-30
ISSN
1750-1326 (ISSN-L)
DOI
10.1186/1750-1326-6-30
PMC
PMC3113299
OpenAlex
W2155633873
Cited by
93
References
8
Citations by year
2026: 4 · 2025: 6 · 2024: 6 · 2023: 17 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 6
FWCI
2.38
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Molecular Neurodegeneration (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (P01AG030128, R01AG035379)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
VLDLR, ApoER2, reelin, apolipoprotein E, low-density lipoprotein receptor family, receptor structure, alternative splicing, receptor expression patterns, receptor signaling, neuronal development, brain

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