Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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FGF-21 as a novel metabolic regulator

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Suppression of Aging in Mice by the Hormone Klotho

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Receptor Specificity of the Fibroblast Growth Factor Family

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

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Klotho converts canonical FGF receptor into a specific receptor for FGF23

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Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

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Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.

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Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

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Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

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Role of FGF19 induced FGFR4 activation in the regulation of glucose homeostasis

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Autofluorescence Imaging of Living Pancreatic Islets Reveals Fibroblast Growth Factor-21 (FGF21)-Induced Metabolism

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Fibroblast growth factor 21 and bone homeostasis

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Fibroblast growth factor 21 as a potential master regulator in metabolic disorders

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Role of fibroblast growth factors in organ regeneration and repair

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Low Body Mass Index and Dyslipidemia in Dialysis Patients Linked to Elevated Plasma Fibroblast Growth Factor 23

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FGF21 as a Therapeutic Reagent

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The role of FGF21 in type 1 diabetes and its complications

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Paracrine-endocrine FGF chimeras as potent therapeutics for metabolic diseases

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Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77–FGF21 pathway

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FGF21 signalling pathway and metabolic traits – genetic association analysis

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Effects of Short-Term Continuous Subcutaneous Insulin Infusion on Fasting Plasma Fibroblast Growth Factor-21 Levels in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

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Fibroblast growth factor 19 is correlated with an unfavorable prognosis and promotes progression by activating fibroblast growth factor receptor 4 in advanced-stage serous ovarian cancer

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Curtailing FGF19’s mitogenicity by suppressing its receptor dimerization ability

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Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain

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Adipose-derived stem cell/FGF19-loaded microfluidic hydrogel microspheres for synergistic restoration of critical ischemic limb

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Metabolic Hormone FGF21 Is Induced in Ground Squirrels during Hibernation but Its Overexpression Is Not Sufficient to Cause Torpor

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Reduction in serum fibroblast growth factor-21 after gastric bypass is related to changes in hepatic fat content

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Implications of Fibroblast Growth Factors (FGFs) in Cancer: From Prognostic to Therapeutic Applications

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QTL mapping for orange shell color and sex in the Pacific oyster (Crassostrea gigas)

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Levels of β-klotho determine the thermogenic responsiveness of adipose tissues: involvement of the autocrine action of FGF21

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Advances of Fibroblast Growth Factor/Receptor Signaling Pathway in Hepatocellular Carcinoma and its Pharmacotherapeutic Targets

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FGF21 Reduces Lipid Accumulation in Bovine Hepatocytes by Enhancing Lipid Oxidation and Reducing Lipogenesis via AMPK Signaling

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Adipokines: Deciphering the cardiovascular signature of adipose tissue

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Adapting to the cold: A role for endogenous fibroblast growth factor 21 in thermoregulation?

Klein Hazebroek, M., & Keipert, S. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00389 · Cited by 27

Current, emerging, and potential therapies for non-alcoholic steatohepatitis

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FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation model

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Unliganded Fibroblast Growth Factor Receptor 1 Forms Density-independent Dimers

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FGF2 Stimulation of the Pyrophosphate-Generating Enzyme, PC-1, in Pre-Osteoblast Cells Is Mediated by RUNX2

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Differential Roles of Fibroblast Growth Factor Receptors (FGFR) 1, 2 and 3 in the Regulation of S115 Breast Cancer Cell Growth

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Targeting FGFR in Squamous Cell Carcinoma of the Lung

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Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism

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Improved FGF21 Sensitivity and Restored FGF21 Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats After Duodenal-Jejunal Bypass and Sleeve Gastrectomy

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Maresin 1 Regulates Hepatic FGF21 in Diet‐Induced Obese Mice and in Cultured Hepatocytes

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α-Klotho Expression in Mouse Tissues Following Acute Exhaustive Exercise

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FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish

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KLB dysregulation mediates disrupted muscle development in intrauterine growth restriction

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Fibroblast growth factor 21 (FGF21) promotes porcine granulosa cell estradiol production and proliferation via PI3K/AKT/mTOR signaling

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Association between insulin resistance and impairment of FGF21 signal transduction in skeletal muscles

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Exercise Is Medicine for Nonalcoholic Fatty Liver Disease: Exploration of Putative Mechanisms

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β-Klotho deficiency shifts the gut-liver bile acid axis and induces hepatic alterations in mice

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Enhanced GIP Secretion in Obesity Is Associated with Biochemical Alteration and miRNA Contribution to the Development of Liver Steatosis

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Fibroblast Growth Factor 21 Facilitates the Homeostatic Control of Feeding Behavior

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FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes

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FGF21 suppresses hepatic glucose production through the activation of atypical protein kinase Cι/λ

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A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk)

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Involvement of heparan sulfate 6-O-sulfation in the regulation of energy metabolism and the alteration of thyroid hormone levels in male mice

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Fibroblast Growth Factor Family in the Progression of Prostate Cancer

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The cell adhesion molecule L1 regulates the expression of FGF21 and enhances neurite outgrowth

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Endocrine Fibroblast Growth Factors in Relation to Stress Signaling

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Role of liver FGF21-KLB signaling in ketogenic diet-induced amelioration of hepatic steatosis

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Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (G9a) and reduced FGF21 gene expression in Sprague–Dawley rats fed prenatal low protein and postnatal high-fat diets

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MicroRNA-34a and Impaired FGF19/21 Signaling in Obesity

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Therapeutic utilities of fibroblast growth factor 19

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Fibroblast growth factor 19-targeted therapies for the treatment of metabolic disease

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Klotho‐beta and fibroblast growth factor 19 expression correlates with early recurrence of resectable hepatocellular carcinoma

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Endoplasmic reticulum stress induces up-regulation of hepatic β-Klotho expression through ATF4 signaling pathway

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Metabolic Syndrome in Pediatrics

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Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function

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Differential receptor selectivity of the FGF15/FGF19 orthologues determines distinct metabolic activities in db/db mice

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N‐acetyl‐seryl‐aspartyl‐lysyl‐proline is a valuable endogenous antifibrotic peptide for kidney fibrosis in diabetes: An update and translational aspects

Kanasaki, K. (2020) · Journal of Diabetes Investigation · doi:10.1111/jdi.13219 · Cited by 23

Serum Endocrine Fibroblast Growth Factors as Potential Biomarkers for Chronic Kidney Disease and Various Metabolic Dysfunctions in Aged Patients

Yamamoto, S., Koyama, D., Igarashi, R., Maki, T., Mizuno, H., Furukawa, Y., & Kuro‐o, M. (2020) · Internal Medicine · doi:10.2169/internalmedicine.3597-19 · Cited by 23

Targeting fibroblast growth factor (FGF)-21: a promising strategy for metabolic dysfunction-associated steatotic liver disease treatment

Cui, X., Sun, Q., & Wang, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1510322 · Cited by 24

Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids

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Fibroblast growth factor 21: A “rheostat” for metabolic regulation?

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FGF19 Exhibits Neuroprotective Effects on Adult Mammalian Photoreceptors In Vitro

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Reduced Levels of Serum FGF19 and Impaired Expression of Receptors for Endocrine FGFs in Adipose Tissue From HIV-Infected Patients

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FGF19 functions as autocrine growth factor for hepatoblastoma

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Circulating Fibroblast Growth Factor 19 in Portal and Systemic Blood

Johansson, H., Mörk, L.-M., Li, M., Lövgren‐Sandblom, A., Björkhem, I., Höijer, J., Ericzon, B., Jorns, C., Gilg, S., Sparrelid, E., et al. (2017) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2017.07.001 · Cited by 22

Decreased placental and muscular expression of the fibroblast growth factor 19 in gestational diabetes mellitus

Wang, D., Xu, S., Ding, W., Zhu, C., Deng, S., Qiu, X., & Wang, Z. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12859 · Cited by 21

The Enterokine Fibroblast Growth Factor 15/19 in Bile Acid Metabolism

Cariello, M., Piglionica, M., Gadaleta, R. M., & Moschetta, A. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_235 · Cited by 22

Frequent overexpression of klotho in fusion-negative phosphaturic mesenchymal tumors with tumorigenic implications

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Supplementary Materials and Methods

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The role of FGF19 in metabolic regulation: insights from preclinical models to clinical trials

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Bile Secretion and the Enterohepatic Circulation

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Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities

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