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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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FGF-21 as a novel metabolic regulator

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Suppression of Aging in Mice by the Hormone Klotho

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Receptor Specificity of the Fibroblast Growth Factor Family

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Klotho converts canonical FGF receptor into a specific receptor for FGF23

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Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

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Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.

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Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

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Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

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Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications

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Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance

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A Unique FGF23 with the Ability to Activate FGFR Signaling through Both αKlotho and βKlotho

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Expression profile and overexpression outcome indicate a role for βKlotho in skeletal muscle fibro/adipogenesis

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Association of serum fibroblast growth factor 19 levels with visceral fat accumulation is independent of glucose tolerance status

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Endocrine Adiponectin‐FGF15/19 Axis in Ethanol-Induced Inflammation and Alcoholic Liver Injury

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Fibroblast growth factor 23 and acute kidney injury

Neyra, J. A., Moe, O. W., & Hu, M. C. (2014) · Pediatric Nephrology · doi:10.1007/s00467-014-3006-1 · Cited by 17

Novel Sandwich Immunoassays for The Measurement of Total and Active Fgf21

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FGF19 Contributes to Tumor Progression in Gastric Cancer by Promoting Migration and Invasion

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FGF-1 modulates pancreatic β-cell functions/metabolism: An in vitro study

Kolodziejski, P. A., Sassek, M., Bień, J., Leciejewska, N., Szczepankiewicz, D., Szczepaniak, B., Wojciechowska, M., Nogowski, L., Nowak, K. W., Strowski, M. Z., et al. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113498 · Cited by 16

Identification and characterization of adipose surface epitopes

Onogi, Y., Khalil, A., & Ussar, S. (2020) · Biochemical Journal · doi:10.1042/bcj20190462 · Cited by 16

Aging and FGF23-klotho system

Kuro‐o, M. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.013 · Cited by 16

Decrease of FGF19 contributes to the increase of fasting glucose in human in an insulin-independent manner

Zhang, J.-L., Li, H., Bai, N., Xu, Y., Song, Q., Zhang, L., Wu, G., Chen, S., Hou, X., Wang, C., et al. (2019) · Journal of Endocrinological Investigation · doi:10.1007/s40618-019-01018-5 · Cited by 16

Discovery of an artificial peptide agonist to the fibroblast growth factor receptor 1c/βKlotho complex from random peptide T7 phage display

Sakamoto, K., Kawata, Y., Masuda, Y., Umemoto, T., Ito, T., Asami, T., Takekawa, S., Ohtaki, T., & Inooka, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.009 · Cited by 15

Gastric Bypass Resolves Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Low-BMI Patients

Billeter, A. T., Scheurlen, K. M., Israel, B., Straub, B. K., Schirmacher, P., Kopf, S., Nawroth, P. P., & Müller-Stich, B. P. (2022) · Annals of Surgery · doi:10.1097/sla.0000000000005631 · Cited by 15

Long-term high-fat diet links the regulation of the insulin-sensitizing fibroblast growth factor-21 and visfatin

Sun, B., Yang, G., Yang, M., Liu, H., Boden, G. H., & Li, L. (2012) · Cytokine · doi:10.1016/j.cyto.2012.03.030 · Cited by 15

γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers

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Successful Glycemic Control Decreases the Elevated Serum FGF21 Level without Affecting Normal Serum GDF15 Levels in a Patient with Mitochondrial Diabetes

Murakami, T., Ueba, Y., Shinoto, Y., Koga, Y., Kaneda, D., Hatoko, T., Kato, T., Yonemitsu, S., Muro, S., & Oki, S. (2016) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.239.89 · Cited by 15

The metabolic hormone FGF21 is associated with endothelial dysfunction in hemodialysis patients

Rusu, C. C., Racasan, S., Kacsó, I. M., Moldovan, D. T., Potra, A. R., Tirinescu, D. C., Budurea, C., Orasan, R. A., Pațiu, I. M., Bondor, C. I., et al. (2016) · International Urology and Nephrology · doi:10.1007/s11255-016-1474-x · Cited by 15

Exploring endocrine FGFs - structures, functions and biomedical applications

Phan, P. (2024) · International Journal of Biochemistry and Molecular Biology · doi:10.62347/palk2137 · Cited by 16

Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein

Park, J. S., Choi, J., Cao, L., Mohanty, J., Suzuki, Y., Park, A., Baker, D. A., Schlessinger, J., & Lee, S. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111545 · Cited by 14

Pharmaceutical Strategies to Improve Druggability of Potential Drug Candidates in Nonalcoholic Fatty Liver Disease Therapy

Amatya, R., Lee, D.-H., Min, K. A., & Shin, M. C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071963 · Cited by 13

FGF19‐Activated Hepatic Stellate Cells Release ANGPTL4 that Promotes Colorectal Cancer Liver Metastasis

Fan, X., Li, B., Zhang, F., Liu, M., Kwan, H. Y., Liu, Z., & Su, T. (2024) · Advanced Science · doi:10.1002/advs.202413525 · Cited by 14

Influence of Klotho Protein Levels in Obesity and Sarcopenia: A Systematic Review

Cobo, D. A., Estébanez, B., Arnáiz, E. G., García-Pérez, M. P., Rivera-Viloria, M., de la Maza, B. P., Galindo, D. E. B., Sastre, D. G., Ballesteros-Pomar, M. D., & Cuevas, M. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051915 · Cited by 14

Tryptophan restriction partially recapitulates the age-dependent effects of total amino acid restriction on energy balance in diet-induced obese rats

Zapata, R. C., Singh, A., Pezeshki, A., & Chelikani, P. K. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.12.006 · Cited by 14

βklotho is essential for the anti‐endothelial mesenchymal transition effects of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline

Gao, R., Kanasaki, K., Li, J., Kitada, M., Okazaki, T., & Koya, D. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12638 · Cited by 14

The Level of FGF 21 as a New Risk Factor for the Occurrence of Cardiometabolic Disorders amongst the Psoriatic Patients

Kiluk, P., Baran, A. M., Kaminski, T. W., Maciaszek, M., & Flisiak, I. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122206 · Cited by 15

Fibroblast growth factor-21 as a novel metabolic factor for regulating thrombotic homeostasis

Li, S., Jia, H., Liu, Z., Wang, N., Guo, X., Cao, M., Fang, F., Yang, J., Li, J., He, Q., et al. (2022) · Scientific Reports · doi:10.1038/s41598-021-00906-2 · Cited by 14

Association between amorphous calcium-phosphate ratios in circulating calciprotein particles and prognostic biomarkers in hemodialysis patients

Nakamura, K., Isoyama, N., Nakayama, Y., Hiroyoshi, T., Fujikawa, K., Miura, Y., Kurosu, H., Matsuyama, H., & Kuro‐o, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-17405-7 · Cited by 14

c-Fos mediates repression of the apical sodium-dependent bile acid transporter by fibroblast growth factor-19 in mice

Ghosh, A., Chen, F., Banerjee, S., Xu, M., & Shneider, B. L. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00276.2013 · Cited by 14

Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan

Kobayashi, M., Nezu, Y., Tagawa, R., & Higami, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062854 · Cited by 14

Serum β-klotho is a potential biomarker in the prediction of clinical outcomes among patients with NSCLC

Zhou, J., Ben, S., Tan, X., Xu, L., & Yao, X. (2021) · Journal of Thoracic Disease · doi:10.21037/jtd-21-798 · Cited by 13

Roles of fibroblast growth factor 21 in the control of depression‐like behaviours after social defeat stress in male rodents

Usui, N., Yoshida, M., Takayanagi, Y., Nasanbuyan, N., Inutsuka, A., Kurosu, H., Mizukami, H., Mori, Y., Kuro‐o, M., & Onaka, T. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13026 · Cited by 13

Tanycytes: bloodhounds of the metabolic brain

Rodriguez-Cortes, B., Gomez-Martínez, R., Spenle, R., Schwaninger, M., Nogueiras, R., Rasika, S., & Prévot, V. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.10.005 · Cited by 15

FGF21 alleviates adipose stem cell senescence via CD90 glycosylation-dependent glucose influx in remodeling healthy white adipose tissue

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Update on Clinical Trials for Nonalcoholic Steatohepatitis.

Nathani, R. R., & Bansal, M. B. (2023) · PubMed Central · Cited by 13

Metabolic Syndrome in Youth: Current Insights and Novel Serum Biomarkers

Santoro, N., & Weiss, R. (2012) · Biomarkers in Medicine · doi:10.2217/bmm.12.85 · Cited by 13

A variant of FGF19 for treatment of disorders of cholestasis and bile acid metabolism.

Walters, J. R. F., & Appleby, R. (2015) · PubMed Central · doi:10.3978/j.issn.2305-5839.2015.03.38 · Cited by 13

Changes in FGF21 Serum Concentrations and Liver mRNA Expression in an Experimental Model of Complete Lipodystrophy and Insulin-Resistant Diabetes

Špolcová, A., Holubová, M., Mikulášková, B., Nagelová, V., Štofková, A., Lacinová, Z., Jur̀čovičová, J., Haluzı́k, M., Maletı́nská, L., & Železná, B. (2014) · Physiological Research · doi:10.33549/physiolres.932714 · Cited by 13

The central melanocortin system mediates the benefits of time-restricted feeding on energy balance

Sorrell, J. E., Yates, E., Rivir, M., Woods, S. C., Hogenesch, J. B., & Pérez–Tilve, D. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113132 · Cited by 13

Epigenetic Regulation of Processes Related to High Level of Fibroblast Growth Factor 21 in Obese Subjects

Płatek, T., Polus, A., Góralska, J., Raźny, U., Dziewońska, A., Micek, A., Dembinska-Kiec, A., Solnica, B., & Malczewska-Malec, M. (2021) · Genes · doi:10.3390/genes12020307 · Cited by 12

Spinal Cord Injury Reduces Serum Levels of Fibroblast Growth Factor-21 and Impairs Its Signaling Pathways in Liver and Adipose Tissue in Mice

Liu, X., Graham, Z., Harlow, L., Pan, J., Azulai, D., Bauman, W. A., Yarrow, J. F., & Cardozo, C. P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.668984 · Cited by 12

Effect of a 6-Week Carbohydrate-Reduced High-Protein Diet on Levels of FGF21 and GDF15 in People With Type 2 Diabetes

Richter, M. M., Thomsen, M. N., Skytte, M. J., Kjeldsen, S. A. S., Samkani, A., Frystyk, J., Magkos, F., Holst, J. J., Madsbad, S., Krarup, T., et al. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae008 · Cited by 13

Characterization of FGF21 Sites of Production and Signaling in Mice

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Two novel intronic polymorphisms of bovine FGF21 gene are associated with body weight at 18 months in Chinese cattle

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Association of fibroblast growth factor 21 with metabolic syndrome and endothelial function in children: a prospective cross-sectional study on novel biomarkers

Domouzoglou, E. M., Vlahos, A. P., Cholevas, V., Papafaklis, M. I., Chaliasos, N., Siomou, E. C., Michalis, L. K., Tsatsoulis, A. A., & Naka, K. Κ. (2021) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2040258.129 · Cited by 12

Increased plasma apoM levels impair triglyceride turnover in mice

Hajny, S., Borup, A., Elsøe, S., & Christoffersen, C. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158969 · Cited by 13

Non-alcoholic fatty liver disease and liver secretome

Khan, M. S., Lee, C.-H., & Kim, S. G. (2022) · Archives of Pharmacal Research · doi:10.1007/s12272-022-01419-w · Cited by 13

Efficacy of a combination of high and low dosage of PEGylated FGF-21 in treatment of diabetes in db/db mice

Xu, P., Zhang, Y., Song, L., Khoso, M. H., Li, J., Jiang, X., He, J., Li, J., Ma, X., Ren, G., et al. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.09.019 · Cited by 12

KLOTHO, FGF21 AND FGF23: NOVEL PATHWAYS TO MUSCULOSKELETAL HEALTH?

Bartali, B., Semba, R. D., & de Araújo, A. B. (2013) · The Journal of Frailty & Aging · doi:10.14283/jfa.2013.26 · Cited by 12

Interrupting the FGF19-FGFR4 Axis to Therapeutically Disrupt Cancer Progression

Lang, L., Shull, A. Y., & Teng, Y. (2018) · Current Cancer Drug Targets · doi:10.2174/1568009618666180319091731 · Cited by 12

Endocrine fibroblast growth factors as potential biomarkers for chronic kidney disease

Kondo, Y., Komaba, H., & Fukagawa, M. (2020) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2020.1780918 · Cited by 12

The endocrine FGFs axis: A systemic anti-fibrotic response that could prevent pulmonary fibrogenesis?

Ghanem, M., Archer, G., Crestani, B., & Mailleux, A. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108669 · Cited by 12

Hepatocyte‐Derived FGF1 Alleviates Isoniazid and Rifampicin‐Induced Liver Injury by Regulating HNF4α‐Mediated Bile Acids Synthesis

Lin, Q., Zhang, J., Qi, J., Tong, J., Chen, S., Zhang, S., Liu, X., Lou, H., Lv, J., Lin, R., et al. (2024) · Advanced Science · doi:10.1002/advs.202408688 · Cited by 11

The Possible Role of Metformin and Fibroblast Growth Factor‐21 in Multiple Sclerosis Neuropathology: Birds of a Feather Flock Together

Abulaban, A. A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Ahmed, E., Alruwaili, M., Alexiou, A. T., Papadakis, M., & Batiha, G. E. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70067 · Cited by 11

Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma

Vachher, M., Bansal, S., Kumar, B., Yadav, S., Arora, T. K., Wali, N. M., & Burman, A. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30252 · Cited by 11

Endocrine FGFs and their signaling in the brain: Relevance for energy homeostasis

Zangerolamo, L., Carvalho, M. U. W. B. D., Velloso, L. A., & Barbosa, H. C. L. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176248 · Cited by 11

Rac-Dependent Signaling from Keratinocytes Promotes Differentiation of Intradermal White Adipocytes

Ueyama, T., Sakuma, M., Nakatsuji, M., Uebi, T., Hamada, T., Aiba, A., & Saito, N. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.06.140 · Cited by 11

Paracrine Fibroblast Growth Factor 1 Functions as Potent Therapeutic Agent for Intrahepatic Cholestasis by Downregulating Synthesis of Bile Acid

Lin, H., Zhou, C., Hou, Y., Li, Q., Qiao, G., Wang, Y., Huang, Z., & Niu, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01515 · Cited by 11

Tethered-variable CL bispecific IgG: an antibody platform for rapid bispecific antibody screening

Kim, H. S., Dunshee, D. R., Yee, A., Tong, R. K., Kim, I., Farahi, F., Hongo, J.-A., Ernst, J. A., Sonoda, J., & Spiess, C. (2017) · Protein Engineering Design and Selection · doi:10.1093/protein/gzx034 · Cited by 11

Signaling Pathways in Liver Cancer

Wu, X., & Li, Y. (2012) · InTech eBooks · doi:10.5772/31381 · Cited by 11

FGFR4-driven plasticity in breast cancer progression and resistance to therapy

Braun, M., Piasecka, D., Sądej, R., & Romanska, H. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02658-y · Cited by 9

New advances in drug development for metabolic dysfunction-associated diseases and alcohol-associated liver disease

Zhang, J., Li, Y., Liu, Y., Ma, N., Qian, S., Chen, Y., Duan, Y., Xiang, X., & He, Y. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01267-9 · Cited by 10

Development of Zalfermin, a Long-Acting Proteolytically Stabilized FGF21 Analog

Sass‐Ørum, K., Tagmose, T. M., Olsen, J., Sjölander, A., Wahlund, P., Han, D., Vegge, A., Reedtz‐Runge, S., Wang, Z., Gao, X., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00391 · Cited by 11

Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency

Jung, Y., Lee, K. W., Cho, J. H., Bae, D., Jeong, B.-G., Jung, Y.-J., Park, S., An, Y. J., Kim, K., Lee, G. S., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-27717-x · Cited by 11

A revisit of drugs and potential therapeutic targets against non-alcoholic fatty liver disease: learning from clinical trials

Zhu, S., Wu, Z., Wang, W., Wei, L., & Zhou, H. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02216-y · Cited by 10

Effect of Osteocyte-Ablation on Inorganic Phosphate Metabolism: Analysis of Bone–Kidney–Gut Axis

Fujii, O., Tatsumi, S., Ogata, M., Arakaki, T., Sakaguchi, H., Nomura, K., Miyagawa, A., Ikuta, K., Hanazaki, A., Kaneko, I., et al. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00359 · Cited by 10

The Pituitary Is a Candidate Organ That Modulates Circulating Klotho Levels

Sato, T., Komaba, H., Nagatani, T., Watanabe, T., Kishida, Y., & Fukagawa, M. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00223 · Cited by 10

Novel Abs targeting the N‐terminus of fibroblast growth factor 19 inhibit hepatocellular carcinoma growth without bile‐acid‐related side‐effects

Liu, H., Zheng, S., Hou, X., Liu, X., Du, K., Lv, X., Li, Y., Yang, F., Li, W., & Sui, J. (2020) · Cancer Science · doi:10.1111/cas.14353 · Cited by 9

Postnatal exercise protects offspring from high-fat diet-induced reductions in subcutaneous adipocyte beiging in C57Bl6/J mice

Larson, K., Bundy, A. N., Lance, E. B., Darland, D. C., Casperson, S. L., & Roemmich, J. N. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108853 · Cited by 10

Highly Selective and Sensitive Measurement of Active forms of FGF21 Using Novel Immunocapture Enrichment with LC–MS/MS

Zhao, Y., Liu, G., Kwok, S., Jones, B. R., Liu, J., Marchisin, D., Joyce, P., Peterson, J. E., & Shen, J. X. (2017) · Bioanalysis · doi:10.4155/bio-2017-0208 · Cited by 10

Circulating fibroblast growth factor 21 is reduced, whereas its production is increased in a fat depot-specific manner in cold-acclimated rats

Sepa-Kishi, D. M., & Ceddia, R. B. (2018) · Adipocyte · doi:10.1080/21623945.2018.1504591 · Cited by 10

The Role of the FGF19 Family in the Pathogenesis of Gestational Diabetes: A Narrative Review

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