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Protein-tyrosine Phosphatases Are Involved in Interferon Resistance Associated with Insulin Resistance in HepG2 Cells and Obese Mice

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Knocking down amygdalar PTP1B in diet-induced obese rats improves insulin signaling/action, decreases adiposity and may alter anxiety behavior

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Design and evaluation of non-carboxylate 5-arylidene-2-thioxo-4-imidazolidinones as novel non-competitive inhibitors of protein tyrosine phosphatase 1B

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Combined Treatment of Betulinic Acid, a PTP1B Inhibitor, with Orthosiphon stamineus Extract Decreases Body Weight in High-Fat–Fed Mice

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Role of PTP1B in POMC neurons during chronic high-fat diet: sex differences in regulation of liver lipids and glucose tolerance

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The Role of Hypothalamic Microglia in the Onset of Insulin Resistance and Type 2 Diabetes: A Neuro-Immune Perspective

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Mechanisms, functions and therapeutic targeting of protein tyrosine phosphatases

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Crosstalk Between Insulin and Toll-like Receptor Signaling Pathways in the Central Nervous system

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Protein tyrosine phosphatase-1B contributes to LPS-induced leptin resistance in male rats

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Activation of tyrosine phosphatase PTP1B in pyramidal neurons impairs endocannabinoid signaling by tyrosine receptor kinase trkB and causes schizophrenia-like behaviors in mice

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Can Allostery Be a Key Strategy for Targeting PTP1B in Drug Discovery? A Lesson from Trodusquemine

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Proteomic analysis reveals cellular pathways regulating carbohydrate metabolism that are modulated in primary human skeletal muscle culture due to treatment with bioactives from Artemisia dracunculus L.

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Essential Role of Protein-tyrosine Phosphatase 1B in the Modulation of Insulin Signaling by Acetaminophen in Hepatocytes

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Protein tyrosine phosphatase 1B inhibitors from a marine-derived fungal strain aspergillus sp. SF-5929

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Protein tyrosine phosphatase 1B (PTP1B) modulates palmitate-induced cytokine production in macrophage cells

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The Anorectic Effect of CNTF Does Not Require Action in Leptin-Responsive Neurons

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Loss of β-catenin via activated GSK3β causes diabetic retinal neurodegeneration by instigating a vicious cycle of oxidative stress-driven mitochondrial impairment

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Severe energy deficit upregulates leptin receptors, leptin signaling, and PTP1B in human skeletal muscle

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Protein tyrosine phosphatase 1B as a therapeutic target for Graves’ orbitopathy in an in vitro model

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βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity

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Inhibition of Protein Tyrosine Phosphatase 1B Improves IGF-I Receptor Signaling and Protects Against Inflammation-Induced Gliosis in the Retina

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Electroacupuncture Treatment of Insulin Resistance in Diabetes Mellitus

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Overexpression of forebrain PTP1B leads to synaptic and cognitive impairments in obesity

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Hypothalamic Inflammation at a Crossroad of Somatic Diseases

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Gsα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling

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Reversal of insulin resistance by Ficus benghalensis bark in fructose-induced insulin-resistant rats

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Natural Products, a Potential Source of New Drugs Discovery to Combat Obesity and Diabetes: Their Efficacy and Multi-targets Actions in Treatment of These Diseases

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Implications of Hypothalamic Neural Stem Cells on Aging and Obesity-Associated Cardiovascular Diseases

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Screening of compounds from Nigerian antidiabetic plants as protein tyrosine phosphatase 1B inhibitor

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Sustained High Protein-tyrosine Phosphatase 1B Activity in the Sperm of Obese Males Impairs the Sperm Acrosome Reaction

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Targeted Inhibition of Protein Tyrosine Phosphatase 1B by Viscosol Ameliorates Type 2 Diabetes Pathophysiology and Histology in Diabetic Mouse Model

Sohail, A., Fayyaz, H., Muneer, H., Raza, I., Ikram, M., Uddin, Z., Gul, S., Almohaimeed, H. M., Alsharif, I., Alaryani, F. S., et al. (2022) · BioMed Research International · doi:10.1155/2022/2323078 · Cited by 16

Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling

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Abelmoschus esculentus (L.) Moench improved blood glucose, lipid, and down‐regulated PPAR‐α , PTP1B genes expression in diabetic rats

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Palmitate induces SHIP2 expression via the ceramide-mediated activation of NF-κB, and JNK in skeletal muscle cells

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Reciprocal signaling between adipose tissue depots and the central nervous system

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Alpha-Linolenic Acid Ameliorates Cognitive Impairment and Liver Damage Caused by Obesity

Zhang, X., Bao, J., Zhang, Y., & Wang, X. (2024) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s434671 · Cited by 14

Signalling Networks Governing Metabolic Inflammation

Dali‐Youcef, N., & Ricci, R. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_4 · Cited by 14

Metformin ameliorates olanzapine-induced obesity and glucose intolerance by regulating hypothalamic inflammation and microglial activation in female mice

Suh, S. B., Lee, N., Kim, J., Kim, S., Jang, S., Park, J. K., Lee, K., Choi, S. Y., Kwon, H., & Lee, C. H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.906717 · Cited by 13

A Potential Role for 5‐Androstene‐3β,7β,17β‐triol in Obesity and Metabolic Syndrome

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Looking into the possibilities of cure of the type 2 diabetes mellitus by nanoparticle-based RNAi and CRISPR-Cas9 system: A review

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The role of autophagy in high-fat diet-induced insulin resistance of adipose tissues in mice

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Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2

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Role of protein tyrosine phosphatase 1B inhibitor in central insulin resistance and associated cognitive deficits

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Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus

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Loss of Protein Tyrosine Phosphatase 1B Increases IGF-I Receptor Tyrosine Phosphorylation but Does Not Rescue Retinal Defects in IRS2-Deficient Mice

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Gene Expression of Protein Tyrosine Phosphatase 1B and Endoplasmic Reticulum Stress During Septic Shock

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Protein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics

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Inflammation in VTA Caused by HFD Induces Activation of Dopaminergic Neurons Accompanied by Binge-like Eating

Sun, R., Sugiyama, M., Wang, S., Kuno, M., Sasaki, T., Hirose, T., Miyata, T., Kobayashi, T., Tsunekawa, T., Onoue, T., et al. (2022) · Nutrients · doi:10.3390/nu14183835 · Cited by 11

Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice

Krüger, J., Trappiel, M., Dagnell, M., Stawowy, P., Meýborg, H., Böhm, C., Bhanot, S., Östman, A., Kintscher, U., & Kappert, K. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-49 · Cited by 11

Upregulation of PTPN1 aggravates endotoxemia-induced cardiac dysfunction through inhibiting mitophagy

Song, Q., Ma, H., Zhu, L., Qi, Z., Lan, Z., Liu, K., Zhang, H., Wang, K., & Wang, N. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111315 · Cited by 10

Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2

Lucas, E., Cruces‐Sande, M., Briones, A. M., Salaíces, M., Mayor, F., Murga, C., & Vila‐Bedmar, R. (2015) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2015.1107589 · Cited by 11

Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue

Reinders, J., Altenbuchinger, M., Limm, K., Schwarzfischer, P., Scheidt, T., Strasser, L., Richter, J., Szczepanowski, M., Huber, C. G., Klapper, W., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-64212-z · Cited by 10

Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models

Stewart, A. F. R., Chen, H., Cruz, S. A., Qin, Z., & Ricke, K. M. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.286970 · Cited by 10

Atropisomeric 9,10-dihydrophenanthrene/bibenzyl trimers with anti-inflammatory and PTP1B inhibitory activities from Bletilla striata

Sun, M.-H., Ma, X.-J., Shao, S.-Y., Jiang, J., Li, J., Tian, J., Zhang, J., Li, L., Ye, F., & Li, S. (2022) · Organic & Biomolecular Chemistry · doi:10.1039/d2ob00489e · Cited by 10

Regulation of Nrf2 and NF-κB activities may contribute to the anti-inflammatory mechanism of xylopic acid

Boakye, Y. D., Osafo, N., Oppong‐Kyekyeku, J., Abotsi, W. K. M., Boakye‐Gyasi, E., Heiß, E. H., & Agyare, C. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-00950-y · Cited by 10

Differential regulation of protein tyrosine kinase signalling by Dock and the PTP 61F variants

Willoughby, L. F., Manent, J., Allan, K., Lee, H. B., Portela, M., Wiede, F., Warr, C. G., Meng, T., Tiganis, T., & Richardson, H. E. (2017) · FEBS Journal · doi:10.1111/febs.14118 · Cited by 9

Isoleucine‐restricted diets improve high‐fat diet‐induced nonalcoholic fatty liver disease via regulating insulin resistance and gut microbiota

Zhou, X., Hao, R., Zhu, X., Tan, X., & Li, D. (2024) · Food Frontiers · doi:10.1002/fft2.379 · Cited by 9

Pharmacological PTP1B inhibition rescues motor learning, neuroinflammation, and hyperglycaemia in a mouse model of Alzheimer's disease

Franklin, Z. J., Hull, C., Delibegović, M., & Platt, B. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115115 · Cited by 9

Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood

Silva, H. B. F., de Almeida, A. P. C., Cardoso, K. B., Ignácio-Souza, L. M., Reis, S. R. D. L., Reis, M. A. D. B., Latorraca, M. Q., Milanski, M., & Arantes, V. C. (2014) · Mediators of Inflammation · doi:10.1155/2014/736506 · Cited by 9

Characterization of Serrulatane Diterpenoids in Eremophila phyllopoda subsp. phyllopoda by Triple High-Resolution α-Glucosidase/PTP1B/Radical Scavenging Profiling, NMR Spectroscopy, DFT-GIAO NMR, and Electronic Circular Dichroism Calculations

Liang, C., Ndi, C. P., Kjærulff, L., Semple, S. J., Buirchell, B. J., Coriani, S., Møller, B. L., & Stærk, D. (2023) · Journal of Natural Products · doi:10.1021/acs.jnatprod.2c00692 · Cited by 9

Upregulation of PTP1B After Rat Spinal Cord Injury

Zhu, X., Zhou, Y., Tao, R., Zhao, J., Chen, J., Liu, C., Xu, Z., Bao, G., Zhang, J., Chen, M., et al. (2015) · Inflammation · doi:10.1007/s10753-015-0169-2 · Cited by 9

Pancreatic Protein Tyrosine Phosphatase 1B Deficiency Exacerbates Acute Pancreatitis in Mice

Bettaieb, A., Koike, S., Chahed, S. L., Bachaalany, S. M., Griffey, S. M., Sastre, J., & Haj, F. G. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.04.012 · Cited by 9

Hypothalamic Dysfunction in Obesity

Velloso, L. A., Torsoni, M. A., & ARAUJO, E. P. D. (2009) · Reviews in the Neurosciences · doi:10.1515/revneuro.2009.20.5-6.441 · Cited by 9

Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes

Delibegović, M., Hoggard, N., Mody, N., & Agouni, A. (2012) · International Journal of General Medicine · doi:10.2147/ijgm.s25879 · Cited by 9

The role of TCPTP on leptin effects on astrocyte morphology

Debarba, L. K., Vechiato, F. M. V., Veida-Silva, H., Borges, B. C., Jamur, M. C., Antunes‐Rodrigues, J., & Elias, L. L. K. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.12.010 · Cited by 10

Myeloid-Specific PTP1B Deficiency Attenuates Inflammation-Induced and Ovariectomy-Induced Bone Loss in Mice by Inhibiting Osteoclastogenesis

Kim, H. J., Ryu, K., Kim, M. O., Kim, M. O., Lee, J. H., Song, M., Youn, Y.-J., Pokhrel, N. K., Kim, J., Kim, J., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4478 · Cited by 8

Pharmacological and physiological activation of TGR5 in the NTS lowers food intake by enhancing leptin-STAT3 signaling

Bruce, K., Zhang, S., Garrido, A. N., Wang, M. T., Bachor, T. P., Wang, P., Xu, A. W., Yang, Z., & Lam, T. K. T. (2025) · Nature Communications · doi:10.1038/s41467-025-60331-1 · Cited by 9

Adherence to the Diabetes Risk Reduction Diet and Bladder Cancer Risk in the Prostate, Lung, Colorectal, Ovarian (PLCO) Cohort

Chen, Y., Zeng, S., Jiao, B., Zhang, H., Gao, L., Zhang, X., & Hu, X. (2023) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-23-0690 · Cited by 8

Evaluation of 147 Kampo prescriptions as novel protein tyrosine phosphatase 1B (PTP1B) inhibitory agents

Onoda, T., Li, W., Higai, K., & Koike, K. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-64 · Cited by 8

Insulin resistance associated to obesity: the link TNF-alpha

Nieto-Vázquez, I., Fernández‐Veledo, S., Kramer, D., Vila‐Bedmar, R., García‐Guerra, L., & Lorenzo, M. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802181047 · Cited by 493

Contribucion del TNF-alfa a la insulinorresistencia asociada a la obesidad

Lorenzo, M., Fernández‐Veledo, S., Vila‐Bedmar, R., Guerra, L. G., de Álvaro, C., & Vázquez, I. N. (2007) · Hispana

Insulin resistance induced by tumor necrosis factor-α in myocytes and brown adipocytes12

Lorenzo, M., Fernández‐Veledo, S., Vila‐Bedmar, R., García‐Guerra, L., de Álvaro, C., & Nieto-Vázquez, I. (2007) · Journal of Animal Science · doi:10.2527/jas.2007-0462 · Cited by 161

TNFα increases hypothalamic PTP1B activity via the NFκB pathway in rat hypothalamic organotypic cultures

Ito, Y., Banno, R., Hagimoto, S., Ozawa, Y., Arima, H., & Oiso, Y. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.11.010 · Cited by 35

Protein tyrosine phosphatase 1B inhibits adipocyte differentiation and mediates TNFα action in obesity

Song, D., Chen, Y., Li, Z., Guan, Y., Zou, D., & Miao, C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.05.006 · Cited by 25