The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.
Open accessAbstract
Protein-tyrosine phosphatase 1B (PTP1B) is a major negative regulator of insulin and leptin sensitivity. PTP1B overexpression in adipose tissue and skeletal muscle of humans and rodents may contribute to insulin resistance and obesity. The mechanisms mediating PTP1B overexpression in obese and diabetic states have been unclear. We find that adipose tissue inflammation and the pro-inflammatory cytokine tumor necrosis factor alpha (TNFalpha) regulate PTP1B expression in vivo. High fat feeding of mice increased PTP1B expression 1.5- to 7-fold in adipose tissue, liver, skeletal muscle, and arcuate nucleus of hypothalamus. PTP1B overexpression in high fat-fed mice coincided with increased adipose tissue expression of the macrophage marker CD68 and TNFalpha, which is implicated in causing obesity-induced insulin resistance. TNFalpha increased PTP1B mRNA and protein levels by 2- to 5-fold in a dose- and time-dependent manner in adipocyte and hepatocyte cell lines. TNFalpha administration in mice increased PTP1B mRNA 1.4- to 4-fold in adipose tissue, liver, skeletal muscle, and hypothalamic arcuate nucleus and PTP1B protein 2-fold in liver. Actinomycin D treatment blocked, and high dose salicylate treatment inhibited by 80%, TNFalpha-induced PTP1B expression in adipocyte cell lines, suggesting TNFalpha may induce PTP1B transcription via nuclear factor kappaB (NFkappaB) activation. Chromatin immunoprecipitation from adipocyte cell lines and liver of mice demonstrated TNFalpha-induced recruitment of NFkappaB subunit p65 to the PTP1B promoter in vitro and in vivo. In mice with diet-induced obesity, TNFalpha deficiency also partly blocked PTP1B overexpression in adipose tissue. Our data suggest that PTP1B overexpression in multiple tissues in obesity is regulated by inflammation and that PTP1B may be a target of anti-inflammatory therapies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Consistent with this, the cellular effects of leptin have been amplified in cells lacking either SOCS3 or PT1b, a phosphotyrosine phosphatase.”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [47]
In the citing paper
“Importantly, mice with haploinsufficiency for either of these genes are resistant to obesity, remain lean on a high-fat diet, and retain leptin sensitivity (46,47).”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [47]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Nieto-Vázquez, I., Fernández‐Veledo, S., de Álvaro, C., Rondinone, C. M., Valverde, Á. M., & Lorenzo, M. (2007) · Diabetes · doi:10.2337/db06-0989 · Cited by 92
RetractedObesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
Self-citationKopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
Elchebly, M., Payette, P., Michaliszyn, E., Cromlish, W., Collins, S., Loy, A. L., Normandin, D., Cheng, A., Himms-Hagen, J., Chan, C.-C., et al. (1999) · Science · doi:10.1126/science.283.5407.1544 · Cited by 2,210
Obesity-induced inflammatory changes in adipose tissue
Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823
Klaman, L. D., Boss, O., Peroni, O. D., Kim, J. K., Martino, J. L., Zabolotny, J. M., Moghal, N., Lubkin, M., Kim, Y.-B., Sharpe, A. H., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5479-5489.2000 · Cited by 1,235
Self-citationIs Type II diabetes mellitus a disease of the innate immune system?
Pickup, J. C., & Crook, M. A. (1998) · Diabetologia · doi:10.1007/s001250051058 · Cited by 1,042
Pro-inflammatory cytokines and adipose tissue
Coppack, S. W. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns2001110 · Cited by 1,021
Leptin in the regulation of immunity, inflammation, and hematopoiesis
Fantuzzi, G., & Faggioni, R. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.4.437 · Cited by 980
PTP1B Regulates Leptin Signal Transduction In Vivo
Zabolotny, J. M., Bence, K. K., Stricker‐Krongrad, A., Haj, F. G., Wang, Y., Minokoshi, Y., Kim, Y., Elmquist, J. K., Tartaglia, L. A., Kahn, B. B., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00148-x · Cited by 818
Self-citationNew Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes
Saltiel, A. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00239-2 · Cited by 688
(1997) · Diabetes reviews · Cited by 671
Inflammation as a Tumor Promoter in Cancer Induction
Philip, M., Rowley, D. A., & Schreiber, H. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.06.006 · Cited by 640
Neuronal PTP1B regulates body weight, adiposity and leptin action
Bence, K. K., Delibegovic, M., Xue, B., Gorgun, C. Z., Hotamisligil, G. S., Neel, B. G., & Kahn, B. B. (2006) · Nature Medicine · doi:10.1038/nm1435 · Cited by 633
Self-citationAttenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B
Cheng, A., Uetani, N., Simoncic, P. D., Chaubey, V. P., Lee-Loy, A., McGlade, C. J., Kennedy, B. P., & Tremblay, M. L. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00149-1 · Cited by 545
Ruan, H., Hacohen, N., Golub, T. R., Parijs, L. V., & Lodish, H. F. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1319 · Cited by 543
Howard, J. K., Cave, B. J., Oksanen, L. J., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Nature Medicine · doi:10.1038/nm1072 · Cited by 490
Good cop, bad cop: the different faces of NF-κB
Perkins, N. D., & Gilmore, T. D. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401838 · Cited by 489
Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance
Shoelson, S. E., Lee, J., & Yuan, M. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802501 · Cited by 474
An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
Rabinovitch, A. (1998) · Diabetes/Metabolism Reviews · doi:10.1002/(sici)1099-0895(199806)14:2 · Cited by 457
Chavey, C., Mari, B. P., Monthouel, M.-N., Bonnafous, S., Anglard, P., OBBERGHEN, E. V., & Tartare‐Deckert, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209196200 · Cited by 451
The role of TNFα in adipocyte metabolism
Sethi, J. K., & Hotamışlıgil, G. S. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1998.0273 · Cited by 433
Goldstein, B. J., Bittner-Kowalczyk, A., White, M. F., & Harbeck, M. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4283 · Cited by 423
Specific Inhibitors of p38 Mitogen-activated Protein Kinase Block 3T3-L1 Adipogenesis
Engelman, J. A., Lisanti, M. P., & Scherer, P. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.48.32111 · Cited by 360
Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases
Alnemri, E. S. (1997) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(199701)64:1 · Cited by 307
Ahmad, F., Azevedo, J. L., Cortright, R. L., Dohm, G. L., & Goldstein, B. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119552 · Cited by 289
Ventre, J. R., Doebber, T. W., Wu, M. S., MacNaul, K. L., Stevens, K. A., Pasparakis, M., Kollias, G. A., & Moller, D. E. (1997) · Diabetes · doi:10.2337/diab.46.9.1526 · Cited by 275
Nowak, D. E., Tian, B., & Brasier, A. R. (2005) · BioTechniques · doi:10.2144/000112014 · Cited by 256
Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP
Bourdeau, A., Dubé, N., & Tremblay, M. L. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.001 · Cited by 246
Taghibiglou, C., Rashid-Kolvear, F., Iderstine, S. C. V., Le‐Tien, H., Fantus, I. G., Lewis, G. F., & Adeli, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106737200 · Cited by 236
Ziotopoulou, M., Mantzoros, C. S., Hileman, S. M., & Flier, J. S. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.4.e838 · Cited by 230
TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL CONTROL OF GENE EXPRESSION IN INFLAMMATION
Kracht, M., & Saklatvala, J. (2002) · Cytokine · doi:10.1006/cyto.2002.0895 · Cited by 229
Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice
Gum, R. J., Gaede, L. L., Koterski, S., Heindel, M. A., Clampit, J. E., Zinker, B. A., Trevillyan, J. M., Ulrich, R. G., Jirousek, M. R., & Rondinone, C. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.21 · Cited by 201
Delibegović, M., Bence, K. K., Mody, N., Hong, E., Ko, H. J., Kim, J. K., Kahn, B. B., & Neel, B. G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00959-07 · Cited by 173
Self-citationEffector Mechanisms in Low‐Dose Streptozotocin‐induced Diabetes
Lukić, M. L., Stošić‐Grujičić, S., & Shahin, A. (1997) · Journal of Immunology Research · doi:10.1155/1998/92198 · Cited by 168
Zabolotny, J. M., Haj, F. G., Kim, Y., Kim, H., Shulman, G. I., Kim, J. K., Neel, B. G., & Kahn, B. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310688200 · Cited by 164
Self-citationAdipocyte differentiation induces dynamic changes in NF-κB expression and activity
Berg, A. H., Lin, Y., Lisanti, M. P., & Scherer, P. E. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00002.2004 · Cited by 160
Flint, A. J., Gebbink, M. F. B. G., Franza, B. R., HILL, D. E., & Tonks, N. K. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05843.x · Cited by 157
Manzotti, C. N., Tipping, H., Perry, L., Mead, K. I., Blair, P. J., Zheng, Y., & Sansom, D. M. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(2002010)32:10 · Cited by 142
Dubé, N., & Tremblay, M. L. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2005.07.030 · Cited by 138
Sykiotis, G. P., & Papavassiliou, A. G. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.11.0725 · Cited by 134
Ahmad, F., Considine, R. V., BAUER, T. L., Ohannesian, J. P., Marco, C. C., & Goldstein, B. J. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90206-7 · Cited by 132
Haj, F. G., Zabolotny, J. M., Kim, Y., Kahn, B. B., & Neel, B. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413240200 · Cited by 132
Self-citationTumor Necrosis Factor-alpha-Induced Insulin Resistance in Adipocytes
Chen, Q., & Pekala, P. H. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22318.x · Cited by 131
Ahmad, F., Considine, R. V., & Goldstein, B. J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117985 · Cited by 127
Ahmad, F., & Goldstein, B. J. (1995) · Metabolism · doi:10.1016/0026-0495(95)90012-8 · Cited by 127
Kusari, J., Kenner, K. A., Suh, K. I., HILL, D. E., & Henry, R. R. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117068 · Cited by 123
Venable, C. L., Frevert, E. U., Kim, Y., Fischer, B., Kamatkar, S., Neel, B. G., & Kahn, B. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m908392199 · Cited by 115
Self-citationSérino, M., Menghini, R., Fiorentino, L., Amoruso, R., Mauriello, A., Lauro, D., Sbraccia, P., Hribal, M. L., Lauro, R., & Federici, M. (2007) · Diabetes · doi:10.2337/db07-0360 · Cited by 114
Regulation of protein tyrosine phosphatase 1B by sumoylation
Dadke, S. S., Cotteret, S., Yip, S., Jaffer, Z. M., Haj, F. G., Ivanov, A. V., Rauscher, F. J., Shuai, K., Ng, T., Neel, B. G., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1522 · Cited by 113
Self-citationCheung, A. T., Wang, J., Ree, D., Kolls, J. K., & Bryer‐Ash, M. (2000) · Diabetes · doi:10.2337/diabetes.49.5.810 · Cited by 92
Insulin resistance: the clinical spectrum.
Mantzoros, C. S., & Flier, J. S. (1995) · PubMed · Cited by 91
Dynamics of Protein-tyrosine Phosphatases in Rat Adipocytes
Calera, M. R., Vallega, G., & Pilch, P. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.9.6308 · Cited by 89
Lu, T., Sathe, S. S., Swiatkowski, S. M., Hampole, C. V., & Stark, G. R. (2003) · Oncogene · doi:10.1038/sj.onc.1207332 · Cited by 80
Koza, R. A., Hohmann, S. M., Guerra, C. E., Rossmeisl, M., & Kozak, L. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002136200 · Cited by 76
Dadke, S. S., Li, H. C., Kusari, A. B., Begum, N., & Kusari, J. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3188 · Cited by 76
Cheung, A., Kusari, J., Jansen, D., Bandyopadhyay, D., Kusari, A. B., & Bryer‐Ash, M. (1999) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(99)90115-4 · Cited by 75
Ahmad, F., & Goldstein, B. J. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.5.e932 · Cited by 69
Prevention of dexamethasone-induced insulin resistance by metformin
Thomas, C. R., Turner, S. L., Jefferson, W., & Bailey, C. J. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00151-8 · Cited by 55
Pharmacokinetics of Murine Tumor Necrosis Factor
Flick, D. A., & Glfford, G. E. (1986) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923978609031087 · Cited by 55
Wu, Y., Ouyang, J. P., Wu, K., Wang, S. S., Wen, C.-Y., & Xia, Z. Y. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706306 · Cited by 54
Leptin Increases Hepatic Insulin Sensitivity and Protein Tyrosine Phosphatase 1B Expression
Lam, N. T., Lewis, J. T., Cheung, A. T., Luk, C. T., Tse, J. W., Wang, J., Bryer‐Ash, M., Kolls, J. K., & Kieffer, T. J. (2004) · Molecular Endocrinology · doi:10.1210/me.2002-0193 · Cited by 53
Leptin resistance following over-expression of protein tyrosine phosphatase 1B in liver
Lam, N., Covey, S. D., Lewis, J. T., Oosman, S. N., Webber, T. D., Hsu, E. C., Cheung, A. T., & Kieffer, T. J. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01937 · Cited by 46
Kipfer-Coudreau, S., Eberlé, D., Sahbatou, M., Bonhomme, A., Guy-grand, B., Froguel, P., Galan, P., Basdevant, A., & Clément, K. (2004) · Diabetologia · doi:10.1007/s00125-004-1432-5 · Cited by 37
Tyrosine phosphatase 1B and leptin receptor genes and their interaction in type 2 diabetes
Santaniemi, M., Ukkola, O. H., & Kesäniemi, Y. A. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01339.x · Cited by 35
Protein tyrosine phosphatase 1B undergoes mitosis-specific phosphorylation on serine.
Schievella, A. R., Paige, L., Johnson, K. A., HILL, D. E., & Erikson, R. L. (1993) · PubMed · Cited by 35
Mensah‐Brown, E. P. K., Stošić‐Grujičić, S., Maksimović‐Ivanić, D., Jasima, A., Shahin, A., & Lukić, M. L. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00021-4 · Cited by 30
High Glucose-Induced Abnormal Epidermal Growth Factor Signaling
Obata, T., Maegawa, H., Kashiwagi, A., Pillay, T. S., & Kikkawa, R. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022009 · Cited by 21
Gouni‐Berthold, I., Giannakidou, E., Müller‐Wieland, D., Faust, M., Kotzka, J., Berthold, H. K., & Krone, W. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01446.x · Cited by 14
Xp, P., Jm, H., & Ae, P. (1991) · PubMed · Cited by 14
[Free fatty acids promoting PTP1B expression in rat skeletal muscle and hepatic cells].
Shao, J., Gao, Y., & Yuan, Z. (1998) · PubMed · Cited by 11
The significance of phosphotyrosine phosphatase (PTPase) 1B in insulin signalling
Available, N. A. N. (1999) · Diabetologia · doi:10.1007/s001250051283 · Cited by 8
Research works printed but not linked: 9
- Ahmad, 1995, Am. J. Physiol., 268, E932
- Wellen, 2003, J. Clin. Invest., 112, 1785, 10.1172/JCI20514 · DOI · Paper page
- Sykiotis, 2001, Mol. Endocrinol., 15, 1864
- Schievella, 1993, Cell Growth & Differ., 4, 239
- DeFronzo, 1997, Diabetes Rev., 5, 177
- Mantzoros, 1995, Adv. Endocrinol. Metab., 6, 193
- Shao, 1998, Zhonghua Yi Xue Za Zhi, 78, 753
- Pang, 1991, Lymphokine Cytokine Res., 10, 301
- Berg, 2004, Am. J. Physiol., 287, E1178
Cited by
Sorted by citations
Lipolysis and lipid mobilization in human adipose tissue
Lafontan, M., & Langin, D. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.05.001 · Cited by 884
Korbecki, J., & Bajdak-Rusinek, K. (2019) · Inflammation Research · doi:10.1007/s00011-019-01273-5 · Cited by 558
Hypothalamic inflammation in obesity and metabolic disease
Jais, A., & Brüning, J. C. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88878 · Cited by 474
Tanti, J.-F., & Jager, J. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.07.004 · Cited by 430
SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes
Yoshizaki, T., Milne, J. C., Imamura, T., Schenk, S., Sonoda, N., Babendure, J. L., Lu, J.-C., Smith, J. J., Jirousek, M. R., & Olefsky, J. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00705-08 · Cited by 420
Metadata
- Authors
- Zabolotny, J. M., Kim, Y.-B., Welsh, L. A., Kershaw, E. E., Neel, B. G., & Kahn, B. B.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Zabolotny, Janice M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 283
- Issue
- 21
- Pages
- 14230-14241
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC2386946
- OpenAlex
- W2120790798
- Cited by
- 404
- References
- 76
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 17 · 2023: 17 · 2022: 22 · 2021: 24 · 2020: 21 · 2019: 25 · 2018: 15 · 2017: 20 · 2016: 25 · 2015: 30 · 2014: 26 · 2013: 33 · 2012: 47
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health (DK057521, DK046200)
- National Cancer Institute (R01CA049152)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK057521, R21DK073530, K01DK062212, P30DK046200, R01DK060839, R01DK060838, K08DK065833)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- PTP1B, adipose tissue inflammation, TNF-α, obesity, insulin resistance, leptin sensitivity, NF-κB, high-fat feeding, diet-induced obesity, CD68+ macrophages, hypothalamic arcuate nucleus, liver, skeletal muscle, anti-inflammatory therapy
- MeSH terms
- Animals, Animal Feed, Base Sequence, Cells, Cultured, Diabetes Mellitus, Inflammation, Insulin, Insulin Resistance, Molecular Sequence Data, Obesity, Transcription, Genetic, Tumor Necrosis Factor-alpha, Gene Expression Regulation, Enzymologic, Leptin, Mice, Rats, Protein Tyrosine Phosphatase, Non-Receptor Type 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
