Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

Adipose Tissue as an Endocrine Organ

Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522

Obesity as a medical problem

Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234

Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1B Gene

Elchebly, M., Payette, P., Michaliszyn, E., Cromlish, W., Collins, S., Loy, A. L., Normandin, D., Cheng, A., Himms-Hagen, J., Chan, C.-C., et al. (1999) · Science · doi:10.1126/science.283.5407.1544 · Cited by 2,210

Obesity-induced inflammatory changes in adipose tissue

Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

Klaman, L. D., Boss, O., Peroni, O. D., Kim, J. K., Martino, J. L., Zabolotny, J. M., Moghal, N., Lubkin, M., Kim, Y.-B., Sharpe, A. H., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5479-5489.2000 · Cited by 1,235

Lipolysis and lipid mobilization in human adipose tissue

Lafontan, M., & Langin, D. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.05.001 · Cited by 884

The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms

Korbecki, J., & Bajdak-Rusinek, K. (2019) · Inflammation Research · doi:10.1007/s00011-019-01273-5 · Cited by 558

Hypothalamic inflammation in obesity and metabolic disease

Jais, A., & Brüning, J. C. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88878 · Cited by 474

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

Tanti, J.-F., & Jager, J. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.07.004 · Cited by 430

SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes

Yoshizaki, T., Milne, J. C., Imamura, T., Schenk, S., Sonoda, N., Babendure, J. L., Lu, J.-C., Smith, J. J., Jirousek, M. R., & Olefsky, J. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00705-08 · Cited by 420

Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity

Cintra, D. E., Ropelle, E. R., Moraes, J. C., Pauli, J. R., Morari, J., de Souza, C. T., Grimaldi, R., Stahl, M., Carvalheira, J. B., Saad, M. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030571 · Cited by 381

Mechanisms Involved in the Development and Healing of Diabetic Foot Ulceration

Dinh, T., Tecilazich, F., Kafanas, A., Doupis, J., Gnardellis, C., Leal, E. C., Tellechea, A., Pradhan, L., Lyons, T. E., Giurini, J. M., et al. (2012) · Diabetes · doi:10.2337/db12-0227 · Cited by 366

Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB

Catrysse, L., & van Loo, G. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.01.006 · Cited by 329

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

Thaler, J. P., & Schwartz, M. W. (2010) · Endocrinology · doi:10.1210/en.2010-0336 · Cited by 313

Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction

Khodabandehloo, H., Gorgani‐Firuzjaee, S., Panahi, G., & Meshkani, R. (2015) · Translational research · doi:10.1016/j.trsl.2015.08.011 · Cited by 307

Leptin revisited: its mechanism of action and potential for treating diabetes

Coppari, R., & Bjørbæk, C. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3757 · Cited by 308

β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice

Shi, H., Yu, Y., Lin, D., Zheng, P., Zhang, P., Hu, M., Wang, Q., Pan, W., Yang, X., Hu, T., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00920-y · Cited by 264

Regulation of Food Intake, Energy Balance, and Body Fat Mass: Implications for the Pathogenesis and Treatment of Obesity

Guyenet, S. J., & Schwartz, M. W. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2525 · Cited by 293

Leptin signalling pathways in hypothalamic neurons

Kwon, O., Kim, K. W., & Kim, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2133-1 · Cited by 306

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

Delibegović, M., Zimmer, D. J., Kauffman, C., Rak, K. J., Hong, E., Cho, Y.-R., Kim, J. K., Kahn, B. B., Neel, B. G., & Bence, K. K. (2008) · Diabetes · doi:10.2337/db08-0913 · Cited by 277

CNS leptin and insulin action in the control of energy homeostasis

Belgardt, B., & Brüning, J. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05799.x · Cited by 287

Leptin at 14 y of age: an ongoing story

Friedman, J. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26788b · Cited by 272

Molecular Mechanism of Insulin Resistance in Obesity and Type 2 Diabetes

Choi, K., & Kim, Y. (2010) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2010.25.2.119 · Cited by 281

PTP1B: a double agent in metabolism and oncogenesis

Yip, S., Saha, S., & Chernoff, J. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.03.004 · Cited by 269

Leptin's Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals

Moon, H., Dalamaga, Μ., Kim, S. Y., Pοlyzos, S. A., Hamnvik, O. R., Magkos, F., Paruthi, J., & Mantzoros, C. S. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1053 · Cited by 265

Neuroinflammation and neurodegeneration in overnutrition-induced diseases

Cai, D. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.11.003 · Cited by 256

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

Williams, K. W., Liu, T., Kong, X., Fukuda, M., Deng, Y., Berglund, E. D., Deng, Z., Gao, Y., Liu, T., Sohn, J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.002 · Cited by 258

A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites

Shi, H., Ge, X., Ma, X., Zheng, M., Cui, X., Pan, W., Zheng, P., Yang, X., Zhang, P., Hu, M., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01172-0 · Cited by 263

Advances in understanding the interrelations between leptin resistance and obesity

Pan, H., Guo, J., & Su, Z. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.003 · Cited by 257

Implication of inflammatory signaling pathways in obesity-induced insulin resistance

Tanti, J., Ceppo, F., Jager, J., & Berthou, F. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00181 · Cited by 255

An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol

Ghanim, H., Sia, C. L., Abuaysheh, S., Korzeniewski, K., Patnaik, P., Marumganti, A., Chaudhuri, A., & Dandona, P. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0482 · Cited by 241

Inhibition of PTP1B by Trodusquemine (MSI‐1436) Causes Fat‐specific Weight Loss in Diet‐induced Obese Mice

Lantz, K. A., HART, S. G. E., Planey, S. L., Roitman, M. F., Ruiz-White, I., Wolfe, H. R., & McLane, M. P. (2010) · Obesity · doi:10.1038/oby.2009.444 · Cited by 242

Leptin resistance in diet‐induced obesity: the role of hypothalamic inflammation

de Git, K. C. G., & Adan, R. A. H. (2015) · Obesity Reviews · doi:10.1111/obr.12243 · Cited by 236

Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

Milanski, M., Arruda, A. P., Coope, A., Ignácio-Souza, L. M., Nuñez, C. E. C., Roman, E. A., Romanatto, T., Pascoal, L. B., Caricilli, A. M., Torsoni, M. A., et al. (2012) · Diabetes · doi:10.2337/db11-0390 · Cited by 233

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

Banno, R., Zimmer, D., De Jonghe, B. C., Atienza, M., Rak, K., Yang, W., & Bence, K. K. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39620 · Cited by 214

Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-α–mediated inflammation and insulin resistance in primary human adipocytes

Chuang, C., Martinez, K., Xie, G., Kennedy, A. J., Bumrungpert, A., Overman, A., Jia, W. P., & McIntosh, M. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29807 · Cited by 209

PTP1B and TCPTP – nonredundant phosphatases in insulin signaling and glucose homeostasis

Tiganis, T. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08563.x · Cited by 209

Hypothalamic Inflammation in the Control of Metabolic Function

Valdearcos, M., Xu, A. W., & Koliwad, S. K. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071656 · Cited by 209

The two faces of PTP1B in cancer

Lessard, L., Stuible, M., & Tremblay, M. L. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.09.018 · Cited by 198

PTP1B: A simple enzyme for a complex world

Feldhammer, M., Uetani, N., Miranda‐Saavedra, D., & Tremblay, M. L. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.819830 · Cited by 201

CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age

Vogt, M. C., & Brüning, J. C. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.11.004 · Cited by 194

Metabolic inflammation: Connecting obesity and insulin resistance

Dali‐Youcef, N., Mecili, M., Ricci, R., & Andrès, E. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.705015 · Cited by 201

Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach

Amen, O. M., Sarker, S. D., Ghildyal, R., & Arya, A. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00977 · Cited by 190

Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

Zhang, Z., Dodd, G. T., & Tiganis, T. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.07.003 · Cited by 186

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

Loh, K., Fukushima, A., Zhang, X., Galić, S., Briggs, D. I., Enriori, P. J., Simonds, S. E., Wiede, F., Reichenbach, A., Hauser, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.09.011 · Cited by 185

Angiogenic Endothelial Cell Signaling in Cardiac Hypertrophy and Heart Failure

Gogiraju, R., Bochenek, M. L., & Schäfer, K. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00020 · Cited by 186

Leptin receptor signaling: pathways to leptin resistance

Wauman, J. (2011) · Frontiers in bioscience · doi:10.2741/3885 · Cited by 182

Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats

Ono, H., Pocai, A., Wang, Y., Sakoda, H., Asano, T., Backer, J., Schwartz, G. J., & Rossetti, L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34277 · Cited by 183

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

Mayoral, R., Osborn, O., McNelis, J., Johnson, A. M., Oh, D. Y., Llorente, C., Chung, H., Li, P., Través, P. G., Bandyopadhyay, G. K., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.02.007 · Cited by 171

Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat

Narasimhan, A., Mayilvanan, C., & Karundevi, B. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0002 · Cited by 166

Leptin and the Regulation of Body Weigh

Friedman, J. M. (2011) · The Keio Journal of Medicine · doi:10.2302/kjm.60.1 · Cited by 169

Hypothalamic inflammation: a double‐edged sword to nutritional diseases

Cai, D., & Liu, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06388.x · Cited by 162

Antidiabetic, Chemical, and Physical Properties of Organic Vanadates as Presumed Transition-State Inhibitors for Phosphatases

Crans, D. C. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b02229 · Cited by 151

HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms

White, C. L., Whittington, A., Barnes, M. J., Wang, Z., Bray, G. A., & Morrison, C. D. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90513.2008 · Cited by 150

Hypothalamic dysfunction in obesity

Williams, L. M. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s002966511200078x · Cited by 148

Neuroinflammatory basis of metabolic syndrome

Purkayastha, S., & Cai, D. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.09.005 · Cited by 150

PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity

Wiede, F., Lu, K., Du, X., Zeissig, M. N., Xu, R., Goh, P. K., Xirouchaki, C. E., Hogarth, S. J., Greatorex, S., Sek, K., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0694 · Cited by 142

Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid

Yang, Y. M., Seo, S. Y., Kim, T. H., & Kim, S. G. (2012) · Hepatology · doi:10.1002/hep.25912 · Cited by 140

Adipose tissue macrophage in obesity-associated metabolic diseases

Yao, J., Wu, D., & Qiu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.977485 · Cited by 151

Diet-Induced Inflammation of the Hypothalamus in Obesity

Velloso, L. A., ARAUJO, E. P. D., & de Souza, C. T. (2008) · NeuroImmunoModulation · doi:10.1159/000153423 · Cited by 135

Molecular mechanisms of central leptin resistance in obesity

Jung, C. H., & Kim, M.-S. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0020-y · Cited by 140

Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice

Daveri, E., Cremonini, E., Mastaloudis, A., Hester, S. N., Wood, S. M., Waterhouse, A. L., Anderson, M., Fraga, C. G., & Oteiza, P. I. (2018) · Redox Biology · doi:10.1016/j.redox.2018.05.012 · Cited by 137

The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance

Abdelsalam, S. S., Korashy, H. M., Zeidan, A., & Agouni, A. (2019) · Biomolecules · doi:10.3390/biom9070286 · Cited by 135

Obesity, leptin, and Alzheimer's disease

Lee, E. B. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06274.x · Cited by 126

C terminus of the P2X7 receptor: treasure hunting

Costa‐Junior, H. M., Vieira, F. S., & Coutinho‐Silva, R. (2011) · Purinergic Signalling · doi:10.1007/s11302-011-9215-1 · Cited by 128

Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation

Zhang, C., Zhou, T., Chen, Z., Meng, Y., Li, B., Lv, H., Wang, C., Xiang, S., Shi, L., Zhu, Y., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316857 · Cited by 125

Molecular Mechanisms Underlying Obesity-Induced Hypothalamic Inflammation and Insulin Resistance: Pivotal Role of Resistin/TLR4 Pathways

Benomar, Y., & Taouis, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00140 · Cited by 131

The role of protein tyrosine phosphatase 1B (PTP1B) in the pathogenesis of type 2 diabetes mellitus and its complications

Teimouri, M., Hosseini, H., Sadeghabadi, Z. A., Khorzoughi, R. B., Gorgani‐Firuzjaee, S., & Meshkani, R. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00860-7 · Cited by 126

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer’s Therapy?

Vieira, M. N. N., Silva, N. M. L. E., Ferreira, S. T., & Felice, F. G. D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00007 · Cited by 123

PTP1B is a negative regulator of interleukin 4–induced STAT6 signaling

Lu, X., Malumbres, R., Shields, B., Jiang, X., Sarosiek, K. A., Natkunam, Y., Tiganis, T., & Lossos, I. S. (2008) · Blood · doi:10.1182/blood-2008-03-148726 · Cited by 122

(−)-Epicatechin prevents TNFα-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes

Prieto, M. A. V., Bettaieb, A., Haj, F. G., Fraga, C. G., & Oteiza, P. I. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.02.019 · Cited by 118

STAT3 phosphorylation in central leptin resistance

Liu, H., Du, T., Li, C., & Yang, G. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00569-w · Cited by 130

Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice

Shi, H., Wang, Q., Zheng, M., Hao, S., Lum, J. S., Chen, X., Huang, X., Yu, Y., & Zheng, K. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01760-1 · Cited by 122

Anthocyanins from Purple Corn Ameliorated Tumor Necrosis Factor‐α‐Induced Inflammation and Insulin Resistance in 3T3‐L1 Adipocytes via Activation of Insulin Signaling and Enhanced GLUT4 Translocation

Luna‐Vital, D. A., Weiss, M., & de Mejı́a, E. G. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700362 · Cited by 114

Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus

Thareja, S., Aggarwal, S., Bhardwaj, T., & Kumar, M. (2010) · Medicinal Research Reviews · doi:10.1002/med.20219 · Cited by 114

Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity

Ryan, K. K., Woods, S. C., & Seeley, R. J. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.013 · Cited by 114

Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media

Overman, A., Chuang, C.-C., & McIntosh, M. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.272 · Cited by 112

Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress

Agouni, A., Mody, N., Owen, C., Czopek, A., Zimmer, D. J., Bentires‐Alj, M., Bence, K. K., & Delibegović, M. (2011) · Biochemical Journal · doi:10.1042/bj20110373 · Cited by 109

A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation

Song, G. J., Jung, M., Kim, J.-H., Park, H., Rahman, M. H., Zhang, S., Zhang, Z., Park, D. H., Kook, H. Y., Lee, I., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0545-3 · Cited by 109

Molecular Mechanisms of Hypothalamic Insulin Resistance

Ono, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061317 · Cited by 112

Type 2 Diabetes Mellitus: Limitations of Conventional Therapies and Intervention with Nucleic Acid-Based Therapeutics

Kokil, G. R., Veedu, R. N., Ramm, G. A., Prins, J. B., & Parekh, H. S. (2015) · Chemical Reviews · doi:10.1021/cr5002832 · Cited by 100

Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

Dodd, G. T., Xirouchaki, C. E., Eramo, M. J., Mitchell, C. A., Andrews, Z. B., Henry, B. A., Cowley, M. A., & Tiganis, T. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.019 · Cited by 95

Over-Expression of Leptin Receptors in Hypothalamic POMC Neurons Increases Susceptibility to Diet-Induced Obesity

Gamber, K. M., Huo, L., Ha, S., Hairston, J. E., Greeley, S., & Bjørbæk, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030485 · Cited by 96

Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge

Través, P. G., Pardo, V., Pimentel-Santillana, M., González‐Rodríguez, Á., Mojena, M., Rico, D., Montenegro, Y., Calés, C., Martín‐Sanz, P., Valverde, Á. M., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.90 · Cited by 94

Arachidonic acid and lipoxin A4 as possible endogenous anti-diabetic molecules

Das, U. N. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2012.11.009 · Cited by 94

High-throughput proteomic profiling of the fish liver following bacterial infection

Causey, D. R., Pohl, M., Stead, D., Martín, S., Secombes, C. J., & Macqueen, D. J. (2018) · BMC Genomics · doi:10.1186/s12864-018-5092-0 · Cited by 92

Regulation of Insulin and Leptin Signaling by Muscle Suppressor of Cytokine Signaling 3 (SOCS3)

Yang, Z., Hulver, M., McMillan, R. P., Cai, L., Kershaw, E. E., Yu, L., Xue, B., & Shi, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047493 · Cited by 90

Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity

Mobasher, M. A., González‐Rodríguez, Á., Santamaría, B., Ramos, S., Martín, M. Á., Goya, L., Rada, P., Letzig, L. G., James, L. P., Cuadrado, A., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.150 · Cited by 88

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

Cao, R. Y., Tian, H., Zhang, Y., Liu, G., Xu, H., Rao, G., Tian, Y., & Fu, X. (2023) · MedComm · doi:10.1002/mco2.283 · Cited by 98

At the crossroad between immunity and metabolism: focus on leptin

Conde, J., Scotece, M., Gómez, R., Gómez-Reino, J. J., Lago, F., & Gualillo, O. (2010) · Expert Review of Clinical Immunology · doi:10.1586/eci.10.48 · Cited by 92

System-based approaches to decode the molecular links in Parkinson's disease and diabetes

Santiago, J. A., & Potashkin, J. A. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.03.019 · Cited by 89

Essential role of protein tyrosine phosphatase 1B in obesity‐induced inflammation and peripheral insulin resistance during aging

González‐Rodríguez, Á., Mas‐Gutierrez, J. A., Mirasierra, M., Fernández-Pérez, A., Lee, Y. J., Ko, H. J., Kim, J. K., Romanos, E., Carrascosa, J. M., Ros, M., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00786.x · Cited by 88

Deletion of Protein Tyrosine Phosphatase 1b Improves Peripheral Insulin Resistance and Vascular Function in Obese, Leptin-Resistant Mice via Reduced Oxidant Tone

Ali, M. I., Ketsawatsomkron, P., de Chantemèle, E. J. B., MINTZ, J. D., Muta, K., Salet, C., Black, S. M., Tremblay, M. L., Fulton, D. J., Marrero, M. B., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.206318 · Cited by 85

Lipids and Adipokines as Risk Factors for Alzheimer's Disease

Warren, M. W., Hynan, L. S., & Weiner, M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111385 · Cited by 86

Recent advances in PTP1B signaling in metabolism and cancer

Villamar-Cruz, O., Loza-Mejía, M. A., Arias-Romero, L. E., & Camacho-Arroyo, I. (2021) · Bioscience Reports · doi:10.1042/bsr20211994 · Cited by 82

Susceptibility to diet-induced obesity and glucose intolerance in the APP SWE/PSEN1 A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein

Mody, N., Agouni, A., Mcilroy, G. D., Platt, B., & Delibegović, M. (2011) · Diabetologia · doi:10.1007/s00125-011-2160-2 · Cited by 84

LPS-Induced Low-Grade Inflammation Increases Hypothalamic JNK Expression and Causes Central Insulin Resistance Irrespective of Body Weight Changes

Rorato, R. C., Borges, B. C., Uchôa, E. T., Antunes‐Rodrigues, J., Elias, C. F., & Elias, L. L. K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071431 · Cited by 81

Hypothalamic inflammation in metabolic disorders and aging

Bhusal, A., Rahman, M. H., & Suk, K. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04019-x · Cited by 87

PTP1B Is an Androgen Receptor–Regulated Phosphatase That Promotes the Progression of Prostate Cancer

Lessard, L., Labbé, D. P., Deblois, G., Bégin, L. R., Hardy, S., Mes‐Masson, A., Fred Saad, C., Trotman, L. C., Giguère, V., & Tremblay, M. L. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2602 · Cited by 79

Neuronal Androgen Receptor Regulates Insulin Sensitivity via Suppression of Hypothalamic NF-κB–Mediated PTP1B Expression

Yu, I.-C. I., Lin, H., Liu, N.-C., Sparks, J. D., Yeh, S., Fang, L., Chen, L., & Chang, C. (2012) · Diabetes · doi:10.2337/db12-0135 · Cited by 79

Functional properties of Claramine: A novel PTP1B inhibitor and insulin-mimetic compound

Qin, Z., Pandey, N. R., Zhou, X., Stewart, C. A., Hari, A., Huang, H., Stewart, A. F. R., Brunel, J. M., & Chen, H. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.040 · Cited by 76

Insulin action in the brain: Roles in energy and glucose homeostasis

Dodd, G. T., & Tiganis, T. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12513 · Cited by 77

Yerba mate extract (Ilex paraguariensis) attenuates both central and peripheral inflammatory effects of diet-induced obesity in rats

Pimentel, G. D., Lira, F. S., Neto, J. C. R., Caris, A. V., Pinheiro, F., Ribeiro, E. B., do Nascimento, C. M. O., & Oyama, L. M. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.04.016 · Cited by 78

Insulin resistance associated to obesity: the link TNF-alpha

Nieto-Vázquez, I., Fernández‐Veledo, S., Kramer, D., Vila‐Bedmar, R., García‐Guerra, L., & Lorenzo, M. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802181047 · Cited by 493

Contribucion del TNF-alfa a la insulinorresistencia asociada a la obesidad

Lorenzo, M., Fernández‐Veledo, S., Vila‐Bedmar, R., Guerra, L. G., de Álvaro, C., & Vázquez, I. N. (2007) · Hispana

Insulin resistance induced by tumor necrosis factor-α in myocytes and brown adipocytes12

Lorenzo, M., Fernández‐Veledo, S., Vila‐Bedmar, R., García‐Guerra, L., de Álvaro, C., & Nieto-Vázquez, I. (2007) · Journal of Animal Science · doi:10.2527/jas.2007-0462 · Cited by 161

TNFα increases hypothalamic PTP1B activity via the NFκB pathway in rat hypothalamic organotypic cultures

Ito, Y., Banno, R., Hagimoto, S., Ozawa, Y., Arima, H., & Oiso, Y. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.11.010 · Cited by 35

Protein tyrosine phosphatase 1B inhibits adipocyte differentiation and mediates TNFα action in obesity

Song, D., Chen, Y., Li, Z., Guan, Y., Zou, D., & Miao, C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.05.006 · Cited by 25