Cited by 1,823Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

Obesity-induced inflammatory changes in adipose tissue

Open access
Wellen, Kathryn E., Hotamisligil, Gökhan S.·2003·Journal of Clinical Investigation

Abstract

Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity.

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Crossref · 10.1172/jci20514

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Authors
Wellen, K. E., & Hotamisligil, G. S.
Affiliations
Harvard University (US)
Venue
Journal of Clinical Investigation
Published
2003-12-15
Volume
112
Issue
12
Pages
1785-1788
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2007194743
Cited by
1,823
References
19
Citations by year
2026: 18 · 2025: 30 · 2024: 53 · 2023: 36 · 2022: 65 · 2021: 47 · 2020: 69 · 2019: 64 · 2018: 84 · 2017: 89 · 2016: 99 · 2015: 95 · 2014: 98 · 2013: 140 · 2012: 112
FWCI
46.76
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
obesity, adipose tissue inflammation, macrophage infiltration, low-grade inflammation, adipose tissue macrophages
MeSH terms
Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Biological Evolution, Humans, Inflammation, Macrophages, Models, Biological, Obesity, Transcription, Genetic

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