Obesity-induced inflammatory changes in adipose tissue
Open accessAbstract
Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity.
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Adipose tissue accumulates and activates macrophages and lymphocytes which secrete inflammatory factors.
“Adipose tissue is known to accumulate and activate macrophages and lymphocytes which secrete inflammatory factors (186, 187).”
From Cytokine Research in Depression: Principles, Challenges, and Open Questions (2019) · cites this paper as [187]
Chronic inflammation with increased circulating levels of cytokines is characteristic of obesity.
“Chronic inflammation with increased circulating levels of cytokines is also characteristic of obesity (162, 186, 187).”
From Cytokine Research in Depression: Principles, Challenges, and Open Questions (2019) · cites this paper as [187]
Ageing is associated with increased concentrations of TNF-a, CRP, and IL-1ra.
“Ageing is also associated with increased concentrations of TNF-a (178,179) , CRP (180) and IL-1ra (176,181) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [179]
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- Authors
- Wellen, K. E., & Hotamisligil, G. S.
- Affiliations
- Harvard University (US)
- ORCID
- Wellen, Kathryn E.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-12-15
- Volume
- 112
- Issue
- 12
- Pages
- 1785-1788
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC297006
- OpenAlex
- W2007194743
- Cited by
- 1,823
- References
- 19
- Citations by year
- 2026: 18 · 2025: 30 · 2024: 53 · 2023: 36 · 2022: 65 · 2021: 47 · 2020: 69 · 2019: 64 · 2018: 84 · 2017: 89 · 2016: 99 · 2015: 95 · 2014: 98 · 2013: 140 · 2012: 112
- FWCI
- 46.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, adipose tissue inflammation, macrophage infiltration, low-grade inflammation, adipose tissue macrophages
- MeSH terms
- Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Biological Evolution, Humans, Inflammation, Macrophages, Models, Biological, Obesity, Transcription, Genetic
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