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The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Growth Factor-induced Phosphorylation of Sterol Regulatory Element-binding Proteins Inhibits Sumoylation, Thereby Stimulating the Expression of Their Target Genes, Low Density Lipoprotein Uptake, and Lipid Synthesis

Arito, Mitsumi, Horiba, Taro, Hachimura, Satoshi, Inoue, Jun, Sato, Ryuichiro·2008·Journal of Biological Chemistry
DOI 10.1074/jbc.m800910200
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  • ERK1/2 signaling has been previously shown to regulate SREBP2 activity in HepG2 cells via direct phosphorylation.

    “ERK1/2 signaling has been previously shown to regulate SREBP2 activity in HepG2 cells via direct phosphorylation (Arito et al., 2008; Kotzka et al., 2004; Kotzka et al., 2000)”

    From GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis (2019) · cites this paper as Arito et al., 2008

    The Ser 455 results (page not available) link ERK activation to SREBP-2 phosphorylation and reduced sumoylation, while the HepG2 experiments show that inhibiting the ERK cascade increases SREBP-2 sumoylation. The phosphorylation experiments described in our copy were performed in COS-1 cells, however; they do not directly demonstrate ERK1/2 phosphorylation of SREBP-2 in HepG2 cells. (LLM, conf=0.84)

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  • The MEK1/ERK cascade directly phosphorylates SREBP2 at Ser-432 and Ser-455, inhibiting its sumoylation and promoting its transcription activity.

    “Previous studies in HepG2 cells showed that MEK1/ERK cascade directly phosphorylates SREBP2 at Ser-432 and Ser-455, which inhibits its sumoylation and subsequently promotes its transcription activity (Arito et al., 2008; Kotzka et al., 2004; Kotzka et al., 2000).”

    From GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis (2019) · cites this paper as Arito et al., 2008

    In “Ser 455 of SREBP-2 Is Critical for SUMO-1 Conjugation” (page unavailable), the paper identifies Ser-432 and Ser-455 as phosphorylation sites, but reports that mutating Ser-432 had no effect on sumoylation; the inhibitory link is specific to Ser-455. The paper connects ERK-pathway activity, reduced sumoylation, and increased transcriptional activity, but its site-specific experiments were chiefly in COS-1 cells and do not directly demonstrate MEK1/ERK phosphorylation at both sites in HepG2 cells. (LLM, conf=0.88)

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Research works printed but not linked: 26

  1. Goldstein, 2006, Cell, 124, 35, 10.1016/j.cell.2005.12.022 · DOI · Paper page
  2. Bengoechea-Alonso, 2005, Proc. Natl. Acad. Sci. U. S. A., 102, 11681, 10.1073/pnas.0501494102 · DOI
  3. Kotzka, 2000, J. Lipid Res., 41, 99, 10.1016/S0022-2275(20)32079-4 · DOI · Paper page
  4. Roth, 2000, J. Biol. Chem., 275, 33302, 10.1074/jbc.M005425200 · DOI
  5. Kotzka, 2004, J. Biol. Chem., 279, 22404, 10.1074/jbc.M401198200 · DOI · Paper page
  6. Punga, 2006, J. Biol. Chem., 281, 25278, 10.1074/jbc.M604983200 · DOI
  7. Sundqvist, 2005, Cell Metab., 1, 379, 10.1016/j.cmet.2005.04.010 · DOI
  8. Hirano, 2003, J. Biol. Chem., 278, 16809, 10.1074/jbc.M212448200 · DOI · Paper page
  9. Hirano, 2001, J. Biol. Chem., 276, 36431, 10.1074/jbc.M105200200 · DOI · Paper page
  10. Hietakangas, 2006, Proc. Natl. Acad. Sci. U. S. A., 103, 45, 10.1073/pnas.0503698102 · DOI
  11. Demoulin, 2004, J. Biol. Chem., 279, 35392, 10.1074/jbc.M405924200 · DOI
  12. Swinnen, 2000, Oncogene, 19, 5173, 10.1038/sj.onc.1203889 · DOI
  13. Yang, 2004, Mol. Cell, 13, 611, 10.1016/S1097-2765(04)00060-7 · DOI
  14. Girdwood, 2003, Mol. Cell, 11, 1043, 10.1016/S1097-2765(03)00141-2 · DOI
  15. Song, 2004, Proc. Natl. Acad. Sci. U. S. A., 101, 14373, 10.1073/pnas.0403498101 · DOI
  16. Uchimura, 2004, Anal. Biochem., 331, 204, 10.1016/S0003-2697(04)00378-1 · DOI
  17. Martin, 2007, Nature, 447, 321, 10.1038/nature05736 · DOI
  18. Biesà, 2002, J. Biol. Chem., 277, 8999, 10.1074/jbc.M110453200 · DOI
  19. Nishida, 2002, J. Biol. Chem., 277, 41311, 10.1074/jbc.M206741200 · DOI
  20. Park, 2007, Proc. Natl. Acad. Sci. U. S. A., 104, 17028, 10.1073/pnas.0609852104 · DOI
  21. Sato, 1999, J. Biol. Chem., 274, 24714, 10.1074/jbc.274.35.24714 · DOI
  22. Ohshima, 2004, J. Biol. Chem., 279, 29551, 10.1074/jbc.M403866200 · DOI
  23. Arimura, 2004, J. Biol. Chem., 279, 10070, 10.1074/jbc.M308522200 · DOI
  24. Nakahara, 2005, J. Biol. Chem., 280, 42283, 10.1074/jbc.M507454200 · DOI
  25. Kanayama, 2007, J. Biol. Chem., 282, 10290, 10.1074/jbc.M700270200 · DOI
  26. Lee, 2003, Oncogene, 22, 3853, 10.1038/sj.onc.1206502 · DOI

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Metadata

Authors
Arito, M., Horiba, T., Hachimura, S., Inoue, J., & Sato, R.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2008-05
Volume
283
Issue
22
Pages
15224-15231
ISSN
0021-9258
DOI
10.1074/jbc.m800910200
Cited by
72
References
1
Language
en
Licence

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