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Insulin-activated Erk-mitogen-activated Protein Kinases Phosphorylate Sterol Regulatory Element-binding Protein-2 at Serine Residues 432 and 455 in Vivo

Kotzka, Jorg, Lehr, Stefan, Roth, Gunther, Avci, Haluk, Knebel, Birgit, Muller-Wieland, Dirk·2004·Journal of Biological Chemistry
DOI 10.1074/jbc.m401198200
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  • The MEK1/ERK cascade directly phosphorylates SREBP2 at Ser-432 and Ser-455, inhibiting its sumoylation and promoting its transcription activity.

    “Previous studies in HepG2 cells showed that MEK1/ERK cascade directly phosphorylates SREBP2 at Ser-432 and Ser-455, which inhibits its sumoylation and subsequently promotes its transcription activity (Arito et al., 2008; Kotzka et al., 2004; Kotzka et al., 2000).”

    From GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis (2019) · cites this paper as Kotzka et al., 2004

    The Results identify Ser-432 and Ser-455 as Erk2 phosphorylation sites and show that activating the Erk pathway with MEK2D increases SREBP-2 transcriptional activity in HepG2 cells. Our copy does not establish that phosphorylation inhibits sumoylation, and the HepG2 experiment uses MEK2D rather than MEK1. (LLM, conf=0.89)

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  • ERK1/2 signaling has been previously shown to regulate SREBP2 activity in HepG2 cells via direct phosphorylation.

    “ERK1/2 signaling has been previously shown to regulate SREBP2 activity in HepG2 cells via direct phosphorylation (Arito et al., 2008; Kotzka et al., 2004; Kotzka et al., 2000)”

    From GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis (2019) · cites this paper as Kotzka et al., 2004

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Research works printed but not linked: 26

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Metadata

Authors
Kotzka, J., Lehr, S., Roth, G., Avci, H., Knebel, B., & Muller-Wieland, D.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2004-05
Volume
279
Issue
21
Pages
22404-22411
ISSN
0021-9258
DOI
10.1074/jbc.m401198200
Cited by
111
References
0
Language
en
Licence

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