The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy
Open accessAbstract
Macroautophagy is a vacuolar lysosomal catabolic pathway that is stimulated during periods of nutrient starvation to preserve cell integrity. Ceramide is a bioactive sphingolipid associated with a large range of cell processes. Here we show that short-chain ceramides (C(2)-ceramide and C(6)-ceramide) and stimulation of the de novo ceramide synthesis by tamoxifen induce the dissociation of the complex formed between the autophagy protein Beclin 1 and the anti-apoptotic protein Bcl-2. This dissociation is required for macroautophagy to be induced either in response to ceramide or to starvation. Three potential phosphorylation sites, Thr(69), Ser(70), and Ser(87), located in the non-structural N-terminal loop of Bcl-2, play major roles in the dissociation of Bcl-2 from Beclin 1. We further show that activation of c-Jun N-terminal protein kinase 1 by ceramide is required both to phosphorylate Bcl-2 and to stimulate macroautophagy. These findings reveal a new aspect of sphingolipid signaling in up-regulating a major cell process involved in cell adaptation to stress.
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1 retracted
Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
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RetractedLC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
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Autophagy fights disease through cellular self-digestion
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Self-citationSuppression of basal autophagy in neural cells causes neurodegenerative disease in mice
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Loss of autophagy in the central nervous system causes neurodegeneration in mice
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The role of autophagy during the early neonatal starvation period
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How to Interpret LC3 Immunoblotting
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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
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Cited by
Regulation mechanisms and signaling pathways of autophagy
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Autophagy and the Integrated Stress Response
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Self-citationULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
Russell, R. C., Tian, Y., Yuan, H., Park, H. W., Chang, Y.-Y., Kim, J., Kim, H., Neufeld, T. P., Dillin, A., & Guan, K.-L. (2013) · Nature Cell Biology · doi:10.1038/ncb2757 · Cited by 1,529
Autophagy gone awry in neurodegenerative diseases
Wong, E., & Cuervo, A. M. (2010) · Nature Neuroscience · doi:10.1038/nn.2575 · Cited by 815
MAPK/JNK signalling: a potential autophagy regulation pathway
Zhou, Y.-Y., Li, Y., Jiang, W.-Q., & Zhou, L.-F. (2015) · Bioscience Reports · doi:10.1042/bsr20140141 · Cited by 444
Metadata
- Authors
- Pattingre, S., Bauvy, C., Carpentier, S., Levade, T., Levine, B., & Codogno, P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 284
- Issue
- 5
- Pages
- 2719-2728
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2001284886
- Cited by
- 279
- References
- 13
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pattingre, S., Bauvy, C., Carpentier, S., Levade, T., Levine, B., & Codogno, P. (2009). Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m805920200
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