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Autophagy gone awry in neurodegenerative diseases

Wong, Esther, Cuervo, Ana Maria·2010·Nature Neuroscience
DOI 10.1038/nn.2575PMC PMC4038747
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  • Autophagic flux dysfunction contributes to AD, PD, HD, and ALS.

    “Autophagic flux, encompassing autophagosome formation, maturation, lysosomal fusion, and degradation, is essential for neuronal homeostasis, and its dysfunction contributes to AD, PD, HD, and ALS (Williams et al. 2006), (Rubinsztein et al. 2007), (Wong and Cuervo 2010).”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Wong and Cuervo 2010

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Metadata

Authors
Wong, E., & Cuervo, A. M.
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2010-06-25
Volume
13
Issue
7
Pages
805-811
ISSN
  • 1097-6256
  • 1546-1726
DOI
10.1038/nn.2575
PMC
PMC4038747
Cited by
815
References
23
Language
en
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