The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy
Open accessAbstract
Macroautophagy is a vacuolar lysosomal catabolic pathway that is stimulated during periods of nutrient starvation to preserve cell integrity. Ceramide is a bioactive sphingolipid associated with a large range of cell processes. Here we show that short-chain ceramides (C(2)-ceramide and C(6)-ceramide) and stimulation of the de novo ceramide synthesis by tamoxifen induce the dissociation of the complex formed between the autophagy protein Beclin 1 and the anti-apoptotic protein Bcl-2. This dissociation is required for macroautophagy to be induced either in response to ceramide or to starvation. Three potential phosphorylation sites, Thr(69), Ser(70), and Ser(87), located in the non-structural N-terminal loop of Bcl-2, play major roles in the dissociation of Bcl-2 from Beclin 1. We further show that activation of c-Jun N-terminal protein kinase 1 by ceramide is required both to phosphorylate Bcl-2 and to stimulate macroautophagy. These findings reveal a new aspect of sphingolipid signaling in up-regulating a major cell process involved in cell adaptation to stress.
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1 retracted
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RetractedLC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
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Cited by
Regulation mechanisms and signaling pathways of autophagy
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Autophagy and the Integrated Stress Response
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Self-citationULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
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Autophagy gone awry in neurodegenerative diseases
Wong, E., & Cuervo, A. M. (2010) · Nature Neuroscience · doi:10.1038/nn.2575 · Cited by 815
MAPK/JNK signalling: a potential autophagy regulation pathway
Zhou, Y.-Y., Li, Y., Jiang, W.-Q., & Zhou, L.-F. (2015) · Bioscience Reports · doi:10.1042/bsr20140141 · Cited by 444
Metadata
- Authors
- Pattingre, S., Bauvy, C., Carpentier, S., Levade, T., Levine, B., & Codogno, P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 284
- Issue
- 5
- Pages
- 2719-2728
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2001284886
- Cited by
- 279
- References
- 13
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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