BNIP3 Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy
Open accessAbstract
Hypoxia and nutrient deprivation are environmental stresses governing the survival and adaptation of tumor cells in vivo. We have identified a novel role for the Rb tumor suppressor in protecting against nonapoptotic cell death in the developing mouse fetal liver, in primary mouse embryonic fibroblasts, and in tumor cell lines. Loss of pRb resulted in derepression of BNip3, a hypoxia-inducible member of the Bcl-2 superfamily of cell death regulators. We identified BNIP3 as a direct target of pRB/E2F-mediated transcriptional repression and showed that pRB attenuates the induction of BNIP3 by hypoxia-inducible factor to prevent autophagic cell death. BNIP3 was essential for hypoxia-induced autophagy, and its ability to promote autophagosome formation was enhanced under conditions of nutrient deprivation. Knockdown of BNIP3 reduced cell death, and remaining deaths were necrotic in nature. These studies identify BNIP3 as a key regulator of hypoxia-induced autophagy and suggest a novel role for the RB tumor suppressor in preventing nonapoptotic cell death by limiting the extent of BNIP3 induction in cells.
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Functional RB may prevent autophagy in response to hypoxia through inhibition of E2F target genes.
“Recent work has demonstrated that the presence of functional RB might prevent autophagy in response to hypoxia through its inhibition of E2F target genes97,98.”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [97]
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- Authors
- Tracy, K., Dibling, B. C., Spike, B. T., Knabb, J. R., Schumacker, P., & Macleod, K. F.
- Affiliations
- University of Chicago (US)
- Northwestern University (US)
- Corresponding author
- Macleod, Kay F.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2007-09-01
- Volume
- 27
- Issue
- 17
- Pages
- 6229-6242
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC1952167
- OpenAlex
- W2122065834
- Cited by
- 369
- References
- 61
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 15 · 2023: 7 · 2022: 19 · 2021: 29 · 2020: 10 · 2019: 20 · 2018: 19 · 2017: 27 · 2016: 15 · 2015: 24 · 2014: 16 · 2013: 21 · 2012: 25
- FWCI
- 19.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- BNIP3, Rb tumor suppressor, E2F transcription factors, autophagic cell death, hypoxia-inducible factor, transcriptional repression, nutrient deprivation, non-apoptotic cell death, autophagosome formation, tumor cell survival
- MeSH terms
- Animals, Hypoxia, Autophagy, Base Sequence, Cells, Cultured, Deferoxamine, Gene Expression Regulation, Humans, Membrane Proteins, Molecular Sequence Data, Promoter Regions, Genetic, Proto-Oncogene Proteins, Retinoblastoma Protein, Sequence Alignment, Cell Death, Siderophores, Mice, Knockout, Mitochondrial Proteins, E2F Transcription Factors, Mice
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