Unfractionated heparin and new heparin analogues from ascidians (chordate-tunicate) ameliorate colitis in rats
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The anti-inflammatory effect of mammalian heparin analogues, named dermatan sulfate and heparin, isolated from the ascidian Styela plicata was accessed in a TNBS-induced colitis model in rats. Subcutaneous administration of the invertebrate compounds during a 7-day period drastically reduced inflammation as observed by the normalization of the macroscopic and histological characteristics of the colon. At the molecular level, a decrease in the production of TNF-alpha, TGF-beta, and VEGF was observed, as well as a reduction of NF-kappaB and MAPK kinase activation. At the cellular level, the heparin analogues attenuated lymphocyte and macrophage recruitment and epithelial cell apoptosis. A drastic reduction in collagen-mediated fibrosis was also observed. No hemorrhagic events were observed after glycan treatment. These results strongly indicate the potential therapeutic use of these compounds for the treatment of colonic inflammation with a lower risk of hemorrhage when compared with mammalian heparin.
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Anti-inflammatory activity of heparin analogues from ascidians and marine shrimps was reported.
“Anti-inflammatory activity of heparin analogues from ascidians and marine shrimps was also reported [156,157].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [157]
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Glycosaminoglycans and Neuroprotection
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Effect of sulfated glycosaminoglycans on tumor invasion and metastasis
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Introduction to the Analysis of Bioactive Compounds in Marine Samples
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- Authors
- Belmiro, C. L. R., Castelo-Branco, M. T. L., Melim, L. M. C., Schanaider, A., Elia, C., Madi, K., Pavão, M. S. G., & de Souza, H. S. P.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 284
- Issue
- 17
- Pages
- 11267-11278
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC2670131
- OpenAlex
- W1970693350
- Cited by
- 57
- References
- 64
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 6 · 2013: 4 · 2012: 2
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mizutani Foundation for Glycoscience
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- unfractionated heparin, heparin analogues, dermatan sulfate, Styela plicata, colitis, TNBS-induced colitis, anti-inflammatory activity, NF-κB activation, MAPK signaling, TNF-α, TGF-beta, vascular endothelial growth factor, lymphocyte recruitment, macrophage recruitment, epithelial apoptosis, colonic fibrosis, bleeding risk
- MeSH terms
- Animals, Colitis, Collagen, Colon, Fibrosis, Hemorrhage, Heparin, Lymphocytes, Macrophages, Male, Models, Biological, Rats, Wistar, Apoptosis, Chordata, Rats
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