The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Physiological Roles
Open accessAbstract
The direct measurement of mitochondrial [Ca(2+)] with highly specific probes demonstrated that major swings in organellar [Ca(2+)] parallel the changes occurring in the cytosol and regulate processes as diverse as aerobic metabolism and cell death by necrosis and apoptosis. Despite great biological relevance, insight was limited by the complete lack of molecular understanding. The situation has changed, and new perspectives have emerged following the very recent identification of the mitochondrial Ca(2+) uniporter, the channel allowing rapid Ca(2+) accumulation across the inner mitochondrial membrane.
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Cites
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Self-citationStore-Operated Calcium Channels
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Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease
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Initiation and perpetuation of NLRP 3 inflammasome activation and assembly
Elliott, E. I., & Sutterwala, F. S. (2015) · Immunological Reviews · doi:10.1111/imr.12286 · Cited by 821
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Chandel, N. S. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.013 · Cited by 555
Regulation and function of the mammalian tricarboxylic acid cycle
Arnold, P. K., & Finley, L. W. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102838 · Cited by 535
“Maintenance of Ca homeostasis is critical for cell viability as mitochondrial Ca overload favors opening of the permeability transition pore, leading to collapse of mitochondrial membrane potential and activation of cell death (147).”
BackgroundMitochondrial dysfunction in neurodegenerative disorders
Klemmensen, M. M., Borrowman, S. H., Pearce, C., Pyles, B., & Chandra, B. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2023.10.002 · Cited by 396
Metadata
- Authors
- Patron, M., Raffaello, A., Granatiero, V., Tosatto, A., Merli, G., De Stefani, D., Wright, L., Pallafacchina, G., Terrin, A., Mammucari, C., & Rizzuto, R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 288
- Issue
- 15
- Pages
- 10750-10758
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2013257413
- Cited by
- 168
- References
- 11
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Patron, M., Raffaello, A., Granatiero, V., Tosatto, A., Merli, G., De Stefani, D., Wright, L., Pallafacchina, G., Terrin, A., Mammucari, C., & Rizzuto, R. (2013). The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Physiological Roles. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.r112.420752
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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