Initiation and perpetuation of NLRP 3 inflammasome activation and assembly

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326 · see citing works

Autophagy and Viruses: Adversaries or Allies?

Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,441 · see citing works

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176 · see citing works

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812 · see citing works

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080 · see citing works

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065 · see citing works

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658 · see citing works

Mitochondria and cell death: outer membrane permeabilization and beyond

Tait, S. W. G., & Green, D. R. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2952 · Cited by 2,593 · see citing works

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

Brookes, P. S., Yoon, Y., Robotham, J. L., Anders, M. W., & Sheu, S.-S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2004 · Cited by 2,575 · see citing works

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442 · see citing works

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441 · see citing works

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W. Z., Strowig, T., Thaiss, C. A., Kau, A. L., Eisenbarth, S. C., Jurczak, M. J., et al. (2012) · Nature · doi:10.1038/nature10809 · Cited by 2,435 · see citing works

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.96 · Cited by 2,421 · see citing works

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

Park, B., Song, D., Kim, H. M., Choi, B.-S., Lee, H., & Lee, J.-O. (2009) · Nature · doi:10.1038/nature07830 · Cited by 2,421 · see citing works

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282 · see citing works

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca ²⁺ Responses

Rizzuto, R., Pinton, P., Carrington, W., Fay, F. S., Fogarty, K. E., Lifshitz, L. M., Tuft, R. A., & Pozzan, T. (1998) · Science · doi:10.1126/science.280.5370.1763 · Cited by 2,257 · see citing works

mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Cheng, S.-C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E. J., Martens, J. H. A., Rao, N. A., Aghajanirefah, A., et al. (2014) · Science · doi:10.1126/science.1250684 · Cited by 2,224 · see citing works

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167 · see citing works

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024 · see citing works

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

Saitoh, T., Fujita, N., Jang, M. H., Uematsu, S., Yang, B., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., et al. (2008) · Nature · doi:10.1038/nature07383 · Cited by 2,020 · see citing works

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

Baughman, J. M., Perocchi, F., Girgis, H. S., Plovanich, M. E., Belcher-Timme, C. A., Sancak, Y., Bao, X., Strittmatter, L., Goldberger, O., Bogorad, R., et al. (2011) · Nature · doi:10.1038/nature10234 · Cited by 1,926 · see citing works

TRP Channels

Venkatachalam, K., & Montell, C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142819 · Cited by 1,915 · see citing works

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

Wen, H., Gris, D., Lei, Y. L., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P. ‐. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,814 · see citing works

Mitochondria as sensors and regulators of calcium signalling

Rizzuto, R., De Stefani, D., Raffaello, A., & Mammucari, C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3412 · Cited by 1,781 · see citing works

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00046-9 · Cited by 1,768 · see citing works

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739 · see citing works

Metabolic Pathways in Immune Cell Activation and Quiescence

Pearce, E. L., & Pearce, E. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.005 · Cited by 1,692 · see citing works

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

Hoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A., & Kolodner, R. D. (2001) · Nature Genetics · doi:10.1038/ng756 · Cited by 1,679 · see citing works

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

Eisenbarth, S. C., Colegio, O. R., O’Connor, W., Sutterwala, F. S., & Flavell, R. A. (2008) · Nature · doi:10.1038/nature06939 · Cited by 1,542 · see citing works

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402195 · Cited by 1,445 · see citing works

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Stefani, D. D., Raffaello, A., Teardo, E., Szabò, I., & Rizzuto, R. (2011) · Nature · doi:10.1038/nature10230 · Cited by 1,431 · see citing works

Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

Pelegrı́n, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,428 · see citing works

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels

Szabadkai, G., Bianchi, K., Várnai, P., De Stefani, D., Wieckowski, M. R., Cavagna, D., Nagy, A. I., Balla, T., & Rizzuto, R. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200608073 · Cited by 1,413 · see citing works

BAX and BAK Regulation of Endoplasmic Reticulum Ca 2+ : A Control Point for Apoptosis

Scorrano, L., Oakes, S. A., Opferman, J. T., Cheng, E. H. Y., Sorcinelli, M. D., Pozzan, T., & Korsmeyer, S. J. (2003) · Science · doi:10.1126/science.1081208 · Cited by 1,387 · see citing works

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

Shi, C.-S., Shenderov, K., Huang, N.-N., Kabat, J., Abu-Asab, M., Fitzgerald, K. A., Sher, A., & Kehrl, J. H. (2012) · Nature Immunology · doi:10.1038/ni.2215 · Cited by 1,367 · see citing works

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schröder, G. F., Fitzgerald, K. A., Wu, H., & Egelman, E. H. (2014) · Cell · doi:10.1016/j.cell.2014.02.008 · Cited by 1,353 · see citing works

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., et al. (2010) · Nature Immunology · doi:10.1038/ni.1935 · Cited by 1,330 · see citing works

The growing landscape of lysine acetylation links metabolism and cell signalling

Choudhary, C., Weinert, B. T., Nishida, Y., Verdin, E., & Mann, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3841 · Cited by 1,324 · see citing works

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

Kagan, V. E., Tyurin, V. A., Jiang, J., Tyurina, Y. Y., Ritov, V. B., Amoscato, A. A., Osipov, A. N., Belikova, N. A., Kapralov, A. A., Kini, V., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio727 · Cited by 1,256 · see citing works

Microdomains with High Ca 2+ Close to IP 3 -Sensitive Channels that Are Sensed by Neighboring Mitochondria

Rizzuto, R., Brini, M., Murgia, M., & Pozzan, T. (1993) · Science · doi:10.1126/science.8235595 · Cited by 1,207 · see citing works

Caspase‐1‐induced pyroptotic cell death

Miao, E. A., Rajan, J. V., & Aderem, A. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01044.x · Cited by 1,139 · see citing works

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

Lee, G., Subramanian, N., Kim, A. I., Aksentijevich, I. A., Goldbach‐Mansky, R. T., Sacks, D. B., Germain, R. N., Kastner, D. L., & Chae, J. J. (2012) · Nature · doi:10.1038/nature11588 · Cited by 1,077 · see citing works

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

Fernandes-Alnemri, T., Wu, J., Yu, J.-W., Datta, P., Miller, B., Jankowski, W., Rosenberg, S., Zhang, J., & Alnemri, E. S. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402194 · Cited by 1,026 · see citing works

Sensing and reacting to microbes through the inflammasomes

Franchi, L., Muñoz-Planillo, R., & Núñez, G. (2012) · Nature Immunology · doi:10.1038/ni.2231 · Cited by 1,013 · see citing works

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980 · see citing works

The NLR Gene Family: A Standard Nomenclature

Ting, J. P. ‐., Lovering, R. C., Alnemri, E. S., Bertin, J., Boss, J. M., Davis, B. K., Flavell, R. A., Girardin, S. E., Godzik, A., Harton, J. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.005 · Cited by 958 · see citing works

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

Iyer, S. S., He, Q., Janczy, J. R., Elliott, E. I., Zhong, Z., Olivier, A. K., Sadler, J. J., Knepper-Adrian, V., Han, R., Qiao, L., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.001 · Cited by 938 · see citing works

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

Murakami, T., Öckinger, J., Yu, J., Byles, V., McColl, A., Hofer, A. M., & Horng, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117765109 · Cited by 925 · see citing works

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Groß, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V. L. J., et al. (2009) · Nature · doi:10.1038/nature07965 · Cited by 922 · see citing works

Three-Dimensional Structure of the Apoptosome

Acehan, D., Jiang, X., Morgan, D. G., Heuser, J. E., Wang, X., & Akey, C. W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00442-2 · Cited by 912 · see citing works

The Nalp3 inflammasome is essential for the development of silicosis

Cassel, S. L., Eisenbarth, S. C., Iyer, S. S., Sadler, J. J., Colegio, O. R., Tephly, L. A., Carter, A. B., Rothman, P. B., Flavell, R. A., & Sutterwala, F. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803933105 · Cited by 907 · see citing works

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

Misawa, T., Takahama, M., Kozaki, T., Lee, H., Zou, J., Saitoh, T., & Akira, S. (2013) · Nature Immunology · doi:10.1038/ni.2550 · Cited by 861 · see citing works

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

Xu, H., Yang, J., Gao, W., Li, L., Li, P., Zhang, L., Gong, Y., Peng, X., Xi, J., Chen, S., et al. (2014) · Nature · doi:10.1038/nature13449 · Cited by 852 · see citing works

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

Lerner, A. G., Upton, J.-P., Praveen, P. V. K., Ghosh, R., Nakagawa, Y., Igbaria, A., Shen, S., Nguyen, V. Q., Backes, B. J., Heiman, M., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.007 · Cited by 848 · see citing works

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

Harris, J., Hartman, M., Roche, C., Zeng, S. G., O'Shea, A., Sharp, F. A., Lambe, E. M., Creagh, E. M., Golenbock, D. T., Tschopp, J., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202911 · Cited by 794 · see citing works

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

Baroja-Mazo, A., Martín-Sánchez, F., Gomez, A. I., Martínez, C. M., Amores-Iniesta, J., Compan, V., Barberà-Cremades, M., Yagüe, J., Ruiz-Ortiz, E., Antón, J., et al. (2014) · Nature Immunology · doi:10.1038/ni.2919 · Cited by 790 · see citing works

ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

Cruz, C. M., Rinna, A., Forman, H. J., Ventura, A. L. M., Persechini, P. M., & Ojcius, D. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608083200 · Cited by 786 · see citing works

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

Bruchard, M., Mignot, G., Dérangère, V., Chalmin, F., Chevriaux, A., Végran, F., Boireau, W., Simon, B., Ryffel, B., Connat, J., et al. (2012) · Nature Medicine · doi:10.1038/nm.2999 · Cited by 775 · see citing works

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

Franklin, B. S., Bossaller, L., De Nardo, D., Ratter, J. M., Stutz, A., Engels, G., Brenker, C., Nordhoff, M., Mirandola, S. R., Al-Amoudi, A., et al. (2014) · Nature Immunology · doi:10.1038/ni.2913 · Cited by 773 · see citing works

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

Juliana, C. A., Fernandes‐Alnemri, T., Kang, S., Farias, A., Qin, F., & Alnemri, E. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407130 · Cited by 771 · see citing works

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

Perregaux, D. G., & Gabel, C. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36591-2 · Cited by 760 · see citing works

Mechanism of NLRP3 inflammasome activation

Sutterwala, F. S., Haasken, S., & Cassel, S. L. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12458 · Cited by 736 · see citing works

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

Py, B. F., Kim, M.-S., Vakifahmetoglu-Norberg, H., & Yuan, J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.11.009 · Cited by 718 · see citing works

Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation

Faustin, B., Lartigue, L., Bruey, J., Luciano, F., Sergienko, E. A., Bailly‐Maitre, B., Volkmann, N., Hanein, D., Rouiller, I., & Reed, J. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.032 · Cited by 709 · see citing works

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal‐onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin‐associated autoinflammatory diseases

Aksentijevich, I. A., Nowak, M., Mallah, M., Chae, J. J., Watford, W. T., Hofmann, S. R., Stein, L. D., Russo, R. A. G., Goldsmith, D. P., Dent, P. B., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10688 · Cited by 707 · see citing works

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

Kerur, N., Veettil, M. V., Sharma-Walia, N., Bottero, V., Sadagopan, S., Otageri, P., & Chandran, B. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.008 · Cited by 702 · see citing works

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

Oslowski, C. M., Hara, T., O’Sullivan-Murphy, B., Kanekura, K., Lu, S., Hara, M., Ishigaki, S., Zhu, L. J., Hayashi, E., Hui, S. T. Y., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.005 · Cited by 678 · see citing works

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

Subramanian, N., Natarajan, K., Clatworthy, M. R., Wang, Z., & Germain, R. N. (2013) · Cell · doi:10.1016/j.cell.2013.02.054 · Cited by 675 · see citing works

Cutting Edge: Inflammasome Activation by Alum and Alum’s Adjuvant Effect Are Mediated by NLRP3

Li, H., Willingham, S. B., Ting, J. P. ‐., & Re, F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.17 · Cited by 674 · see citing works

STIM proteins: dynamic calcium signal transducers

Soboloff, J., Rothberg, B. S., Madesh, M., & Gill, D. L. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3414 · Cited by 661 · see citing works

Mitochondrial calcium and the permeability transition in cell death

Lemasters, J. J., Theruvath, T. P., Zhong, Z., & Nieminen, A. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.06.009 · Cited by 656 · see citing works

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

Kool, M., Pétrilli, V., Smedt, T. D., Rolaz, A., Hammad, H., van Nimwegen, M., Bergen, I. M., Castillo, R., Lambrecht, B. N., & Tschopp, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3755 · Cited by 612 · see citing works

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

Li, G., Mongillo, M., Chin, K., Harding, H. P., Ron, D., Marks, A. R., & Tabas, I. A. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200904060 · Cited by 597 · see citing works

Making heads or tails of phospholipids in mitochondria

Osman, C., Voelker, D. R., & Langer, T. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201006159 · Cited by 580 · see citing works

Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

Martinon, F., Agostini, L., Meylan, E., & Tschopp, J. (2004) · Current Biology · doi:10.1016/j.cub.2004.10.027 · Cited by 579 · see citing works

Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

Franchi, L., Eigenbrod, T., & Núñez, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900173 · Cited by 574 · see citing works

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

Heid, M. E., Keyel, P. A., Kamga, C., Shiva, S., Watkins, S. C., & Salter, R. D. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301490 · Cited by 570 · see citing works

Oxidative stress caused by mitochondrial calcium overload

Peng, T., & Jou, M. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05634.x · Cited by 569 · see citing works

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

Cai, X., Chen, J., Xu, H., Liu, S., Jiang, Q., Halfmann, R., & Chen, Z. J. (2014) · Cell · doi:10.1016/j.cell.2014.01.063 · Cited by 567 · see citing works

The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes

Feldmeyer, L., Keller, M., Niklaus, G., Hohl, D., Werner, S., & Beer, H.-D. (2007) · Current Biology · doi:10.1016/j.cub.2007.05.074 · Cited by 544 · see citing works

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

Poeck, H., Bscheider, M., Groß, O., Finger, K., Roth, S., Rebsamen, M., Hannesschläger, N., Schlee, M., Rothenfußer, S., Barchet, W., et al. (2009) · Nature Immunology · doi:10.1038/ni.1824 · Cited by 518 · see citing works

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

Sagulenko, V., Thygesen, S. J., Sester, D. P., Idris, A., Cridland, J. A., Vajjhala, P. R., Roberts, T. L., Schroder, K., Vince, J. E., Hill, J. M., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.37 · Cited by 511 · see citing works

Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

Duncan, J. A., Bergstralh, D. T., Wang, Y., Willingham, S. B., Ye, Z., Zimmermann, A. G., & Ting, J. P.-Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611496104 · Cited by 503 · see citing works

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

Rossol, M., Pierer, M., Raulien, N., Quandt, D., Meusch, U., Rothe, K., Schubert, K. A., Schöneberg, T., Schaefer, M., Krügel, U., et al. (2012) · Nature Communications · doi:10.1038/ncomms2339 · Cited by 492 · see citing works

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

Mallilankaraman, K. B., Cárdenas, C., Doonan, P. J., Chandramoorthy, H. C. K., Irrinki, K. M., Golenár, T., Csordás, G., Madireddi, P., Yang, J., Müller, M., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2622 · Cited by 487 · see citing works

The Permeabilizing ATP Receptor, P2X7

Rassendren, F., Buell, G. N., Virginio, C., Collo, G., North, R. A., & Surprenant, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5482 · Cited by 479 · see citing works

Cardiolipin provides specificity for targeting of tBid to mitochondria

Lutter, M. L., Fang, M., Luo, X., Nishijima, M., Xie, X., & Wang, X. (2000) · Nature Cell Biology · doi:10.1038/35036395 · Cited by 472 · see citing works

Apoptosome: a platform for the activation of initiator caspases

Bao, Q., & Shi, Y. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402028 · Cited by 467 · see citing works

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1β and IL-18 secretion in an autocrine way

Piccini, A., Carta, S., Tassi, S., Lasigliè, D., Fossati, G., & Rubartelli, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709684105 · Cited by 460 · see citing works

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

Groß, O., Yazdi, A. S., Thomas, C. J., Masin, M., Heinz, L. X., Guarda, G., Quadroni, M., Drexler, S. K., & Tschopp, J. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.018 · Cited by 460 · see citing works

Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1

Poyet, J., Srinivasula, S. M., Tnani, M., Razmara, M., Fernandes‐Alnemri, T., & Alnemri, E. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100250200 · Cited by 456 · see citing works

The Nlrp3 inflammasome is critical for aluminium hydroxide‐mediated IL‐1β secretion but dispensable for adjuvant activity

Franchi, L., & Núñez, G. (2008) · European Journal of Immunology · doi:10.1002/eji.200838549 · Cited by 452 · see citing works

Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy

Yu, J.-J., Nagasu, H., Murakami, T., Hoang, H., Broderick, L., Hoffman, H., & Horng, T. (2014) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1414859111 · Cited by 449 · see citing works

Mitochondrial contact sites. Lipid composition and dynamics.

Ardail, D., Privat, J., Egret-Charlier, M., Levrat, C., Lermé, F., & Louisot, P. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30583-5 · Cited by 445 · see citing works

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

Oakes, S. A., Scorrano, L., Opferman, J. T., Bassik, M. C., Nishino, M., Pozzan, T., & Korsmeyer, S. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408352102 · Cited by 428 · see citing works

Erratum: Corrigenda: MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

Mallilankaraman, K. B., Cárdenas, C., Doonan, P. J., Chandramoorthy, H. C. K., Irrinki, K. M., Golenár, T., Csordás, G., Madireddi, P., Yang, J., Müller, M., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3202 · Cited by 418 · see citing works

Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5

Reikine, S., Nguyen, J. B., & Modis, Y. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00342 · Cited by 410 · see citing works

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate

Chen, R., Valencia, I., Zhong, F., McColl, K. S., Roderick, H. L., Bootman, M. D., Berridge, M. J., Conway, S. J., Holmes, A. B., Mignery, G. A., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200309146 · Cited by 404 · see citing works

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

Mao, K., Chen, S., Chen, M., Ma, Y., Wang, Y., Huang, B., He, Z., Zeng, Y., Hu, Y., Sun, S., et al. (2013) · Cell Research · doi:10.1038/cr.2013.6 · Cited by 397 · see citing works

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

Dostert, C., Guarda, G., Romero, J. F., Menu, P., Groß, O., Tardivel, A., Suvà, M.-L., Stehle, J., Köpf, M., Stamenkovic, I., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006510 · Cited by 397 · see citing works

Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

Compan, V., Baroja‐Mazo, A., López‐Castejón, G., Gomez, A. I., Martínez, C. M., Angosto-Bazarra, D., Montero, M. T., Herranz, A. S., Bazán, E., Reimers, D., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.013 · Cited by 390 · see citing works

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

Lupfer, C., Thomas, P. G., Anand, P. K., Vogel, P., Milasta, S., Martinez, J., Huang, G., Green, M., Kundu, M., Chi, H., et al. (2013) · Nature Immunology · doi:10.1038/ni.2563 · Cited by 384 · see citing works

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

Hara, H., Tsuchiya, K., Kawamura, I., Fang, R., Hernández-Cuellar, E., Shen, Y., Mizuguchi, J., Schweighoffer, E., Tybulewicz, V. L. J., & Mitsuyama, M. (2013) · Nature Immunology · doi:10.1038/ni.2749 · Cited by 382 · see citing works

TRPM2 links oxidative stress to NLRP3 inflammasome activation

Zhong, Z., Zhai, Y., Liang, S., Mori, Y., Han, R., Sutterwala, F. S., & Qiao, L. (2013) · Nature Communications · doi:10.1038/ncomms2608 · Cited by 374 · see citing works

The NLRP12 Inflammasome Recognizes Yersinia pestis

Vladimer, G. I., Weng, D., Paquette, S. W. M., Vanaja, S. K., Rathinam, V. A. K., Aune, M. H., Conlon, J. E., Burbage, J. J., Proulx, M. K., Liu, Q., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.07.006 · Cited by 367 · see citing works

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

Qu, Y., Misaghi, S., Newton, K., Gilmour, L. L., Louie, S., Cupp, J. E., Dubyak, G., Hackos, D. H., & Dixit, V. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100478 · Cited by 365 · see citing works

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

Triantafilou, K., Hughes, T. R., Triantafilou, M., & Morgan, B. P. (2013) · Journal of Cell Science · doi:10.1242/jcs.124388 · Cited by 361 · see citing works

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

Man, S. M., Hopkins, L., Nugent, E., Cox, S., Glück, I. M., Tourlomousis, P., Wright, J. A., Cicuta, P., Monie, T. P., & Bryant, C. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402911111 · Cited by 351 · see citing works

Cryopyrin and pyrin activate caspase-1, but not NF-κB, via ASC oligomerization

Yu, J., Wu, J., Zhang, Z., Datta, P., Ibrahimi, I., Taniguchi, S., Sagara, J., Fernandes‐Alnemri, T., & Alnemri, E. S. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401734 · Cited by 347 · see citing works

Inflammasomes: too big to miss

Stutz, A., Golenbock, D. T., & Latz, E. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40599 · Cited by 345 · see citing works

An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages

Khare, S., Dorfleutner, A., Bryan, N. B., Yun, C., Radian, A. D., de Almeida, L., Rojanasakul, Y., & Stehlik, C. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.001 · Cited by 340 · see citing works

Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release

Kahlenberg, J. M., & Dubyak, G. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00494.2003 · Cited by 337 · see citing works

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

Wang, X., Jiang, W., Yan, Y., Gong, T., Han, J., Tian, Z., & Zhou, R. (2014) · Nature Immunology · doi:10.1038/ni.3015 · Cited by 323 · see citing works

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

Menu, P., Mayor, A., Zhou, R., Tardivel, A., Ichijo, H., Mori, K., & Tschopp, J. (2012) · Cell Death and Disease · doi:10.1038/cddis.2011.132 · Cited by 321 · see citing works

Phosphorylation of NLRC4 is critical for inflammasome activation

Qu, Y., Misaghi, S., Izrael-Tomasevic, A., Newton, K., Gilmour, L. L., Lamkanfi, M., Louie, S., Kayagaki, N., Liu, J., Kömüves, L. G., et al. (2012) · Nature · doi:10.1038/nature11429 · Cited by 320 · see citing works

Pannexin-1 Couples to Maitotoxin- and Nigericin-induced Interleukin-1β Release through a Dye Uptake-independent Pathway

Pelegrı́n, P., & Surprenant, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610351200 · Cited by 301 · see citing works

Cardiolipin provides an essential activating platform for caspase-8 on mitochondria

Gonzalvez, F., Schug, Z. T., Houtkooper, R. H., MacKenzie, E. D., Brooks, D. G., Wanders, R. J. A., PETIT, P. X., Vaz, F. M., & Gottlieb, E. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803129 · Cited by 297 · see citing works

Cutting Edge: <i>Candida albicans</i> Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome

Joly, S., Ma, N., Sadler, J. J., Soll, D. R., Cassel, S. L., & Sutterwala, F. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901323 · Cited by 296 · see citing works

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF‐κB and caspase‐1

Grenier, J. M., Wang, L., Manji, G. A., Huang, W.-J., Al-Garawi, A. A., Kelly, R., Carlson, A., Merriam, S., Lora, J. M., Briskin, M., et al. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03416-6 · Cited by 296 · see citing works

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

Lin, K.-M., Hu, W., Troutman, T. D., Jennings, M., Brewer, T., Li, X., Nanda, S. K., Cohen, P., Thomas, J. A., & Pasare, C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320294111 · Cited by 288 · see citing works

Pyrin Activates the ASC Pyroptosome in Response to Engagement by Autoinflammatory PSTPIP1 Mutants

Yu, J., Fernandes‐Alnemri, T., Datta, P., Wu, J., Juliana, C. A., Solórzano, L., McCormick, M., Zhang, Z., & Alnemri, E. S. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.08.029 · Cited by 287 · see citing works

Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection

Ichinohe, T., Yamazaki, T., Koshiba, T., & Yanagi, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312571110 · Cited by 284 · see citing works

Sensing damage by the NLRP3 inflammasome

Leemans, J. C., Cassel, S. L., & Sutterwala, F. S. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01043.x · Cited by 281 · see citing works

MCUR1は細胞代謝を制御するミトコンドリアCa 2MCUR1+ 取込の必須成分である

Mallilankaraman, K. B., Cesar, C., Patrick, J., Harish, C. C., Krishna, M. I., Golenár, T., Gyoergy, C., Madireddi, P., Jun, Y., Müller, M., et al. (2012) · Nature Cell Biology · Cited by 270 · see citing works

The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity

Park, S., Juliana, C. A., Hong, S., Datta, P., Hwang, I., Fernandes‐Alnemri, T., Yu, J., & Alnemri, E. S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301170 · Cited by 266 · see citing works

Targeting Bcl-2-IP3 Receptor Interaction to Reverse Bcl-2's Inhibition of Apoptotic Calcium Signals

Rong, Y.-P., Aromolaran, A. S., Bultynck, G., Zhong, F., Li, X., McColl, K. S., Matsuyama, S., Herlitze, S., Roderick, H. L., Bootman, M. D., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.014 · Cited by 263 · see citing works

Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain

Bryan, N. B., Dorfleutner, A., Rojanasakul, Y., & Stehlik, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802367 · Cited by 260 · see citing works

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

Riteau, N., Baron, L., Villeret, B., Guillou, N., Savigny, F., Ryffel, B., Rassendren, F., Bert, M. L., Gombault, A., & Couillin, I. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.144 · Cited by 258 · see citing works

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

Rodgers, M. A., Bowman, J. W., Fujita, H., Orazio, N., Shi, M., Liang, Q., Amatya, R., Kelly, T. J., Iwai, K., Ting, J., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20132486 · Cited by 247 · see citing works

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming

Allam, R., Lawlor, K. E., Yu, E. C.-W., Mildenhall, A., Moujalled, D. M., Lewis, R. S., Ke, F., Mason, K. D., White, M. J., Stacey, K. J., et al. (2014) · EMBO Reports · doi:10.15252/embr.201438463 · Cited by 238 · see citing works

Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

Fernandes‐Alnemri, T., Kang, S., Anderson, C., Sagara, J., Fitzgerald, K. A., & Alnemri, E. S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301681 · Cited by 235 · see citing works

How Metabolism Generates Signals during Innate Immunity and Inflammation

McGettrick, A. F., & O'Neill, L. A. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.486464 · Cited by 224 · see citing works

The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation

Okada, M., Matsuzawa, A., Yoshimura, A., & Ichijo, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.579961 · Cited by 213 · see citing works

Cutting Edge: NLRC5-Dependent Activation of the Inflammasome

Davis, B. K., Roberts, R. A., Huang, M. T.-H., Willingham, S. B., Conti, B. J., Brickey, W. J., Barker, B. R., Kwan, M., Taxman, D. J., Accavitti-Loper, M. A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1003111 · Cited by 208 · see citing works

Human nlrp3 inflammasome activation is nox1-4 independent

van Bruggen, R., Köker, M. Y., Jansen, M., van Houdt, M., Roos, D., Kuijpers, T. W., & van den Berg, T. K. (2010) · Blood · doi:10.1182/blood-2009-10-250803 · Cited by 202 · see citing works

Inflammasome Priming by Lipopolysaccharide Is Dependent upon ERK Signaling and Proteasome Function

Ghonime, M. G., Shamaa, O. R., Das, S., El-Domany, R. A., Fernandes‐Alnemri, T., Alnemri, E. S., Gavrilin, M. A., & Wewers, M. D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301974 · Cited by 200 · see citing works

Crystal Structure of NALP3 Protein Pyrin Domain (PYD) and Its Implications in Inflammasome Assembly

Bae, J. Y., & Park, H. H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.278812 · Cited by 197 · see citing works

Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation

Vanderheyden, V., Devogelaere, B., Missiaen, L., SMEDT, H. D., Bultynck, G., & Parys, J. B. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.12.003 · Cited by 192 · see citing works

Mycobacterium tuberculosis Phagosomes Exhibit Altered Calmodulin-Dependent Signal Transduction: Contribution to Inhibition of Phagosome-Lysosome Fusion and Intracellular Survival in Human Macrophages

Malik, Z. A., Iyer, S. S., & Kusner, D. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3392 · Cited by 188 · see citing works

Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

Ataide, M. A., Andrade, W. A., Zamboni, D. S., Wang, D., Souza, M. D. C., Franklin, B. S., Andrade, S. D. D. E., Martins, F. S., Pereira, D. B., Reed, G. W., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003885 · Cited by 187 · see citing works

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

Hernandez-Cuellar, E., Tsuchiya, K., Hara, H., Fang, R., Sakai, S., Kawamura, I., Akira, S., & Mitsuyama, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202479 · Cited by 184 · see citing works

Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux

Franchi, L., Eigenbrod, T., Muñoz-Planillo, R., Ozkurede, U., Kim, Y., Chakrabarti, A., Gale, M., Silverman, R. H., Colonna, M., Akira, S., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400582 · Cited by 183 · see citing works

Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction

Schroder, K., Sagulenko, V., Zamoshnikova, A., Richards, A. A., Cridland, J. A., Irvine, K. M., Stacey, K. J., & Sweet, M. J. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.07.020 · Cited by 182 · see citing works

Early changes in intramitochondrial cardiolipin distribution during apoptosis.

Garcia‐Fernandez, M. I., Troiano, L., Moretti, L., Nasi, M., Pinti, M., Salvioli, S., Dobrucki, J. W., & Cossarizza, A. (2002) · PubMed · Cited by 181 · see citing works

CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages

Liu, X., Yao, M., Li, N., Wang, C., Zheng, Y., & Cao, X. (2008) · Blood · doi:10.1182/blood-2008-03-144022 · Cited by 180 · see citing works

The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Physiological Roles

Patrón, M., Raffaello, A., Granatiero, V., Tosatto, A., Merli, G., Stefani, D. D., Wright, L. E., Pallafacchina, G., Terrin, A., Mammucari, C., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.420752 · Cited by 168 · see citing works

Ca2+ Stores and Ca2+ Entry Differentially Contribute to the Release of IL-1β and IL-1α from Murine Macrophages

Brough, D., Feuvre, R. A. L., Wheeler, R. D., Solovyova, N. A., Hilfiker, S., Rothwell, N. J., & Verkhratsky, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3029 · Cited by 168 · see citing works

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

López‐Castejón, G., Luheshi, N., Compan, V., High, S., Whitehead, R. C., Flitsch, S. L., Kirov, A., Prudovsky, I. A., Swanton, E., & Brough, D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.422238 · Cited by 166 · see citing works

Evolutionary Diversity of the Mitochondrial Calcium Uniporter

Bick, A. G., Calvo, S. E., & Mootha, V. K. (2012) · Science · doi:10.1126/science.1214977 · Cited by 158 · see citing works

Apoptosis regulation by Bcl-x L modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating

Li, C., Wang, X., Vais, H., Thompson, C. B., Foskett, J. K., & White, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702489104 · Cited by 156 · see citing works

Cardiolipin deficiency releases cytochrome c from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis

Choi, S.-Y., Gonzalvez, F., Jenkins, G. M., Slomianny, C., Chrétien, D., Arnoult, D., PETIT, P. X., & Frohman, M. A. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402020 · Cited by 151 · see citing works

Fungal Zymosan and Mannan Activate the Cryopyrin Inflammasome

Lamkanfi, M., Malireddi, R. K. S., & Kanneganti, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.023689 · Cited by 147 · see citing works

The Death-domain Fold of the ASC PYRIN Domain, Presenting a Basis for PYRIN/PYRIN Recognition

Liepinsh, E., Barbals, R., Dahl, E., Sharipo, A., Staub, E., & Otting, G. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.07.007 · Cited by 144 · see citing works

Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner

Chu, J., Thomas, L. M., Watkins, S. C., Franchi, L., Núñez, G., & Salter, R. D. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0309164 · Cited by 142 · see citing works

IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin

Perregaux, D. G., Barberia, J. T., Lanzetti, A. J., Geoghegan, K. F., Carty, T. J., & Gabel, C. A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.4.1294 · Cited by 135 · see citing works

Cyclooxygenase‐2 Regulates NLRP3 Inflammasome‐Derived IL‐1β Production

Hua, K., Chou, J., Ka, S., Tasi, Y., Chen, A., Wu, S., Chiu, H., Wong, W.-T., Wang, Y., Tsai, C., et al. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24815 · Cited by 132 · see citing works

Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways

Kim, S., Joe, Y., Jeong, S. O., Zheng, M., Back, S. H., Park, S. W., Ryter, S. W., & Chung, H. (2013) · Innate Immunity · doi:10.1177/1753425913508593 · Cited by 132 · see citing works

Caspase-1 Dependent IL-1β Secretion Is Critical for Host Defense in a Mouse Model of Chlamydia pneumoniae Lung Infection

Shimada, K., Crother, T. R., Karlin, J. N., Chen, S., Chiba, N., Ramanujan, V. K., Vergnes, L., Ojcius, D. M., & Arditi, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021477 · Cited by 118 · see citing works

Cardiolipin‐enriched raft‐like microdomains are essential activating platforms for apoptotic signals on mitochondria

Sorice, M., Manganelli, V., Matarrese, P., Tinari, A., Misasi, R., Malorni, W., & Garofalo, T. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.018 · Cited by 114 · see citing works

Structural mechanisms in NLR inflammasome signaling

Lechtenberg, B. C., Mace, P. D., & Riedl, S. J. (2014) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2014.08.011 · Cited by 112 · see citing works

NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections

Kumar, H., Pandey, S., Zou, J., Kumagai, Y., Takahashi, K., Akira, S., & Kawai, T. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002094 · Cited by 108 · see citing works

Reduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor

Son, S. M., Byun, J., Roh, S.-E., Kim, S. J., & Mook‐Jung, I. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.129 · Cited by 107 · see citing works

Human Monocyte Interleukin-1β Posttranslational Processing

Perregaux, D. G., Laliberte, R. E., & Gabel, C. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.29830 · Cited by 100 · see citing works

Keeping the immune system in check: a role for mitophagy

Lazarou, M. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.75 · Cited by 92 · see citing works

Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion

van der Burgh, R., Nijhuis, L., Pervolaraki, K., Compeer, E. B., Jongeneel, L. H., van Gijn, M. E., Coffer, P. J., Murphy, M. P., Mastroberardino, P. G., Frenkel, J., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.536920 · Cited by 92 · see citing works

The E3 Ubiquitin Ligase Tripartite Motif 33 Is Essential for Cytosolic RNA–Induced NLRP3 Inflammasome Activation

Weng, L., Mitoma, H., Tricot, C., Bao, M., Liu, Y., Zhang, Z., & Liu, Y.-J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401448 · Cited by 90 · see citing works

CA-074Me Protection against Anthrax Lethal Toxin

Newman, Z. L., Leppla, S. H., & Moayeri, M. (2009) · Infection and Immunity · doi:10.1128/iai.00730-09 · Cited by 90 · see citing works

Special regulatory T‐cell review: FOXP3 biochemistry in regulatory T cells – how diverse signals regulate suppression

Li, B., & Greene, M. I. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02774.x · Cited by 88 · see citing works

Coordinate control of cytoskeletal remodeling and calcium mobilization during T‐cell activation

Babich, A., & Burkhardt, J. K. (2013) · Immunological Reviews · doi:10.1111/imr.12123 · Cited by 79 · see citing works

Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation

Wu, Y., Kuo, W.-C., Wu, Y.-J., Yang, K.-T., Chen, S.-T., Jiang, S.-T., Gordy, C. L., He, Y., & Lai, M.-Z. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.165 · Cited by 73 · see citing works

TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis

Park, Y., Yoon, S., Suh, H., Kim, D. O., Park, J.-R., Jung, H., Kim, T., Yoon, S. R., Min, J., Na, H.-J., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003646 · Cited by 62 · see citing works

Cellular localization of NLRP3 inflammasome

Wang, Y., Yang, C., Mao, K., Chen, S., Meng, G., & Sun, B. (2013) · Protein & Cell · doi:10.1007/s13238-013-2113-2 · Cited by 59 · see citing works

Modeling AAA+ ring complexes from monomeric structures

Diemand, A. V., & Lupas, A. N. (2006) · Journal of Structural Biology · doi:10.1016/j.jsb.2006.04.011 · Cited by 56 · see citing works

The cardiolipin-binding domain of Bid affects mitochondrial respiration and enhances cytochrome c release

Liu, J., Weiss, A., Durrant, D., Chi, N., & Lee, R. M. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000038034.16230.ea · Cited by 55 · see citing works

Calmodulin kinase II regulates the maturation and antigen presentation of human dendritic cells

Herrmann, T. L., Morita, C. T., Lee, K. P., & Kusner, D. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0205105 · Cited by 51 · see citing works

Rift Valley fever virus infection induces activation of the NLRP3 inflammasome

Ermler, M. E., Traylor, Z., Patel, K., Schattgen, S., Vanaja, S. K., Fitzgerald, K. A., & Hise, A. G. (2013) · Virology · doi:10.1016/j.virol.2013.11.015 · Cited by 48 · see citing works

Mechanistic Issues of the Interaction of the Hairpin-Forming Domain of tBid with Mitochondrial Cardiolipin

Gonzalvez, F., Pariselli, F., Jalmar, O., Pauline, D., Sureau, F., Dellinger, M., Hendrickson, E. A., Bernard, S., & PETIT, P. X. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009342 · Cited by 46 · see citing works

Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis

Heit, B., Yeung, T., & Grinstein, S. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2010 · Cited by 40 · see citing works

Caspase-8 Binding to Cardiolipin in Giant Unilamellar Vesicles Provides a Functional Docking Platform for Bid

Jalmar, O., François‐Moutal, L., García‐Sáez, A. J., Perry, M., Granjon, T., Gonzalvez, F., Gottlieb, E., Ayala‐Sanmartín, J., Klösgen, B., Schwille, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055250 · Cited by 33 · see citing works

The interaction between tBid and cardiolipin or monolysocardiolipin

白石, 篤., Durrant, D., Yang, H.-S., He, Y., Whitby, F. G., Myszka, D. G., & Lee, R. M. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.048 · Cited by 32 · see citing works

Pannexin-1 influences peritoneal cavity cell population but is not involved in NLRP3 inflammasome activation

Wang, H., Xing, Y., Mao, L., Luo, Y., Kang, L., & Meng, G. (2013) · Protein & Cell · doi:10.1007/s13238-013-2114-1 · Cited by 23 · see citing works

Mechanism and Regulation of NLRP3 Inflammasome Activation

He, Y., Hara, H., & Núñez, G. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.09.002 · Cited by 2,759 · see citing works

Pattern recognition receptors in health and diseases

Li, D., & Wu, M. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00687-0 · Cited by 1,807 · see citing works

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

Zhong, Z., Umemura, A., Sanchez-Lopez, E., Liang, S., Shalapour, S., Wong, J., He, F., Boassa, D., Perkins, G., Ali, S. R., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.057 · Cited by 1,197 · see citing works

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

Dunn, J. D., Álvarez, L., Zhang, X., & Soldati, T. (2015) · Redox Biology · doi:10.1016/j.redox.2015.09.005 · Cited by 1,199 · see citing works

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Zhong, Z., Liang, S., Sanchez-Lopez, E., He, F., Shalapour, S., Lin, X.-J., Wong, J., Ding, S., Seki, E., Schnabl, B., et al. (2018) · Nature · doi:10.1038/s41586-018-0372-z · Cited by 1,208 · see citing works

Mitochondrial DNA in innate immune responses and inflammatory pathology

West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.21 · Cited by 1,115 · see citing works

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Xian, H., Watari, K., Sanchez-Lopez, E., Offenberger, J., Onyuru, J., Sampath, H., Ying, W., Hoffman, H. M., Shadel, G. S., & Karin, M. (2022) · Immunity · doi:10.1016/j.immuni.2022.06.007 · Cited by 850 · see citing works

Signaling pathways and targeted therapy for myocardial infarction

Zhang, Q., Wang, L., Wang, S., Cheng, H., Xu, L., Pei, G., Wang, Y., Fu, C., Jiang, Y., He, C., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00925-z · Cited by 855 · see citing works

Pyroptosis in inflammatory diseases and cancer

Rao, Z., Zhu, Y., Yang, P., Chen, Z., Xia, Y., Qiao, C., Liu, W., Deng, H., Li, J., Ning, P., et al. (2022) · Theranostics · doi:10.7150/thno.71086 · Cited by 812 · see citing works

Pathophysiology of Sickle Cell Disease

Sundd, P., Gladwin, M. T., & Novelli, E. M. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012838 · Cited by 813 · see citing works

Limiting inflammation—the negative regulation of NF-κB and the NLRP3 inflammasome

Afonina, I. S., Zhong, Z., Karin, M., & Beyaert, R. (2017) · Nature Immunology · doi:10.1038/ni.3772 · Cited by 772 · see citing works

Reparative inflammation takes charge of tissue regeneration

Karin, M., & Clevers, H. (2016) · Nature · doi:10.1038/nature17039 · Cited by 767 · see citing works

Role of pyroptosis in inflammation and cancer

Xiang, W. D., Xie, F., Zhou, X., Wu, Y., Yan, H., Liu, T., Huang, J. S., Wang, F., Zhou, F., & Zhang, L. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00905-x · Cited by 711 · see citing works

Hyperuricemia and its related diseases: mechanisms and advances in therapy

Du, L., Yao, Z., Li, H., Wang, Q., Xie, L., Yang, B., Pang, Y., Zhang, C., Zhong, Z., & Gao, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01916-y · Cited by 719 · see citing works

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

Zhong, Z., Sánchez‐López, E., & Karin, M. (2016) · Cell · doi:10.1016/j.cell.2016.05.051 · Cited by 574 · see citing works

ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis

Zheng, D., Liu, J., Piao, H., Zhu, Z., Wei, R., & Liu, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1039241 · Cited by 573 · see citing works

Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy

Han, X., Xu, T., Fang, Q., Zhang, H., Yue, L., Hu, G., & Sun, L. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102010 · Cited by 554 · see citing works

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

Nieto-Torres, J. L., Verdiá-Báguena, C., Jiménez-Guardeño, J. M., Regla-Nava, J. Á., Castaño-Rodríguez, C., Fernández‐Delgado, R., Torres, J., Aguilella, V. M., & Enjuanes, L. (2015) · Virology · doi:10.1016/j.virol.2015.08.010 · Cited by 506 · see citing works

The role of mitochondria in NLRP3 inflammasome activation

Liu, Q., Zhang, D., Hu, D., Zhou, X., & Zhou, Y. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.09.010 · Cited by 475 · see citing works

Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis

Hao, H., Cao, L., Jiang, C., Che, Y., Zhang, S., Takahashi, S., Wang, G., & Gonzalez, F. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.007 · Cited by 479 · see citing works

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

Lee, E., Hwang, I., Park, S., Hong, S., Hwang, B., Cho, Y., Son, J., & Yu, J.-W. (2019) · Cell Death &amp; Differentiation · doi:10.1038/s41418-018-0124-5 · Cited by 431 · see citing works

Mitochondria in innate immune signaling

Banoth, B., & Cassel, S. L. (2018) · Translational Research · doi:10.1016/j.trsl.2018.07.014 · Cited by 410 · see citing works

ASC filament formation serves as a signal amplification mechanism for inflammasomes

Dick, M. S., Sborgi, L., Rühl, S., Hiller, S., & Brož, P. (2016) · Nature Communications · doi:10.1038/ncomms11929 · Cited by 405 · see citing works

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

Aglietti, R. A., & Dueber, E. C. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.01.003 · Cited by 408 · see citing works

Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy

Wyler, E., Mösbauer, K., Franke, V., Diag, A., Gottula, L. T., Arsiè, R., Klironomos, F., Koppstein, D., Hönzke, K., Ayoub, S., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102151 · Cited by 306 · see citing works

NLRP3 Inflammasome and Inflammatory Diseases

Wang, Z., Zhang, S., Xiao, Y., Zhang, W., Wu, S., Qin, T., Yue, Y., Qian, W., & Li, L. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4063562 · Cited by 315 · see citing works

Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity

Hou, J., Hsu, J.-M., & Hung, M. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.09.003 · Cited by 304 · see citing works

Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome

Sun, L., Ma, W., Gao, W., Xing, Y., Chen, L., Xia, Z., Zhang, Z., & Dai, Z. (2019) · Cell Death &amp; Disease · doi:10.1038/s41419-019-1761-4 · Cited by 296 · see citing works

Cell Death Mechanisms in Cerebral Ischemia–Reperfusion Injury

Zhang, Q., Jia, M., Wang, Y., Wang, Q., & Wu, J. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03697-8 · Cited by 295 · see citing works

Spotlight on the NLRP3 inflammasome pathway

Groslambert, M., & Py, B. F. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s141220 · Cited by 267 · see citing works

Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases

Liu, D., Zeng, X., Xiao, L., Mehta, J. L., & Wang, X. (2017) · Basic Research in Cardiology · doi:10.1007/s00395-017-0663-9 · Cited by 259 · see citing works

Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome

Li, H., Guan, Y., Liang, B., Ding, P., Hou, X., Wei, W., & Ma, Y. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175091 · Cited by 258 · see citing works

Fatigue, Sleep, and Autoimmune and Related Disorders

Zielinski, M. R., Systrom, D. M., & Rose, N. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01827 · Cited by 266 · see citing works

Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases

Lu, F., Lan, Z., Xin, Z., He, C., Guo, Z., Xia, X., & Hu, T. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29268 · Cited by 248 · see citing works

Mitophagy in tumorigenesis and metastasis

Poole, L. P., & Macleod, K. F. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03774-1 · Cited by 250 · see citing works

Mitochondrial dysfunction in the development and progression of neurodegenerative diseases

Johnson, J., Mercado‐Ayón, E., Mercado-Ayon, Y., Dong, Y., Halawani, S. M., Ngaba, L. V., & Lynch, D. R. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108698 · Cited by 246 · see citing works

NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension

Sun, H., Ren, X., Xiong, X., Chen, Y.-Z., Zhao, M., Wang, J., Zhou, Y., Han, Y., Chen, Q., Li, Y., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.470 · Cited by 244 · see citing works

Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production

Sánchez‐López, E., Zhong, Z., Stubelius, A., Sweeney, S., Booshehri, L. M., Antonucci, L., Liu‐Bryan, R., Lodi, A., Terkeltaub, R. A., Lacal, J. C., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.03.011 · Cited by 235 · see citing works

Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors

Cheng, S., Nakashima, A., Huber, W. J., Davis, S., Banerjee, S., Huang, Z., Saito, S., Sadovsky, Y., & Sharma, S. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2162-4 · Cited by 238 · see citing works

Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjögren’s syndrome

Barrera, M.-J., Aguilera, S., Castro, I., Carvajal, P., Jara, D., Molina, C., González, S., & González, M.-J. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102867 · Cited by 213 · see citing works

Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease

Ahmed, S., Kwatra, M., Panda, S. R., Murty, U. S. N., & Naidu, V. G. M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.017 · Cited by 218 · see citing works

NLRP3 activation induced by neutrophil extracellular traps sustains inflammatory response in the diabetic wound.

Liu, D., Yang, P.-L., Gao, M., Yu, T., Shi, Y., Zhang, M., Yao, M., Liu, Y., & Zhang, X. (2019) · Clinical science · doi:10.1042/cs20180600 · Cited by 180 · see citing works

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Fleshner, M., Frank, M., & Maier, S. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.125 · Cited by 216 · see citing works

The role of the PI3K/AKT signalling pathway in the corneal epithelium: recent updates

Chen, K., Li, Y., Zhang, X., Ullah, R., Tong, J., & Shen, Y. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04963-x · Cited by 214 · see citing works

Origin and Consequences of Necroinflammation

Sarhan, M., Land, W. G., Tonnus, W., Hugo, C., & Linkermann, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00041.2016 · Cited by 210 · see citing works

NLRP3 inflammasome pathways in atherosclerosis

Baldrighi, M., Mallat, Z., & Li, X. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.10.027 · Cited by 202 · see citing works

Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming

Elliott, E. I., Miller, A. N., Banoth, B., Iyer, S. S., Stotland, A. B., Weiss, J. P., Gottlieb, R. A., Sutterwala, F. S., & Cassel, S. L. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701723 · Cited by 198 · see citing works

Mitochondrial dysfunction as a trigger of innate immune responses and inflammation

West, A. P. (2017) · Toxicology · doi:10.1016/j.tox.2017.07.016 · Cited by 199 · see citing works

The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease

Mukherjee, T., Kumar, N., Chawla, M., Philpott, D. J., & Basak, S. (2024) · Science Signaling · doi:10.1126/scisignal.adh1641 · Cited by 204 · see citing works

The role of lysosomal cysteine cathepsins in NLRP3 inflammasome activation

Campden, R. I., & Zhang, Y. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.02.015 · Cited by 203 · see citing works

Immune Factors in Deep Vein Thrombosis Initiation

Budnik, I., & Brill, A. G. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.04.010 · Cited by 196 · see citing works

Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation

Mai, C.-T., Wu, M., Wang, C., Su, Z., Cheng, Y., & Zhang, X. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.10.015 · Cited by 194 · see citing works

Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles

Wang, X., Eagen, W. J., & Lee, J. C. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1915829117 · Cited by 189 · see citing works

Molecular mechanisms of inflammasome signaling

Mathur, A., Hayward, J. A., & Man, S. M. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3mr0617-250r · Cited by 189 · see citing works

Role of inflammatory signaling in atrial fibrillation

Scott, L., Li, N., & Dobrev, D. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.10.020 · Cited by 188 · see citing works

Expanding perspectives on the significance of mitophagy in cancer

Drake, L. E., Springer, M. Z., Poole, L. P., Kim, C., & Macleod, K. F. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.04.008 · Cited by 190 · see citing works

A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications

Yu, Z.-W., Zhang, J., Li, X., Wang, Y., Fu, Y., & Gao, X. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117138 · Cited by 181 · see citing works

25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

Jang, J., Park, S., Hur, H., Cho, H., Hwang, I., Kang, Y. P., Im, I., Lee, H., Lee, E., Yang, W., et al. (2016) · Nature Communications · doi:10.1038/ncomms13129 · Cited by 171 · see citing works

Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19

Shah, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01021 · Cited by 167 · see citing works

A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection

Liu, X., & Lieberman, J. (2017) · Advances in immunology · doi:10.1016/bs.ai.2017.02.002 · Cited by 164 · see citing works

Transplantation and Damage-Associated Molecular Patterns (DAMPs)

Land, W. G., Agostinis, P., Gasser, S., Garg, A. D., & Linkermann, A. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13963 · Cited by 166 · see citing works

Deoxycholic acid disrupts the intestinal mucosal barrier and promotes intestinal tumorigenesis

Liu, L., Dong, W., Wang, S., Zhang, Y., Liu, T., Xie, R., Wang, B., & Cao, H. (2018) · Food & Function · doi:10.1039/c8fo01143e · Cited by 162 · see citing works

Dihydrolipoic Acid–Gold Nanoclusters Regulate Microglial Polarization and Have the Potential To Alter Neurogenesis

Xiao, L., Wei, F., Zhou, Y., Anderson, G. J., Frazer, D. M., Lim, Y. C., Liu, T., & Xiao, Y. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b04216 · Cited by 160 · see citing works

NF-κB: a double-edged sword controlling inflammation

Liu, D., Zhong, Z., & Karin, M. (2022) · Biomedicines · doi:10.3390/biomedicines10061250 · Cited by 157 · see citing works

Crosstalks between inflammasome and autophagy in cancer

Chung, C., Seo, W., Silwal, P., & Jo, E. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00936-9 · Cited by 149 · see citing works

NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias

Scott, L., Fender, A. C., Saljic, A., Li, L., Chen, X., Wang, X., Linz, D., Lang, J., Hohl, M., Twomey, D. J., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab024 · Cited by 154 · see citing works

Role of NLRP3 in the pathogenesis and treatment of gout arthritis

Liu, Y., Wang, J., & Li, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1137822 · Cited by 147 · see citing works

Diet in Parkinson’s Disease: Critical Role for the Microbiome

Jackson, A., Forsyth, C. B., Shaikh, M., Voigt, R. M., Engen, P. A., Ramirez, V., & Keshavarzian, A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01245 · Cited by 145 · see citing works

NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders

Ramachandran, R., Manan, A., Kim, J., & Choi, S. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01261-8 · Cited by 142 · see citing works

Neuroprotective effect of glycosides in Buyang Huanwu Decoction on pyroptosis following cerebral ischemia-reperfusion injury in rats

She, Y., Shao, L., Zhang, Y., Hao, Y., Cai, Y., Cheng, Z., Deng, C.-Q., & Liu, X. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112051 · Cited by 140 · see citing works

Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression

Zhong, F., Liang, S., & Zhong, Z. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.10.008 · Cited by 133 · see citing works

Inflammasome biology, molecular pathology and therapeutic implications

Awad, F., Assrawi, E., Louvrier, C., Jumeau, C., Georgin‐Lavialle, S., Grateau, G., Amselem, S., Giurgea, I., & Karabina, S. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.02.011 · Cited by 134 · see citing works

The NLRP6 inflammasome in health and disease

Ghimire, L., Paudel, S., Jin, L., & Jeyaseelan, S. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0256-z · Cited by 134 · see citing works

Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release

Pan, J., Ou, Z., Cai, C., Li, P., Gong, J., Ruan, X. Z., & He, K. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.08.006 · Cited by 132 · see citing works

Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression

Du, R., Tan, J., Sun, X., Lu, M., Ding, J., & Hu, G. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw037 · Cited by 128 · see citing works

Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome

Wang, Z., Xu, G., Gao, Y., Zhan, X., Qin, N., Fu, S., Li, R., Niu, M., Wang, J., Liu, Y., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.02.003 · Cited by 129 · see citing works

Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1 β Production

Tőzsér, J., & Benkő, S. (2016) · Mediators of Inflammation · doi:10.1155/2016/5460302 · Cited by 129 · see citing works

The gasdermin family: emerging therapeutic targets in diseases

Zhu, C., Xu, S., Jiang, R., Yu, Y., Bian, J., & Zou, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01801-8 · Cited by 139 · see citing works

Mycobacterial EST12 activates a RACK1–NLRP3–gasdermin D pyroptosis–IL-1β immune pathway

Qu, Z., Zhou, J., Zhou, Y., Xie, Y., Jiang, Y., Wu, J., Luo, Z., Liu, G., Yin, L., & Zhang, X. (2020) · Science Advances · doi:10.1126/sciadv.aba4733 · Cited by 126 · see citing works

Relevance of the NLRP3 Inflammasome in the Pathogenesis of Chronic Liver Disease

Wu, X., Dong, L., Lin, X., & Li, J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01728 · Cited by 122 · see citing works

Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration

Liao, Z., Liu, H., Ma, L., Lei, J., Tong, B., Li, G., Ke, W., Wang, K., Feng, X., Hua, W., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c04514 · Cited by 124 · see citing works

Pyroptosis-Induced Inflammation and Tissue Damage

Wei, Y., Yang, L., Pandeya, A., Cui, J., Zhang, Y., & Li, Z. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167301 · Cited by 127 · see citing works

The NLRP6 inflammasome

Zheng, D., Kern, L., & Elinav, E. (2020) · Immunology · doi:10.1111/imm.13293 · Cited by 120 · see citing works

SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway

Campbell, G. R., To, R. K., Hanna, J., & Spector, S. A. (2021) · iScience · doi:10.1016/j.isci.2021.102295 · Cited by 120 · see citing works

Deletion of Nlrp3 Augments Survival during Polymicrobial Sepsis by Decreasing Autophagy and Enhancing Phagocytosis

Jin, L., Batra, S., & Jeyaseelan, S. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601745 · Cited by 118 · see citing works

Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation

Lordén, G., Sanjuán-García, I., de Pablo, N., Meana, C., Álvarez‐Miguel, I., Pérez-García, M. T., Pelegrı́n, P., Balsinde, J., & Balboa, M. A. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20161452 · Cited by 117 · see citing works

Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium

Sharkey, K. A., Beck, P. L., & McKay, D. M. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0051-4 · Cited by 116 · see citing works

Cell pyroptosis in health and inflammatory diseases

Wu, Y., Zhang, J., Yu, S., Li, Y., Zhu, J., Zhang, K., & Zhang, R. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00998-3 · Cited by 117 · see citing works

Targeting NLRP3 Inflammasome Activation in Severe Asthma

Theofani, E., Semitekolou, M., Morianos, I., Samitas, Κ., & Xanthou, G. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101615 · Cited by 118 · see citing works

Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): Relevant signaling pathways and therapeutic strategies

Jin, J., Duan, J., Du, L., Xing, W., Peng, X., & Zhao, Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1027756 · Cited by 115 · see citing works

Piezo1 activates the NLRP3 inflammasome in nucleus pulposus cell-mediated by Ca2+/NF-κB pathway

Sun, Y., Leng, P., Song, M., Li, D., Guo, P., Xu, X., Gao, H., Li, Z., Li, C., & Zhang, H. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106681 · Cited by 113 · see citing works

Inhibiting NLRP3 inflammasome activation prevents copper-induced neuropathology in a murine model of Wilson’s disease

Dong, J., Wang, X., Xu, C., Gao, M., Wang, S., Zhang, J. C., Tong, H., Wang, L., Han, Y., Cheng, N., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03397-1 · Cited by 113 · see citing works

Silybin inhibits NLRP3 inflammasome assembly through the NAD + /SIRT2 pathway in mice with nonalcoholic fatty liver disease

Zhang, B., Xu, D., She, L., Wang, Z., Yang, N., Sun, R., Zhang, Y., Yan, C., Wei, Q., Aa, J., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700602r · Cited by 112 · see citing works

Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice

Shao, S., Xu, C.-B., Chen, C.-J., Shi, G.-N., Guo, Q.-L., Zhou, Y., Wei, Y.-Z., Wu, L., Shi, J.-G., & Zhang, T.-T. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02178-z · Cited by 112 · see citing works

ROS-induced NLRP3 inflammasome priming and activation mediate PCB 118- induced pyroptosis in endothelial cells

Long, Y., Liu, X., Tan, X., Jiang, C., Chen, S.-W., Liang, G.-N., He, X., Wu, J., Chen, T., & Xu, Y. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.109937 · Cited by 111 · see citing works

ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia

Ye, X., Zuo, D., Lu, Y., Zhang, L., Tang, J., Cui, C., Bao, L., Zan, K., Zhang, Z., Yang, X., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.02.019 · Cited by 110 · see citing works

TRPM2 dependence of ROS-induced NLRP3 activation in Alzheimer's disease

Aminzadeh, M., Roghani, M., Sarfallah, A., & Riazi, G. H. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.10.024 · Cited by 109 · see citing works

The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E–mediated pyroptosis

Li, J.-Y., Wang, Y.-Y., Shao, T., Fan, D., Lin, A., Xiang, L., & Shao, J.-Z. (2020) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)49920-0 · Cited by 109 · see citing works

NLRP3 Gene Deletion Attenuates Angiotensin II-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Vascular Remodeling

Ren, X., Tong, Y., Ling, L., Chen, D., Sun, H., Zhou, H., Qi, X., Chen, Q., Li, Y., Kang, Y., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000486061 · Cited by 107 · see citing works

Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases

Han, Y., Liu, X., Jin, M., Sun, H., & Kwon, T. (2023) · Inflammation Research · doi:10.1007/s00011-023-01790-4 · Cited by 109 · see citing works

Regulation of NLRP3 inflammasome activation by mitochondria

Elliott, E. I., Colgan, J. D., Grumbach, I. M., Strack, S., Cassel, S. L., Weiss, J. P., & Sutterwala, F. S. (2018) · doi:10.17077/etd.sjblxfjh · Cited by 1 · see citing works

Ambiguities in NLRP3 inflammasome regulation: Is there a role for mitochondria?

Lawlor, K. E., & Vince, J. E. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.08.014 · Cited by 122 · see citing works

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works

The role of mitochondria in NLRP3 inflammasome activation

Liu, Q., Zhang, D., Hu, D., Zhou, X., & Zhou, Y. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.09.010 · Cited by 475 · see citing works

Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming

Elliott, E. I., Miller, A. N., Banoth, B., Iyer, S. S., Stotland, A. B., Weiss, J. P., Gottlieb, R. A., Sutterwala, F. S., & Cassel, S. L. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701723 · Cited by 198 · see citing works