The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Eosinophil Granule Proteins: Form and Function
Open accessAbstract
Experimental and clinical data strongly support a role for the eosinophil in the pathogenesis of asthma, allergic and parasitic diseases, and hypereosinophilic syndromes, in addition to more recently identified immunomodulatory roles in shaping innate host defense, adaptive immunity, tissue repair/remodeling, and maintenance of normal tissue homeostasis. A seminal finding was the dependence of allergic airway inflammation on eosinophil-induced recruitment of Th2-polarized effector T-cells to the lung, providing a missing link between these innate immune effectors (eosinophils) and adaptive T-cell responses. Eosinophils come equipped with preformed enzymatic and nonenzymatic cationic proteins, stored in and selectively secreted from their large secondary (specific) granules. These proteins contribute to the functions of the eosinophil in airway inflammation, tissue damage, and remodeling in the asthmatic diathesis. Studies using eosinophil-deficient mouse models, including eosinophil-derived granule protein double knock-out mice (major basic protein-1/eosinophil peroxidase dual gene deletion) show that eosinophils are required for all major hallmarks of asthma pathophysiology: airway epithelial damage and hyperreactivity, and airway remodeling including smooth muscle hyperplasia and subepithelial fibrosis. Here we review key molecular aspects of these eosinophil-derived granule proteins in terms of structure-function relationships to advance understanding of their roles in eosinophil cell biology, molecular biology, and immunobiology in health and disease.
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Cites
Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia
Nair, P., Pizzichini, M. M. M., Kjarsgaard, M., Inman, M. D., Efthimiadis, A., Pizzichini, E., Hargreave, F. E., & O'Byrne, P. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805435 · Cited by 1,356
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Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense
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A Critical Role for Eosinophils in Allergic Airways Remodeling
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Eosinophils: Biological Properties and Role in Health and Disease
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Self-citationTreatment of Patients with the Hypereosinophilic Syndrome with Mepolizumab
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The Biology of the Eosinophilic Leukocyte
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Action of Antimicrobial Peptides against Bacterial Biofilms
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Eosinophils in Health and Disease: A State-of-the-Art Review
Wechsler, M. E., Munitz, A., Ackerman, S. J., Drake, M. G., Jackson, D. J., Wardlaw, A. J., Dougan, S. K., Berdnikovs, S., Schleich, F., Matucci, A., et al. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2021.04.025 · Cited by 312
Self-citationThe Role of Iron Regulation in Immunometabolism and Immune-Related Disease
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Metadata
- Authors
- Acharya, K. R., & Ackerman, S. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 289
- Issue
- 25
- Pages
- 17406-17415
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2049426078
- Cited by
- 526
- References
- 80
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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