The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses
Open accessAbstract
Eosinophil-derived neurotoxin (EDN) is an eosinophil granule–derived secretory protein with ribonuclease and antiviral activity. We have previously shown that EDN can induce the migration and maturation of dendritic cells (DCs). Here, we report that EDN can activate myeloid DCs by triggering the Toll-like receptor (TLR)2–myeloid differentiation factor 88 signaling pathway, thus establishing EDN as an endogenous ligand of TLR2. EDN activates TLR2 independently of TLR1 or TLR6. When mice were immunized with ovalbumin (OVA) together with EDN or with EDN-treated OVA-loaded DCs, EDN enhanced OVA-specific T helper (Th)2-biased immune responses as indicated by predominant production of OVA-specific interleukin (IL)-5, IL-6, IL-10, and IL-13, as well as higher levels of immunoglobulin (Ig)G1 than IgG2a. Based on its ability to serve as a chemoattractant and activator of DCs, as well as the capacity to enhance antigen-specific immune responses, we consider EDN to have the properties of an endogenous alarmin that alerts the adaptive immune system for preferential enhancement of antigen-specific Th2 immune responses.
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Cites
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Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
Termeer, C., Benedix, F., Sleeman, J., Fieber, C., Voith, U., Ahrens, T., Miyake, K., Freudenberg, M., Galanos, C., & Simon, J. C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20001858 · Cited by 1,378
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Self-citationHyaluronan Fragments Stimulate Endothelial Recognition of Injury through TLR4
Taylor, K. R., Trowbridge, J. M., Rudisill, J. A., Termeer, C. C., Simon, J. C., & Gallo, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310859200 · Cited by 545
Heat Shock Proteins as Endogenous Adjuvants in Sterile and Septic Inflammation
Quintana, F. J., & Cohen, I. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.2777 · Cited by 219
Cited by
Eosinophils: changing perspectives in health and disease
Rosenberg, H. F., Dyer, K. D., & Foster, P. S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3341 · Cited by 989
Self-citationHow are TH2-type immune responses initiated and amplified?
Paul, W. E., & Zhu, J. (2010) · Nature Reviews Immunology · doi:10.1038/nri2735 · Cited by 963
Kedmi, R., Ben-Arie, N., & Peer, D. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.027 · Cited by 546
Eosinophil Granule Proteins: Form and Function
Acharya, K. R., & Ackerman, S. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.546218 · Cited by 526
Pathophysiology of Eosinophilic Esophagitis
O’Shea, K. M., Aceves, S. S., Dellon, E. S., Gupta, S. K., Spergel, J. M., Furuta, G. T., & Rothenberg, M. E. (2018) · Gastroenterology · doi:10.1053/j.gastro.2017.06.065 · Cited by 502
Metadata
- Authors
- Yang, D., Chen, Q., Su, S. B., Zhang, P., Kurosaka, K., Caspi, R. R., Michalek, S. M., Rosenberg, H. F., Zhang, N., & Oppenheim, J. J.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-01-14
- Volume
- 205
- Issue
- 1
- Pages
- 79-90
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2171373028
- Cited by
- 352
- References
- 7
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, D., Chen, Q., Su, S. B., Zhang, P., Kurosaka, K., Caspi, R. R., Michalek, S. M., Rosenberg, H. F., Zhang, N., & Oppenheim, J. J. (2008). Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20062027
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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