The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Transcriptional Regulation of Adipocyte Differentiation: A Central Role for CCAAT/Enhancer-binding Protein (C/EBP) β
Open accessAbstract
A detailed understanding of the processes controlling adipogenesis is instrumental in the fight against the obesity epidemic. Adipogenesis is controlled by a transcriptional cascade composed of a large number of transcriptional factors, among which CCAAT/enhancer-binding protein (C/EBP) β plays an essential role. During 3T3-L1 adipocyte differentiation, C/EBPβ is induced early to transactivate the expression of C/EBPα and peroxisome proliferator-activated receptor γ (PPARγ), two master transcription factors for terminal adipocyte differentiation. Studies in recent years have revealed many new target genes of C/EBPβ, implicating its participation in many other processes during adipogenesis, such as mitotic clonal expansion, epigenetic regulation, unfolded protein response, and autophagy. Moreover, the function of C/EBPβ is highly regulated by post-translational modifications, which are crucial for the proper activation of the adipogenic program. Advances toward elucidation of the function and roles of the post-translational modification of C/EBPβ during adipogenesis will greatly improve our understanding of the molecular mechanisms governing adipogenesis.
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BackgroundTranscriptional control of adipocyte formation
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Metadata
- Authors
- Guo, L., Li, X., & Tang, Q.-Q.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 290
- Issue
- 2
- Pages
- 755-761
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2067913177
- Cited by
- 353
- References
- 69
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Guo, L., Li, X., & Tang, Q.-Q. (2015). Transcriptional Regulation of Adipocyte Differentiation: A Central Role for CCAAT/Enhancer-binding Protein (C/EBP) β. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.r114.619957
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