Activating transcription factor 3, glucolipid metabolism, and metabolic diseases
Open accessAbstract
Lipids and glucose exert many essential physiological functions, such as providing raw materials or energy for cellular biosynthesis, regulating cell signal transduction, and maintaining a constant body temperature. Dysregulation of lipid and glucose metabolism can lead to glucolipid metabolic disorders linked to various metabolic diseases, such as obesity, diabetes, and cardiovascular disease. Therefore, intervention in glucolipid metabolism is a key therapeutic strategy for the treatment of metabolic diseases. Activating transcription factor 3 (ATF3) is a transcription factor that acts as a hub of the cellular adaptive-response network and plays a pivotal role in the regulation of inflammation, apoptosis, DNA repair, and oncogenesis. Emerging evidence has illustrated the vital roles of ATF3 in glucolipid metabolism. ATF3 inhibits intestinal lipid absorption, enhances hepatic triglyceride hydrolysis and fatty acid oxidation, promotes macrophage reverse cholesterol transport, and attenuates the progression of western diet-induced nonalcoholic fatty liver disease and atherosclerosis. In addition to its role in lipid metabolism, ATF3 has also been identified as an important regulator of glucose metabolism. Here, we summarize the recent advances in the understanding of ATF3, mainly focusing on its role in glucose and lipid metabolism and potential therapeutic implications.
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ATF3 is an important regulator of glucose and lipid metabolism in various tissues.
“The literature data suggest that ATF3 also is an important regulator of glucose and lipid metabolism in various tissues [43].”
From 20-Hydroxyecdysone Boosts Energy Production and Biosynthetic Processes in Non-Transformed Mouse Cells (2024) · cites this paper as [43]
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- Authors
- Hu, S., Zhao, X., Li, R., Hu, C., Wu, H., Li, J., Zhang, Y., & Xu, Y.
- Affiliations
- Northeast Ohio Medical University (US)
- Shanghai Medical College of Fudan University (CN)
- Capital Medical University (CN)
- Corresponding author
- Hu, Shuwei
- Zhang, Yanqiao
- Xu, Yanyong
- Venue
- Journal of Molecular Cell Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-10
- Volume
- 14
- Issue
- 10
- ISSN
- 1674-2788 (ISSN-L)
- 1759-4685
- PMC
- PMC10076183
- OpenAlex
- W4310780158
- Cited by
- 33
- References
- 75
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 10 · 2023: 3
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Molecular Cell Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (32271218, 81670519)
- Science and Technology Commission of Shanghai Municipality (22ZR1414300)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- ATF3, glucolipid metabolism, glucose metabolism, lipid metabolism, metabolic disorders, obesity, diabetes mellitus, cardiovascular disease, intestinal lipid absorption, fatty acid oxidation, reverse cholesterol transport, macrophages, non-alcoholic fatty liver disease, atherosclerosis, Western diet, transcriptional regulation
- MeSH terms
- Glucose, Humans, Lipids, Liver, Metabolic Diseases, Lipid Metabolism, Activating Transcription Factor 3
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