The DOI matches its Crossref record; 75 of the 76 references it cites were found in a registry or an index.
Receptors, Ion Channels, and Signaling Mechanisms Underlying Microglial Dynamics
Open accessAbstract
Microglia, the innate immune cells of the CNS, play a pivotal role in brain injury and disease. Microglia are extremely motile; their highly ramified processes constantly survey the brain parenchyma, and they respond promptly to brain damage with targeted process movement toward the injury site. Microglia play a key role in brain development and function by pruning synapses during development, phagocytosing apoptotic newborn neurons, and regulating neuronal activity by direct microglia-neuron or indirect microglia-astrocyte-neuron interactions, which all depend on their process motility. This review highlights recent discoveries about microglial dynamics, focusing on the receptors, ion channels, and signaling pathways involved.
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“In contrast, stMg are enriched in mRNAs encoding mature microglia-specific homeostatic surveillance proteins14,15, including those that mediate G-protein-coupled chemosensing, chemotaxis, GTP signaling, and actin polymerization20 (Fig. 1d,e, Supplementary Fig. 5a,b, Supplementary Table 3).”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [20]
Citations
Cites
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · cited 9×
“Increases in neuronal activity evoked by glutamate (or analogues like NMDA, AMPA, or kainate), or by blocking GABAergic inhibition, led to microglial process extension and enhanced baseline motility, whereas block of AMPA receptors had the opposite effect (5, 37, 50, 75).”
BackgroundResultInfluentialFate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · cited 1×
“Microglia are brain-resident macrophages, but originate from primitive macrophages in the yolk sac during embryogenesis (2).”
BackgroundZhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · cited 1×
“ATP signaling is diversified by enzymatic hydrolysis; the microglia-specific membrane-bound ectonucleotidase NTPDase1 (CD39), or the pyrophosphatase NPP1 (expressed on microglia but also on oligodendrocyte lineage cells (36)), converts ATP and ADP into AMP, which is then degraded into adenosine by ecto-5 -nucleotidase…”
BackgroundSynaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244 · cited 2×
“Fractalkine receptor deficiency leads to a transient reduction of microglial number during early postnatal development (12, 13), microglia-mediated neurotoxicity (65– 67), and impaired phagocytosis of apoptotic newborn neurons, thus causing reduced neurogenesis and deficits in synaptic pruning associated with weaker s…”
BackgroundMicroglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
ATP mediates rapid microglial response to local brain injury in vivo
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“3), where they converge in less than 30 min to form a spherical shield preventing further spread of the affected area (4, 5, 19, 21).”
BackgroundInfluentialHeterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045
Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis
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“This is essential for regulating the number of neurons in the adult brain; progenitor cells produce neurons in excess, only a fraction of which mature and become integrated into neuronal circuits (14, 15).”
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“In a more extreme model of visual deprivation (binocular eye enucleation), microglia in the visual cortex had shorter processes that made less frequent contacts with synapses (8), unlike the findings of Tremblay et al.”
BackgroundResult
Cited by
Sorted by citations
Inflammation as a central mechanism in Alzheimer's disease
Kinney, J. W., Bemiller, S. M., Murtishaw, A. S., Leisgang, A. M., Salazar, A. M., & Lamb, B. T. (2018) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.06.014 · Cited by 2,253
“Overall surveillance of the surrounding neuronal environment is accomplished via a large number of signaling mechanisms [99,102].”
BackgroundAmyloid β-based therapy for Alzheimer’s disease: Challenges, successes and future
Zhang, Y., Chen, H., Li, R., Sterling, K., & Song, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01484-7 · Cited by 988
“These cells communicate with surrounding environments including neurons, astrocytes and blood vessels to maintain the development and homeostasis of the CNS.(163,164) When microglia recognize the insults of the CNS, they respond to the injury or invasion by a morphological change, resulting in cell enlargement and mig…”
BackgroundEpigenetic regulation of brain region-specific microglia clearance activity
Ayata, P., Badimon, A., Strasburger, H. J., Duff, M. K., Montgomery, S. E., Loh, Y.-H. E., Ebert, A., Pimenova, A. A., Ramirez, B. R., Chan, A. T., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0192-3 · Cited by 460
CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease
Jentsch, T. J., & Pusch, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00047.2017 · Cited by 462
GABA-Receptive Microglia Selectively Sculpt Developing Inhibitory Circuits
Favuzzi, E., Huang, S., Saldi, G.-A., Binan, L., Ibrahim, L. A., Fernández-Otero, M., Cao, Y., Zeine, A., Sefah, A., Zheng, K., et al. (2020) · Cell · doi:10.1016/j.cell.2021.06.018 · Cited by 327
“In response to various chemotactic signals, microglia are attracted to and interact with neurons and synapses (Badimon et al., 2020; Cserép et al., 2020; Madry and Attwell, 2015).”
Metadata
- Authors
- Madry, C., & Attwell, D.
- Affiliations
- University College London (GB)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 290
- Issue
- 20
- Pages
- 12443-12450
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC4432265
- OpenAlex
- W2081351019
- Cited by
- 109
- References
- 76
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 8 · 2023: 10 · 2022: 15 · 2021: 21 · 2020: 11 · 2019: 10 · 2018: 6 · 2017: 9 · 2016: 5 · 2015: 2
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (099222/Z/12/Z, 99222)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- microglia, microglial motility, microglial receptors, ion channels, signaling pathways, brain injury, synaptic pruning, microglia-neuron interaction
- MeSH terms
- Animals, Astrocytes, Brain Injuries, Cell Communication, Cell Movement, Humans, Ion Channels, Neurons, Phagocytosis, Receptors, Cell Surface, Synapses, Apoptosis, Microglia
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