Ion Channels and Receptors as Determinants of Microglial Function
Open accessAbstract
Microglia provide immune surveillance of the CNS. They display diverse behaviors, including nondirectional and directed motility of their processes, phagocytosis of targets such as dying neurons or superfluous synapses, and generation of reactive oxygen species (ROS) and cytokines. Many of these functions are mediated by ion channels and cell surface receptors, the expression of which varies with the many morphological and functional states that microglial cells can adopt. Recent progress in understanding microglial function has been facilitated by applying classical cell physiological techniques in situ, such as patch-clamping and live imaging, and cell-specific transcriptomic analyses. Here, we review the contribution of microglial ion channels and receptors to microglial and brain function.
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Microglia express major classes of neurotransmitter receptors and ion channels that critically regulate microglial physiology, which inherently controls microglial function and activation.
“Microglia express major classes of neurotransmitter receptors and ion channels that critically regulate microglial physiology, which inherently controls microglial function and activation (Domercq et al., 2013; Izquierdo et al., 2019).”
From Overexpressing low‐density lipoprotein receptor reduces tau‐associated neurodegeneration in relation to apoE‐linked mechanisms (2021) · cites this paper as Izquierdo et al., 2019
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- Authors
- Izquierdo, P., Attwell, D., & Madry, C.
- Affiliations
- University College London (GB)
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Attwell, David
- Madry, Christian
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 42
- Issue
- 4
- Pages
- 278-292
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2913073762
- Cited by
- 102
- References
- 31
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 13 · 2023: 4 · 2022: 22 · 2021: 25 · 2020: 19 · 2019: 3
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust Senior Investigator Award (099222)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- microglia, ion channels, cell surface receptors, microglial motility, phagocytosis, reactive oxygen species, cytokine production, microglial heterogeneity, patch clamp, live imaging, transcriptomics
- MeSH terms
- Animals, Brain, Humans, Ion Channels, Microglia
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