The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Control of cellular responses to mechanical cues through YAP/TAZ regulation
Open accessAbstract
To perceive their three-dimensional environment, cells and tissues must be able to sense and interpret various physical forces like shear, tensile, and compression stress. These forces can be generated both internally and externally in response to physical properties, like substrate stiffness, cell contractility, and forces generated by adjacent cells. Mechanical cues have important roles in cell fate decisions regarding proliferation, survival, and differentiation as well as the processes of tissue regeneration and wound repair. Aberrant remodeling of the extracellular space and/or defects in properly responding to mechanical cues likely contributes to various disease states, such as fibrosis, muscle diseases, and cancer. Mechanotransduction involves the sensing and translation of mechanical forces into biochemical signals, like activation of specific genes and signaling cascades that enable cells to adapt to their physical environment. The signaling pathways involved in mechanical signaling are highly complex, but numerous studies have highlighted a central role for the Hippo pathway and other signaling networks in regulating the YAP and TAZ (YAP/TAZ) proteins to mediate the effects of mechanical stimuli on cellular behavior. How mechanical cues control YAP/TAZ has been poorly understood. However, rapid progress in the last few years is beginning to reveal a surprisingly diverse set of pathways for controlling YAP/TAZ. In this review, we will focus on how mechanical perturbations are sensed through changes in the actin cytoskeleton and mechanosensors at focal adhesions, adherens junctions, and the nuclear envelope to regulate YAP/TAZ.
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“However, beyond acting as a physical barrier, ECM stiffness also triggers mechanotransduction pathways that profoundly influence tumor cell behavior [91,92]. Mechanical cues generated by a stiffened matrix are sensed through integrin-based focal adhesions and transmitted via cytoskeletal tension to activate intracellular signaling cascades, including Yes-associated protein/Transcriptional coactiv”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [95]
In the citing paper
“Similarly, the Hippo pathway has gained attention as an important pathway in mechanotransduction and skeletal physiology. Downstream YAP/TAZ regulation is in fact tightly involved in mechanosensing and mechanotransduction both in bone and muscle as well as in many other cells, especially endothelial cells (see Section 3.3).”
From Interactions between Muscle and Bone—Where Physics Meets Biology (2020) · cites this paper as [55]
Citations
Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979
Geometric Control of Cell Life and Death
Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M., & Ingber, D. E. (1997) · Science · doi:10.1126/science.276.5317.1425 · Cited by 4,710
Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment
McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K., & Chen, C. S. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00075-9 · Cited by 4,182
Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092
TEAD mediates YAP-dependent gene induction and growth control
Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498
Mechanotransduction and extracellular matrix homeostasis
Humphrey, J. D., Dufresne, E. R., & Schwartz, M. A. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3896 · Cited by 2,124
Mechanisms of Hippo pathway regulation
Meng, Z., Moroishi, T., & Guan, K.-L. (2016) · Genes & Development · doi:10.1101/gad.274027.115 · Cited by 1,667
Aragona, M., Panciera, T., Manfrin, A., Giulitti, S., Michielin, F., Elvassore, N., Dupont, S., & Piccolo, S. (2013) · Cell · doi:10.1016/j.cell.2013.07.042 · Cited by 1,651
Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
Yu, F.-X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.037 · Cited by 1,628
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Yang, J., Zhang, Y., Wang, S., Wang, P., Dong, L., Li, L., Cheng, Y., Huang, X., Xue, B., Wang, W., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63854-9 · Cited by 25
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Han, Y., Zeger, L., Tripathi, R., Egli, M., Ille, F., Lockowandt, C., Florin, G., Atic, E., Redwan, I. N., Fredriksson, R., et al. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.27858 · Cited by 23
Li, H., Sun, Y., Li, Q., Luo, Q., & Song, G. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00558 · Cited by 23
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Kamal, K. Y., & Trombetta-Lima, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062802 · Cited by 25
Kanniyappan, H., Rathnayake, R. A. C., Osamor, J., Islam, M., & Wang, R. R. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1679625 · Cited by 30
Lv, H., & Ai, D. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.09.007 · Cited by 25
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Suh, K., Cho, Y. K., Breinyn, I. B., & Cohen, D. J. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113743 · Cited by 22
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Yoo, H., Singh, A., Li, H., Strat, A. N., Bagué, T., Ganapathy, P. S., & Herberg, S. (2023) · Current Eye Research · doi:10.1080/02713683.2023.2206067 · Cited by 19
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Jimi, S., Koizumi, S., Sato, K., Miyazaki, M., & Saparov, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-98407-9 · Cited by 20
The role of YAP/TAZ on joint and arthritis
Lu, M., Zhu, M., Wu, Z., Liu, W., Cao, C., & Shi, J. (2024) · The FASEB Journal · doi:10.1096/fj.202302273rr · Cited by 23
Sutural fibroblasts exhibit the function of vascular endothelial cells upon mechanical strain
Guan, L., Liang, W., Ding, P., & Zhao, Z. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.109046 · Cited by 19
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Missirlis, D., Baños, M., Lussier, F., & Spatz, J. P. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c17901 · Cited by 19
Zhou, Y., Guo, P., Jin, Z., Chai, M., Zhang, S., Wang, X., Tan, W., & Zhou, Y. (2024) · Biotechnology Journal · doi:10.1002/biot.202300714 · Cited by 18
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Liu, Y., Pan, X., Zhang, X., Sun, J., Mao, Y., Yang, Y., & Wei, Z. (2023) · Andrology · doi:10.1111/andr.13438 · Cited by 19
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Sun, D., Ma, J., Du, L., Liu, Q., Yue, H., Peng, C., Chen, H., Wang, G., Liu, X., & Shen, Y. (2024) · APL Bioengineering · doi:10.1063/5.0174825 · Cited by 16
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Yoshimura, K., Zou, G., Fan, Y., Yamashita, K., Wang, L., Wu, J., Wang, R., Shao, S., Scott, A. W., Jin, J., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217354 · Cited by 17
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del Rosario-Gilabert, D., Valenzuela-Miralles, A., & Esquiva, G. (2024) · Biophysical Reviews · doi:10.1007/s12551-024-01242-1 · Cited by 17
Taş, S., Rehnberg, E., Bölükbas, D. A., Beech, J. P., Kazado, L. N., Svenningsson, I., Arvidsson, M., Sandberg, A., Dahlgren, K. A., Edthofer, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.02.450873 · Cited by 14
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Shen, X., Peng, X., Guo, Y., Dai, Z., Cui, L., Yu, W., Liu, Y., & Liu, C. (2023) · eLife · doi:10.7554/elife.88573 · Cited by 21
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Brandt, J. P., & Smith, C. J. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002319 · Cited by 12
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de Oliveira, N. B., Irioda, A. C., Stricker, P. E. F., Mogharbel, B. F., da Rosa, N. N., Dziedzic, D. S. M., & de Carvalho, K. A. T. (2021) · Membranes · doi:10.3390/membranes11090687 · Cited by 11
Chi, W., Hsiao, T., Lee, G., Su, I.-H., Chen, B., Tang, M., & Fu, T.-F. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04425-9 · Cited by 10
Miyoshi, H., Yamazaki, M., Fujie, H., & Kidoaki, S. (2023) · Biophysics and Physicobiology · doi:10.2142/biophysico.bppb-v20.0018 · Cited by 10
Davila, J. G. F., Singh, A. K., Moore, D. W., Kim, J., Khan, J. A., Lemma, M., King, C. S., Nathan, S. D., Rodríguez, L. R., Grant, G. M., et al. (2024) · Molecular Biology of the Cell · doi:10.1091/mbc.e23-11-0428 · Cited by 11
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Missirlis, D., Heckmann, L., Haraszti, T., & Spatz, J. P. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121646 · Cited by 10
Kim, K. W., Shin, Y. J., & Lee, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314690 · Cited by 11
Su, M., Zhan, L., Zhang, Y., & Zhang, J. (2021) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-21-258 · Cited by 10
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Martynova, N. Y., Parshina, E. A., & Zaraisky, A. G. (2021) · FEBS Journal · doi:10.1111/febs.16308 · Cited by 9
Li, H., Liu, Y., Zhang, J., Cai, M., Cao, Z., Gao, J., Xu, H., Shao, L., Sun, J., Shi, Y. P., et al. (2022) · Nanoscale · doi:10.1039/d2nr03366f · Cited by 9
Anwar, T., Sinnett‐Smith, J. W., Jin, Y., Reed, E. F., & Rozengurt, E. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200568 · Cited by 9
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Lu, Y., Mu, Y., Chen, J., Guan, X., Guo, L., & Wu, C. (2022) · Theranostics · doi:10.7150/thno.72365 · Cited by 8
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Mackey, C., Feng, Y., Liang, C., Liang, A., Tian, H., Narayan, O. P., Dong, J., Tai, Y., Hu, J., Mu, Y., et al. (2025) · Cancers · doi:10.3390/cancers17111851 · Cited by 7
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Metadata
- Authors
- Dasgupta, I., & McCollum, D.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- McCollum, Dannel
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 294
- Issue
- 46
- Pages
- 17693-17706
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC6873206
- OpenAlex
- W2980104037
- Cited by
- 360
- References
- 138
- Citations by year
- 2026: 47 · 2025: 57 · 2024: 49 · 2023: 64 · 2022: 45 · 2021: 64 · 2020: 33 · 2019: 1
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institutes of Health (RO1 GM058406)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- YAP/TAZ, mechanotransduction, Hippo signaling pathway, mechanical cues, substrate stiffness, actin cytoskeleton, focal adhesions, adherens junctions, nuclear envelope, mechanosensors, cell fate determination, tissue regeneration, fibrosis, cancer
- MeSH terms
- YAP-Signaling Proteins, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Animals, Humans, Actin Cytoskeleton, Transcription Factors, Signal Transduction, Trans-Activators, Focal Adhesions, Adherens Junctions, Mechanotransduction, Cellular, Adaptor Proteins, Signal Transducing
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