Cited by 362Hippo pathway signaling and YAP/TAZCellular Mechanics and InteractionsMicrotubule and mitosis dynamics

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Control of cellular responses to mechanical cues through YAP/TAZ regulation

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Dasgupta, Ishani, McCollum, Dannel·2019·Journal of Biological Chemistry

DOI 10.1074/jbc.rev119.007963PMC PMC6873206

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Abstract

To perceive their three-dimensional environment, cells and tissues must be able to sense and interpret various physical forces like shear, tensile, and compression stress. These forces can be generated both internally and externally in response to physical properties, like substrate stiffness, cell contractility, and forces generated by adjacent cells. Mechanical cues have important roles in cell fate decisions regarding proliferation, survival, and differentiation as well as the processes of tissue regeneration and wound repair. Aberrant remodeling of the extracellular space and/or defects in properly responding to mechanical cues likely contributes to various disease states, such as fibrosis, muscle diseases, and cancer. Mechanotransduction involves the sensing and translation of mechanical forces into biochemical signals, like activation of specific genes and signaling cascades that enable cells to adapt to their physical environment. The signaling pathways involved in mechanical signaling are highly complex, but numerous studies have highlighted a central role for the Hippo pathway and other signaling networks in regulating the YAP and TAZ (YAP/TAZ) proteins to mediate the effects of mechanical stimuli on cellular behavior. How mechanical cues control YAP/TAZ has been poorly understood. However, rapid progress in the last few years is beginning to reveal a surprisingly diverse set of pathways for controlling YAP/TAZ. In this review, we will focus on how mechanical perturbations are sensed through changes in the actin cytoskeleton and mechanosensors at focal adhesions, adherens junctions, and the nuclear envelope to regulate YAP/TAZ.

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Authors: Dasgupta, I., & McCollum, D.
Affiliations: University of Massachusetts Chan Medical School (US)
Corresponding author: McCollum, Dannel
ORCID: Dasgupta, Ishani
McCollum, Dannel
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2019-11
Volume: 294
Issue: 46
Pages: 17693-17706
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.rev119.007963
PMC: PMC6873206
OpenAlex: W2980104037
Cited by: 360
References: 138
Citations by year: 2026: 47 · 2025: 57 · 2024: 49 · 2023: 64 · 2022: 45 · 2021: 64 · 2020: 33 · 2019: 1
FWCI: 4.13
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 288 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Institutes of Health (RO1 GM058406)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: YAP/TAZ, mechanotransduction, Hippo signaling pathway, mechanical cues, substrate stiffness, actin cytoskeleton, focal adhesions, adherens junctions, nuclear envelope, mechanosensors, cell fate determination, tissue regeneration, fibrosis, cancer
MeSH terms: YAP-Signaling Proteins, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Animals, Humans, Actin Cytoskeleton, Transcription Factors, Signal Transduction, Trans-Activators, Focal Adhesions, Adherens Junctions, Mechanotransduction, Cellular, Adaptor Proteins, Signal Transducing

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Control of cellular responses to mechanical cues through YAP/TAZ regulation

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