The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Lysine Acetylation Is a Highly Abundant and Evolutionarily Conserved Modification in Escherichia Coli
Open accessAbstract
Lysine acetylation and its regulatory enzymes are known to have pivotal roles in mammalian cellular physiology. However, the extent and function of this modification in prokaryotic cells remain largely unexplored, thereby presenting a hurdle to further functional study of this modification in prokaryotic systems. Here we report the first global screening of lysine acetylation, identifying 138 modification sites in 91 proteins from Escherichia coli. None of the proteins has been previously associated with this modification. Among the identified proteins are transcriptional regulators, as well as others with diverse functions. Interestingly, more than 70% of the acetylated proteins are metabolic enzymes and translation regulators, suggesting an intimate link of this modification to energy metabolism. The new dataset suggests that lysine acetylation could be abundant in prokaryotic cells. In addition, these results also imply that functions of lysine acetylation beyond regulation of gene expression are evolutionarily conserved from bacteria to mammals. Furthermore, we demonstrate that bacterial lysine acetylation is regulated in response to stress stimuli.
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Cites
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Regulation of cellular metabolism by protein lysine acetylation
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The growing landscape of lysine acetylation links metabolism and cell signalling
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Identification of lysine succinylation as a new post-translational modification
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Self-citationSIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways
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Self-citationAcetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux
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Metadata
- Authors
- Zhang, J., Sprung, R., Pei, J., Tan, X., Kim, S., Zhu, H., Liu, C.-F., Grishin, N. V., & Zhao, Y.
- Venue
- Molecular & Cellular Proteomics
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 8
- Issue
- 2
- Pages
- 215-225
- ISSN
- 1535-9476 (ISSN-L)
- OpenAlex
- W2131233236
- Cited by
- 473
- References
- 55
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zhang, J., Sprung, R., Pei, J., Tan, X., Kim, S., Zhu, H., Liu, C.-F., Grishin, N. V., & Zhao, Y. (2009). Lysine Acetylation Is a Highly Abundant and Evolutionarily Conserved Modification in Escherichia Coli. Molecular & Cellular Proteomics. https://doi.org/10.1074/mcp.m800187-mcp200
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